{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:25:52Z","timestamp":1790875552375,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal for Parasitology"],"published-print":{"date-parts":[[2009,2]]},"DOI":"10.1016\/j.ijpara.2008.07.007","type":"journal-article","created":{"date-parts":[[2008,8,13]],"date-time":"2008-08-13T08:24:25Z","timestamp":1218615865000},"page":"315-326","source":"Crossref","is-referenced-by-count":6,"title":["Effects of SDPNFLRF-amide (PF1) on voltage-activated currents in Ascaris suum muscle"],"prefix":"10.1016","volume":"39","author":[{"given":"S.","family":"Verma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.P.","family":"Robertson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.J.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijpara.2008.07.007_bib1","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1016\/S0140-6736(06)68653-4","article-title":"Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm","volume":"367","author":"Bethony","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.ijpara.2008.07.007_bib2","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1152\/jn.1995.74.5.1880","article-title":"Nitric oxide mediates the inhibitory effects of SDPNFLRFamide, a nematode FMRFamide-related neuropeptide, in Ascaris suum","volume":"74","author":"Bowman","year":"1995","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.ijpara.2008.07.007_bib3","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1016\/S0020-7519(02)00213-8","article-title":"Structure\u2013activity relationships of an inhibitory nematode FMRFamide-related peptide, SDPNFLRFamide (PF1), on Ascaris suum muscle","volume":"32","author":"Bowman","year":"2002","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.ijpara.2008.07.007_bib4","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0169-4758(96)10052-1","article-title":"Nematode neuropeptides: localization, isolation and functions","volume":"12","author":"Brownlee","year":"1996","journal-title":"Parasitol. Today"},{"key":"10.1016\/j.ijpara.2008.07.007_bib5","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/j.1749-6632.1999.tb07894.x","article-title":"Actions of nematode FMRFamide-related peptides on the pharyngeal muscle of the parasitic nematode, Ascaris suum","volume":"897","author":"Brownlee","year":"1999","journal-title":"Ann. NY Acad. Sci."},{"key":"10.1016\/j.ijpara.2008.07.007_bib6","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.ijpara.2006.10.013","article-title":"Effects of the novel anthelmintic emodepside on the locomotion, egg-laying behaviour and development of Caenorhabditis elegans","volume":"37","author":"Bull","year":"2007","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.ijpara.2008.07.007_bib7","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1124\/pr.57.4.5","article-title":"International union of pharmacology. XLVIII. Nomenclature and structure\u2013function relationships of voltage-gated calcium channels","volume":"57","author":"Catterall","year":"2005","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.ijpara.2008.07.007_bib8","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0304-4017(01)00421-6","article-title":"The future of veterinary parasitology","volume":"98","author":"Coles","year":"2001","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.ijpara.2008.07.007_bib9","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/0196-9781(94)00211-N","article-title":"Neuropeptides isolated from the nematode Ascaris suum","volume":"16","author":"Cowden","year":"1995","journal-title":"Pepides."},{"key":"10.1016\/j.ijpara.2008.07.007_bib10","doi-asserted-by":"crossref","first-page":"3909","DOI":"10.1093\/emboj\/17.14.3909","article-title":"Vesicle exocytosis stimulated by \u03b1-latrotoxin is mediated by latrophilin and requires both external and stored Ca2+","volume":"17","author":"Davletov","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/j.ijpara.2008.07.007_bib11","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.pt.2003.10.002","article-title":"Soil-transmitted helminth infections: updating the global picture","volume":"19","author":"de Silva","year":"2003","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.ijpara.2008.07.007_bib12","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1038\/nature06529","article-title":"A modular switch for spatial Ca2+ selectivity in the calmodulin regulation of CaV channels","volume":"451","author":"Dick","year":"2008","journal-title":"Nature"},{"issue":"Pt. 2","key":"10.1016\/j.ijpara.2008.07.007_bib13","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1017\/S0031182000068335","article-title":"A nematode FMRFamide-like peptide, SDPNFLRFamide (PF1), relaxes the dorsal muscle strip preparation of Ascaris suum","volume":"108","author":"Franks","year":"1994","journal-title":"Parasitology"},{"key":"10.1016\/j.ijpara.2008.07.007_bib14","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0196-9781(92)90098-N","article-title":"Two FMRFamide-like peptides from the free-living nematode Panagrellus redivivus","volume":"13","author":"Geary","year":"1992","journal-title":"Peptides"},{"key":"10.1016\/j.ijpara.2008.07.007_bib15","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/j.1749-6632.1999.tb07893.x","article-title":"Pharmacology of FMRFamide-related peptides in helminths","volume":"897","author":"Geary","year":"1999","journal-title":"Ann. NY Acad. Sci."