{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T20:58:21Z","timestamp":1791147501950,"version":"4.1.0"},"reference-count":53,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal for Parasitology"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1016\/j.ijpara.2011.01.011","type":"journal-article","created":{"date-parts":[[2011,3,16]],"date-time":"2011-03-16T14:26:29Z","timestamp":1300285589000},"page":"711-719","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Dissecting the impact of protein versus energy host nutrition on the expression of immunity to gastrointestinal parasites during lactation"],"prefix":"10.1016","volume":"41","author":[{"given":"L.A.","family":"Jones","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.G.M.","family":"Houdijk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Sakkas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.D.","family":"Bruce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.P.","family":"Knox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Kyriazakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijpara.2011.01.011_b0005","series-title":"Energy and protein requirements of ruminants. An advisory manual prepared by the AFRC Technical Committee on Responses to Nutrients","author":"Agricultural and Food Research Council (AFRC)","year":"1993"},{"key":"10.1016\/j.ijpara.2011.01.011_b0010","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.imlet.2005.01.009","article-title":"T helper (h)1\/Th2 and Leishmania: paradox rather than paradigm","volume":"99","author":"Alexander","year":"2005","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.ijpara.2011.01.011_b0015","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.2174\/1381612033454252","article-title":"Nutrition and immunity: laboratory and clinical aspects","volume":"9","author":"Amati","year":"2003","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.ijpara.2011.01.011_b0020","series-title":"Introduction to Human Nutrition","first-page":"31","article-title":"Energy metabolism","author":"Astrup","year":"2009"},{"key":"10.1016\/j.ijpara.2011.01.011_b0025","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.1016\/j.vaccine.2006.12.055","article-title":"The effect of vaccination with a recombinant Nippostrongylus brasiliensis acetylcholinesterase on infection outcome in the rat","volume":"25","author":"Ball","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.ijpara.2011.01.011_b0030","first-page":"187","article-title":"The immunology and pathogenesis of malaria during pregnancy","volume":"297","author":"Beeson","year":"2005","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.ijpara.2011.01.011_b0035","doi-asserted-by":"crossref","first-page":"5816","DOI":"10.4049\/jimmunol.0900944","article-title":"Expulsion of secondary Trichinella spiralis infection in rats occurs independently of mucosal mast cell release of mast cell protease II","volume":"183","author":"Blum","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijpara.2011.01.011_b0040","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1017\/S0031182098002431","article-title":"Dietary protein and zinc restrictions independently modify a Heligmosomoides polygyrus (Nematoda) infection in mice","volume":"116","author":"Boulay","year":"1998","journal-title":"Parasitology"},{"key":"10.1016\/j.ijpara.2011.01.011_b0045","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1079\/095442200108728981","article-title":"Undernutrition, infection and immune function","volume":"13","author":"Calder","year":"2000","journal-title":"Nutr. Res. Rev."},{"key":"10.1016\/j.ijpara.2011.01.011_b0050","doi-asserted-by":"crossref","first-page":"1433S","DOI":"10.1093\/jn\/124.suppl_8.1433S","article-title":"Nutrition and immunity: an overview","volume":"124","author":"Chandra","year":"1994","journal-title":"J. Nutr."},{"key":"10.1016\/j.ijpara.2011.01.011_b0055","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","article-title":"Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction","volume":"162","author":"Chomczynski","year":"1987","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ijpara.2011.01.011_b0060","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1128\/iai.33.1.54-58.1981","article-title":"Rejection of the intestinal parasite Nippostrongylus brasiliensis by mast cell-deficient W\/Wv anemic mice","volume":"33","author":"Crowle","year":"1981","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijpara.2011.01.011_b0065","first-page":"187","volume":"84","author":"Coop","year":"1999","journal-title":"Nutrition\u2013parasite interaction"},{"key":"10.1016\/j.ijpara.2011.01.011_b0070","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S1471-4922(01)01900-6","article-title":"Influence of host nutrition on the development and consequences of nematode parasitism in ruminants","volume":"17","author":"Coop","year":"2001","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.ijpara.2011.01.011_b0075","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1017\/S1357729800032951","article-title":"The effect of nutrition on the periparturient parasite status of mature ewes","volume":"67","author":"Donaldson","year":"1998","journal-title":"Animal Science"},{"key":"10.1016\/j.ijpara.2011.01.011_b0080","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1079\/BJN19930009","article-title":"Interactions between major nutrients in the diet and the lactational performance of rats","volume":"69","author":"Friggens","year":"1993","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.ijpara.2011.01.011_b0085","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.4049\/jimmunol.174.2.1063","article-title":"Mast cells, basophils, and eosinophils acquire constitutive IL-4 and IL-13 transcripts during lineage differentiation that are sufficient for rapid cytokine production","volume":"174","author":"Gessner","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijpara.2011.01.011_b0090","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1006\/meth.2001.1261","article-title":"An overview of real-time quantitative PCR: applications to quantify cytokine gene expression","volume":"25","author":"Giulietti","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.ijpara.2011.01.011_b0095","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1079\/BJN2003961","article-title":"Breakdown of immunity to Nippostrongylus brasiliensis in lactating rats","volume":"90","author":"Houdijk","year":"2003","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.ijpara.2011.01.011_b0100","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1079\/PNS2001114","article-title":"Nutrient partitioning between reproductive and immune functions between in animals","volume":"60","author":"Houdijk","year":"2001","journal-title":"Proc. Nutr. Soc."