{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T20:40:14Z","timestamp":1780432814692,"version":"3.54.1"},"reference-count":70,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DFG-RTG2740"],"award-info":[{"award-number":["DFG-RTG2740"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DFG-FOR2886"],"award-info":[{"award-number":["DFG-FOR2886"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009379","name":"Interdisziplin\u00e4res Zentrum f\u00fcr Klinische Forschung, Universit\u00e4tsklinikum W\u00fcrzburg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009379","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal for Parasitology"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.ijpara.2022.04.004","type":"journal-article","created":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T01:33:35Z","timestamp":1654479215000},"page":"591-601","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Acetate, a metabolic product of Heligmosomoides polygyrus, facilitates intestinal epithelial barrier breakdown in a FFAR2-dependent manner"],"prefix":"10.1016","volume":"52","author":[{"given":"Fabian","family":"Sch\u00e4lter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Frech","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"D\u00fcrholz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Lucas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Sarter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Lebon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Esser-von Bieren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lalit K.","family":"Dubey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Voehringer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Schett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola L.","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario M.","family":"Zaiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijpara.2022.04.004_b0005","doi-asserted-by":"crossref","first-page":"F867","DOI":"10.1152\/ajprenal.90264.2008","article-title":"Biology of claudins","volume":"295","author":"Angelow","year":"2008","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.ijpara.2022.04.004_b0010","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/nri2199","article-title":"Protective immune mechanisms in helminth infection","volume":"7","author":"Anthony","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ijpara.2022.04.004_b0015","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1038\/s41467-020-15855-z","article-title":"Ethanol consumption inhibits TFH cell responses and the development of autoimmune arthritis","volume":"11","author":"Azizov","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ijpara.2022.04.004_b0020","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.3390\/nu13041324","article-title":"Alcohol consumption in rheumatoid arthritis: A path through the immune system","volume":"13","author":"Azizov","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.ijpara.2022.04.004_b0025","doi-asserted-by":"crossref","first-page":"101383","DOI":"10.1016\/j.scr.2019.101383","article-title":"Permeability analyses and three dimensional imaging of interferon gamma-induced barrier disintegration in intestinal organoids","volume":"35","author":"Bardenbacher","year":"2019","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.ijpara.2022.04.004_b0030","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1017\/S0031182009006003","article-title":"Heligmosomoides bakeri: a model for exploring the biology and genetics of resistance to chronic gastrointestinal nematode infections","volume":"136","author":"Behnke","year":"2009","journal-title":"Parasitology"},{"key":"10.1016\/j.ijpara.2022.04.004_b0035","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/2045-8118-10-5","article-title":"Impedance-based cell monitoring: barrier properties and beyond","volume":"10","author":"Benson","year":"2013","journal-title":"Fluids Barriers CNS"},{"key":"10.1016\/j.ijpara.2022.04.004_b0040","doi-asserted-by":"crossref","first-page":"11312","DOI":"10.1074\/jbc.M211609200","article-title":"The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids","volume":"278","author":"Brown","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijpara.2022.04.004_b0045","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1089\/dna.2005.24.54","article-title":"A family of fatty acid binding receptors","volume":"24","author":"Brown","year":"2005","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.ijpara.2022.04.004_b0050","doi-asserted-by":"crossref","first-page":"7485","DOI":"10.3390\/ijms22147485","article-title":"The immune system through the lens of alcohol intake and gut microbiota","volume":"22","author":"Calleja-Conde","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ijpara.2022.04.004_b0055","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1038\/s41598-018-36941-9","article-title":"Prominent action of