{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T17:43:27Z","timestamp":1777657407109,"version":"3.51.4"},"reference-count":53,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST-110-2320-B-320-004"],"award-info":[{"award-number":["MOST-110-2320-B-320-004"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal for Parasitology"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.ijpara.2021.11.007","type":"journal-article","created":{"date-parts":[[2021,12,4]],"date-time":"2021-12-04T10:15:02Z","timestamp":1638612902000},"page":"275-284","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Resolution of systemic complications in Schistosoma mansoni-infected mice by concomitant treatment with praziquantel and Schisandrin B"],"prefix":"10.1016","volume":"52","author":[{"given":"Ho Yin Pekkle","family":"Lam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po-Ching","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shih-Yi","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijpara.2021.11.007_b0005","doi-asserted-by":"crossref","first-page":"G723","DOI":"10.1152\/ajpgi.00414.2010","article-title":"Fibrosis is regulated by Th2 and Th17 responses and by dynamic interactions between fibroblasts and macrophages","volume":"300","author":"Barron","year":"2011","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.ijpara.2021.11.007_b0010","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.jare.2013.01.005","article-title":"Human schistosomiasis: clinical perspective: review","volume":"4","author":"Barsoum","year":"2013","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.ijpara.2021.11.007_b0015","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1038\/ni.3202","article-title":"The receptor NLRP3 is a transcriptional regulator of TH2 differentiation","volume":"16","author":"Bruchard","year":"2015","journal-title":"Nature Immunol."},{"key":"10.1016\/j.ijpara.2021.11.007_b0020","doi-asserted-by":"crossref","first-page":"S96","DOI":"10.1016\/j.jceh.2014.02.004","article-title":"Pathogenesis of hepatic encephalopathy and brain edema in acute liver failure","volume":"5","author":"Butterworth","year":"2015","journal-title":"J. Clin. Exp. Hepatol."},{"key":"10.1016\/j.ijpara.2021.11.007_b0025","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/hep.20051","article-title":"Apoptosis: the nexus of liver injury and fibrosis","volume":"39","author":"Canbay","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.ijpara.2021.11.007_b0030","first-page":"328","article-title":"Conditions affecting the accuracy of potassium hydroxide digestion techniques for counting Schistosoma mansoni eggs in tissues","volume":"39","author":"Cheever","year":"1968","journal-title":"Bull. World Health Organ."},{"key":"10.1016\/j.ijpara.2021.11.007_b0035","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1248\/bpb.31.1387","article-title":"Schisandrin B enhances cerebral mitochondrial antioxidant status and structural integrity, and protects against cerebral ischemia\/reperfusion injury in rats","volume":"31","author":"Chen","year":"2008","journal-title":"Biol. Pharmaceut. Bull."},{"key":"10.1016\/j.ijpara.2021.11.007_b0040","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.2147\/DDDT.S137507","article-title":"Schisandrin B attenuates CCl(4)-induced liver fibrosis in rats by regulation of Nrf2-ARE and TGF-\u03b2\/Smad signaling pathways","volume":"11","author":"Chen","year":"2017","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.ijpara.2021.11.007_b0045","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/j.1365-2613.2008.00576.x","article-title":"Single dose intravenous thioacetamide administration as a model of acute liver damage in rats","volume":"89","author":"Chen","year":"2008","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/j.ijpara.2021.11.007_b0050","doi-asserted-by":"crossref","DOI":"10.1007\/s10753-021-01494-z","article-title":"Schisandrin B attenuates airway inflammation and airway remodeling in asthma by inhibiting NLRP3 inflammasome activation and reducing pyroptosis","volume":"44","author":"Chen","year":"2021","journal-title":"Inflammation"},{"key":"10.1016\/j.ijpara.2021.11.007_b0055","doi-asserted-by":"crossref","first-page":"a020412","DOI":"10.1101\/cshperspect.a020412","article-title":"The blood-brain barrier","volume":"7","author":"Daneman","year":"2015","journal-title":"Cold Spring Harb Perspect Biol."