},{"key":"10.1016\/j.ijpara.2008.07.007_bib16","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.tips.2004.12.006","article-title":"Neuropeptide G-protein-coupled receptors, their cognate ligands and behavior in Caenorhabditis elegans","volume":"26","author":"Geary","year":"2005","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.ijpara.2008.07.007_bib17","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1128\/CMR.13.2.207-222.2000","article-title":"Drug resistance in human helminths: current situation and lessons from livestock","volume":"13","author":"Geerts","year":"2000","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.ijpara.2008.07.007_bib18","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/j.ijpara.2007.05.006","article-title":"The calcium-activated potassium channel, SLO-1, is required for the action of the novel cyclo-octadepsipeptide anthelmintic, emodepside, in Caenorhabditis elegans","volume":"37","author":"Guest","year":"2007","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.ijpara.2008.07.007_bib19","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S0924-8579(03)00219-X","article-title":"Cyclooctadepsipeptides \u2013 an anthelmintically active class of compounds exhibiting a novel mode of action","volume":"22","author":"Harder","year":"2003","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.ijpara.2008.07.007_bib20","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1056\/NEJMra064142","article-title":"Control of neglected tropical diseases","volume":"357","author":"Hotez","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijpara.2008.07.007_bib21","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.bbrc.2005.07.044","article-title":"Discovering neuropeptides in Caenorhabditis elegans by two dimensional liquid chromatography and mass spectrometry","volume":"335","author":"Husson","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ijpara.2008.07.007_bib22","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1242\/jeb.203.5.841","article-title":"The molecular biology of invertebrate voltage-gated Ca2+ channels","volume":"203","author":"Jeziorski","year":"2000","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.ijpara.2008.07.007_bib23","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1083\/jcb.200203055","article-title":"The L-type voltage-dependent Ca2+ channel EGL-19 controls body wall muscle function in Caenorhabditis elegans","volume":"159","author":"Jospin","year":"2002","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ijpara.2008.07.007_bib24","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.pt.2004.08.001","article-title":"Drug resistance in nematodes of veterinary importance: a status report","volume":"20","author":"Kaplan","year":"2004","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.ijpara.2008.07.007_bib25","doi-asserted-by":"crossref","first-page":"6066","DOI":"10.1093\/emboj\/16.20.6066","article-title":"Mutations in the alpha1 subunit of an L-type voltage-activated Ca2+ channel cause myotonia in Caenorhabditis elegans","volume":"16","author":"Lee","year":"1997","journal-title":"Embo J."},{"issue":"Suppl.","key":"10.1016\/j.ijpara.2008.07.007_bib26","first-page":"S109","article-title":"The ever-expanding neuropeptide gene families in the nematode Caenorhabditis elegans","volume":"131","author":"Li","year":"2005","journal-title":"Parasitology"},{"key":"10.1016\/j.ijpara.2008.07.007_bib27","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1242\/jeb.173.1.75","article-title":"Voltage-activated currents in somatic muscle of the nematode parasite Ascaris suum","volume":"173","author":"Martin","year":"1992","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.ijpara.2008.07.007_bib28","doi-asserted-by":"crossref","first-page":"6537","DOI":"10.1523\/JNEUROSCI.23-16-06537.2003","article-title":"Critical residues of the Caenorhabditis elegans unc-2 voltage-gated calcium channel that affect behavioral and physiological properties","volume":"23","author":"Mathews","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ijpara.2008.07.007_bib29","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/BF02211027","article-title":"Inhibitory effects of nematode FMRFamide-related peptides (FaRPs) on muscle strips from Ascaris suum","volume":"1","author":"Maule","year":"1995","journal-title":"Invert. Neurosci."},{"key":"10.1016\/j.ijpara.2008.07.007_bib30","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.ijpara.2005.05.010","article-title":"Analysis of FMRFamide-like peptide (FLP) diversity in phylum Nematoda","volume":"35","author":"McVeigh","year":"2005","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.ijpara.2008.07.007_bib31","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.pt.2006.06.010","article-title":"The FLP-side of nematodes","volume":"22","author":"McVeigh","year":"2006","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.ijpara.2008.07.007_bib32","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1016\/S0140-6736(07)60942-8","article-title":"Prevalence and intensity of Onchocerca volvulus infection and efficacy of ivermectin in endemic communities in Ghana: a two-phase epidemiological study","volume":"369","author":"Osei-Atweneboana","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.ijpara.2008.07.007_bib33","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1523\/JNEUROSCI.12-06-02356.1992","article-title":"Alternatively spliced transcripts of the flp-1 gene encode distinct FMRFamide-like peptides in Caenorhabditis elegans","volume":"12","author":"Rosoff","year":"1992","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ijpara.2008.07.007_bib34","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1096\/fj.00-0664fje","article-title":"Latrophilin-like receptor from the parasitic nematode Haemonchus contortus as target for the anthelmintic depsipeptide PF1022A","volume":"15","author":"Saeger","year":"2001","journal-title":"FASEB J."