{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T17:53:52Z","timestamp":1764784432552,"version":"3.44.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"6-7","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100011787","name":"Heilongjiang Provincial Science and Technology Department","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011787","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal for Parasitology"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.ijpara.2020.03.004","type":"journal-article","created":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T22:13:39Z","timestamp":1588630419000},"page":"487-499","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["TgMAP1c is involved in apicoplast biogenesis in Toxoplasma gondii"],"prefix":"10.1016","volume":"50","author":[{"given":"Jun","family":"Zheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenqiang","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinuo","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoxia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Honglin","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijpara.2020.03.004_b0005","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005765","article-title":"Apicoplast-localized Lysophosphatidic acid precursor assembly is required for bulk phospholipid synthesis in Toxoplasma gondii and relies on an algal\/plant-like glycerol 3-phosphate acyltransferase","volume":"12","author":"Amiar","year":"2016","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ijpara.2020.03.004_b0010","doi-asserted-by":"crossref","first-page":"7714","DOI":"10.1073\/pnas.92.17.7714","article-title":"Eukaryotic methionyl aminopeptidases: two classes of cobalt-dependent enzymes","volume":"92","author":"Arfin","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ijpara.2020.03.004_b0015","doi-asserted-by":"crossref","first-page":"5128","DOI":"10.1016\/j.bmcl.2009.07.029","article-title":"antiparasitic activities of novel, orally available Fumagillin analogs","volume":"19","author":"Arico-Muendel","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ijpara.2020.03.004_b0020","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1021\/jm501790e","article-title":"Identification of the molecular basis of inhibitor selectivity between the human and streptococcal type I methionine aminopeptidases","volume":"58","author":"Arya","year":"2015","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ijpara.2020.03.004_b0025","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01468-17","article-title":"Autophagy-related protein ATG18 regulates apicoplast biogenesis in apicomplexan parasites","volume":"8","author":"Bansal","year":"2017","journal-title":"mBio"},{"key":"10.1016\/j.ijpara.2020.03.004_b0030","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1002\/jcb.20493","article-title":"Methionine aminopeptidases type I and type II are essential to control cell proliferation","volume":"95","author":"Bernier","year":"2005","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.ijpara.2020.03.004_b0035","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006836","article-title":"Two essential thioredoxins mediate apicoplast biogenesis, protein import, and gene expression in Toxoplasma gondii","volume":"14","author":"Biddau","year":"2018","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ijpara.2020.03.004_b0040","doi-asserted-by":"crossref","unstructured":"Boucherit, H., Chikhi, A., Bensegueni, A., Merzoug, A., Bolla, J.M., 2019. The research of new inhibitors of bacterial methionine aminopeptidase by structure based virtual screening approach of ZINC DATABASE and in vitro validation. Curr. Comput. Aided Drug Des.","DOI":"10.2174\/1573409915666190617165643"},{"key":"10.1016\/j.ijpara.2020.03.004_b0045","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0968-0004(98)01227-4","article-title":"N-terminal processing: the methionine aminopeptidase and N alpha-acetyl transferase families","volume":"23","author":"Bradshaw","year":"1998","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.ijpara.2020.03.004_b0050","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.gene.2003.08.008","article-title":"Apicoplast genome of the Coccidian Eimeria tenella","volume":"321","author":"Cai","year":"2003","journal-title":"Gene"},{"key":"10.1016\/j.ijpara.2020.03.004_b0055","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/mmi.14411","article-title":"The Sec1\/Munc18-like proteins TgSec1 and TgVps45 play pivotal roles in assembly of the pellicle and sub-pellicle network in Toxoplasma gondii","volume":"113","author":"Cao","year":"2020","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.ijpara.2020.03.004_b0060","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.1016\/j.ejmech.2011.04.056","article-title":"Growth inhibition of Escherichia coli and methicillin-resistant Staphylococcus aureus by targeting cellular methionine aminopeptidase","volume":"46","author":"Chai","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ijpara.2020.03.004_b0065","doi-asserted-by":"crossref","first-page":"4071","DOI":"10.1128\/jb.171.7.4071-4072.1989","article-title":"Methionine