{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T14:12:07Z","timestamp":1780582327243,"version":"3.54.1"},"reference-count":50,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31970420"],"award-info":[{"award-number":["31970420"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32373038"],"award-info":[{"award-number":["32373038"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Jiangsu Province Natural Science Foundation","doi-asserted-by":"publisher","award":["BK20240507"],"award-info":[{"award-number":["BK20240507"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004921","name":"Shanghai Jiao Tong University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016099","name":"Jiangsu Agri-animal Husbandry Vocational College","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016099","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007219","name":"Shanghai Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["24ZR1479300"],"award-info":[{"award-number":["24ZR1479300"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal for Parasitology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.ijpara.2025.08.008","type":"journal-article","created":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:00:29Z","timestamp":1755648029000},"page":"104720","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["The key glycolytic enzyme phosphofructokinase is involved in Eimeria tenella resistance to maduramycin"],"prefix":"10.1016","volume":"56","author":[{"given":"Huanzhi","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiping","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunhai","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liushu","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinwen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sishi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1905-5936","authenticated-orcid":false,"given":"Hui","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijpara.2025.08.008_b0005","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/BF01116304","article-title":"A transport model for the (Na+\/K+)ATPase in liposomes including the (Na+\/K+)-channel function","volume":"1","author":"Anner","year":"1981","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.ijpara.2025.08.008_b0010","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1111\/j.1600-0463.2009.02453.x","article-title":"Communication between Toxoplasma gondii and its host: impact on parasite growth, development, immune evasion, and virulence","volume":"117","author":"Blader","year":"2009","journal-title":"APMIS"},{"key":"10.1016\/j.ijpara.2025.08.008_b0015","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s13567-020-00837-2","article-title":"Re-calculating the cost of coccidiosis in chickens","volume":"51","author":"Blake","year":"2020","journal-title":"Vet. Res."},{"key":"10.1016\/j.ijpara.2025.08.008_b0020","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0076-6879(09)63032-9","article-title":"Elution of proteins from gels","volume":"463","author":"Burgess","year":"2009","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.ijpara.2025.08.008_b0025","doi-asserted-by":"crossref","DOI":"10.3390\/cancers16010016","article-title":"Hitting the sweet spot: how glucose metabolism is orchestrated in space and time by phosphofructokinase-1","volume":"16","author":"Campos","year":"2023","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.ijpara.2025.08.008_b0030","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.3382\/ps.2010-00931","article-title":"Forty years of monensin for the control of coccidiosis in poultry","volume":"89","author":"Chapman","year":"2010","journal-title":"Poult. Sci."},{"key":"10.1016\/j.ijpara.2025.08.008_b0035","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ijpddr.2022.01.001","article-title":"Focused review: the role of drug combinations for the control of coccidiosis in commercially reared chickens","volume":"18","author":"Chapman","year":"2022","journal-title":"Int. J. Parasitol. Drugs Drug Resist."