{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:31:30Z","timestamp":1791174690542,"version":"4.1.0"},"reference-count":53,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal for Parasitology"],"published-print":{"date-parts":[[2009,3]]},"DOI":"10.1016\/j.ijpara.2008.08.007","type":"journal-article","created":{"date-parts":[[2008,9,20]],"date-time":"2008-09-20T04:21:00Z","timestamp":1221884460000},"page":"457-464","source":"Crossref","is-referenced-by-count":119,"title":["Schistosoma mansoni infection reduces severity of collagen-induced arthritis via down-regulation of pro-inflammatory mediators"],"prefix":"10.1016","volume":"39","author":[{"given":"Yoshio","family":"Osada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoichi","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kumagai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohsuke","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamotsu","family":"Kanazawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijpara.2008.08.007_bib1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1590\/S0074-02762004000900005","article-title":"Schistosoma mansoni infection modulates the immune response against allergic and auto-immune diseases","volume":"99","author":"Ara\u00fajo","year":"2004","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.ijpara.2008.08.007_bib2","doi-asserted-by":"crossref","first-page":"7481","DOI":"10.4049\/jimmunol.174.12.7481","article-title":"Infections and autoimmunity\u2013good or bad?","volume":"174","author":"Christen","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijpara.2008.08.007_bib3","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1002\/art.22453","article-title":"Interferon-gamma regulates susceptibility to collagen-induced arthritis through suppression of interleukin-17","volume":"56","author":"Chu","year":"2007","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.ijpara.2008.08.007_bib4","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1046\/j.1365-3024.1999.00213.x","article-title":"Infection with Schistosoma mansoni prevents insulin dependent diabetes mellitus in non-obese diabetic mice","volume":"21","author":"Cooke","year":"1999","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.ijpara.2008.08.007_bib5","doi-asserted-by":"crossref","first-page":"R220","DOI":"10.1186\/ar1167","article-title":"Enhanced osteoclast development in collagen-induced arthritis in interferon-gamma receptor knock-out mice as related to increased splenic CD11b+ myelopoiesis","volume":"6","author":"De Klerck","year":"2004","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.ijpara.2008.08.007_bib6","doi-asserted-by":"crossref","first-page":"G385","DOI":"10.1152\/ajpgi.00049.2002","article-title":"Exposure to schistosome eggs protects mice from TNBS-induced colitis","volume":"284","author":"Elliott","year":"2003","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.ijpara.2008.08.007_bib7","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1002\/eji.200323717","article-title":"Schistosome N-glycans containing core alpha 3-fucose and core beta 2-xylose epitopes are strong inducers of Th2 responses in mice","volume":"33","author":"Faveeuw","year":"2003","journal-title":"Eur J. Immunol."},{"key":"10.1016\/j.ijpara.2008.08.007_bib8","doi-asserted-by":"crossref","first-page":"R18","DOI":"10.1186\/ar601","article-title":"Collagen-induced arthritis is exacerbated in IL-10-deficient mice","volume":"5","author":"Finnegan","year":"2003","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.ijpara.2008.08.007_bib9","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.4049\/jimmunol.146.4.1322","article-title":"Egg deposition is the major stimulus for the production of Th2 cytokines in murine schistosomiasis mansoni","volume":"146","author":"Grzych","year":"1991","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijpara.2008.08.007_bib10","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1038\/ni1254","article-title":"Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages","volume":"6","author":"Harrington","year":"2005","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ijpara.2008.08.007_bib11","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1002\/art.1780390513","article-title":"Anticytokine treatment of established type II collagen-induced arthritis in DBA\/1 mice. A comparative study using anti-TNF alpha, anti-IL-1 alpha\/beta, and IL-1Ra","volume":"39","author":"Joosten","year":"1996","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.ijpara.2008.08.007_bib12","doi-asserted-by":"crossref","first-page":"4094","DOI":"10.4049\/jimmunol.159.8.4094","article-title":"Dual role of IL-12 in early and late stages of murine collagen type II arthritis","volume":"159","author":"Joosten","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijpara.2008.08.007_bib13","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/ar14","article-title":"Protection against cartilage and bone destruction by systemic interleukin-4 treatment in established murine type II collagen-induced arthritis","volume":"1","author":"Joosten","year":"1999","journal-title":"Arthritis Res."},{"key":"10.1016\/j.ijpara.2008.08.007_bib14","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.4049\/jimmunol.161.3.1542","article-title":"Reduced susceptibility to collagen-induced arthritis in mice deficient in IFN-gamma receptor","volume":"161","author":"Kageyama","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijpara.2008.08.007_bib15","first-page":"S16","article-title":"Interleukin-6 inhibition and clinical efficacy in rheumatoid arthritis treatment\u2013data from randomized clinical trials","volume":"65","author":"Kavanaugh","year":"2007","journal-title":"Bull. NYU Hosp. Jt. Dis."