butyrate over beta-hydroxybutyrate as histone deacetylase inhibitor, transcriptional modulator and anti-inflammatory molecule","volume":"9","author":"Chriett","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ijpara.2022.04.004_b0060","doi-asserted-by":"crossref","first-page":"e0180190","DOI":"10.1371\/journal.pone.0180190","article-title":"Differing roles for short chain fatty acids and GPR43 agonism in the regulation of intestinal barrier function and immune responses","volume":"12","author":"D'Souza","year":"2017","journal-title":"PLoS ONE"},{"issue":"7","key":"10.1016\/j.ijpara.2022.04.004_b0065","doi-asserted-by":"crossref","first-page":"e144156","DOI":"10.1172\/jci.insight.144156","article-title":"Gut-derived acetate promotes B10 cells with antiinflammatory effects","volume":"6","author":"Da\u00efen","year":"2021","journal-title":"JCI Insight"},{"key":"10.1016\/j.ijpara.2022.04.004_b0070","doi-asserted-by":"crossref","first-page":"2485S","DOI":"10.1093\/jn\/133.7.2485S","article-title":"Inhibition of histone deacetylase activity by butyrate","volume":"133","author":"Davie","year":"2003","journal-title":"J. Nutr."},{"key":"10.1016\/j.ijpara.2022.04.004_b0075","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.pt.2003.10.002","article-title":"Soil-transmitted helminth infections: updating the global picture","volume":"19","author":"de Silva","year":"2003","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.ijpara.2022.04.004_b0080","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1194\/jlr.R036012","article-title":"The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism","volume":"54","author":"den Besten","year":"2013","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.ijpara.2022.04.004_b0085","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.3945\/jn.113.179549","article-title":"Short-chain fatty acids activate AMP-activated protein kinase and ameliorate ethanol-induced intestinal barrier dysfunction in Caco-2 cell monolayers","volume":"143","author":"Elamin","year":"2013","journal-title":"J. Nutr."},{"key":"10.1016\/j.ijpara.2022.04.004_b0090","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.3389\/fimmu.2020.01489","article-title":"Helminth sensing at the intestinal epithelial barrier-a taste of things to come","volume":"11","author":"Faniyi","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ijpara.2022.04.004_b0095","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1749-6632.2012.06538.x","article-title":"Zonulin, regulation of tight junctions, and autoimmune diseases","volume":"1258","author":"Fasano","year":"2012","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.ijpara.2022.04.004_b0100","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1159\/000492853","article-title":"Short-chain fatty acids manifest stimulative and protective effects on intestinal barrier function through the inhibition of NLRP3 inflammasome and autophagy","volume":"49","author":"Feng","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.ijpara.2022.04.004_b0105","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1002\/eji.200636751","article-title":"Expansion and activation of CD4(+)CD25(+) regulatory T cells in Heligmosomoides polygyrus infection","volume":"37","author":"Finney","year":"2007","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.ijpara.2022.04.004_b0110","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1369\/jhc.6A6944.2006","article-title":"Differential expression and subcellular localization of claudin-7, -8, -12, -13, and -15 along the mouse intestine","volume":"54","author":"Fujita","year":"2006","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.ijpara.2022.04.004_b0115","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1084\/jem.20101074","article-title":"Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-\u03b2 pathway","volume":"207","author":"Grainger","year":"2010","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ijpara.2022.04.004_b0120","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.it.2010.11.005","article-title":"To B or not to B: B cells and the Th2-type immune response to helminths","volume":"32","author":"Harris","year":"2011","journal-title":"Trends Immunol."