},{"key":"10.1016\/j.ijpara.2021.11.007_b0060","doi-asserted-by":"crossref","first-page":"483","DOI":"10.4269\/ajtmh.1967.16.483","article-title":"An improved perfusion technique for recovering adult schistosomes from laboratory animals","volume":"16","author":"Duvall","year":"1967","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.ijpara.2021.11.007_b0065","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1365-3083.1986.tb02093.x","article-title":"Production of specific antibodies by cerebrospinal fluid lymphocytes in patients with herpes zoster, mumps meningitis and herpes simplex virus encephalitis","volume":"24","author":"Forsberg","year":"1986","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.ijpara.2021.11.007_b0070","doi-asserted-by":"crossref","unstructured":"Giamarellos-Bourboulis, E. J., V. Tziortzioti, P. Koutoukas, F. Baziaka, M. Raftogiannis, A. Antonopoulou, T. Adamis, L. Sabracos, H. Giamarellou, 2006. Clarithromycin is an effective immunomodulator in experimental pyelonephritis caused by pan-resistant Klebsiella pneumoniae. J. Antimicrob. Chemother. 57, 937-944.","DOI":"10.1093\/jac\/dkl084"},{"key":"10.1016\/j.ijpara.2021.11.007_b0075","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3109\/10715762.2011.638291","article-title":"Schisandrin B, attenuates cisplatin-induced oxidative stress, genotoxicity and neurotoxicity through modulating NF-\u03baB pathway in mice","volume":"46","author":"Giridharan","year":"2012","journal-title":"Free Radic Res."},{"key":"10.1016\/j.ijpara.2021.11.007_b0080","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/S0002-9440(10)64607-X","article-title":"NOS-2 mediates the protective anti-inflammatory and antifibrotic effects of the Th1-inducing adjuvant, IL-12, in a Th2 model of granulomatous disease","volume":"157","author":"Hesse","year":"2000","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ijpara.2021.11.007_b0085","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1080\/09540105.2011.615062","article-title":"Spleen transcriptome profiles of BALB\/c mouse in response to egg ovomucoid sensitisation and challenge","volume":"23","author":"Husain","year":"2012","journal-title":"Food Agric. Immunol."},{"key":"10.1016\/j.ijpara.2021.11.007_b0090","doi-asserted-by":"crossref","first-page":"459","DOI":"10.3389\/fphar.2017.00459","article-title":"Lack of the Nlrp3 inflammasome improves mice recovery following traumatic brain injury","volume":"8","author":"Irrera","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ijpara.2021.11.007_b0095","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1007\/s10753-018-0931-3","article-title":"Schisandrin B attenuates inflammation in LPS-induced sepsis through miR-17-5p downregulating TLR4","volume":"42","author":"Ji","year":"2019","journal-title":"Inflammation"},{"key":"10.1016\/j.ijpara.2021.11.007_b0100","doi-asserted-by":"crossref","first-page":"561","DOI":"10.4065\/mcp.2011.0203","article-title":"Antiparasitic therapy","volume":"86","author":"Kappagoda","year":"2011","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.ijpara.2021.11.007_b0105","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.2307\/3277532","article-title":"Evaluation of Kato's quantitative method through the recovery of Schistosoma mansoni eggs added to human feces","volume":"56","author":"Katz","year":"1970","journal-title":"J. Parasitol."},{"key":"10.1016\/j.ijpara.2021.11.007_b0110","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1046\/j.1440-1746.2003.03023.x","article-title":"Peripheral neuropathy in liver cirrhosis","volume":"18","author":"Kharbanda","year":"2003","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.ijpara.2021.11.007_b0115","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.pt.2011.10.008","article-title":"A review of female genital schistosomiasis","volume":"28","author":"Kjetland","year":"2012","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.ijpara.2021.11.007_b0120","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1023\/A:1019907316129","article-title":"Schisandrin B protects against tert-butylhydroperoxide induced cerebral toxicity by enhancing glutathione antioxidant status in mouse brain","volume":"238","author":"Ko","year":"2002","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.ijpara.2021.11.007_b0125","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.00005-17","article-title":"Praziquantel targets M1 macrophages and ameliorates splenomegaly in chronic schistosomiasis","volume":"62","author":"Kong","year":"2018","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ijpara.2021.11.007_b0130","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.vph.2006.06.016","article-title":"Inhaled activated protein C attenuates lung injury induced by aerosolized endotoxin in mice","volume":"45","author":"Kotanidou","year":"2006","journal-title":"Vasc Pharmacol."