},{"key":"10.1016\/j.ijpara.2008.08.007_bib16","doi-asserted-by":"crossref","first-page":"R402","DOI":"10.1186\/ar1500","article-title":"Defective CD4+CD25+ regulatory T cell functioning in collagen-induced arthritis: an important factor in pathogenesis, counter-regulated by endogenous IFN-gamma","volume":"7","author":"Kelchtermans","year":"2005","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.ijpara.2008.08.007_bib17","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/j.ijpara.2005.05.012","article-title":"A glycoprotein from Spirometra erinaceieuropaei plerocercoids suppresses osteoclastogenesis and proinflammatory cytokine gene expression","volume":"35","author":"Kina","year":"2005","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.ijpara.2008.08.007_bib18","doi-asserted-by":"crossref","first-page":"566","DOI":"10.4049\/jimmunol.177.1.566","article-title":"IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis","volume":"177","author":"Komiyama","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijpara.2008.08.007_bib19","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1172\/JCI5703","article-title":"IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis","volume":"103","author":"Kotake","year":"1999","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ijpara.2008.08.007_bib20","doi-asserted-by":"crossref","first-page":"4996","DOI":"10.1128\/IAI.71.9.4996-5004.2003","article-title":"Schistosomiasis decreases central nervous system inflammation and alters the progression of experimental autoimmune encephalomyelitis","volume":"71","author":"La Flamme","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijpara.2008.08.007_bib21","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1084\/jem.20041257","article-title":"IL-23 drives a pathogenic T cell population that induces autoimmune inflammation","volume":"201","author":"Langrish","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ijpara.2008.08.007_bib22","doi-asserted-by":"crossref","first-page":"3831","DOI":"10.1002\/art.20637","article-title":"Effects of disease-modifying antirheumatic drugs and antiinflammatory cytokines on human osteoclastogenesis through interaction with receptor activator of nuclear factor kappaB, osteoprotegerin, and receptor activator of nuclear factor kappaB ligand","volume":"50","author":"Lee","year":"2004","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.ijpara.2008.08.007_bib23","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.1002\/art.10607","article-title":"Increase in expression of receptor activator of nuclear factor kappaB at sites of bone erosion correlates with progression of inflammation in evolving collagen-induced arthritis","volume":"46","author":"Lubberts","year":"2002","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.ijpara.2008.08.007_bib24","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.4049\/jimmunol.170.5.2655","article-title":"IL-17 promotes bone erosion in murine collagen-induced arthritis through loss of the receptor activator of NF-kappa B ligand\/osteoprotegerin balance","volume":"170","author":"Lubberts","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijpara.2008.08.007_bib25","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1002\/art.20001","article-title":"Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion","volume":"50","author":"Lubberts","year":"2004","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.ijpara.2008.08.007_bib26","doi-asserted-by":"crossref","first-page":"138","DOI":"10.4049\/jimmunol.176.1.138","article-title":"Helminth-modified pulmonary immune response protects mice from allergen-induced airway hyperresponsiveness","volume":"176","author":"Mangan","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijpara.2008.08.007_bib27","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1365-2249.2006.03204.x","article-title":"Remission of collagen-induced arthritis is associated with high levels of transforming growth factor-beta expression in the joint","volume":"146","author":"Marinova-Mutafchieva","year":"2006","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.ijpara.2008.08.007_bib28","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1046\/j.1365-2249.2000.01384.x","article-title":"Parasite-mediated down-regulation of collagen-induced arthritis (CIA) in DA rats","volume":"122","author":"Mattsson","year":"2000","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.ijpara.2008.08.007_bib29","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1002\/art.10832","article-title":"Down-regulation of Th1-mediated pathology in experimental arthritis by stimulation of the Th2 arm of the immune response","volume":"48","author":"Mauri","year":"2003","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.ijpara.2008.08.007_bib30","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.4049\/jimmunol.171.4.2127","article-title":"A novel therapeutic approach targeting articular inflammation using the filarial nematode-derived phosphorylcholine-containing glycoprotein ES-62","volume":"171","author":"McInnes","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijpara.2008.08.007_bib31","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.exppara.2007.02.009","article-title":"Schistosoma japonicum eggs modulate the activity of CD4+ CD25+ Tregs and prevent development of colitis in mice","volume":"116","author":"Mo","year":"2007","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.ijpara.2008.08.007_bib32","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1002\/art.21195","article-title":"Effective treatment of collagen-induced arthritis by adoptive transfer of CD25+ regulatory T cells","volume":"52","author":"Morgan","year":"2005","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.ijpara.2008.08.007_bib33","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.4049\/jimmunol.173.3.2167","article-title":"Schistosoma mansoni and alpha-galactosylceramide: prophylactic effect of Th1 Immune suppression in a mouse model of Graves\u2019 hyperthyroidism","volume":"173","author":"Nagayama","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijpara.2008.08.007_bib34","doi-asserted-by":"crossref","first-page":"6173","DOI":"10.4049\/jimmunol.171.11.6173","article-title":"Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice","volume":"171","author":"Nakae","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijpara.2008.08.007_bib35","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1002\/eji.200323810","article-title":"Induction of arthritis by single monoclonal IgG anti-collagen type II antibodies and enhancement of arthritis in mice lacking inhibitory FcgammaRIIB","volume":"33","author":"Nandakumar","year":"2003","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.ijpara.2008.08.007_bib36","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1084\/jem.173.1.159","article-title":"Downregulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth, Schistosoma