aminopeptidase gene of Escherichia coli is essential for cell growth","volume":"171","author":"Chang","year":"1989","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ijpara.2020.03.004_b0070","doi-asserted-by":"crossref","first-page":"14548","DOI":"10.1073\/pnas.0604101103","article-title":"Inhibitors of Plasmodium falciparum methionine aminopeptidase 1B possess antimalarial activity","volume":"103","author":"Chen","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ijpara.2020.03.004_b0075","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.chembiol.2009.01.006","article-title":"Fumagillin and fumarranol interact with P. falciparum methionine aminopeptidase 2 and inhibit malaria parasite growth in vitro and in vivo","volume":"16","author":"Chen","year":"2009","journal-title":"Chem. Biol."},{"key":"10.1016\/j.ijpara.2020.03.004_b0080","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1111\/cmi.12383","article-title":"Lipid kinases are essential for apicoplast homeostasis in Toxoplasma gondii","volume":"17","author":"Daher","year":"2015","journal-title":"Cell. Microbiol."},{"issue":"9","key":"10.1016\/j.ijpara.2020.03.004_b0085","doi-asserted-by":"crossref","DOI":"10.1007\/s13205-018-1411-z","article-title":"Molecular characterization of Nosema bombycis methionine aminopeptidase 2 (MetAP2) gene and evaluation of anti-microsporidian activity of Fumagilin-B in silkworm Bombyx mori","volume":"8","author":"Esvaran","year":"2018","journal-title":"3 Biotech"},{"key":"10.1016\/j.ijpara.2020.03.004_b0090","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00950-17","article-title":"A plastid protein that evolved from ubiquitin and is required for apicoplast protein import in Toxoplasma gondii","volume":"8","author":"Fellows","year":"2017","journal-title":"mBio"},{"key":"10.1016\/j.ijpara.2020.03.004_b0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1475-2875-5-1","article-title":"Real-time quantitative PCR with SYBR green I detection for estimating copy numbers of nine drug resistance candidate genes in Plasmodium Falciparum","volume":"5","author":"Ferreira","year":"2006","journal-title":"Malar J."},{"key":"10.1016\/j.ijpara.2020.03.004_b0100","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1749-6632.1981.tb46519.x","article-title":"The chloroplasts of some algal groups may have evolved from endosymbiotic eukaryotic algae","volume":"361","author":"Gibbs","year":"1981","journal-title":"Ann N Y Acad Sci."},{"key":"10.1016\/j.ijpara.2020.03.004_b0105","doi-asserted-by":"crossref","first-page":"5916","DOI":"10.1093\/emboj\/19.21.5916","article-title":"Identification of eukaryotic peptide deformylases reveals universality of N-terminal protein processing mechanisms","volume":"19","author":"Giglione","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/j.ijpara.2020.03.004_b0110","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.1574-6976.1996.tb00247.x","article-title":"Bacterial Aminopeptidases: properties and functions","volume":"18","author":"Gonzales","year":"1996","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.ijpara.2020.03.004_b0115","doi-asserted-by":"crossref","first-page":"5025","DOI":"10.1021\/acs.jmedchem.9b00041","article-title":"Discovery and structure-based optimization of next-generation reversible methionine aminopeptidase-2 (MetAP-2) inhibitors","volume":"62","author":"Heinrich","year":"2019","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ijpara.2020.03.004_b0120","doi-asserted-by":"crossref","first-page":"397","DOI":"10.2174\/1568026615666150813145410","article-title":"Advances in bacterial methionine aminopeptidase inhibition","volume":"16","author":"Helgren","year":"2016","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.ijpara.2020.03.004_b0125","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1111\/j.1600-0854.2007.00637.x","article-title":"A membrane protease is targeted to the relict plastid of Toxoplasma via an internal signal sequence","volume":"8","author":"Karnataki","year":"2007","journal-title":"Traffic."},{"key":"10.1016\/j.ijpara.2020.03.004_b0135","doi-asserted-by":"crossref","first-page":"12357","DOI":"10.1073\/pnas.92.26.12357","article-title":"Amino-terminal protein processing in Saccharomyces cerevisiae is an essential function that requires two distinct methionine aminopeptidases","volume":"92","author":"Li","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ijpara.2020.03.004_b0140","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.ijpara.2020.03.004_b0145","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.2768","article-title":"CRISPR-mediated tagging with BirA allows proximity labeling in Toxoplasma gondii","volume":"8","author":"Long","year":"2018","journal-title":"Bio-Protocol"},{"key":"10.1016\/j.ijpara.2020.03.004_b0150","doi-asserted-by":"crossref","first-page":"13192","DOI":"10.1073\/pnas.0603391103","article-title":"Apicoplast fatty acid synthesis is essential for