},{"key":"10.1016\/j.ijpara.2011.01.011_b0105","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1079\/BJN20041391","article-title":"Secondary infection of Nippostrongylus brasiliensis in lactating rats is sensitive to dietary protein content","volume":"93","author":"Houdijk","year":"2005","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.ijpara.2011.01.011_b0110","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.vetpar.2004.12.023","article-title":"Effects of protein supply and reproductive status on local and systemic immune responses to Teladorsagia circumcincta in sheep","volume":"129","author":"Houdijk","year":"2005","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.ijpara.2011.01.011_b0115","doi-asserted-by":"crossref","first-page":"7078","DOI":"10.1073\/pnas.97.13.7078","article-title":"Suppressed T helper 2 immunity and prolonged survival of a nematode parasite in protein-malnourished mice","volume":"20","author":"Ing","year":"2000","journal-title":"Proc. Nat. Acad. Sci. USA"},{"key":"10.1016\/j.ijpara.2011.01.011_b0120","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/j.1365-3024.2009.01121.x","article-title":"Immunomodulatory effects of dietary protein during Nippostrongylus brasiliensis re-infection in lactating rats","volume":"31","author":"Jones","year":"2009","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.ijpara.2011.01.011_b0125","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1038\/ni.f.216","article-title":"New developments in mast cell biology","volume":"9","author":"Kalesnukoff","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ijpara.2011.01.011_b0130","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0950-351X(97)80990-1","article-title":"Immunonutrition","volume":"11","author":"Keith","year":"1997","journal-title":"Baillieres Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ijpara.2011.01.011_b0135","doi-asserted-by":"crossref","first-page":"336S","DOI":"10.1093\/jn\/133.1.336S","article-title":"The history of nutrition: malnutrition, infection and immunity","volume":"133","author":"Keusch","year":"2003","journal-title":"J. Nutr."},{"key":"10.1016\/j.ijpara.2011.01.011_b0140","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1071\/EA02202","article-title":"Regulation of the resistance and resilience of periparturient ewes to infection with gastrointestinal nematode parasites by dietary supplementation","volume":"43","author":"Khan","year":"2003","journal-title":"Austr. J. Exp. Agric."},{"key":"10.1016\/j.ijpara.2011.01.011_b0145","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/j.1365-3024.1995.tb00919.x","article-title":"Reduced amount of intestinal mucus by treatment with anti-CD4 antibody interferes with the spontaneous cure of Nippostrongylus brasiliensis-infection in mice","volume":"17","author":"Khan","year":"1995","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.ijpara.2011.01.011_b0150","first-page":"653","article-title":"Anaphylactic release of mucosal mast cell protease and its relationship to gut permeability in Nippostrongylus-primed rats","volume":"51","author":"King","year":"1984","journal-title":"Immunology"},{"key":"10.1016\/j.ijpara.2011.01.011_b0155","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0165-2478(80)90019-X","article-title":"Prolonged infection of Nippostrongylus brasiliensis in genetically mast cell-depleted W\/Wv mice","volume":"2","author":"Kojima","year":"1980","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.ijpara.2011.01.011_b0160","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.ijpara.2011.01.011_b0165","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1139\/y94-040","article-title":"The gut: central organ in nutrient requirements and metabolism","volume":"72","author":"McBurney","year":"1994","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.ijpara.2011.01.011_b0170","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0960-9822(98)70134-4","article-title":"A distinct role for interleukin-13 in Th2-cell-mediated immune responses","volume":"8","author":"McKenzie","year":"1998","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ijpara.2011.01.011_b0175","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1172\/JCI30974","article-title":"Tales from the crypts: regulatory peptides and cytokines in gastrointestinal homeostasis and disease","volume":"117","author":"Merchant","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ijpara.2011.01.011_b0180","first-page":"325","article-title":"Expulsion of Nippostrongylus brasiliensis from rats protected with serum. 