{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:09:37Z","timestamp":1793210977682,"version":"4.5.0"},"reference-count":62,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T00:00:00Z","timestamp":1594252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["Z03128\/Z\/16\/Z\/WT"],"award-info":[{"award-number":["Z03128\/Z\/16\/Z\/WT"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["Z10661\/Z\/18\/Z\/WT"],"award-info":[{"award-number":["Z10661\/Z\/18\/Z\/WT"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000288","name":"Royal Society","doi-asserted-by":"publisher","award":["IC160132"],"award-info":[{"award-number":["IC160132"]}],"id":[{"id":"10.13039\/501100000288","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000833","name":"Rosetrees Trust","doi-asserted-by":"publisher","award":["M813"],"award-info":[{"award-number":["M813"]}],"id":[{"id":"10.13039\/501100000833","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010757","name":"National Centre for the Replacement Refinement and Reduction of Animals in Research","doi-asserted-by":"publisher","award":["NC\/P001521\/1"],"award-info":[{"award-number":["NC\/P001521\/1"]}],"id":[{"id":"10.13039\/501100010757","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal for Parasitology"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.ijpara.2020.06.001","type":"journal-article","created":{"date-parts":[[2020,7,11]],"date-time":"2020-07-11T02:08:44Z","timestamp":1594433324000},"page":"707-718","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"title":["Development of caecaloids to study host\u2013pathogen interactions: new insights into immunoregulatory functions of Trichuris muris extracellular vesicles in the caecum"],"prefix":"10.1016","volume":"50","author":[{"given":"Mar\u00eda A.","family":"Duque-Correa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"Schreiber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faye H.","family":"Rodgers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Goulding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally","family":"Forrest","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruby","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Buck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard K.","family":"Grencis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Berriman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijpara.2020.06.001_b0005","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.ydbio.2012.07.008","article-title":"FGF9-Pitx2-FGF10 signaling controls cecal formation in mice","volume":"369","author":"Al Alam","year":"2012","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ijpara.2020.06.001_b0010","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/mi.2008.21","article-title":"The intestinal epithelium: sensors to effectors in nematode infection","volume":"1","author":"Artis","year":"2008","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.ijpara.2020.06.001_b0015","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1126\/science.1104816","article-title":"Host-bacterial mutualism in the human intestine","volume":"307","author":"Backhed","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.ijpara.2020.06.001_b0020","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1038\/s41467-019-09996-z","article-title":"The major secreted protein of the whipworm parasite tethers to matrix and inhibits interleukin-13 function","volume":"10","author":"Bancroft","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ijpara.2020.06.001_b0025","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/nrm3721","article-title":"Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration","volume":"15","author":"Barker","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ijpara.2020.06.001_b0030","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.stem.2009.11.013","article-title":"Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro","volume":"6","author":"Barker","year":"2010","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.ijpara.2020.06.001_b0035","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00282-18","article-title":"Modeling host-pathogen interactions in the context of the microenvironment: three-dimensional cell culture comes of age","volume":"86","author":"Barrila","year":"2018","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijpara.2020.06.001_b0040","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1128\/IAI.71.5.2839-2858.2003","article-title":"Pretreatment of mice with streptomycin provides a Salmonella enterica serovar Typhimurium colitis model that allows analysis of both pathogen and host","volume":"71","author":"Barthel","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijpara.2020.06.001_b0045","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/nbt.3519","article-title":"Near-optimal probabilistic RNA-seq quantification","volume":"34","author":"Bray","year":"2016","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ijpara.2020.06.001_b0050","doi-asserted-by":"crossref","first-page":"D1228","DOI":"10.1093\/nar\/gks1147","article-title":"InnateDB: systems biology of innate immunity and beyond\u2013recent updates and continuing curation","volume":"41","author":"Breuer","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ijpara.2020.06.001_b0055","doi-asserted-by":"crossref","first-page":"5488","DOI":"10.1038\/ncomms6488","article-title":"Exosomes secreted by nematode parasites transfer small RNAs to mammalian cells and modulate innate immunity","volume":"5","author":"Buck","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ijpara.2020.06.001_b0060","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ydbio.2003.09.021","article-title":"Requirement for fibroblast growth factor 10 or fibroblast growth factor receptor 2-IIIb signaling for cecal development in mouse","volume":"265","author":"Burns","year":"2004","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ijpara.2020.06.001_b0065","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s12915-019-0652-6","article-title":"Derivation of adult canine intestinal organoids for translational research in gastroenterology","volume":"17","author":"Chandra","year":"2019","journal-title":"BMC Biol."