},{"key":"10.1016\/j.ijpara.2025.08.008_b0040","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms11102401","article-title":"Understanding the effect of different glucose concentrations in the oligotrophic bacterium Bacillus subtilis BS-G1 through transcriptomics analysis","volume":"11","author":"Chen","year":"2023","journal-title":"Microorganisms"},{"key":"10.1016\/j.ijpara.2025.08.008_b0045","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.pt.2016.08.007","article-title":"Are eimeria genetically diverse, and does it matter?","volume":"33","author":"Clark","year":"2017","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.ijpara.2025.08.008_b0050","doi-asserted-by":"crossref","unstructured":"Dubey, J.P., 2020. Coccidiosis in Livestock, Poultry, Companion Animals, and Humans.","DOI":"10.1201\/9780429294105"},{"key":"10.1016\/j.ijpara.2025.08.008_b0055","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1006\/mben.1998.0109","article-title":"Glucose catabolism of Escherichia coli strains with increased activity and altered regulation of key glycolytic enzymes","volume":"1","author":"Emmerling","year":"1999","journal-title":"Metab. Eng."},{"key":"10.1016\/j.ijpara.2025.08.008_b0060","doi-asserted-by":"crossref","first-page":"262","DOI":"10.31083\/j.fbl2709262","article-title":"PGAM1 promotes glycolytic metabolism and paclitaxel resistance via pyruvic acid production in ovarian cancer cells","volume":"27","author":"Feng","year":"2022","journal-title":"Front. Biosci. (Landmark Ed)"},{"key":"10.1016\/j.ijpara.2025.08.008_b0065","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02842-20","article-title":"The key glycolytic enzyme phosphofructokinase is involved in resistance to antiplasmodial glycosides","volume":"11","author":"Fisher","year":"2020","journal-title":"mBio"},{"key":"10.1016\/j.ijpara.2025.08.008_b0070","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1186\/s12917-022-03369-3","article-title":"Epidemiological investigation and drug resistance of Eimeria species in Korean chicken farms","volume":"18","author":"Flores","year":"2022","journal-title":"BMC Vet. Res."},{"key":"10.1016\/j.ijpara.2025.08.008_b0075","doi-asserted-by":"crossref","first-page":"537","DOI":"10.2307\/3283663","article-title":"Penetration of Eimeria tenella sporozoites under different oxygen concentrations in vitro","volume":"78","author":"Fukata","year":"1992","journal-title":"J. Parasitol."},{"key":"10.1016\/j.ijpara.2025.08.008_b0080","first-page":"87","article-title":"Glycolysis inhibition as a cancer treatment and its role in an anti-tumour immune response","volume":"1866","author":"Gill","year":"2016","journal-title":"BBA"},{"key":"10.1016\/j.ijpara.2025.08.008_b0085","first-page":"138","article-title":"Experimental induction of drugresistant strains of Eimeria tenella to diclazuril and maduramycin","volume":"24","author":"Han","year":"2004","journal-title":"Chinese J. Vet. Parasitol."},{"key":"10.1016\/j.ijpara.2025.08.008_b0090","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1017\/S003118200300458X","article-title":"Amylopectin: a major component of the residual body in Cryptosporidium parvum oocysts","volume":"128","author":"Harris","year":"2004","journal-title":"Parasitology"},{"key":"10.1016\/j.ijpara.2025.08.008_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.114914","article-title":"PFKFB3 confers cisplatin resistance in gastric cancer by inhibiting ferroptosis through SLC7A11\/xCT dephosphorylation","volume":"159","author":"He","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ijpara.2025.08.008_b0100","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.pt.2015.09.001","article-title":"Apicomplexan energy metabolism: carbon source promiscuity and the quiescence hyperbole","volume":"32","author":"Jacot","year":"2016","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.ijpara.2025.08.008_b0105","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.3382\/ps.0591731","article-title":"Experimental development of monensin resistance in Eimeria meleagrimitis","volume":"59","author":"Jeffers","year":"1980","journal-title":"Poult. Sci."},{"key":"10.1016\/j.ijpara.2025.08.008_b0110","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1007\/s00436-011-2568-0","article-title":"Identification and partial characterization of a serine protease inhibitor (serpin) of Eimeria tenella","volume":"110","author":"Jiang","year":"2012","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.ijpara.2025.08.008_b0115","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/0014-4894(70)90063-9","article-title":"Anticoccidial drugs: lesion scoring techniques in battery and floor-pen experiments with chickens","volume":"28","author":"Johnson","year":"1970","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.ijpara.2025.08.008_b0120","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.ijantimicag.2017.09.004","article-title":"The value of anticoccidials for sustainable global poultry production","volume":"51","author":"Kadykalo","year":"2018","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.ijpara.2025.08.008_b0125","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1111\/omi.12078","article-title":"Moonlighting proteins as virulence factors of pathogenic fungi, parasitic protozoa and multicellular parasites","volume":"29","author":"Karkowska-Kuleta","year":"2014","journal-title":"Mol. Oral Microbiol."