{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T04:05:08Z","timestamp":1775707508358,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"2-3","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772222"],"award-info":[{"award-number":["81772222"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971965"],"award-info":[{"award-number":["81971965"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal for Parasitology"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.ijpara.2021.08.009","type":"journal-article","created":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T02:28:25Z","timestamp":1638325705000},"page":"111-123","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Helminth-induced CD9+ B-cell subset alleviates obesity-associated inflammation via IL-10 production"],"prefix":"10.1016","volume":"52","author":[{"given":"Maining","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiquan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangyue","family":"Ni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuejun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhipeng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minjun","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijpara.2021.08.009_b0005","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/imr.12800","article-title":"Regulatory B cells: Development, phenotypes, functions, and role in transplantation","volume":"292","author":"Alhabbab","year":"2019","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.ijpara.2021.08.009_b0010","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.jhep.2016.05.005","article-title":"A diet-induced animal model of non-alcoholic fatty liver disease and hepatocellular cancer","volume":"65","author":"Asgharpour","year":"2016","journal-title":"J. Hepatol."},{"key":"10.1016\/j.ijpara.2021.08.009_b0015","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1002\/eji.201141869","article-title":"Macrophage activation governs schistosomiasis-induced inflammation and fibrosis","volume":"41","author":"Barron","year":"2011","journal-title":"Eur. J. Immunol."},{"issue":"9","key":"10.1016\/j.ijpara.2021.08.009_b0020","doi-asserted-by":"crossref","first-page":"5374","DOI":"10.4049\/jimmunol.176.9.5374","article-title":"Naturally occurring CD4+Foxp3+ regulatory T cells are an essential, IL-10-independent part of the immunoregulatory network in Schistosoma mansoni egg-induced inflammation","volume":"176","author":"Baumgart","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijpara.2021.08.009_b0025","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.immuni.2009.11.009","article-title":"CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patients","volume":"32","author":"Blair","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.ijpara.2021.08.009_b0030","doi-asserted-by":"crossref","first-page":"2692","DOI":"10.1002\/eji.201344245","article-title":"Exacerbated experimental arthritis in Wiskott-Aldrich syndrome protein deficiency: modulatory role of regulatory B cells","volume":"44","author":"Bouma","year":"2014","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.ijpara.2021.08.009_b0035","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1111\/all.12697","article-title":"A regulatory CD9(+) B-cell subset inhibits HDM-induced allergic airway inflammation","volume":"70","author":"Braza","year":"2015","journal-title":"Allergy"},{"key":"10.1016\/j.ijpara.2021.08.009_b0040","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.611795","article-title":"Immunosuppressive mechanisms of regulatory B cells","volume":"12","author":"Catalan","year":"2021","journal-title":"Front Immunol."},{"key":"10.1016\/j.ijpara.2021.08.009_b0045","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1681\/ASN.2013080837","article-title":"Immunologic human renal allograft injury associates with an altered IL-10\/TNF-\u03b1 expression ratio in regulatory B cells","volume":"25","author":"Cherukuri","year":"2014","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.ijpara.2021.08.009_b0050","doi-asserted-by":"crossref","first-page":"20210200","DOI":"10.1098\/rsif.2021.0200","article-title":"Probability distributions of helminth parasite burdens within the human host population following repeated rounds of mass drug administration and their impact on the transmission breakpoint","volume":"18","author":"Collyer","year":"2021","journal-title":"J. R. Soc. Interface."},{"key":"10.1016\/j.ijpara.2021.08.009_b0055","first-page":"1091","article-title":"Alterations in the levels and lipid composition of plasma lipoproteins (VLDL, LDL and HDL) in Brazilian patients with hepatosplenic schistosomiasis mansoni","volume":"25","author":"Dimenstein","year":"1992","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.ijpara.2021.08.009_b0060","doi-asserted-by":"crossref","first-page":"173ra23","DOI":"10.1126\/scitranslmed.3005407","article-title":"CD19+CD24hiCD38hi B cells maintain regulatory T cells while limiting TH1 and TH17 differentiation","volume":"5","author":"Flores-Borja","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ijpara.2021.08.009_b0065","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1189\/jlb.0804453","article-title":"Binding of pregnancy-specific glycoprotein 17 to CD9 on macrophages induces secretion of IL-10, IL-6, PGE2, and TGF-beta1","volume":"77","author":"Ha","year":"2005","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.ijpara.2021.08.009_b0070","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1182\/blood-2008-02-078071","article-title":"B lymphocytes: how they develop and function","volume":"112","author":"LeBien","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.ijpara.2021.08.009_b0075","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/j.bbrc.2018.06.109","article-title":"RNA interference in vivo in Schistosoma japonicum: Establishing and optimization of RNAi mediated suppression of gene expression by long dsRNA in the intra-mammalian life stages of worms","volume":"503","author":"Li","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ijpara.2021.08.009_b0080","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1186\/s13071-017-2400-5","article-title":"Praziquantel treatment after Schistosoma japonicum infection maintains hepatic insulin sensitivity and improves glucose metabolism in mice","volume":"10","author":"Luo","year":"2017","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.ijpara.2021.08.009_b0085","doi-asserted-by":"crossref","unstructured":"Matsushita, T., D. Le Huu, T. Kobayashi, Y. Hamaguchi, M. Hasegawa, K. Naka, A. Hirao, M. Muramatsu, K. Takehara, M. Fujimoto. 2016. A novel splenic B1 regulatory cell subset suppresses allergic disease through phosphatidylinositol 3-kinase-Akt pathway activation. J. Allergy Clin. Immunol. 