{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T10:49:35Z","timestamp":1789728575864,"version":"4.0.1"},"reference-count":19,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,8,24]],"date-time":"2017-08-24T00:00:00Z","timestamp":1503532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004385","name":"Universiteit Gent","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004385","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal for Parasitology"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.ijpara.2017.07.002","type":"journal-article","created":{"date-parts":[[2017,8,31]],"date-time":"2017-08-31T01:15:36Z","timestamp":1504142136000},"page":"41-49","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Comparative analysis of the immune responses induced by native versus recombinant versions of the ASP-based vaccine against the bovine intestinal parasite Cooperia oncophora"],"prefix":"10.1016","volume":"48","author":[{"given":"Ana","family":"Gonz\u00e1lez-Hern\u00e1ndez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimmy","family":"Borloo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Peelaers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stijn","family":"Casaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georges","family":"Leclercq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin","family":"Claerebout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Geldhof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijpara.2017.07.002_b0005","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1107\/S0907444911008560","article-title":"Structure of a two-CAP-domain protein from the human hookworm parasite Necator americanus","volume":"67","author":"Asojo","year":"2011","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.ijpara.2017.07.002_b0010","doi-asserted-by":"crossref","first-page":"3900","DOI":"10.1021\/pr400114y","article-title":"In-depth proteomic and glycomic analysis of the adult-stage Cooperia oncophora excretome\/secretome","volume":"12","author":"Borloo","year":"2013","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.ijpara.2017.07.002_b0015","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1107\/S0907444912050019","article-title":"Structure of Ostertagia ostertagi ASP-1: insights into disulfide-mediated cyclization and dimerization","volume":"69","author":"Borloo","year":"2013","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.ijpara.2017.07.002_b0020","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.pt.2014.04.009","article-title":"Chasing helminths and their economic impact on farmed ruminants","volume":"3","author":"Charlier","year":"2014","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.ijpara.2017.07.002_b0025","first-page":"113","article-title":"Anthelmintic resistance of gastrointestinal cattle nematodes","volume":"82","author":"De Graef","year":"2013","journal-title":"Vlaams. Diergeneeskd. Tijdschr."},{"issue":"11","key":"10.1016\/j.ijpara.2017.07.002_b0030","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.pt.2007.08.012","article-title":"Recombinant expression systems: the obstacle to helminth vaccines?","volume":"23","author":"Geldhof","year":"2007","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.ijpara.2017.07.002_b0035","first-page":"163","article-title":"Anthelmintic resistance to ivermectin and moxidectin in gastrointestinal nematodes of cattle in Europe","volume":"5","author":"Geurden","year":"2015","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.ijpara.2017.07.002_b0040","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1210\/er.2008-0032","article-title":"The CAP superfamily: cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins\u2013roles in reproduction, cancer, and immune defense","volume":"29","author":"Gibbs","year":"2008","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.ijpara.2017.07.002_b0045","doi-asserted-by":"crossref","first-page":"29496","DOI":"10.1038\/srep29496","article-title":"Host protective ASP-based vaccine against the parasitic nematode Ostertagia ostertagi triggers NK cell activation and mixed IgG1-IgG2 response","volume":"6","author":"Gonzalez-Hernandez","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ijpara.2017.07.002_b0050","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1111\/j.1365-3024.2011.01322.x","article-title":"Trichinella spiralis antigens prime mixed Th1\/Th2 response but do not induce de novo generation of Foxp3+ T cells in vitro","volume":"33","author":"Ilic","year":"2011","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.ijpara.2017.07.002_b0055","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1016\/S0020-7519(03)00211-X","article-title":"T-cell mediated immune responses in calves primary-infected or re-infected with Cooperia oncophora: similar effector cells but different timing","volume":"33","author":"Kanobana","year":"2003","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.ijpara.2017.07.002_b0060","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1046\/j.1365-3024.2001.00426.x","article-title":"Characterization of host responder types after a single Cooperia oncophora infection: kinetics of the systemic immune response","volume":"23","author":"Kanobana","year":"2001","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.ijpara.2017.07.002_b0065","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1111\/pim.12391","article-title":"Progress in the development of subunit vaccines for gastrointestinal nematodes of ruminants","volume":"38","author":"Matthews","year":"2016","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.ijpara.2017.07.002_b0070","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.vetpar.2007.08.014","article-title":"Vaccination against Ostertagia ostertagi with subfractions of the protective ES-thiol fraction","volume":"149","author":"Meyvis","year":"2007","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.ijpara.2017.07.002_b0075","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/pim.12094","article-title":"Analysis of the mucosal immune responses induced by single and trickle infections with the bovine abomasal nematode Ostertagia ostertagi","volume":"36","author":"Mihi","year":"2014","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.ijpara.2017.07.002_b0080","doi-asserted-by":"crossref","first-page":"428593","DOI":"10.1155\/2010\/428593","article-title":"Immunity against helminths: interactions with the host and the intercurrent infections","volume":"2010","author":"Moreau","year":"2010","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1016\/j.ijpara.2017.07.002_b0085","doi-asserted-by":"crossref","first-page":"4017","DOI":"10.1016\/j.vaccine.2013.05.026","article-title":"Successful immunization against a parasitic nematode by vaccination with recombinant proteins","volume":"31","author":"Nisbet","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.ijpara.2017.07.002_b0090","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.ijpara.2015.03.007","article-title":"Analysis of the protective immune response following intramuscular vaccination of calves against the intestinal parasite Cooperia oncophora","volume":"45","author":"Van Meulder","year":"2015","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.ijpara.2017.07.002_b0095","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.ijpara.2014.11.001","article-title":"Vaccination of calves against Cooperia oncophora with a double-domain activation-associated secreted protein reduces parasite egg output and pasture contamination","volume":"45","author":"Vlaminck","year":"2015","journal-title":"Int. J. Parasitol."}],"container-title":["International Journal for Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020751917302278?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020751917302278?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T15:49:21Z","timestamp":1762184961000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0020751917302278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["S0020751917302278"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpara.2017.07.002","relation":{},"ISSN":["0020-7519"],"issn-type":[{"value":"0020-7519","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparative analysis of the immune responses induced by native versus recombinant versions of the ASP-based vaccine against the bovine intestinal parasite Cooperia oncophora","name":"articletitle","label":"Article Title"},{"value":"International Journal for Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijpara.2017.07.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Author(s). Published by Elsevier Ltd on behalf of Australian Society for Parasitology.","name":"copyright","label":"Copyright"}]}}