{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T11:39:55Z","timestamp":1790509195835,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,9,22]],"date-time":"2018-09-22T00:00:00Z","timestamp":1537574400000},"content-version":"am","delay-in-days":356,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100005825","name":"National Institute of Food and Agriculture","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI111341"],"award-info":[{"award-number":["R01AI111341"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HD080670"],"award-info":[{"award-number":["R01HD080670"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI089441"],"award-info":[{"award-number":["R01AI089441"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["2014-06183"],"award-info":[{"award-number":["2014-06183"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal for Parasitology"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.ijpara.2017.08.006","type":"journal-article","created":{"date-parts":[[2017,9,9]],"date-time":"2017-09-09T13:16:45Z","timestamp":1504963005000},"page":"753-763","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"title":["Advances in bumped kinase inhibitors for human and animal therapy for cryptosporidiosis"],"prefix":"10.1016","volume":"47","author":[{"given":"Matthew A.","family":"Hulverson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel L.M.","family":"Arnold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah A.","family":"Schaefer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Hemphill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly C.","family":"McCloskey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana P.","family":"Betzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rama S.R.","family":"Vidadala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant R.","family":"Whitman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasey L.","family":"Rivas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn K.","family":"Barrett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Hackman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa S.","family":"Love","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Case W.","family":"McNamara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas K.","family":"Shaughnessy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Kondratiuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Kurnick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia N.","family":"Banfor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James J.","family":"Lynch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail M.","family":"Freiberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dale J.","family":"Kempf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dustin J.","family":"Maly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.","family":"Riggs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayode K.","family":"Ojo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wesley C.","family":"Van Voorhis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijpara.2017.08.006_b0005","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/S0140-6736(02)11401-2","article-title":"Effect of nitazoxanide on morbidity and mortality in Zambian children with cryptosporidiosis: a randomised controlled trial","volume":"360","author":"Amadi","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.ijpara.2017.08.006_b0010","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1186\/1471-2334-9-195","article-title":"High dose prolonged treatment with nitazoxanide is not effective for cryptosporidiosis in HIV positive Zambian children: a randomised controlled trial","volume":"9","author":"Amadi","year":"2009","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.ijpara.2017.08.006_b0015","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1093\/infdis\/jix247","article-title":"Necessity of bumped kinase inhibitor gastrointestinal exposurein treating Cryptosporidium infection","volume":"216","author":"Arnold","year":"2017","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ijpara.2017.08.006_b0020","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.vascn.2016.07.002","article-title":"A novel intravenous vehicle for preclinical cardiovascular screening of small molecule drug candidates in rat","volume":"82","author":"Banfor","year":"2016","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"10.1016\/j.ijpara.2017.08.006_b0025","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.2174\/138161212799504858","article-title":"Non-systemic drugs: a critical review","volume":"18","author":"Charmot","year":"2012","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.ijpara.2017.08.006_b0030","doi-asserted-by":"crossref","first-page":"203","DOI":"10.3389\/fphar.2014.00203","article-title":"Early identification of hERG liability in drug discovery programs by automated patch clamp","volume":"5","author":"Danker","year":"2014","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ijpara.2017.08.006_b0035","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.mrgentox.2011.10.014","article-title":"Reduction of misleading (\u201cfalse\u201d) positive results in mammalian cell genotoxicity assays. I. Choice of cell type","volume":"742","author":"Fowler","year":"2012","journal-title":"Mutat. Res."},{"key":"10.1016\/j.ijpara.2017.08.006_b0040","doi-asserted-by":"crossref","first-page":"4573","DOI":"10.1074\/jbc.M114.595181","article-title":"Tricyclic covalent inhibitors selectively target Jak3 through an active site thiol","volume":"290","author":"Goedken","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijpara.2017.08.006_b0045","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1021\/acs.jproteome.6b00817","article-title":"Kinobead and single-shot LC-MS profiling identifies selective PKD inhibitors","volume":"16","author":"Golkowski","year":"2017","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.ijpara.2017.08.006_b0050","doi-asserted-by":"crossref","DOI":"10.1093\/infdis\/jix120","article-title":"Bumped-kinase inhibitors for therapy of cryptosporidiosis","author":"Hulverson","year":"2017","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ijpara.2017.08.006_b0055","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1128\/CMR.15.1.145-154.2002","article-title":"Epidemiology and clinical features of Cryptosporidium infection in immunocompromised