138, 1170-82.e9.","DOI":"10.1016\/j.jaci.2015.12.1319"},{"key":"10.1016\/j.ijpara.2021.08.009_b0090","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/978-1-60761-869-0_7","article-title":"Identifying regulatory B cells (B10 cells) that produce IL-10 in mice","volume":"677","author":"Matsushita","year":"2011","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.ijpara.2021.08.009_b0095","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1128\/CMR.05040-11","article-title":"Helminth infections and host immune regulation","volume":"25","author":"McSorley","year":"2012","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.ijpara.2021.08.009_b0100","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.jhep.2019.08.005","article-title":"Microbiota-driven gut vascular barrier disruption is a prerequisite for non-alcoholic steatohepatitis development","volume":"71","author":"Mouries","year":"2019","journal-title":"J. Hepatol."},{"key":"10.1016\/j.ijpara.2021.08.009_b0105","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.7150\/thno.49354","article-title":"Therapeutic inhibition of miR-802 protects against obesity through AMPK-mediated regulation of hepatic lipid metabolism","volume":"11","author":"Ni","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.ijpara.2021.08.009_b0110","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.cmet.2013.09.017","article-title":"Adipose natural regulatory B cells negatively control adipose tissue inflammation","volume":"18","author":"Nishimura","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.ijpara.2021.08.009_b0115","doi-asserted-by":"crossref","first-page":"168","DOI":"10.4168\/aair.2011.3.3.168","article-title":"Regulatory B cells and allergic diseases","volume":"3","author":"Noh","year":"2011","journal-title":"Allergy Asthma Immunol. Res."},{"key":"10.1016\/j.ijpara.2021.08.009_b0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2249.2010.04139.x","article-title":"The 'hygiene hypothesis' for autoimmune and allergic diseases: an update","volume":"160","author":"Okada","year":"2010","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.ijpara.2021.08.009_b0125","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nri843","article-title":"The immunobiology of schistosomiasis","volume":"2","author":"Pearce","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ijpara.2021.08.009_b0130","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1111\/j.1398-9995.2010.02524.x","article-title":"Tetraspanins CD9 and CD81 are molecular partners of trimeric Fc\u025bRI on human antigen-presenting cells","volume":"66","author":"Peng","year":"2011","journal-title":"Allergy"},{"key":"10.1016\/j.ijpara.2021.08.009_b0135","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/cmi.2017.35","article-title":"B cell regulation in cancer and anti-tumor immunity","volume":"14","author":"Sarvaria","year":"2017","journal-title":"Cell Mol. Immunol."},{"key":"10.1016\/j.ijpara.2021.08.009_b0140","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.it.2005.11.003","article-title":"To 'B' regulated: B cells as members of the regulatory workforce","volume":"27","author":"Serra","year":"2006","journal-title":"Trends Immunol."},{"key":"10.1016\/j.ijpara.2021.08.009_b0145","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1080\/20477724.2017.1308902","article-title":"What do we know about the role of regulatory B cells (Breg) during the course of infection of two major parasitic diseases, malaria and leishmaniasis?","volume":"111","author":"Soares","year":"2017","journal-title":"Pathog. Glob. Health"},{"key":"10.1016\/j.ijpara.2021.08.009_b0150","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.celrep.2015.09.070","article-title":"Transcriptomics identify CD9 as a marker of murine IL-10-competent regulatory B cells","volume":"13","author":"Sun","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.ijpara.2021.08.009_b0155","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s11010-019-03561-4","article-title":"Role and mechanism of the Th17\/Treg cell balance in the development and progression of insulin resistance","volume":"459","author":"Tao","year":"2019","journal-title":"Mol. Cell Biochem."},{"key":"10.1016\/j.ijpara.2021.08.009_b0160","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.jaci.2016.07.006","article-title":"Role of regulatory B cells in immune tolerance to allergens and beyond","volume":"138","author":"van de Veen","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.ijpara.2021.08.009_b0165","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0030883","article-title":"Schistosomes induce regulatory features in human and mouse CD1d(hi) B cells: inhibition of allergic inflammation by IL-10 and regulatory T cells","volume":"7","author":"van der Vlugt","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ijpara.2021.08.009_b0170","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1002\/oby.21769","article-title":"PPAR-\u03b3 agonist ameliorates liver pathology accompanied by increasing regulatory B and T cells in high-fat-diet mice","volume":"25","author":"Xu","year":"2017","journal-title":"Obesity"},{"issue":"12","key":"10.1016\/j.ijpara.2021.08.009_b0175","doi-asserted-by":"crossref","first-page":"7459","DOI":"10.4049\/jimmunol.0900270","article-title":"The development and function of regulatory B cells expressing IL-10 (B10 cells) requires antigen receptor diversity and TLR signals","volume":"182","author":"Yanaba","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijpara.2021.08.009_b0180","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/cmi.2012.60","article-title":"Regulatory B cells in autoimmune diseases","volume":"10","author":"Yang","year":"2013","journal-title":"Cell Mol. Immunol."}],"container-title":["International Journal for Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020751921003143?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020751921003143?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T14:07:45Z","timestamp":1758118065000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0020751921003143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":36,"journal-issue":{"issue":"2-3","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["S0020751921003143"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpara.2021.08.009","relation":{},"ISSN":["0020-7519"],"issn-type":[{"value":"0020-7519","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Helminth-induced CD9+ B-cell subset alleviates obesity-associated inflammation via IL-10 production","name":"articletitle","label":"Article Title"},{"value":"International Journal for Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijpara.2021.08.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Australian Society for Parasitology. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}