},{"key":"10.1016\/j.ijpara.2021.11.007_b0135","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.3390\/biom10071001","article-title":"Albendazole-Schisandrin B Co-therapy on Angiostrongylus cantonensis-induced meningoencephalitis in mice","volume":"10","author":"Lam","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.ijpara.2021.11.007_b0140","doi-asserted-by":"crossref","first-page":"e0009554","DOI":"10.1371\/journal.pntd.0009554","article-title":"Ameliorative effects of Schisandrin B on Schistosoma mansoni-induced hepatic fibrosis in vivo","volume":"15","author":"Lam","year":"2021","journal-title":"PLOS Negl Trop Dis."},{"key":"10.1016\/j.ijpara.2021.11.007_b0145","doi-asserted-by":"crossref","first-page":"4239","DOI":"10.1016\/j.fct.2012.08.047","article-title":"Neuroprotective effects of Schisandrin B against transient focal cerebral ischemia in Sprague-Dawley rats","volume":"50","author":"Lee","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ijpara.2021.11.007_b0150","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1600-065X.2011.01043.x","article-title":"Sensing damage by the NLRP3 inflammasome","volume":"243","author":"Leemans","year":"2011","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.ijpara.2021.11.007_b0155","doi-asserted-by":"crossref","first-page":"6171658","DOI":"10.1155\/2016\/6171658","article-title":"Schisandrin B: a double-edged sword in nonalcoholic fatty liver disease","volume":"2016","author":"Leong","year":"2016","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.ijpara.2021.11.007_b0160","doi-asserted-by":"crossref","first-page":"391","DOI":"10.3109\/00365517709091497","article-title":"Principles of albumin and IgG analyses in neurological disorders. II. Relation of the concentration of the proteins in serum and cerebrospinal fluid","volume":"37","author":"Link","year":"1977","journal-title":"Scand. J. Clin. Lab. Invest."},{"key":"10.1016\/j.ijpara.2021.11.007_b0165","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1007\/s10753-017-0544-2","article-title":"Anti-inflammatory effects of Schisandrin B on LPS-stimulated BV2 microglia via activating PPAR-\u03b3","volume":"40","author":"Liu","year":"2017","journal-title":"Inflammation"},{"key":"10.1016\/j.ijpara.2021.11.007_b0170","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1042\/BCJ20180086","article-title":"NLRP3 regulates macrophage M2 polarization through up-regulation of IL-4 in asthma","volume":"475","author":"Liu","year":"2018","journal-title":"Biochem. J."},{"key":"10.1016\/j.ijpara.2021.11.007_b0175","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.ijpara.2021.11.007_b0180","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.cyto.2014.11.008","article-title":"The cytokines of pulmonary fibrosis: much learned, much more to learn","volume":"74","author":"Luzina","year":"2015","journal-title":"Cytokine"},{"key":"10.1016\/j.ijpara.2021.11.007_b0185","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.jhep.2017.01.022","article-title":"NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice","volume":"66","author":"Mridha","year":"2017","journal-title":"J. Hepatol."},{"key":"10.1016\/j.ijpara.2021.11.007_b0190","doi-asserted-by":"crossref","first-page":"10638","DOI":"10.1038\/s41598-020-67514-4","article-title":"Investigating the antifibrotic effect of the antiparasitic drug Praziquantel in in vitro and in vivo preclinical models","volume":"10","author":"Nono","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ijpara.2021.11.007_b0195","doi-asserted-by":"crossref","first-page":"135","DOI":"10.4172\/2329-9088.1000135","article-title":"Bilharzia: pathology, diagnosis, management and control","volume":"1","author":"Olveda","year":"2013","journal-title":"Trop. Med. Surg."},{"key":"10.1016\/j.ijpara.2021.11.007_b0200","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/1476-511X-11-120","article-title":"Dietary Fructus Schisandrae extracts and fenofibrate regulate the serum\/hepatic lipid-profile in normal and hypercholesterolemic mice, with attention to hepatotoxicity","volume":"11","author":"Pan","year":"2012","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.ijpara.2021.11.007_b0205","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1089\/jmf.2013.2849","article-title":"Schisandra chinensis prevents alcohol-induced fatty liver disease in rats","volume":"17","author":"Park","year":"2014","journal-title":"J. Med. Food"},{"key":"10.1016\/j.ijpara.2021.11.007_b0210","doi-asserted-by":"crossref","first-page":"G1307","DOI":"10.1152\/ajpgi.2000.279.6.G1307","article-title":"IGF-I and procollagen alpha1(I) are coexpressed in a subset of mesenchymal cells in active