{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T19:57:00Z","timestamp":1758139020713,"version":"3.44.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,30]],"date-time":"2022-10-30T00:00:00Z","timestamp":1667088000000},"content-version":"am","delay-in-days":363,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["16fk0108110j0001"],"award-info":[{"award-number":["16fk0108110j0001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["15H04592"],"award-info":[{"award-number":["15H04592"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal for Parasitology"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.ijpara.2021.04.004","type":"journal-article","created":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T01:56:41Z","timestamp":1622426201000},"page":"999-1006","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Releasing latent Toxoplasma gondii cysts from host cells to the extracellular environment induces excystation"],"prefix":"10.1016","volume":"51","author":[{"given":"Taizo","family":"Saito","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsunori","family":"Masatani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuya","family":"Kitoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Takashima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijpara.2021.04.004_b0005","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.parint.2019.01.001","article-title":"Native SAG1 in Toxoplasma gondii lysates is superior to recombinant SAG1 for serodiagnosis of T. gondii infections in chickens","volume":"69","author":"Appiah-Kwarteng","year":"2019","journal-title":"Parasitol. Int."},{"key":"10.1016\/j.ijpara.2021.04.004_b0010","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.ijpara.2003.11.017","article-title":"Role of calcium during Toxoplasma gondii invasion and egress","volume":"34","author":"Arrizabalaga","year":"2004","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.ijpara.2021.04.004_b0015","first-page":"99","article-title":"Murine model of drug-induced reactivation of Toxoplasma gondii","volume":"40","author":"Djurkovi","year":"2001","journal-title":"Acta Protozool."},{"key":"10.1016\/j.ijpara.2021.04.004_b0020","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/S0092-8674(00)81071-5","article-title":"Toxoplasma invasion of mammalian cells is powered by the actin cytoskeleton of the parasite","volume":"84","author":"Dobrowolski","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.ijpara.2021.04.004_b0025","doi-asserted-by":"crossref","first-page":"11703","DOI":"10.1073\/pnas.90.24.11703","article-title":"Stable molecular transformation of Toxoplasma gondii: a selectable dihydrofolate reductase\u2013thymidylate synthase marker based on drug-resistance mutations in malaria","volume":"90","author":"Donald","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ijpara.2021.04.004_b0030","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1128\/CMR.11.2.267","article-title":"Structures of Toxoplasma gondii tachyzoites, bradyzoites, and sporozoites and biology and development of tissue cysts","volume":"11","author":"Dubey","year":"1998","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.ijpara.2021.04.004_b0035","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1111\/j.1550-7408.1997.tb05965.x","article-title":"Bradyzoite-induced murine toxoplasmosis: stage conversion, pathogenesis, and tissue cyst formation in mice fed bradyzoites of different strains of Toxoplasma gondii","volume":"44","author":"Dubey","year":"2007","journal-title":"J. Euk. Microbiol."},{"key":"10.1016\/j.ijpara.2021.04.004_b0040","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/BF00930955","article-title":"Tissue cyst rupture in mice chronically infected with Toxoplasma gondii: An immunocytochemical and ultrastructural study","volume":"75","author":"Ferguson","year":"1989","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.ijpara.2021.04.004_b0045","doi-asserted-by":"crossref","first-page":"4394","DOI":"10.1128\/iai.60.10.4394-4401.1992","article-title":"Opportunistic infections and retrovirus-induced immunodeficiency: studies of acute and chronic infections with Toxoplasma gondii in mice infected with LP-BM5 murine leukemia viruses","volume":"60","author":"Gazzinelli","year":"1992","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijpara.2021.04.004_b0050","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1128\/IAI.01126-12","article-title":"Replication and distribution of Toxoplasma gondii in the small intestine after oral infection with tissue cysts","volume":"81","author":"Gregg","year":"2013","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijpara.2021.04.004_b0055","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1079\/AHR2005100","article-title":"Biology and epidemiology of Toxoplasma gondii in man and animals","volume":"6","author":"Hill","year":"2005","journal-title":"Anim. Health. Res. Rev."},{"key":"10.1016\/j.ijpara.2021.04.004_b0060","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1128\/iai.51.1.147-156.1986","article-title":"In vitro cultivation of Toxoplasma gondii cysts in astrocytes in the presence of gamma interferon","volume":"51","author":"Jones","year":"1986","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijpara.2021.04.004_b0065","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1093\/clinids\/15.2.211","article-title":"Toxoplasmic encephalitis in AIDS","volume":"15","author":"Luft","year":"1992","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.ijpara.2021.04.004_b0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4303\/jnp\/N100505","article-title":"Host cell preference of Toxoplasma gondii cysts in murine brain: a confocal study","volume":"1","author":"Melzer","year":"2010","journal-title":"J. Neuroparasitol."