{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T11:42:24Z","timestamp":1785757344942,"version":"3.56.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"5-6","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal for Parasitology"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.ijpara.2016.01.005","type":"journal-article","created":{"date-parts":[[2016,2,19]],"date-time":"2016-02-19T11:27:56Z","timestamp":1455881276000},"page":"333-341","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Phenotypic and molecular analysis of the effect of 20-hydroxyecdysone on the human filarial parasite Brugia malayi"],"prefix":"10.1016","volume":"46","author":[{"given":"Amruta S.","family":"Mhashilkar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swamy R.","family":"Adapa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rays H.Y.","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven A.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weam","family":"Zaky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barton E.","family":"Slatko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley N.","family":"Luck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew R.","family":"Moorhead","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas R.","family":"Unnasch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijpara.2016.01.005_b0005","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1186\/1475-2883-2-S1-S6","article-title":"Clinical picture and outcome of serious adverse events in the treatment of Onchocerciasis","volume":"2","author":"Awadzi","year":"2003","journal-title":"Filaria J."},{"key":"10.1016\/j.ijpara.2016.01.005_b0010","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/(SICI)1520-6327(1996)33:3\/4<231::AID-ARCH5>3.0.CO;2-V","article-title":"Ecdysone signaling cascade and regulation of Drosophila metamorphosis","volume":"33","author":"Baehrecke","year":"1996","journal-title":"Arch. Insect Biochem. Physiol."},{"key":"10.1016\/j.ijpara.2016.01.005_b0015","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1021\/pr301038f","article-title":"Quantitative proteomic characterization of ethanol-responsive pathways in rat microglial cells","volume":"12","author":"Bell-Temin","year":"2013","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.ijpara.2016.01.005_b0020","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1074\/mcp.M200008-MCP200","article-title":"Discordant protein and mRNA expression in lung adenocarcinomas","volume":"1","author":"Chen","year":"2002","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.ijpara.2016.01.005_b0025","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S1097-2765(00)80114-8","article-title":"A genome-wide transcriptional analysis of the mitotic cell cycle","volume":"2","author":"Cho","year":"1998","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ijpara.2016.01.005_b0030","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0001409","article-title":"A deep sequencing approach to comparatively analyze the transcriptome of lifecycle stages of the filarial worm, Brugia malayi","volume":"5","author":"Choi","year":"2011","journal-title":"PLoS Negl. Trop. Dis."},{"issue":"Suppl. 1","key":"10.1016\/j.ijpara.2016.01.005_b0035","doi-asserted-by":"crossref","first-page":"S100","DOI":"10.1016\/j.actatropica.2010.08.009","article-title":"Elimination of human onchocerciasis: history of progress and current feasibility using ivermectin (Mectizan\u00ae) monotherapy","volume":"120","author":"Cupp","year":"2011","journal-title":"Acta Trop."},{"key":"10.1016\/j.ijpara.2016.01.005_b0040","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1101\/gr.138420.112","article-title":"Analysis of gene expression from the Wolbachia genome of a filarial nematode supports both metabolic and defensive roles within the symbiosis","volume":"22","author":"Darby","year":"2012","journal-title":"Genome Res."},{"key":"10.1016\/j.ijpara.2016.01.005_b0045","doi-asserted-by":"crossref","first-page":"R80","DOI":"10.1186\/gb-2004-5-10-r80","article-title":"Bioconductor: open software development for computational biology and bioinformatics","volume":"5","author":"Gentleman","year":"2004","journal-title":"Genome Biol."},{"key":"10.1016\/j.ijpara.2016.01.005_b0050","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1001393","article-title":"Comparative analysis of proteome and transcriptome variation in mouse","volume":"7","author":"Ghazalpour","year":"2011","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ijpara.2016.01.005_b0055","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/gb-2003-4-9-117","article-title":"Comparing protein abundance and mRNA expression levels on a genomic scale","volume":"4","author":"Greenbaum","year":"2003","journal-title":"Genome Biol."},{"key":"10.1016\/j.ijpara.2016.01.005_b0060","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s00436-009-1655-y","article-title":"Use of microarray hybridization to identify Brugia genes involved in mosquito infectivity","volume":"106","author":"Griffiths","year":"2009","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.ijpara.2016.01.005_b0065","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1128\/JB.161.3.939-943.1985","article-title":"Mutations in the rpoH (htpR) gene of Escherichia coli K-12 phenotypically suppress a temperature-sensitive mutant defective in the sigma 70 subunit of RNA polymerase","volume":"161","author":"Grossman","year":"1985","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ijpara.2016.01.005_b0070","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.tibtech.2004.04.006","article-title":"Codon bias and heterologous protein expression","volume":"22","author":"Gustafsson","year":"2004","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.ijpara.2016.01.005_b0075","doi-asserted-by":"crossref","first-page":"91","DOI":"10.2174\/1389202911314020003","article-title":"Integrated analysis of transcriptomic and proteomic data","volume":"14","author":"Haider","year":"2013","journal-title":"Curr. Genomics"},{"key":"10.1016\/j.ijpara.2016.01.005_b0080","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.1096\/fasebj.3.12.2676679","article-title":"The role of mRNA and protein stability in gene expression","volume":"3","author":"Hargrove","year":"1989","journal-title":"FASEB J."