},{"key":"10.1016\/j.ijpara.2022.04.004_b0125","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/pim.12057","article-title":"Understanding the role of antibodies in murine infections with Heligmosomoides (polygyrus) bakeri: 35 years ago, now and 35 years ahead","volume":"36","author":"Harris","year":"2014","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.ijpara.2022.04.004_b0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molimm.2014.03.003","article-title":"Excreted\/secreted Trichuris suis products reduce barrier function and suppress inflammatory cytokine production of intestinal epithelial cells","volume":"60","author":"Hiemstra","year":"2014","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.ijpara.2022.04.004_b0135","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.0269-2813.2004.01803.x","article-title":"Review article: helminths as therapeutic agents for inflammatory bowel disease","volume":"19","author":"Hunter","year":"2004","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.ijpara.2022.04.004_b0140","article-title":"Cultivation of Heligmosomoides polygyrus: an immunomodulatory nematode parasite and its secreted products","volume":"98","author":"Johnston","year":"2015","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.ijpara.2022.04.004_b0145","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1038\/s41423-020-00625-0","article-title":"Control of lymphocyte functions by gut microbiota-derived short-chain fatty acids","volume":"18","author":"Kim","year":"2021","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.ijpara.2022.04.004_b0150","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.3748\/wjg.v22.i11.3117","article-title":"Tight junctions in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer","volume":"22","author":"Landy","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.ijpara.2022.04.004_b0155","doi-asserted-by":"crossref","unstructured":"Le Poul, E., Loison C., S., Struyf S., Springael J.-Y., Lannoy, V., Decobecq M.-E., Brezillon S., Dupriez V., Vassart G., Van Damme, J., Parmentier, M., Detheux, M., 2003. Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation. 278, 25481\u201325489.","DOI":"10.1074\/jbc.M301403200"},{"key":"10.1016\/j.ijpara.2022.04.004_b0160","doi-asserted-by":"crossref","first-page":"709","DOI":"10.2353\/ajpath.2007.060343","article-title":"Dysregulation of claudin-7 leads to loss of E-cadherin expression and the increased invasion of esophageal squamous cell carcinoma cells","volume":"170","author":"Lioni","year":"2007","journal-title":"Am. J. Pathol."},{"issue":"25","key":"10.1016\/j.ijpara.2022.04.004_b0165","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aat1604","article-title":"Type 2 immunity: Expanding our view","volume":"3","author":"Lloyd","year":"2018","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.ijpara.2022.04.004_b0170","doi-asserted-by":"crossref","first-page":"e24978","DOI":"10.4161\/tisb.24978","article-title":"Claudins in intestines: Distribution and functional significance in health and diseases","volume":"1","author":"Lu","year":"2013","journal-title":"Tissue Barriers"},{"key":"10.1016\/j.ijpara.2022.04.004_b0175","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41467-017-02490-4","article-title":"Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss","volume":"9","author":"Lucas","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ijpara.2022.04.004_b0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1515\/helm-2017-0048","article-title":"Helminth therapy: advances in the use of parasitic worms against inflammatory bowel diseases and its challenges","volume":"55","author":"Maruszewska-Cheruiyot","year":"2018","journal-title":"Helminthologia"},{"key":"10.1016\/j.ijpara.2022.04.004_b0185","doi-asserted-by":"crossref","first-page":"13968","DOI":"10.1073\/pnas.0906367106","article-title":"Helminth products bypass the need for TSLP in Th2 immune responses by directly modulating dendritic cell function","volume":"106","author":"Massacand","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ijpara.2022.04.004_b0190","doi-asserted-by":"crossref","DOI":"10.1080\/21688370.2017.1283385","article-title":"Helminths and intestinal barrier function","volume":"5","author":"McKay","year":"2017","journal-title":"Tissue Barriers"},{"key":"10.1016\/j.ijpara.2022.04.004_b0195","doi-asserted-by":"crossref","first-page":"3657","DOI":"10.1128\/IAI.00266-15","article-title":"Parasite proximity drives the expansion of regulatory T cells in peyer's patches following intestinal helminth infection","volume":"83","author":"Mosconi","year":"2015","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijpara.2022.04.004_b0200","doi-asserted-by":"crossref","DOI":"10.1002\/cti2.1089","article-title":"The interplay of type 2 immunity, helminth infection and the microbiota in regulating metabolism","volume":"8","author":"Moyat","year":"2019","journal-title":"Clin. Transl. Immunol."