mansoni","volume":"173","author":"Pearce","year":"1991","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ijpara.2008.08.007_bib37","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1365-2249.2004.02499.x","article-title":"Joint cytokine quantification in two rodent arthritis models: kinetics of expression, correlation of mRNA and protein levels and response to prednisolone treatment","volume":"137","author":"Rioja","year":"2004","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.ijpara.2008.08.007_bib38","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1128\/IAI.01085-07","article-title":"Protective Effect of an extract from Ascaris suum in experimental arthritis models","volume":"76","author":"Rocha","year":"2008","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijpara.2008.08.007_bib39","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1186\/ar432","article-title":"Paradoxical roles of IFN-gamma in models of Th1-mediated autoimmunity","volume":"4","author":"Rosloniec","year":"2002","journal-title":"Arthritis Res."},{"key":"10.1016\/j.ijpara.2008.08.007_bib40","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1084\/jem.20061775","article-title":"Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction","volume":"203","author":"Sato","year":"2006","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ijpara.2008.08.007_bib41","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1093\/intimm\/dxg012","article-title":"Immunomodulation of experimental autoimmune encephalomyelitis by helminth ova immunization","volume":"15","author":"Sewell","year":"2003","journal-title":"Int. Immunol."},{"key":"10.1016\/j.ijpara.2008.08.007_bib42","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1084\/jem.20050955","article-title":"Schistosoma mansoni secretes a chemokine binding protein with antiinflammatory activity","volume":"202","author":"Smith","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ijpara.2008.08.007_bib43","doi-asserted-by":"crossref","first-page":"4557","DOI":"10.4049\/jimmunol.178.7.4557","article-title":"Infection with a helminth parasite prevents experimental colitis via a macrophage-mediated mechanism","volume":"178","author":"Smith","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijpara.2008.08.007_bib44","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1172\/JCI110495","article-title":"Nature and specificity of the immune response to collagen in type II collagen-induced arthritis in mice","volume":"69","author":"Stuart","year":"1982","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ijpara.2008.08.007_bib45","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1002\/1529-0131(199812)41:12<2117::AID-ART6>3.0.CO;2-P","article-title":"Blockage of interleukin-6 receptor ameliorates joint disease in murine collagen-induced arthritis","volume":"41","author":"Takagi","year":"1998","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.ijpara.2008.08.007_bib46","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.4049\/jimmunol.148.7.2103","article-title":"Induction of arthritis with monoclonal antibodies to collagen","volume":"148","author":"Terato","year":"1992","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijpara.2008.08.007_bib47","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1002\/art.22414","article-title":"Proinflammatory mediator-induced reversal of CD4+, CD25+ regulatory T cell-mediated suppression in rheumatoid arthritis","volume":"56","author":"van Amelsfort","year":"2007","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.ijpara.2008.08.007_bib48","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1073\/pnas.91.1.18","article-title":"Oligosaccharide-specific induction of interleukin 10 production by B220+ cells from schistosome-infected mice. a mechanism for regulation of CD4+ T-cell subsets","volume":"91","author":"Velupillai","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ijpara.2008.08.007_bib49","doi-asserted-by":"crossref","first-page":"338","DOI":"10.4049\/jimmunol.158.1.338","article-title":"B-1 cell (CD5+B220+) outgrowth in murine schistosomiasis is genetically restricted and is largely due to activation by polylactosamine sugars","volume":"158","author":"Velupillai","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijpara.2008.08.007_bib50","doi-asserted-by":"crossref","first-page":"7240","DOI":"10.4049\/jimmunol.165.12.7240","article-title":"Evaluation of TNF-alpha and IL-1 blockade in collagen-induced arthritis and comparison with combined anti-TNF-alpha\/anti-CD4 therapy","volume":"165","author":"Williams","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijpara.2008.08.007_bib51","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1365-2567.2006.02472.x","article-title":"Schistosoma japonicum egg antigens stimulate CD4+CD25+T cells and modulate airway inflammation in a murine model of asthma","volume":"120","author":"Yang","year":"2007","journal-title":"Immunology"},{"key":"10.1016\/j.ijpara.2008.08.007_bib52","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1002\/eji.200323910","article-title":"Schistosoma mansoni antigens modulate the activity of the innate immune response and prevent onset of type 1 diabetes","volume":"33","author":"Zaccone","year":"2003","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.ijpara.2008.08.007_bib53","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/j.1365-3024.2006.00879.x","article-title":"Parasitic worms and inflammatory diseases","volume":"28","author":"Zaccone","year":"2006","journal-title":"Parasite Immunol."}],"container-title":["International Journal for Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002075190800369X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002075190800369X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T21:09:41Z","timestamp":1684530581000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002075190800369X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3]]},"references-count":53,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["S002075190800369X"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpara.2008.08.007","relation":{},"ISSN":["0020-7519"],"issn-type":[{"value":"0020-7519","type":"print"}],"subject":[],"published":{"date-parts":[[2009,3]]}}}