patients","volume":"15","author":"Hunter","year":"2002","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.ijpara.2017.08.006_b0060","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0140-6736(13)60844-2","article-title":"Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study","volume":"382","author":"Kotloff","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.ijpara.2017.08.006_b0065","doi-asserted-by":"crossref","first-page":"e0005373","DOI":"10.1371\/journal.pntd.0005373","article-title":"A high-throughput phenotypic screen identifies clofazimine as a potential treatment for cryptosporidiosis","volume":"11","author":"Love","year":"2017","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.ijpara.2017.08.006_b0070","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1093\/mutage\/ger021","article-title":"Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells","volume":"26","author":"Magkoufopoulou","year":"2011","journal-title":"Mutagenesis"},{"key":"10.1016\/j.ijpara.2017.08.006_b0075","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1021\/ml100096t","article-title":"Discovery of Potent and Selective Inhibitors of Calcium-Dependent Protein Kinase 1 (CDPK1) from C. parvum and T. gondii","volume":"1","author":"Murphy","year":"2010","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.ijpara.2017.08.006_b0080","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/em.20631","article-title":"In vitro micronucleus screening of pharmaceutical candidates by flow cytometry in Chinese hamster V79 cells","volume":"52","author":"Nicolette","year":"2011","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.ijpara.2017.08.006_b0085","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1093\/infdis\/jit522","article-title":"A Specific Inhibitor of PfCDPK4 Blocks Malaria Transmission: Chemical-genetic Validation","volume":"209","author":"Ojo","year":"2014","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ijpara.2017.08.006_b0090","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1172\/JCI61822","article-title":"Transmission of malaria to mosquitoes blocked by bumped kinase inhibitors","volume":"122","author":"Ojo","year":"2012","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.ijpara.2017.08.006_b0095","doi-asserted-by":"crossref","first-page":"e564","DOI":"10.1016\/S2214-109X(15)00151-5","article-title":"Pathogen-specific burdens of community diarrhoea in developing countries: a multisite birth cohort study (MAL-ED)","volume":"3","author":"Platts-Mills","year":"2015","journal-title":"Lancet Glob. Health"},{"key":"10.1016\/j.ijpara.2017.08.006_b0100","doi-asserted-by":"crossref","first-page":"F590","DOI":"10.1152\/ajprenal.00324.2003","article-title":"Serial determination of glomerular filtration rate in conscious mice using FITC-inulin clearance","volume":"286","author":"Qi","year":"2004","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"10.1016\/j.ijpara.2017.08.006_b0105","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.4049\/jimmunol.143.4.1340","article-title":"Neutralization-sensitive epitopes are exposed on the surface of infectious Cryptosporidium parvum sporozoites","volume":"143","author":"Riggs","year":"1989","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijpara.2017.08.006_b0110","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1128\/iai.55.9.2081-2087.1987","article-title":"Infectivity and neutralization of Cryptosporidium parvum sporozoites","volume":"55","author":"Riggs","year":"1987","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijpara.2017.08.006_b0115","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1093\/infdis\/jiw488","article-title":"Novel Bumped Kinase Inhibitors Are Safe and Effective Therapeutics in the Calf Clinical Model for Cryptosporidiosis","volume":"214","author":"Schaefer","year":"2016","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ijpara.2017.08.006_b0120","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.vetpar.2008.10.094","article-title":"Prophylactic and therapeutic efficacy of nitazoxanide against Cryptosporidium parvum in experimentally challenged neonatal calves","volume":"160","author":"Schnyder","year":"2009","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.ijpara.2017.08.006_b0125","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1021\/jm401178t","article-title":"Substituted 2-phenylimidazopyridines: a new class of drug leads for human African trypanosomiasis","volume":"57","author":"Tatipaka","year":"2014","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ijpara.2017.08.006_b0130","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1128\/AAC.42.8.1959","article-title":"Efficacy of nitazoxanide against Cryptosporidium parvum in cell culture and in animal models","volume":"42","author":"Theodos","year":"1998","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ijpara.2017.08.006_b0135","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1099\/00222615-47-1-71","article-title":"Cryptosporidium parvum biliary tract infection in adult immunocompetent and immunosuppressed mice","volume":"47","author":"Verdon","year":"1998","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.ijpara.2017.08.006_b0140","doi-asserted-by":"crossref","first-page":"6531","DOI":"10.1021\/acs.jmedchem.6b00760","article-title":"Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis","volume":"59","author":"Vidadala","year":"2016","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ijpara.2017.08.006_b0145","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/nature14651","article-title":"Genetic modification of the diarrhoeal pathogen Cryptosporidium parvum","volume":"523","author":"Vinayak","year":"2015","journal-title":"Nature"}],"container-title":["International Journal for Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020751917302515?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020751917302515?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T14:00:33Z","timestamp":1758117633000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0020751917302515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":29,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["S0020751917302515"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpara.2017.08.006","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.731182683.793549973","asserted-by":"object"}]},"ISSN":["0020-7519"],"issn-type":[{"value":"0020-7519","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Advances in bumped kinase inhibitors for human and animal therapy for cryptosporidiosis","name":"articletitle","label":"Article Title"},{"value":"International Journal for Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijpara.2017.08.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Australian Society for Parasitology. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}