},{"key":"10.1016\/j.ijpara.2020.06.001_b0070","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/j.celrep.2017.05.001","article-title":"Extracellular vesicles from a helminth parasite suppress macrophage activation and constitute an effective vaccine for protective immunity","volume":"19","author":"Coakley","year":"2017","journal-title":"Cell Rep"},{"key":"10.1016\/j.ijpara.2020.06.001_b0075","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/nrmicro3315","article-title":"Citrobacter rodentium: infection, inflammation and the microbiota","volume":"12","author":"Collins","year":"2014","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.ijpara.2020.06.001_b0080","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1084\/jem.20160470","article-title":"Th2 responses are primed by skin dendritic cells with distinct transcriptional profiles","volume":"214","author":"Connor","year":"2017","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ijpara.2020.06.001_b0085","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1146\/annurev-cellbio-100814-125218","article-title":"Mini-gut organoids: reconstitution of the stem cell niche","volume":"31","author":"Date","year":"2015","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.ijpara.2020.06.001_b0090","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.pt.2019.10.013","article-title":"Organoids - new models for host-helminth interactions","volume":"36","author":"Duque-Correa","year":"2020","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.ijpara.2020.06.001_b0095","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1126\/science.1110591","article-title":"Diversity of the human intestinal microbial flora","volume":"308","author":"Eckburg","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.ijpara.2020.06.001_b0100","doi-asserted-by":"crossref","first-page":"850","DOI":"10.3389\/fimmu.2018.00850","article-title":"Hookworm secreted extracellular vesicles interact with host cells and prevent inducible colitis in mice","volume":"9","author":"Eichenberger","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ijpara.2020.06.001_b0105","doi-asserted-by":"crossref","first-page":"1428004","DOI":"10.1080\/20013078.2018.1428004","article-title":"Characterization of Trichuris muris secreted proteins and extracellular vesicles provides new insights into host-parasite communication","volume":"7","author":"Eichenberger","year":"2018","journal-title":"J. Extracell. Vesic."},{"key":"10.1016\/j.ijpara.2020.06.001_b0110","doi-asserted-by":"crossref","first-page":"3471","DOI":"10.1128\/IAI.01793-14","article-title":"Colonization of cecum is important for development of persistent infection by Yersinia pseudotuberculosis","volume":"82","author":"Fahlgren","year":"2014","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijpara.2020.06.001_b0115","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/ncb3312","article-title":"Organoids as an in vitro model of human development and disease","volume":"18","author":"Fatehullah","year":"2016","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ijpara.2020.06.001_b0120","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1146\/annurev-immunol-032713-120218","article-title":"Immunity to helminths: resistance, regulation, and susceptibility to gastrointestinal nematodes","volume":"33","author":"Grencis","year":"2015","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.ijpara.2020.06.001_b0125","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1645\/14-714.1","article-title":"Secretion of RNA-Containing Extracellular Vesicles by the Porcine Whipworm, Trichuris suis","volume":"101","author":"Hansen","year":"2015","journal-title":"J. Parasitol."},{"key":"10.1016\/j.ijpara.2020.06.001_b0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molimm.2014.03.003","article-title":"Excreted\/secreted Trichuris suis products reduce barrier function and suppress inflammatory cytokine production of intestinal epithelial cells","volume":"60","author":"Hiemstra","year":"2014","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.ijpara.2020.06.001_b0135","doi-asserted-by":"crossref","first-page":"4496","DOI":"10.4049\/jimmunol.169.8.4496","article-title":"The mouse model of amebic colitis reveals mouse strain susceptibility to infection and exacerbation of disease by CD4+ T cells","volume":"169","author":"Houpt","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijpara.2020.06.001_b0140","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/s41590-020-0602-z","article-title":"Distinct microbial and immune niches of the human colon","volume":"21","author":"James","year":"2020","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ijpara.2020.06.001_b0145","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.ijpara.2012.10.021","article-title":"Trichuris suis-induced modulation of human dendritic cell function is glycan-mediated","volume":"43","author":"Klaver","year":"2013","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.ijpara.2020.06.001_b0150","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1007\/s00281-012-0348-2","article-title":"Trichuris muris: a model of gastrointestinal parasite infection","volume":"34","author":"Klementowicz","year":"2012","journal-title":"Sem. Immunopathol."