organelle biogenesis and parasite survival in Toxoplasma gondii","volume":"103","author":"Mazumdar","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ijpara.2020.03.004_b0155","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.sbi.2013.07.015","article-title":"Working in concert: the metalloaminopeptidases from Plasmodium falciparum","volume":"23","author":"McGowan","year":"2013","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.ijpara.2020.03.004_b0160","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ab.2006.06.012","article-title":"A new colorimetric assay for methionyl aminopeptidases: examination of the binding of a new class of pseudopeptide analog inhibitors","volume":"357","author":"Mitra","year":"2006","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ijpara.2020.03.004_b0165","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1056\/NEJMoa012924","article-title":"Fumagillin treatment of intestinal microsporidiosis","volume":"346","author":"Molina","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijpara.2020.03.004_b0170","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1084\/jem.20110039","article-title":"Apicoplast isoprenoid precursor synthesis and the molecular basis of fosmidomycin resistance in Toxoplasma gondii","volume":"208","author":"Nair","year":"2011","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ijpara.2020.03.004_b0175","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1093\/molbev\/msi230","article-title":"Mosaic origin of the Heme biosynthesis pathway in photosynthetic eukaryotes","volume":"22","author":"Obornik","year":"2005","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.ijpara.2020.03.004_b0180","doi-asserted-by":"crossref","first-page":"3567","DOI":"10.1073\/pnas.1315156111","article-title":"Toxoplasma aldolase is required for metabolism but dispensable for host-cell invasion","volume":"111","author":"Shen","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ijpara.2020.03.004_b0185","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/j.cell.2016.08.019","article-title":"A genome-wide CRISPR screen in Toxoplasma identifies essential apicomplexan genes","volume":"166","author":"Sidik","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.ijpara.2020.03.004_b0190","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1126\/science.8469986","article-title":"Transient transfection and expression in the obligate intracellular parasite Toxoplasma gondii","volume":"260","author":"Soldati","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.ijpara.2020.03.004_b0195","doi-asserted-by":"crossref","first-page":"12352","DOI":"10.1073\/pnas.95.21.12352","article-title":"Nuclear-encoded proteins target to the plastid in Toxoplasma gondii and Plasmodium falciparum","volume":"95","author":"Waller","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ijpara.2020.03.004_b0200","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1006\/jmbi.1996.0449","article-title":"Complete gene map of the plastid-Like DNA of the malaria parasite Plasmodium falciparum","volume":"261","author":"Wilson","year":"1996","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.ijpara.2020.03.004_b0205","first-page":"88","article-title":"N-terminal methionine processing","author":"Wingfield","year":"2017","journal-title":"Curr. Prot. Prot. Sci."},{"key":"10.1016\/j.ijpara.2020.03.004_b0210","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1096\/fj.201700994R","article-title":"Translationally controlled tumor protein is required for the fast growth of Toxoplasma gondii and maintenance of its intracellular development","volume":"32","author":"Zheng","year":"2018","journal-title":"FASEB J."},{"key":"10.1016\/j.ijpara.2020.03.004_b0215","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.ijpara.2014.09.003","article-title":"Knockout of Leucine Aminopeptidase in Toxoplasma gondii Using CRISPR\/Cas9","volume":"45","author":"Zheng","year":"2015","journal-title":"Int. J. Parasitol."}],"container-title":["International Journal for Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020751920300953?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020751920300953?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T14:04:47Z","timestamp":1758117887000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0020751920300953"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":42,"journal-issue":{"issue":"6-7","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["S0020751920300953"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpara.2020.03.004","relation":{},"ISSN":["0020-7519"],"issn-type":[{"type":"print","value":"0020-7519"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TgMAP1c is involved in apicoplast biogenesis in Toxoplasma gondii","name":"articletitle","label":"Article Title"},{"value":"International Journal for Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijpara.2020.03.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Australian Society for Parasitology. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}