{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:12:10Z","timestamp":1791234730660,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal for Parasitology"],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.1016\/j.ijpara.2010.03.004","type":"journal-article","created":{"date-parts":[[2010,4,2]],"date-time":"2010-04-02T08:25:07Z","timestamp":1270196707000},"page":"1193-1202","source":"Crossref","is-referenced-by-count":44,"title":["Mitochondrial genes for heme-dependent respiratory chain complexes are up-regulated after depletion of Wolbachia from filarial nematodes"],"prefix":"10.1016","volume":"40","author":[{"given":"Uta","family":"Str\u00fcbing","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Lucius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achim","family":"Hoerauf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth M.","family":"Pfarr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijpara.2010.03.004_bib1","doi-asserted-by":"crossref","first-page":"5454","DOI":"10.1128\/IAI.68.9.5454-5458.2000","article-title":"Analysis of genes expressed at the infective larval stage validates utility of Litomosoides sigmodontis as a murine model for filarial vaccine development","volume":"68","author":"Allen","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijpara.2010.03.004_bib2","doi-asserted-by":"crossref","first-page":"e217","DOI":"10.1371\/journal.pntd.0000217","article-title":"Of mice, cattle, and humans: the immunology and treatment of river blindness","volume":"2","author":"Allen","year":"2008","journal-title":"PLoS. Negl. Trop. Dis."},{"key":"10.1016\/j.ijpara.2010.03.004_bib3","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1128\/IAI.65.6.2457-2461.1997","article-title":"Infection of BALB\/c mice with the filarial nematode Litomosoides sigmodontis: role of CD4+ T cells in controlling larval development","volume":"65","author":"Al-Qaoud","year":"1997","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijpara.2010.03.004_bib4","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.ijpara.2007.12.006","article-title":"Infection of the intermediate mite host with Wolbachia-depleted Litomosoides sigmodontis microfilariae: impaired L1 to L3 development and subsequent sex-ratio distortion in adult worms","volume":"38","author":"Arumugam","year":"2008","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.ijpara.2010.03.004_bib5","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/S0092-8674(00)00216-6","article-title":"The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit","volume":"103","author":"Brodersen","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.ijpara.2010.03.004_bib6","doi-asserted-by":"crossref","first-page":"e92","DOI":"10.1371\/journal.ppat.0020092","article-title":"Doxycycline reduces plasma VEGF-C\/sVEGFR-3 and improves pathology in lymphatic filariasis","volume":"2","author":"Debrah","year":"2006","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ijpara.2010.03.004_bib7","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1111\/j.1365-3156.2007.01949.x","article-title":"Macrofilaricidal effect of 4 weeks of treatment with doxycycline on Wuchereria bancrofti","volume":"12","author":"Debrah","year":"2007","journal-title":"Trop. Med. Int. Health"},{"key":"10.1016\/j.ijpara.2010.03.004_bib8","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/j.trstmh.2006.04.006","article-title":"Efficacy of co-administered diethylcarbamazine and albendazole against adult Wuchereria bancrofti","volume":"100","author":"Dreyer","year":"2006","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.ijpara.2010.03.004_bib9","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1046\/j.1365-3156.2001.00682.x","article-title":"The impact of 34 years of massive DEC chemotherapy on Wuchereria bancrofti infection and transmission: the Maupiti cohort","volume":"6","author":"Esterre","year":"2001","journal-title":"Trop. Med. Int. Health"},{"key":"10.1016\/j.ijpara.2010.03.004_bib10","doi-asserted-by":"crossref","first-page":"e121","DOI":"10.1371\/journal.pbio.0030121","article-title":"The Wolbachia genome of Brugia malayi: endosymbiont evolution within a human pathogenic nematode","volume":"3","author":"Foster","year":"2005","journal-title":"PLoS Biol."