},{"key":"10.1016\/j.ijpara.2020.06.001_b0155","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.molimm.2012.03.020","article-title":"Soluble helminth products suppress clinical signs in murine experimental autoimmune encephalomyelitis and differentially modulate human dendritic cell activation","volume":"51","author":"Kuijk","year":"2012","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.ijpara.2020.06.001_b0160","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.3389\/fmicb.2018.02182","article-title":"Pathogen-derived extracellular vesicle-associated molecules that affect the host immune system: an overview","volume":"9","author":"Kuipers","year":"2018","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.ijpara.2020.06.001_b0165","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1096\/fj.201600841R","article-title":"The whipworm (Trichuris suis) secretes prostaglandin E2 to suppress proinflammatory properties in human dendritic cells","volume":"31","author":"Laan","year":"2017","journal-title":"FASEB J."},{"key":"10.1016\/j.ijpara.2020.06.001_b0170","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1128\/iai.51.2.536-546.1986","article-title":"Mucus colonization as a determinant of pathogenicity in intestinal infection by Campylobacter jejuni: a mouse cecal model","volume":"51","author":"Lee","year":"1986","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijpara.2020.06.001_b0175","doi-asserted-by":"crossref","first-page":"15921","DOI":"10.1038\/s41598-018-34174-4","article-title":"Analysis of the Trichuris suis excretory\/secretory proteins as a function of life cycle stage and their immunomodulatory properties","volume":"8","author":"Leroux","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ijpara.2020.06.001_b0180","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1056\/NEJMra1806175","article-title":"Organoids - preclinical models of human disease","volume":"380","author":"Li","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijpara.2020.06.001_b0185","first-page":"662","article-title":"Host and viral modulation of RIG-I-mediated antiviral immunity","volume":"7","author":"Liu","year":"2016","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ijpara.2020.06.001_b0190","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.ijpara.2020.06.001_b0195","doi-asserted-by":"crossref","first-page":"5564","DOI":"10.1073\/pnas.1812901116","article-title":"Infection by the parasitic helminth Trichinella spiralis activates a Tas2r-mediated signaling pathway in intestinal tuft cells","volume":"116","author":"Luo","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1068\u20131078","key":"10.1016\/j.ijpara.2020.06.001_b0200","article-title":"Enteric helminth-induced type I interferon signaling protects against pulmonary virus infection through interaction with the microbiota","volume":"140","author":"McFarlane","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.ijpara.2020.06.001_b0205","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/nrmicro2538","article-title":"Mucin dynamics and enteric pathogens","volume":"9","author":"McGuckin","year":"2011","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.ijpara.2020.06.001_b0210","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1038\/nprot.2013.153","article-title":"In vitro expansion and genetic modification of gastrointestinal stem cells in spheroid culture","volume":"8","author":"Miyoshi","year":"2013","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.ijpara.2020.06.001_b0215","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/nri3738","article-title":"Regional specialization within the intestinal immune system","volume":"14","author":"Mowat","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ijpara.2020.06.001_b0220","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1242\/dmm.017400","article-title":"How informative is the mouse for human gut microbiota research?","volume":"8","author":"Nguyen","year":"2015","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.ijpara.2020.06.001_b0225","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/s41579-018-0020-5","article-title":"ISG15 in antiviral immunity and beyond","volume":"16","author":"Perng","year":"2018","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.ijpara.2020.06.001_b0230","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1128\/iai.57.7.2092-2097.1989","article-title":"Effect of streptomycin administration on association of enteric pathogens with cecal tissue of mice","volume":"57","author":"Pongpech","year":"1989","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijpara.2020.06.001_b0235","doi-asserted-by":"crossref","first-page":"2984","DOI":"10.4049\/jimmunol.1401056","article-title":"MyD88 signaling inhibits protective immunity to the gastrointestinal helminth parasite Heligmosomoides polygyrus","volume":"193","author":"Reynolds","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijpara.2020.06.001_b0240","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1126\/science.1234852","article-title":"Growing