},{"key":"10.1016\/j.ijpara.2021.04.004_b0075","doi-asserted-by":"crossref","first-page":"41492","DOI":"10.1074\/jbc.M106154200","article-title":"The loss of cytoplasmic potassium upon host cell breakdown triggers egress of Toxoplasma gondii","volume":"276","author":"Moudy","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijpara.2021.04.004_b0080","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1016\/S0020-7519(03)00204-2","article-title":"Characterisation of Toxoplasma gondii engineered to express mouse interferon-gamma","volume":"33","author":"Nishikawa","year":"2003","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.ijpara.2021.04.004_b0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00936173","article-title":"Toxoplasma gondii: differentiation and death of bradyzoites","volume":"78","author":"Pavesio","year":"1992","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.ijpara.2021.04.004_b0090","doi-asserted-by":"crossref","first-page":"e26218","DOI":"10.1371\/journal.pone.0026218","article-title":"Identification of intracellular and plasma membrane calcium channel homologues in pathogenic parasites","volume":"6","author":"Prole","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ijpara.2021.04.004_b0095","doi-asserted-by":"crossref","first-page":"e105","DOI":"10.1371\/journal.ppat.0020105","article-title":"Changes in the expression of human cell division autoantigen-1 influence Toxoplasma gondii growth and development","volume":"2","author":"Radke","year":"2006","journal-title":"PLOS Pathog."},{"key":"10.1016\/j.ijpara.2021.04.004_b0100","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1471-2105-12-77","article-title":"PROC: an open-source package for R and S + to analyze and compare ROC curves","volume":"12","author":"Robin","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.ijpara.2021.04.004_b0105","doi-asserted-by":"crossref","first-page":"e1004488","DOI":"10.1371\/journal.ppat.1004488","article-title":"Acidification activates Toxoplasma gondii motility and egress by enhancing protein secretion and cytolytic activity","volume":"10","author":"Roiko","year":"2014","journal-title":"PLOS Pathog."},{"key":"10.1016\/j.ijpara.2021.04.004_b0110","doi-asserted-by":"crossref","first-page":"193","DOI":"10.7326\/0003-4819-84-2-193","article-title":"Toxoplasmosis in the compromised host","volume":"84","author":"Ruskin","year":"1976","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.ijpara.2021.04.004_b0115","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.ijpara.2007.09.017","article-title":"Detection of the initial site of Toxoplasma gondii reactivation in brain tissue","volume":"38","author":"Takashima","year":"2008","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.ijpara.2021.04.004_b0120","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.parint.2018.05.010","article-title":"Atypical virulence in a type III Toxoplasma gondii strain isolated in Japan","volume":"67","author":"Taniguchi","year":"2018","journal-title":"Parasitol. Int."},{"key":"10.1016\/j.ijpara.2021.04.004_b0125","doi-asserted-by":"crossref","first-page":"15851588","DOI":"10.1126\/science.290.5496.1585","article-title":"\u2018Fluorescent Timer\u2019: protein that changes color with time","volume":"290","author":"Terskikh","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.ijpara.2021.04.004_b0130","doi-asserted-by":"crossref","unstructured":"Uboldi, A.D., Wilde, M., Bader, S.M., Tonkin, C.J., 2020. Environmental sensing and regulation of motility in Toxoplasma. Mol. Microbiol. in press. https:\/\/doi.org\/10.1111\/mmi.14661.","DOI":"10.1111\/mmi.14661"},{"key":"10.1016\/j.ijpara.2021.04.004_b0135","doi-asserted-by":"crossref","unstructured":"Zuzarte-Lu\u00eds, V., Mota, M.M., 2018. Parasite sensing of host nutrients and environmental cues. Cell Host Microbe 23, 749\u2013758.","DOI":"10.1016\/j.chom.2018.05.018"}],"container-title":["International Journal for Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020751921001934?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020751921001934?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T14:07:16Z","timestamp":1758118036000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0020751921001934"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":27,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["S0020751921001934"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpara.2021.04.004","relation":{},"ISSN":["0020-7519"],"issn-type":[{"type":"print","value":"0020-7519"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Releasing latent Toxoplasma gondii cysts from host cells to the extracellular environment induces excystation","name":"articletitle","label":"Article Title"},{"value":"International Journal for Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijpara.2021.04.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Australian Society for Parasitology. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}