},{"key":"10.1016\/j.ijpara.2010.03.004_bib11","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1126\/science.1145406","article-title":"Draft genome of the filarial nematode parasite Brugia malayi","volume":"317","author":"Ghedin","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.ijpara.2010.03.004_bib12","doi-asserted-by":"crossref","first-page":"e525","DOI":"10.1371\/journal.pntd.0000525","article-title":"Brugia malayi gene expression in response to the targeting of the Wolbachia endosymbiont by tetracycline treatment","volume":"3","author":"Ghedin","year":"2009","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.ijpara.2010.03.004_bib13","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ijmm.2005.12.019","article-title":"Differential display of genes expressed in the filarial nematode Litomosoides sigmodontis reveals a putative phosphate permease up-regulated after depletion of Wolbachia endobacteria","volume":"296","author":"Heider","year":"2006","journal-title":"Int. J. Med. Microbiol."},{"key":"10.1016\/j.ijpara.2010.03.004_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molbiopara.2009.04.008","article-title":"Helminth immunoregulation: the role of parasite secreted proteins in modulating host immunity","volume":"167","author":"Hewitson","year":"2009","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.ijpara.2010.03.004_bib15","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1126\/science.168.3927.143","article-title":"Heme requirement for reproduction of a free-living nematode","volume":"168","author":"Hieb","year":"1970","journal-title":"Science"},{"key":"10.1016\/j.ijpara.2010.03.004_bib16","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1017\/S0031182098002996","article-title":"Juvenile female Litomosoides sigmodontis produce an excretory\/secretory antigen (Juv-p120) highly modified with dimethylaminoethanol","volume":"117","author":"Hintz","year":"1998","journal-title":"Parasitology"},{"key":"10.1016\/j.ijpara.2010.03.004_bib17","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1172\/JCI4768","article-title":"Tetracycline therapy targets intracellular bacteria in the filarial nematode Litomosoides sigmodontis and results in filarial infertility","volume":"103","author":"Hoerauf","year":"1999","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ijpara.2010.03.004_bib18","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1016\/S0140-6736(00)02095-X","article-title":"Endosymbiotic bacteria in worms as targets for a novel chemotherapy in filariasis","volume":"355","author":"Hoerauf","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.ijpara.2010.03.004_bib19","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/S0140-6736(00)04581-5","article-title":"Depletion of Wolbachia endobacteria in Onchocerca volvulus by doxycycline and microfilaridermia after ivermectin treatment","volume":"357","author":"Hoerauf","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.ijpara.2010.03.004_bib20","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/S1471-4922(00)01849-3","article-title":"Of filariasis, mice and men","volume":"17","author":"Hoerauf","year":"2001","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.ijpara.2010.03.004_bib21","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S1286-4579(03)00026-1","article-title":"Doxycycline in the treatment of human onchocerciasis: kinetics of Wolbachia endobacteria reduction and of inhibition of embryogenesis in female Onchocerca worms","volume":"5","author":"Hoerauf","year":"2003","journal-title":"Microbes Infect."},{"key":"10.1016\/j.ijpara.2010.03.004_bib22","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s00430-007-0062-1","article-title":"Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study","volume":"197","author":"Hoerauf","year":"2008","journal-title":"Med. Microbiol. Immunol."},{"key":"10.1016\/j.ijpara.2010.03.004_bib23","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1097\/QCO.0b013e328315cde7","article-title":"Filariasis: new drugs and new opportunities for lymphatic filariasis and onchocerciasis","volume":"21","author":"Hoerauf","year":"2008","journal-title":"Curr. Opin. Infect. Dis."