1. The efficacy of sera from singly and multiply infected donors related to time of administration and volume of serum injected","volume":"40","author":"Miller","year":"1980","journal-title":"Immunology"},{"key":"10.1016\/j.ijpara.2011.01.011_b0185","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1017\/S0007114507205781","article-title":"The effects of changes in nutritional demand on gastrointestinal parasitism in lactating rats","volume":"97","author":"Normanton","year":"2007","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.ijpara.2011.01.011_b0190","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.immuni.2010.08.011","article-title":"Basophils orchestrate chronic allergic dermatitis and protective immunity against helminths","volume":"33","author":"Ohnmacht","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.ijpara.2011.01.011_b0195","doi-asserted-by":"crossref","first-page":"2816","DOI":"10.1182\/blood-2008-05-154773","article-title":"Basophil effector function and homeostasis during helminth infection","volume":"113","author":"Ohnmacht","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.ijpara.2011.01.011_b0200","doi-asserted-by":"crossref","first-page":"344","DOI":"10.4049\/jimmunol.0901841","article-title":"Basophils protect against reinfection with hookworms independently of mast cells and memory Th2 cells","volume":"184","author":"Ohnmacht","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijpara.2011.01.011_b0205","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1079\/PNS19890007","article-title":"Sources of variability in lactational performance","volume":"48","author":"Oldham","year":"1989","journal-title":"Proc. Nutr. Soc."},{"key":"10.1016\/j.ijpara.2011.01.011_b0210","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1017\/S0031182002001592","article-title":"Impact of protein energy malnutrition on Trichuris suis infection in pigs concomitantly infected with Ascaris suum","volume":"124","author":"Pedersen","year":"2002","journal-title":"Parasitology"},{"key":"10.1016\/j.ijpara.2011.01.011_b0215","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1079\/BJN19940087","article-title":"Maternal protein reserves and their influence on lactational performance in rats. 3. The effects of dietary protein restriction and stage of lactation on milk consumption","volume":"72","author":"Pine","year":"1994","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.ijpara.2011.01.011_b0220","doi-asserted-by":"crossref","unstructured":"Sakkas, P., Houdijk, J.G.M., Jones, L.A., Knox, D.P., Kyriazakis, I., in press. Dietary protein and energy supplies differentially affect resistance to parasites in lactating mammals. Br. J. Nutr. doi:10.1017\/S0007114511001565.","DOI":"10.1017\/S0007114511001565"},{"key":"10.1016\/j.ijpara.2011.01.011_b0225","doi-asserted-by":"crossref","first-page":"464S","DOI":"10.1093\/ajcn\/66.2.464S","article-title":"Synergism of nutrition, infection, and immunity: an overview","volume":"66","author":"Scrimshaw","year":"1997","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.ijpara.2011.01.011_b0230","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1046\/j.1365-3024.1997.d01-223.x","article-title":"Zinc deficiency and energy restriction modify immune responses in mice during primary and challenge infection with Heligmosomoides polygyrus (Nematoda)","volume":"19","author":"Shi","year":"1997","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.ijpara.2011.01.011_b0235","doi-asserted-by":"crossref","first-page":"S73","DOI":"10.1016\/j.jaci.2009.11.017","article-title":"IgE, mast cells, basophils, and eosinophils","volume":"125","author":"Stone","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.ijpara.2011.01.011_b0240","series-title":"Proceedings of the 7th International Symposium of the Nutrition of Herbivores","first-page":"329","article-title":"Opportunities to control herbivore nematodes through manipulation of the grazing environment","author":"Sykes","year":"2007"},{"key":"10.1016\/j.ijpara.2011.01.011_b0245","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1139\/y89-060","article-title":"Thermogenesis and the energetics of pregnancy and lactation","volume":"67","author":"Trayhurn","year":"1989","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.ijpara.2011.01.011_b0250","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1017\/S0031182007003617","article-title":"Mechanisms underlying reduced expulsion of a murine nematode infection during protein deficiency","volume":"135","author":"Tu","year":"2008","journal-title":"Parasitology"},{"key":"10.1016\/j.ijpara.2011.01.011_b0255","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1017\/S0031182007002314","article-title":"Re-feeding restores protection against Heligmosomoides bakeri (Nematoda) in protein-deficient mice","volume":"134","author":"Tu","year":"2007","journal-title":"Parasitology"},{"key":"10.1016\/j.ijpara.2011.01.011_b0260","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S1074-7613(00)80477-X","article-title":"Il-13, IL-4R\u03b1, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis","volume":"8","author":"Urban","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/j.ijpara.2011.01.011_b0265","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1084\/jem.20052448051806c","article-title":"Type 2 immunity is controlled by the IL-4\/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system","volume":"203","author":"Voehringer","year":"2006","journal-title":"J. Exp. Med."}],"container-title":["International Journal for Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020751911000713?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020751911000713?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T15:48:02Z","timestamp":1762184882000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0020751911000713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":53,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["S0020751911000713"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpara.2011.01.011","relation":{},"ISSN":["0020-7519"],"issn-type":[{"value":"0020-7519","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dissecting the impact of protein versus energy host nutrition on the expression of immunity to gastrointestinal parasites during lactation","name":"articletitle","label":"Article Title"},{"value":"International Journal for Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijpara.2011.01.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}