Crohn's disease","volume":"279","author":"Pucilowska","year":"2000","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.ijpara.2021.11.007_b0215","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jns.2003.12.002","article-title":"What determines the CSF concentrations of albumin and plasma-derived IgG?","volume":"219","author":"Seyfert","year":"2004","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.ijpara.2021.11.007_b0220","doi-asserted-by":"crossref","first-page":"ofab438","DOI":"10.1093\/ofid\/ofab438","article-title":"Association of female genital schistosomiasis with the cervicovaginal microbiota and sexually transmitted infections in Zambian women","volume":"8","author":"Sturt","year":"2021","journal-title":"Open Forum Infect. Dis."},{"key":"10.1016\/j.ijpara.2021.11.007_b0225","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1089\/neu.2013.3193","article-title":"Methylene blue is neuroprotective against mild traumatic brain injury","volume":"31","author":"Talley Watts","year":"2014","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.ijpara.2021.11.007_b0230","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00005-014-0301-2","article-title":"Caspases as the key effectors of inflammatory responses against bacterial infection","volume":"63","author":"Uchiyama","year":"2015","journal-title":"Arch. Immunol. Ther. Exp. (Warsz)"},{"key":"10.1016\/j.ijpara.2021.11.007_b0235","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/S0020-7519(01)00297-1","article-title":"The potential of artemether for the control of schistosomiasis","volume":"31","author":"Utzinger","year":"2001","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.ijpara.2021.11.007_b0240","first-page":"450","article-title":"Schisandrin B protects rat cortical neurons against Abeta1-42-induced neurotoxicity","volume":"64","author":"Wang","year":"2009","journal-title":"Pharmazie"},{"key":"10.1016\/j.ijpara.2021.11.007_b0245","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/sj.icb.7100014","article-title":"Immunopathology of schistosomiasis","volume":"85","author":"Wilson","year":"2007","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.ijpara.2021.11.007_b0250","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.3748\/wjg.v10.i20.2944","article-title":"Down-modulation of heat shock protein 70 and up-modulation of Caspase-3 during schisandrin B-induced apoptosis in human hepatoma SMMC-7721 cells","volume":"10","author":"Wu","year":"2004","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.ijpara.2021.11.007_b0255","doi-asserted-by":"crossref","first-page":"533","DOI":"10.3892\/mmr.2017.6622","article-title":"Schisandrin B attenuates the inflammatory response, oxidative stress and apoptosis induced by traumatic spinal cord injury via inhibition of p53 signaling in adult rats","volume":"16","author":"Xin","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.ijpara.2021.11.007_b0260","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ejphar.2012.05.030","article-title":"Schisandrin B exerts anti-neuroinflammatory activity by inhibiting the Toll-like receptor 4-dependent MyD88\/IKK\/NF-\u03baB signaling pathway in lipopolysaccharide-induced microglia","volume":"692","author":"Zeng","year":"2012","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ijpara.2021.11.007_b0265","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3389\/fnins.2016.00033","article-title":"Toll-like receptor 4 deficiency impairs motor coordination","volume":"10","author":"Zhu","year":"2016","journal-title":"Front. Neurosci."}],"container-title":["International Journal for Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020751921003155?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020751921003155?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T14:07:44Z","timestamp":1758118064000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0020751921003155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":53,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["S0020751921003155"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpara.2021.11.007","relation":{},"ISSN":["0020-7519"],"issn-type":[{"value":"0020-7519","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Resolution of systemic complications in Schistosoma mansoni-infected mice by concomitant treatment with praziquantel and Schisandrin B","name":"articletitle","label":"Article Title"},{"value":"International Journal for Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijpara.2021.11.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Australian Society for Parasitology. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}