},{"key":"10.1016\/j.ijpara.2010.03.004_bib24","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1017\/S0031182007003642","article-title":"Does Litomosoides sigmodontis synthesize dimethylethanolamine from choline?","volume":"135","author":"Houston","year":"2008","journal-title":"Parasitology"},{"key":"10.1016\/j.ijpara.2010.03.004_bib25","doi-asserted-by":"crossref","first-page":"471","DOI":"10.4269\/ajtmh.2004.71.471","article-title":"Duplex Doppler sonographic assessment of the effects of diethylcarbamazine and albendazole therapy on adult filarial worms and adjacent host tissues in bancroftian filariasis","volume":"71","author":"Hussein","year":"2004","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.ijpara.2010.03.004_bib26","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: Kyoto encyclopedia of genes and genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ijpara.2010.03.004_bib27","doi-asserted-by":"crossref","first-page":"663","DOI":"10.4269\/ajtmh.1977.26.663","article-title":"Intracytoplasmic bacteria in Onchocerca volvulus","volume":"26","author":"Kozek","year":"1977","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.ijpara.2010.03.004_bib28","doi-asserted-by":"crossref","first-page":"992","DOI":"10.2307\/3279832","article-title":"Transovarially-transmitted intracellular microorganisms in adult and larval stages of Brugia malayi","volume":"63","author":"Kozek","year":"1977","journal-title":"J. Parasitol."},{"key":"10.1016\/j.ijpara.2010.03.004_bib29","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1098\/rspb.2000.1110","article-title":"Macrofilaricidal activity of tetracycline against the filarial nematode Onchocerca ochengi: elimination of Wolbachia precedes worm death and suggests a dependent relationship","volume":"267","author":"Langworthy","year":"2000","journal-title":"Proc. Biol. Sci."},{"key":"10.1016\/j.ijpara.2010.03.004_bib30","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.molbiopara.2005.05.005","article-title":"Profiling of gender-regulated gene transcripts in the filarial nematode Brugia malayi by cDNA oligonucleotide array analysis","volume":"143","author":"Li","year":"2005","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.ijpara.2010.03.004_bib31","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1186\/1471-2164-10-267","article-title":"Transcriptomes and pathways associated with infectivity, survival and immunogenicity in Brugia malayi L3","volume":"10","author":"Li","year":"2009","journal-title":"BMC Genom."},{"key":"10.1016\/j.ijpara.2010.03.004_bib32","first-page":"22","article-title":"Acanthocheilonema viteae: rational design of the life cycle to increase production of parasite material using less experimental animals","volume":"36","author":"Lucius","year":"1995","journal-title":"Appl. Parasitol."},{"key":"10.1016\/j.ijpara.2010.03.004_bib33","doi-asserted-by":"crossref","first-page":"702","DOI":"10.4269\/ajtmh.2009.09-0155","article-title":"Macrofilaricidal activity and amelioration of lymphatic pathology in bancroftian filariasis after 3 weeks of doxycycline followed by single-dose diethylcarbamazine","volume":"81","author":"Mand","year":"2009","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.ijpara.2010.03.004_bib34","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1128\/AAC.01411-05","article-title":"Inhibition of mammalian mitochondrial protein synthesis by oxazolidinones","volume":"50","author":"McKee","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ijpara.2010.03.004_bib35","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/0035-9203(75)90110-8","article-title":"Micro-organisms in filarial larvae (Nematoda)","volume":"69","author":"McLaren","year":"1975","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.ijpara.2010.03.004_bib36","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1251\/bpo126","article-title":"Microarray validation: factors influencing correlation between oligonucleotide microarrays and real-time PCR","volume":"8","author":"Morey","year":"2006","journal-title":"Biol. Proc. Online"},{"key":"10.1016\/j.ijpara.2010.03.004_bib37","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1091\/mbc.E04-03-0179","article-title":"Tropomyosin and troponin are required for ovarian contraction in the Caenorhabditis elegans reproductive system","volume":"15","author":"Ono","year":"2004","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.ijpara.2010.03.004_bib38","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1016\/S0140-6736(07)60942-8","article-title":"Prevalence and intensity of Onchocerca volvulus infection and efficacy of ivermectin in endemic communities in Ghana: a two-phase epidemiological study","volume":"369","author":"Osei-Atweneboana","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.ijpara.2010.03.004_bib39","first-page":"491","article-title":"Strategies and tools for the control\/elimination of lymphatic filariasis","volume":"75","author":"Ottesen","year":"1997","journal-title":"Bull. World Health Organ."