{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T12:02:15Z","timestamp":1768824135025,"version":"3.49.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["230927"],"award-info":[{"award-number":["230927"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008459","name":"University of Calgary","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008459","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012095","name":"Scottish Government","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012095","id-type":"DOI","asserted-by":"crossref"}]},{"name":"BBRSC Strategic Lola","award":["BB\/M003949\/1"],"award-info":[{"award-number":["BB\/M003949\/1"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal for Parasitology"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.ijpara.2016.04.007","type":"journal-article","created":{"date-parts":[[2016,5,22]],"date-time":"2016-05-22T15:51:21Z","timestamp":1463932281000},"page":"653-661","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Evidence from two independent backcross experiments supports genetic linkage of microsatellite Hcms8a20, but not other candidate loci, to a major ivermectin resistance locus in Haemonchus contortus"],"prefix":"10.1016","volume":"46","author":[{"given":"Andrew M.","family":"Rezansoff","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roz","family":"Laing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John S.","family":"Gilleard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijpara.2016.04.007_b0005","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1017\/S0031182009990345","article-title":"P-glycoprotein interfering agents potentiate ivermectin susceptibility in ivermectin sensitive and resistant isolates of Teladorsagia circumcincta and Haemonchus contortus","volume":"136","author":"Bartley","year":"2009","journal-title":"Parasitology"},{"key":"10.1016\/j.ijpara.2016.04.007_b0015","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.pt.2010.04.003","article-title":"Nematode parasite genes: what\u2019s in a name?","volume":"26","author":"Beech","year":"2010","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.ijpara.2016.04.007_b0010","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.molbiopara.2010.02.004","article-title":"Association of ion-channel genotype and macrocyclic lactone sensitivity traits in Haemonchus contortus","volume":"171","author":"Beech","year":"2010","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.ijpara.2016.04.007_b0020","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1017\/S0031182010001198","article-title":"Anthelmintic resistance: markers for resistance, or susceptibility?","volume":"138","author":"Beech","year":"2011","journal-title":"Parasitology"},{"key":"10.1016\/j.ijpara.2016.04.007_b0030","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1006\/expr.1998.4316","article-title":"Haemonchus contortus: selection at a glutamate-gated chloride channel","volume":"48","author":"Blackhall","year":"1998","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.ijpara.2016.04.007_b0025","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0166-6851(98)00087-5","article-title":"Selection at a P-glycoprotein gene in ivermectin- and moxidectin-selected strains of Haemonchus contortus","volume":"95","author":"Blackhall","year":"1998","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.ijpara.2016.04.007_b0035","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0166-6851(03)00201-9","article-title":"Selection at a \u03b3-aminobutyric acid receptor gene in Haemonchus contortus resistant to avermectins\/milbemycins","volume":"131","author":"Blackhall","year":"2003","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.ijpara.2016.04.007_b0040","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.ijpara.2015.04.007","article-title":"Genetic evidence for the spread of a benzimidazole resistance mutation across southern India from a single origin in the parasitic nematode Haemonchus contortus","volume":"45","author":"Chaudhry","year":"2015","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.ijpara.2016.04.007_b0045","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.1073\/pnas.97.6.2674","article-title":"The genetics of ivermectin resistance in Caenorhabditis elegans","volume":"97","author":"Dent","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ijpara.2016.04.007_b0050","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1093\/nar\/gkh340","article-title":"MUSCLE: multiple sequence alignment with high accuracy and high throughput","volume":"32","author":"Edgar","year":"2004","journal-title":"Nucleic Acid Res."