},{"key":"10.1016\/j.ijpara.2008.07.007_bib35","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/375073a0","article-title":"A calcium-channel homologue required for adaptation to dopamine and serotonin in Caenorhabditis elegans","volume":"375","author":"Schafer","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.ijpara.2008.07.007_bib36","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1242\/jeb.01615","article-title":"CCA-1, EGL-19 and EXP-2 currents shape action potentials in the Caenorhabditis elegans pharynx","volume":"208","author":"Shtonda","year":"2005","journal-title":"J. Exp. Biol."},{"issue":"Suppl.","key":"10.1016\/j.ijpara.2008.07.007_bib37","doi-asserted-by":"crossref","first-page":"S107","DOI":"10.1017\/S0031182000073339","article-title":"Neuropeptides in the nematode Ascaris suum","volume":"102","author":"Stretton","year":"1991","journal-title":"Parasitology"},{"key":"10.1016\/j.ijpara.2008.07.007_bib38","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1124\/pr.58.4.11","article-title":"Direct G protein modulation of Cav2 calcium channels","volume":"58","author":"Tedford","year":"2006","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.ijpara.2008.07.007_bib39","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1113\/expphysiol.1987.sp003053","article-title":"A high-conductance calcium-dependent chloride channel in Ascaris suum muscle","volume":"72","author":"Thorn","year":"1987","journal-title":"Q. J. Exp. Physiol."},{"key":"10.1016\/j.ijpara.2008.07.007_bib40","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.molbiopara.2004.10.001","article-title":"Brief application of AF2 produces long lasting potentiation of nAChR responses in Ascaris suum","volume":"139","author":"Trailovic","year":"2005","journal-title":"Mol. Biochem. Parasitol."},{"issue":"Pt 2","key":"10.1016\/j.ijpara.2008.07.007_bib41","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1017\/S0031182097001224","article-title":"The effects of the peptides AF3 (AVPGVLRFamide) and AF4 (GDVPGVLRFamide) on the somatic muscle of the parasitic nematodes Ascaris suum and Ascaridia galli","volume":"115","author":"Trim","year":"1997","journal-title":"Parasitology"},{"key":"10.1016\/j.ijpara.2008.07.007_bib42","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1038\/sj.bjp.0707296","article-title":"The nematode neuropeptide, AF2 (KHEYLRF-NH2), increases voltage-activated calcium currents in Ascaris suum muscle","volume":"151","author":"Verma","year":"2007","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ijpara.2008.07.007_bib43","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1017\/S0031182004006523","article-title":"Efficacy of two cyclooctadepsipeptides, PF1022A and emodepside, against anthelmintic-resistant nematodes in sheep and cattle","volume":"130","author":"von Samson-Himmelstjerna","year":"2005","journal-title":"Parasitology"},{"key":"10.1016\/j.ijpara.2008.07.007_bib44","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/BF03543237","article-title":"Physiological and pharmacological studies on nematodes","volume":"51","author":"Walker","year":"2000","journal-title":"Acta Biol. Hung."},{"key":"10.1016\/j.ijpara.2008.07.007_bib45","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1017\/S0031182002002639","article-title":"The effect of the anthelmintic emodepside at the neuromuscular junction of the parasitic nematode Ascaris suum","volume":"126","author":"Willson","year":"2003","journal-title":"Parasitology"},{"key":"10.1016\/j.ijpara.2008.07.007_bib46","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/j.cub.2004.07.056","article-title":"Latrotoxin receptor signaling engages the UNC-13-dependent vesicle-priming pathway in C. elegans","volume":"14","author":"Willson","year":"2004","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ijpara.2008.07.007_bib47","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.pt.2004.07.010","article-title":"Drug resistance in veterinary helminths","volume":"20","author":"Wolstenholme","year":"2004","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.ijpara.2008.07.007_bib48","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1002\/cne.20587","article-title":"Mass spectrometric map of neuropeptide expression in Ascaris suum","volume":"488","author":"Yew","year":"2005","journal-title":"J. Comp. Neurol."}],"container-title":["International Journal for Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020751908002786?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020751908002786?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T20:30:33Z","timestamp":1631651433000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0020751908002786"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":48,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["S0020751908002786"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpara.2008.07.007","relation":{},"ISSN":["0020-7519"],"issn-type":[{"value":"0020-7519","type":"print"}],"subject":[],"published":{"date-parts":[[2009,2]]}}}