},{"key":"10.1016\/j.ijpara.2010.03.004_bib40","doi-asserted-by":"crossref","unstructured":"Page, A.P., Johnstone, I.L., 2007. The Cuticle. In: WormBook (Ed.), The C. elegans Research Community, WormBook, doi\/10.1895\/wormbook.1.7.1. Available form http:\/\/www.wormbook.org.","DOI":"10.1895\/wormbook.1.138.1"},{"key":"10.1016\/j.ijpara.2010.03.004_bib41","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1017\/S003118200700409X","article-title":"The mitochondrial heat shock protein 60 (HSP60) is up-regulated in Onchocerca volvulus after the depletion of Wolbachia","volume":"135","author":"Pfarr","year":"2008","journal-title":"Parasitology"},{"key":"10.1016\/j.ijpara.2010.03.004_bib42","doi-asserted-by":"crossref","first-page":"4270","DOI":"10.1073\/pnas.0500877102","article-title":"Lack of heme synthesis in a free-living eukaryote","volume":"102","author":"Rao","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ijpara.2010.03.004_bib43","doi-asserted-by":"crossref","first-page":"6978","DOI":"10.1128\/IAI.71.12.6978-6985.2003","article-title":"Synergism of gamma interferon and interleuking-5 in the control of murine filariasis","volume":"71","author":"Saeftel","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijpara.2010.03.004_bib44","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0065-308X(05)60004-8","article-title":"Wolbachia bacterial endosymbionts of filarial nematodes","volume":"60","author":"Taylor","year":"2005","journal-title":"Adv. Parasitol."},{"key":"10.1016\/j.ijpara.2010.03.004_bib45","unstructured":"Taylor, M., Hoerauf, A., Bockarie, M., in press. Lymphatic filariasis and onchocerciasis. Lancet."},{"key":"10.1016\/j.ijpara.2010.03.004_bib46","doi-asserted-by":"crossref","first-page":"5116","DOI":"10.1073\/pnas.091062498","article-title":"Significance analysis of microarrays applied to the ionizing radiation response","volume":"98","author":"Tusher","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ijpara.2010.03.004_bib47","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s00430-002-0155-9","article-title":"Murine filariasis: interleukin 4 and interleukin 5 lead to containment of different worm developmental stages","volume":"192","author":"Volkmann","year":"2003","journal-title":"Med. Microbiol. Immunol."},{"key":"10.1016\/j.ijpara.2010.03.004_bib48","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/1756-3305-2-39","article-title":"Community-directed delivery of doxycycline for the treatment of onchocerciasis in areas of co-endemicity with loiasis in Cameroon","volume":"2","author":"Wanji","year":"2009","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.ijpara.2010.03.004_bib49","unstructured":"WHO, 2010. African programme for onchocerciasis control \u2013 report of the sixth meeting of national task forces, October 2009. Wkly. Epidemiol. Rec. 85, 23\u201328."},{"key":"10.1016\/j.ijpara.2010.03.004_bib50","doi-asserted-by":"crossref","first-page":"e475","DOI":"10.1371\/journal.pntd.0000475","article-title":"The heme biosynthetic pathway of the obligate Wolbachia endosymbiont of Brugia malayi as a potential anti-filarial drug target","volume":"3","author":"Wu","year":"2009","journal-title":"PLoS Negl. Trop. Dis."}],"container-title":["International Journal for Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002075191000113X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002075191000113X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T13:11:48Z","timestamp":1591189908000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002075191000113X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8]]},"references-count":50,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["S002075191000113X"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpara.2010.03.004","relation":{},"ISSN":["0020-7519"],"issn-type":[{"value":"0020-7519","type":"print"}],"subject":[],"published":{"date-parts":[[2010,8]]}}}