},{"key":"10.1016\/j.ijpara.2016.01.005_b0085","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang","year":"2008","journal-title":"Nat. Protocols"},{"key":"10.1016\/j.ijpara.2016.01.005_b0090","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0092-8674(91)90572-G","article-title":"The Drosophila EcR Gene encodes an ecdysone receptor, a new member of the steroid receptor superfamily","volume":"67","author":"Koelle","year":"1991","journal-title":"Cell"},{"key":"10.1016\/j.ijpara.2016.01.005_b0095","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1186\/gb-2009-10-3-r25","article-title":"Ultrafast and memory-efficient alignment of short DNA sequences to the human genome","volume":"10","author":"Langmead","year":"2009","journal-title":"Genome Biol."},{"key":"10.1016\/j.ijpara.2016.01.005_b0100","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.ijpara.2016.01.005_b0105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0000114","article-title":"Measuring the burden of neglected tropical diseases: the global burden of disease framework","volume":"1","author":"Mathers","year":"2007","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.ijpara.2016.01.005_b0110","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0166-6851(83)90098-1","article-title":"Ecdysteroids in adults of the nematode, Dirofilaria immitis","volume":"9","author":"Mendis","year":"1983","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.ijpara.2016.01.005_b0115","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1186\/1471-2164-9-246","article-title":"Correlation of mRNA and protein levels: cell type-specific gene expression of cluster designation antigens in the prostate","volume":"9","author":"Pascal","year":"2008","journal-title":"BMC Genomics"},{"key":"10.1016\/j.ijpara.2016.01.005_b0120","first-page":"203","article-title":"Hormone receptors and the regulation of insect metamorphosis","volume":"3","author":"Riddiford","year":"1993","journal-title":"Receptor"},{"key":"10.1016\/j.ijpara.2016.01.005_b0125","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1093\/bib\/bbt086","article-title":"Comparison of software packages for detecting differential expression in RNA-seq studies","volume":"16","author":"Seyednasrollah","year":"2015","journal-title":"Brief Bioinform."},{"key":"10.1016\/j.ijpara.2016.01.005_b0130","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/362471a0","article-title":"Heterodimerization of the Drosophila ecdysone receptor with retinoid X receptor and ultraspiracle","volume":"362","author":"Thomas","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.ijpara.2016.01.005_b0135","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/nprot.2012.016","article-title":"Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks","volume":"7","author":"Trapnell","year":"2012","journal-title":"Nat. Protocols"},{"key":"10.1016\/j.ijpara.2016.01.005_b0140","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/nbt0509-455","article-title":"How to map billions of short reads onto genomes","volume":"27","author":"Trapnell","year":"2009","journal-title":"Nat. Biotech."},{"key":"10.1016\/j.ijpara.2016.01.005_b0145","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nbt.1621","article-title":"Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation","volume":"28","author":"Trapnell","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ijpara.2016.01.005_b0150","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/cid\/ciu467","article-title":"Reaching the London Declaration on neglected tropical diseases goals for onchocerciasis: an economic evaluation of increasing the frequency of ivermectin treatment in Africa","volume":"59","author":"Turner","year":"2014","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.ijpara.2016.01.005_b0155","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1186\/1475-2883-2-S1-S3","article-title":"Serious adverse events following treatment with ivermectin for onchocerciasis control: a review of reported cases","volume":"2","author":"Twum-Danso","year":"2003","journal-title":"Filaria J."},{"key":"10.1016\/j.ijpara.2016.01.005_b0160","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0000625","article-title":"Molecular evidence for a functional ecdysone signaling system in Brugia malayi","volume":"4","author":"Tzertzinis","year":"2010","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.ijpara.2016.01.005_b0165","series-title":"Lymphatic Filariasis \u2013 Epidemiology","author":"World Health Organization","year":"2010"},{"key":"10.1016\/j.ijpara.2016.01.005_b0170","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/366476a0","article-title":"Functional ecdysone receptor is the product of EcR and ultraspiracle genes","volume":"366","author":"Yao","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.ijpara.2016.01.005_b0175","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/1471-2105-13-134","article-title":"Primer-BLAST: a tool to design target-specific primers for polymerase chain reaction","volume":"13","author":"Ye","year":"2012","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.ijpara.2016.01.005_b0180","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1002\/anie.201005969","article-title":"Genome-wide correlation between mRNA and protein in a single cell","volume":"50","author":"Yeung","year":"2011","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.ijpara.2016.01.005_b0185","doi-asserted-by":"crossref","first-page":"W741","DOI":"10.1093\/nar\/gki475","article-title":"WebGestalt: an integrated system for exploring gene sets in various biological contexts","volume":"33","author":"Zhang","year":"2005","journal-title":"Nucleic Acids Res."}],"container-title":["International Journal for Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020751916000394?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020751916000394?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T20:06:14Z","timestamp":1600200374000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0020751916000394"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":37,"journal-issue":{"issue":"5-6","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["S0020751916000394"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpara.2016.01.005","relation":{},"ISSN":["0020-7519"],"issn-type":[{"value":"0020-7519","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phenotypic and molecular analysis of the effect of 20-hydroxyecdysone on the human filarial parasite Brugia malayi","name":"articletitle","label":"Article Title"},{"value":"International Journal for Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijpara.2016.01.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Australian Society for Parasitology. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}