},{"key":"10.1016\/j.ijpara.2022.04.004_b0205","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/S0006-291X(03)00488-1","article-title":"Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids","volume":"303","author":"Nilsson","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ijpara.2022.04.004_b0210","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.nut.2004.12.004","article-title":"Short-chain fatty acids alter tight junction permeability in intestinal monolayer cells via lipoxygenase activation","volume":"21","author":"Ohata","year":"2005","journal-title":"Nutrition"},{"key":"10.1016\/j.ijpara.2022.04.004_b0215","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3389\/fimmu.2019.00277","article-title":"Short chain fatty acids (SCFAs)-mediated gut epithelial and immune regulation and its relevance for inflammatory bowel diseases","volume":"10","author":"Parada Venegas","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ijpara.2022.04.004_b0220","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3389\/fimmu.2019.00277","article-title":"Short chain fatty acids (SCFAs)-mediated gut epithelial and immune regulation and its relevance for inflammatory bowel diseases","volume":"10","author":"Parada Venegas","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ijpara.2022.04.004_b0225","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1203\/01.pdr.0000250014.92242.f3","article-title":"Effects of butyrate on intestinal barrier function in a Caco-2 cell monolayer model of intestinal barrier","volume":"61","author":"Peng","year":"2007","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.ijpara.2022.04.004_b0230","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.3945\/jn.109.104638","article-title":"Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers","volume":"139","author":"Peng","year":"2009","journal-title":"J. Nutr."},{"key":"10.1016\/j.ijpara.2022.04.004_b0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2019.04.022","article-title":"Acetate promotes T Cell effector function during glucose restriction","volume":"27","author":"Qiu","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.ijpara.2022.04.004_b0240","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ijpara.2019.09.005","article-title":"Infection with a small intestinal helminth, Heligmosomoides polygyrus bakeri, consistently alters microbial communities throughout the murine small and large intestine","volume":"50","author":"Rapin","year":"2020","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.ijpara.2022.04.004_b0245","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.vetpar.2016.03.017","article-title":"Excretory\/secretory products of adult Haemonchus contortus and Teladorsagia circumcincta which increase the permeability of Caco-2 cell monolayers are neutralised by antibodies from immune hosts","volume":"221","author":"Rehman","year":"2016","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.ijpara.2022.04.004_b0250","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1007\/s00281-012-0347-3","article-title":"Immunity to the model intestinal helminth parasite Heligmosomoides polygyrus","volume":"34","author":"Reynolds","year":"2012","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.ijpara.2022.04.004_b0255","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/nature07935","article-title":"Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche","volume":"459","author":"Sato","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.ijpara.2022.04.004_b0260","doi-asserted-by":"crossref","first-page":"4655","DOI":"10.1128\/IAI.00358-07","article-title":"Heligmosomoides polygyrus promotes regulatory T-cell cytokine production in the murine normal distal intestine","volume":"75","author":"Setiawan","year":"2007","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijpara.2022.04.004_b0265","doi-asserted-by":"crossref","unstructured":"Sina, C., Gavrilova O., F\u00f6rster, M., Till, A., Derer, S., Hildebrand, F., Raabe, B., Chalaris, A., Scheller, J., Rehmann, A., Franke, A., Ott, S., H\u00e4sler, R., Nikolaus, S., F\u00f6lsch, U.R., Rose-John, S., Jiang, H.-P., Li, J., Schreiber, S., Rosenstiel, P., 2009. G protein-coupled receptor 43 is essential for neutrophil recruitment during intestinal inflammation. J. Immunol. 183, 7514-7522.","DOI":"10.4049\/jimmunol.0900063"},{"key":"10.1016\/j.ijpara.2022.04.004_b0270","doi-asserted-by":"crossref","first-page":"6009","DOI":"10.3748\/wjg.v23.i33.6009","article-title":"Helminths as an alternative therapy for intestinal diseases","volume":"23","author":"Sipahi","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.ijpara.2022.04.004_b0275","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.pharmthera.2016.04.007","article-title":"Benefits of short-chain fatty acids and their receptors in inflammation and carcinogenesis","volume":"164","author":"Sivaprakasam","year":"2016","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ijpara.2022.04.004_b0280","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1089\/biores.2012.0223","article-title":"Butyrate histone deacetylase inhibitors","volume":"1","author":"Steliou","year":"2012","journal-title":"Biores. Open Access"},{"key":"10.1016\/j.ijpara.2022.04.004_b0285","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1128\/IAI.01123-10","article-title":"Duodenal helminth infection alters barrier function of the colonic epithelium via adaptive immune activation","volume":"79","author":"Su","year":"2011","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijpara.2022.04.004_b0290","doi-asserted-by":"crossref","first-page":"4772","DOI":"10.1128\/IAI.00744-07","article-title":"Anti-Inflammatory