},{"key":"10.1016\/j.ijpara.2025.08.008_b0130","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1016\/j.ijpara.2006.08.011","article-title":"Eimeria tenella enolase and pyruvate kinase: a likely role in glycolysis and in others functions","volume":"36","author":"Labb\u00e9","year":"2006","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.ijpara.2025.08.008_b0135","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2024.1375026","article-title":"Epidemiological investigation of coccidiosis and associated risk factors in broiler chickens immunized with live anticoccidial vaccines in China","volume":"11","author":"Liao","year":"2024","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.ijpara.2025.08.008_b0140","first-page":"201","article-title":"A guide to laboratory techniques used in the study and diagnosis of avian coccidiosis","volume":"6","author":"Long","year":"1976","journal-title":"Folia Vet. Lat."},{"key":"10.1016\/j.ijpara.2025.08.008_b0145","doi-asserted-by":"crossref","DOI":"10.3390\/cells9030668","article-title":"Glucose Metabolic reprogramming of ER breast cancer in acquired resistance to the CDK4\/6 inhibitor palbociclib(\u00a0)","volume":"9","author":"Lorito","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.ijpara.2025.08.008_b0150","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.neo.2020.12.009","article-title":"Glycolysis-induced drug resistance in tumors \u2013 a response to danger signals?","volume":"23","author":"Marcucci","year":"2021","journal-title":"Neoplasia"},{"key":"10.1016\/j.ijpara.2025.08.008_b0155","doi-asserted-by":"crossref","first-page":"690","DOI":"10.2307\/1590570","article-title":"Drug-sensitivity of 99 isolates of coccidia from broiler farms","volume":"30","author":"McDougald","year":"1986","journal-title":"Avian Dis."},{"key":"10.1016\/j.ijpara.2025.08.008_b0160","doi-asserted-by":"crossref","first-page":"302","DOI":"10.2307\/1590876","article-title":"Efficacy of maduramicin against ionophore-tolerant field isolates of coccidia in broilers","volume":"31","author":"McDougald","year":"1987","journal-title":"Avian Dis."},{"key":"10.1016\/j.ijpara.2025.08.008_b0165","doi-asserted-by":"crossref","first-page":"126","DOI":"10.2307\/1588563","article-title":"Efficacy of buquinolate against ten strains of Eimeria tenella and the development of a resistant strain","volume":"14","author":"McLoughlin","year":"1970","journal-title":"Avian Dis."},{"key":"10.1016\/j.ijpara.2025.08.008_b0170","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1002\/bit.260400607","article-title":"Enhanced beta-galactosidase production by high cell-density culture of recombinant Bacillus subtilis with glucose concentration control","volume":"40","author":"Park","year":"1992","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.ijpara.2025.08.008_b0175","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1080\/01652176.2011.605247","article-title":"Coccidiosis in poultry: anticoccidial products, vaccines and other prevention strategies","volume":"31","author":"Peek","year":"2011","journal-title":"Vet. Q."},{"key":"10.1016\/j.ijpara.2025.08.008_b0180","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000188","article-title":"Host cell egress and invasion induce marked relocations of glycolytic enzymes in Toxoplasma gondii tachyzoites","volume":"4","author":"Pomel","year":"2008","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ijpara.2025.08.008_b0185","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.exppara.2008.12.014","article-title":"Cryptosporidium: genomic and biochemical features","volume":"124","author":"Rider","year":"2010","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.ijpara.2025.08.008_b0190","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1186\/s12885-024-12752-2","article-title":"Effect of short-term fasting on the cisplatin activity in human oral squamous cell carcinoma cell line HN5 and chemotherapy side effects","volume":"24","author":"Sheykhbahaei","year":"2024","journal-title":"BMC Cancer"},{"key":"10.1016\/j.ijpara.2025.08.008_b0195","series-title":"Biotechnology \u2013 guidelines on techniques in coccidiosis research","first-page":"9","article-title":"Eimeria species and strains