},{"key":"10.1016\/j.ijpara.2016.04.007_b0055","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1177\/117693430500100003","article-title":"Arlequin (version 3.0): an integrated software package for population genetics data analysis","volume":"1","author":"Excoffier","year":"2005","journal-title":"Evol. Bioinform. Online"},{"issue":"6068","key":"10.1016\/j.ijpara.2016.04.007_b0060","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1126\/science.1214318","article-title":"Natural variation in a chloride channel subunit confers avermectin resistance in C. elegans","volume":"335","author":"Ghosh","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.ijpara.2016.04.007_b0065","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/j.ijpara.2006.06.010","article-title":"Understanding anthelmintic resistance: the need for genomics and genetics","volume":"36","author":"Gilleard","year":"2006","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.ijpara.2016.04.007_b0070","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1017\/S0031182013001145","article-title":"Haemonchus contortus as a paradigm and model to study anthelmintic drug resistance","volume":"140","author":"Gilleard","year":"2013","journal-title":"Parasitology"},{"key":"10.1016\/j.ijpara.2016.04.007_b0075","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1017\/S0031182007000066","article-title":"Population genetics of anthelmintic resistance in parasitic nematodes","volume":"134","author":"Gilleard","year":"2007","journal-title":"Parasitology"},{"key":"10.1016\/j.ijpara.2016.04.007_b0080","doi-asserted-by":"crossref","first-page":"e22390","DOI":"10.1371\/journal.pone.0022390","article-title":"Glutamate-gated chloride channels of Haemonchus contortus restore drug sensitivity to ivermectin resistant Caenorhabditis elegans","volume":"6","author":"Glendinning","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.ijpara.2016.04.007_b0085","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.cell.2009.01.057","article-title":"DEX-1 and DYF-7 establish sensory dendrite length by anchoring dendritic tips during cell migration","volume":"137","author":"Heiman","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.ijpara.2016.04.007_b0090","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0166-6851(99)00120-6","article-title":"Ligand-gated chloride channel subunits encoded by the Haemonchus contortus and Ascaris suum orthologues of the Caenorhabditis elegans gbr-2 (avr-14) gene","volume":"103","author":"Jagannathan","year":"1999","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.ijpara.2016.04.007_b0095","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.pt.2009.04.004","article-title":"Drug resistance mechanisms in helminths: is it survival of the fittest?","volume":"25","author":"James","year":"2009","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.ijpara.2016.04.007_b0100","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.vetpar.2011.11.048","article-title":"An inconvenient truth: global worming and anthelmintic resistance","volume":"186","author":"Kaplan","year":"2012","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.ijpara.2016.04.007_b0105","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1093\/bioinformatics\/bts199","article-title":"Geneious Basic: an integrated and extendable desktop software platform for the organization and analysis of sequence data","volume":"28","author":"Kearse","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ijpara.2016.04.007_b0110","doi-asserted-by":"crossref","first-page":"e23216","DOI":"10.1371\/journal.pone.0023216","article-title":"Annotation of two large contiguous regions from the Haemonchus contortus genome using RNA-seq and comparative analysis with Caenorhabditis elegans","volume":"6","author":"Laing","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.ijpara.2016.04.007_b0115","doi-asserted-by":"crossref","first-page":"R88","DOI":"10.1186\/gb-2013-14-8-r88","article-title":"The genome and transcriptome of Haemonchus contortus, a key model parasite for drug and vaccine discovery","volume":"14","author":"Laing","year":"2013","journal-title":"Genome Biol."},{"key":"10.1016\/j.ijpara.2016.04.007_b0120","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.ijpara.2016.03.010","article-title":"Analysis of putative resistance gene loci in UK field populations of Haemonchus contortus after six years of macrocyclic lactone","volume":"46","author":"Laing","year":"2016","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.ijpara.2016.04.007_b0125","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/0020-7519(94)00200-8","article-title":"Characterization of an avermectin resistant strain of Australian Haemonchus contortus","volume":"25","author":"Le Jambre","year":"1995","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.ijpara.2016.04.007_b0130","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1016\/S0020-7519(99)00157-5","article-title":"A hybridisation technique to identify anthelmintic resistance genes in Haemonchus","volume":"29","author":"Le Jambre","year":"1999","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.ijpara.2016.04.007_b0135","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1017\/S0031182007000042","article-title":"Nematode ligand-gated chloride channels: an appraisal of their involvement in macrocyclic lactone resistance and prospects for developing molecular markers","volume":"134","author":"McCavera","year":"2007","journal-title":"Parasitology"},{"key":"10.1016\/j.ijpara.2016.04.007_b0140","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1124\/mol.108.053363","article-title":"An ivermectin-sensitive glutamate-gated chloride channel from the parasitic nematode Haemonchus