mechanisms of enteric Heligmosomoides polygyrus infection against trinitrobenzene sulfonic acid-induced colitis in a murine model","volume":"76","author":"Sutton","year":"2008","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijpara.2022.04.004_b0295","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1038\/s41467-020-15831-7","article-title":"Targeting zonulin and intestinal epithelial barrier function to prevent onset of arthritis","volume":"11","author":"Tajik","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ijpara.2022.04.004_b0300","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/s41586-021-03727-5","article-title":"Acetate differentially regulates IgA reactivity to commensal bacteria","volume":"595","author":"Takeuchi","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.ijpara.2022.04.004_b0305","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1136\/gutjnl-2014-308419","article-title":"Intestinal deletion of Claudin-7 enhances paracellular organic solute flux and initiates colonic inflammation in mice","volume":"64","author":"Tanaka","year":"2015","journal-title":"Gut"},{"key":"10.1016\/j.ijpara.2022.04.004_b0310","doi-asserted-by":"crossref","first-page":"7320","DOI":"10.1038\/ncomms8320","article-title":"Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites","volume":"6","author":"Thorburn","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ijpara.2022.04.004_b0315","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.ijpara.2009.12.006","article-title":"Acetate formation in the energy metabolism of parasitic helminths and protists","volume":"40","author":"Tielens","year":"2010","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.ijpara.2022.04.004_b0320","doi-asserted-by":"crossref","first-page":"3741","DOI":"10.2147\/CMAR.S175383","article-title":"Emerging clinical significance of claudin-7 in colorectal cancer: a review","volume":"10","author":"Wang","year":"2018","journal-title":"Cancer Manage. Res."},{"key":"10.1016\/j.ijpara.2022.04.004_b0325","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.3389\/fimmu.2020.01830","article-title":"The helminth parasite Heligmosomoides polygyrus attenuates EAE in an IL-4Ralpha-dependent manner","volume":"11","author":"White","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ijpara.2022.04.004_b0330","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.immuni.2009.01.006","article-title":"Cytokine-producing effector B cells regulate type 2 immunity to H. polygyrus","volume":"30","author":"Wojciechowski","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.ijpara.2022.04.004_b0335","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.pt.2012.02.008","article-title":"Helminthic therapy: improving mucosal barrier function","volume":"28","author":"Wolff","year":"2012","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.ijpara.2022.04.004_b0340","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.jcmgh.2019.12.005","article-title":"Tight junction protein claudin-7 is essential for intestinal epithelial stem cell self-renewal and differentiation","volume":"9","author":"Xing","year":"2020","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.ijpara.2022.04.004_b0345","doi-asserted-by":"crossref","first-page":"e1233","DOI":"10.1002\/cti2.1233","article-title":"An acetate-yielding diet imprints an immune and anti-microbial programme against enteric infection","volume":"10","author":"Yap","year":"2021","journal-title":"Clin. Transl. Immunol."},{"key":"10.1016\/j.ijpara.2022.04.004_b0350","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.immuni.2015.09.012","article-title":"The intestinal microbiota contributes to the ability of helminths to modulate allergic inflammation","volume":"43","author":"Zaiss","year":"2015","journal-title":"Immunity"}],"container-title":["International Journal for Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020751922000856?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020751922000856?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T01:18:54Z","timestamp":1778635134000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0020751922000856"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":70,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["S0020751922000856"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpara.2022.04.004","relation":{},"ISSN":["0020-7519"],"issn-type":[{"value":"0020-7519","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acetate, a metabolic product of Heligmosomoides polygyrus, facilitates intestinal epithelial barrier breakdown in a FFAR2-dependent manner","name":"articletitle","label":"Article Title"},{"value":"International Journal for Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijpara.2022.04.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Australian Society for Parasitology. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}