self-organizing mini-guts from a single intestinal stem cell: mechanism and applications","volume":"340","author":"Sato","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.ijpara.2020.06.001_b0245","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1053\/j.gastro.2011.07.050","article-title":"Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium","volume":"141","author":"Sato","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ijpara.2020.06.001_b0250","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/nature07935","article-title":"Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche","volume":"459","author":"Sato","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.ijpara.2020.06.001_b0255","doi-asserted-by":"crossref","DOI":"10.1111\/pim.12536","article-title":"Extracellular vesicles induce protective immunity against Trichuris muris","volume":"40","author":"Shears","year":"2018","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.ijpara.2020.06.001_b0260","doi-asserted-by":"crossref","first-page":"4508","DOI":"10.1038\/s41598-018-22783-y","article-title":"Vaccination against whipworm: identification of potential immunogenic proteins in Trichuris muris excretory\/secretory material","volume":"8","author":"Shears","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ijpara.2020.06.001_b0265","doi-asserted-by":"crossref","first-page":"453","DOI":"10.3389\/fimmu.2017.00453","article-title":"Helminth immunomodulation in autoimmune disease","volume":"8","author":"Smallwood","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ijpara.2020.06.001_b0270","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1126\/science.aaw7567","article-title":"Organoids by design","volume":"364","author":"Takebe","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.ijpara.2020.06.001_b0275","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1002\/jez.a.214","article-title":"Adaptation of a nematode parasite to living within the mammalian epithelium","volume":"303","author":"Tilney","year":"2005","journal-title":"J. Exp. Zool. A: Comp. Exp. Biol."},{"key":"10.1016\/j.ijpara.2020.06.001_b0280","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.exppara.2017.05.003","article-title":"Excretory\/secretory products from the gastrointestinal nematode Trichuris muris","volume":"178","author":"Tritten","year":"2017","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.ijpara.2020.06.001_b0285","doi-asserted-by":"crossref","first-page":"G537","DOI":"10.1152\/ajpgi.00024.2017","article-title":"Helminths in the gastrointestinal tract as modulators of immunity and pathology","volume":"312","author":"Varyani","year":"2017","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.ijpara.2020.06.001_b0290","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.15252\/embj.201695345","article-title":"Type I interferon is required for T helper (Th) 2 induction by dendritic cells","volume":"36","author":"Webb","year":"2017","journal-title":"EMBO J."},{"key":"10.1016\/j.ijpara.2020.06.001_b0295","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.ijpara.2020.06.002","article-title":"Extracellular vesicles from Heligmosomoides bakeri and Trichuris muris contain distinct microRNA families and small RNAs that could underpin different functions in the host","volume":"50","author":"White","year":"2020","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.ijpara.2020.06.001_b0300","first-page":"D682","article-title":"Ensembl 2020","volume":"48","author":"Yates","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ijpara.2020.06.001_b0305","doi-asserted-by":"crossref","first-page":"G112","DOI":"10.1152\/ajpgi.00294.2016","article-title":"Critical role of microbiota within cecal crypts on the regenerative capacity of the intestinal epithelium following surgical stress","volume":"312","author":"Zaborin","year":"2017","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.ijpara.2020.06.001_b0310","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1242\/dev.02175","article-title":"Reciprocal epithelial-mesenchymal FGF signaling is required for cecal development","volume":"133","author":"Zhang","year":"2006","journal-title":"Development"}],"container-title":["International Journal for Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020751920301624?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020751920301624?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T15:51:12Z","timestamp":1762185072000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0020751920301624"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":62,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["S0020751920301624"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpara.2020.06.001","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.05.11.087684","asserted-by":"object"}]},"ISSN":["0020-7519"],"issn-type":[{"value":"0020-7519","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of caecaloids to study host\u2013pathogen interactions: new insights into immunoregulatory functions of Trichuris muris extracellular vesicles in the caecum","name":"articletitle","label":"Article Title"},{"value":"International Journal for Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijpara.2020.06.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier Ltd on behalf of Australian Society for Parasitology.","name":"copyright","label":"Copyright"}]}}