contortus","volume":"75","author":"McCavera","year":"2009","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ijpara.2016.04.007_b0145","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.ijpara.2007.06.008","article-title":"Microsatellite analysis reveals marked genetic differentiation between Haemonchus contortus laboratory isolates and provides a rapid system of genetic fingerprinting","volume":"38","author":"Redman","year":"2008","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.ijpara.2016.04.007_b0150","doi-asserted-by":"crossref","first-page":"e1002534","DOI":"10.1371\/journal.ppat.1002534","article-title":"Introgression of ivermectin resistance genes into a susceptible Haemonchus contortus strain by multiple backcrossing","volume":"8","author":"Redman","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ijpara.2016.04.007_b0155","doi-asserted-by":"crossref","first-page":"e0003494","DOI":"10.1371\/journal.pntd.0003494","article-title":"The emergence of resistance to the benzimidazole anthlemintics in parasitic nematodes of livestock is characterised by multiple independent hard and soft selective sweeps","volume":"9","author":"Redman","year":"2015","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.ijpara.2016.04.007_b0160","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.ijpara.2003.10.002","article-title":"Genetic analysis of inbreeding of two strains of the parasitic nematode Haemonchus contortus","volume":"34","author":"Roos","year":"2004","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.ijpara.2016.04.007_b0165","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1006\/expr.1998.4373","article-title":"Haemonchus contortus: sequence heterogeneity of internucleotide binding domains from P-glycoproteins","volume":"91","author":"Sangster","year":"1999","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.ijpara.2016.04.007_b0170","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0169-409X(98)00085-4","article-title":"P-glycoprotein, a gatekeeper in the blood\u2013brain barrier","volume":"36","author":"Schinkel","year":"1999","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ijpara.2016.04.007_b0175","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.ijpara.2014.08.005","article-title":"A dyf-7 haplotype causes sensory neuron defects and is associated with macrocyclic lactone resistance worldwide in the nematode parasite Haemonchus contortus","volume":"44","author":"Urdaneta-Marquez","year":"2014","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.ijpara.2016.04.007_b0180","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1136\/vr.123.9.226","article-title":"Resistance of field strains of Haemonchus contortus to ivermectin, closantel, rafoxanide and the benzimidazoles in South Africa","volume":"123","author":"Van Wyk","year":"1988","journal-title":"Vet. Rec."},{"key":"10.1016\/j.ijpara.2016.04.007_b0185","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1017\/S0022149X11000216","article-title":"P-glycoproteins of Haemonchus contortus: development of real-time PCR assays for gene expression studies","volume":"86","author":"Williamson","year":"2012","journal-title":"J. Helminthol."},{"key":"10.1016\/j.ijpara.2016.04.007_b0190","first-page":"S85","article-title":"Glutamate-gated chloride channels and the mode of action of the avermectin\/milbemycin anthelmintics","volume":"131 Suppl","author":"Wolstenholme","year":"2005","journal-title":"Parasitology"},{"key":"10.1016\/j.ijpara.2016.04.007_b0195","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0166-6851(97)00215-6","article-title":"Ivermectin resistance in nematodes may be caused by alteration of P-glycoprotein homolog","volume":"91","author":"Xu","year":"1998","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.ijpara.2016.04.007_b0200","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1089\/10665270050081478","article-title":"A greedy algorithm for aligning DNA sequences","volume":"7","author":"Zhang","year":"2000","journal-title":"J. Comput. Biol."}],"container-title":["International Journal for Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020751916300856?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020751916300856?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T23:36:25Z","timestamp":1572478585000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0020751916300856"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":40,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["S0020751916300856"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpara.2016.04.007","relation":{},"ISSN":["0020-7519"],"issn-type":[{"value":"0020-7519","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evidence from two independent backcross experiments supports genetic linkage of microsatellite Hcms8a20, but not other candidate loci, to a major ivermectin resistance locus in Haemonchus contortus","name":"articletitle","label":"Article Title"},{"value":"International Journal for Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijpara.2016.04.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Australian Society for Parasitology. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}