of chickens","author":"Shirley","year":"1995"},{"key":"10.1016\/j.ijpara.2025.08.008_b0200","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1111\/j.1365-2958.2006.05205.x","article-title":"Leishmania histone H1 overexpression delays parasite cell-cycle progression, parasite differentiation and reduces Leishmania infectivity in vivo","volume":"60","author":"Smirlis","year":"2006","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.ijpara.2025.08.008_b0205","doi-asserted-by":"crossref","first-page":"666","DOI":"10.2307\/3281137","article-title":"Influence of monensin on cation influx and glycolysis of Eimeria tenella sporozoites in vitro","volume":"69","author":"Smith","year":"1983","journal-title":"J. Parasitol."},{"key":"10.1016\/j.ijpara.2025.08.008_b0210","doi-asserted-by":"crossref","first-page":"511","DOI":"10.2307\/3280482","article-title":"Effect of ionophores on survival, penetration, and development of Eimeria tenella sporozoites in vitro","volume":"67","author":"Smith","year":"1981","journal-title":"J. Parasitol."},{"key":"10.1016\/j.ijpara.2025.08.008_b0215","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.1016\/j.bpj.2016.09.042","article-title":"Intracellular requirements for passive proton transport through the Na(+),K(+)-ATPase","volume":"111","author":"Stanley","year":"2016","journal-title":"Biophys. J."},{"key":"10.1016\/j.ijpara.2025.08.008_b0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.106334","article-title":"EtcPRS (mut) as a molecular marker of Halofuginone resistance in Eimeria tenella and Toxoplasma gondii","volume":"26","author":"Sun","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.ijpara.2025.08.008_b0225","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1073\/pnas.77.1.62","article-title":"Isozymes of human phosphofructokinase: identification and subunit structural characterization of a new system","volume":"77","author":"Vora","year":"1980","journal-title":"PNAS"},{"key":"10.1016\/j.ijpara.2025.08.008_b0230","first-page":"50","article-title":"Resistant assessment of maduramicin resistant strain and diclazuril resistant strain of Eimeria tenella","volume":"24","author":"Xie","year":"2016","journal-title":"Chinese J. Anim. Infect. Dis."},{"key":"10.1016\/j.ijpara.2025.08.008_b0235","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1010293","article-title":"Essential role of pyrophosphate homeostasis mediated by the pyrophosphate-dependent phosphofructokinase in Toxoplasma gondii","volume":"18","author":"Yang","year":"2022","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ijpara.2025.08.008_b0240","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/s41416-022-01834-2","article-title":"Inhibition of PFKFB3 in HER2-positive gastric cancer improves sensitivity to trastuzumab by inducing tumour vessel normalisation","volume":"127","author":"Yao","year":"2022","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.ijpara.2025.08.008_b0245","article-title":"In vitro transcriptional response of Eimeria tenella to toltrazuril reveals that oxidative stress and autophagy contribute to its anticoccidial effect","volume":"24","author":"Zhang","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ijpara.2025.08.008_b0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpddr.2024.100526","article-title":"Integrated application of transcriptomics and metabolomics provides insight into the mechanism of Eimeria tenella resistance to maduramycin","volume":"24","author":"Zhao","year":"2024","journal-title":"Int. J. Parasitol. Drugs Drug Resist."}],"container-title":["International Journal for Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020751925001420?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020751925001420?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T04:28:25Z","timestamp":1779942505000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0020751925001420"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S0020751925001420"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpara.2025.08.008","relation":{},"ISSN":["0020-7519"],"issn-type":[{"value":"0020-7519","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The key glycolytic enzyme phosphofructokinase is involved in Eimeria tenella resistance to maduramycin","name":"articletitle","label":"Article Title"},{"value":"International Journal for Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijpara.2025.08.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Australian Society for Parasitology. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104720"}}