{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T06:28:22Z","timestamp":1793946502544,"version":"4.8.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100015956","name":"Special Project for Research and Development in Key areas of Guangdong Province","doi-asserted-by":"publisher","award":["2019B020218004"],"award-info":[{"award-number":["2019B020218004"]}],"id":[{"id":"10.13039\/501100015956","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal for Parasitology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.ijpara.2026.104847","type":"journal-article","created":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T15:08:03Z","timestamp":1775315283000},"page":"104847","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Primary infection with Cystoisospora suis modulates systemic immunity and the gut microbiota during secondary infection in piglets"],"prefix":"10.1016","volume":"56","author":[{"given":"Xin","family":"Ye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1879-6834","authenticated-orcid":false,"given":"Yi-Juan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Ling","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Ying","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-jia","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7746-0035","authenticated-orcid":false,"given":"Xiao","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-qiu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Biao","family":"Weng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Jian","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2125-3934","authenticated-orcid":false,"given":"Rui-Qing","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijpara.2026.104847_b0005","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13567-015-0290-0","article-title":"Systemic and local immune responses in sheep after Neospora caninum experimental infection at early, mid and late gestation","volume":"47","author":"Arranz-Sol\u00eds","year":"2016","journal-title":"Vet. Res."},{"key":"10.1016\/j.ijpara.2026.104847_b0010","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1080\/10408398.2011.619671","article-title":"Immune system stimulation by probiotic microorganisms","volume":"54","author":"Ashraf","year":"2014","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.ijpara.2026.104847_b0015","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.chom.2009.06.005","article-title":"Gut commensal bacteria direct a protective immune response against Toxoplasma gondii","volume":"6","author":"Benson","year":"2009","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.ijpara.2026.104847_b0020","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/s41587-019-0209-9","article-title":"Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2","volume":"37","author":"Bolyen","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ijpara.2026.104847_b0025","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nmeth.3869","article-title":"DADA2: High-resolution sample inference from Illumina amplicon data","volume":"13","author":"Callahan","year":"2016","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ijpara.2026.104847_b0030","doi-asserted-by":"crossref","first-page":"5972","DOI":"10.1038\/s41598-022-09714-8","article-title":"The transcriptome from asexual to sexual in vitro development of Cystoisospora suis (Apicomplexa: Coccidia)","volume":"12","author":"Cruz-Bustos","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ijpara.2026.104847_b0035","doi-asserted-by":"crossref","first-page":"5461","DOI":"10.1038\/s41598-025-89372-8","article-title":"Deciphering the code of resistance: a genomic and transcriptomic exploration of the Cystoisospora suis Holland-I strain","volume":"15","author":"Cruz-Bustos","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ijpara.2026.104847_b0040","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.immuni.2009.08.027","article-title":"Selective expression of the chemokine receptor XCR1 on cross-presenting dendritic cells determines cooperation with CD8+ T cells","volume":"31","author":"Dorner","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.ijpara.2026.104847_b0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0304-4017(01)00610-0","article-title":"Eimeria infections in cows in the periparturient phase and their calves: oocyst excretion and levels of specific serum and colostrum antibodies","volume":"104","author":"Faber","year":"2002","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.ijpara.2026.104847_b0050","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1186\/s13071-018-2974-6","article-title":"Antibody and cytokine response to Cystoisospora suis infections in immune-competent young pigs","volume":"11","author":"Freudenschuss","year":"2018","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.ijpara.2026.104847_b0055","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/nature12721","article-title":"Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells","volume":"504","author":"Furusawa","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.ijpara.2026.104847_b0060","doi-asserted-by":"crossref","first-page":"663","DOI":"10.3390\/biology13090663","article-title":"The role of milk oligosaccharides in enhancing intestinal microbiota, intestinal integrity, and immune function in pigs: a comparative review","volume":"13","author":"Gormley","year":"2024","journal-title":"Biology"},{"key":"10.1016\/j.ijpara.2026.104847_b0065","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0304-4017(84)90062-1","article-title":"Life cycle of Isospora suis in gnotobiotic and conventionalized piglets","volume":"17","author":"Harleman","year":"1984","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.ijpara.2026.104847_b0070","doi-asserted-by":"crossref","first-page":"8785","DOI":"10.4049\/jimmunol.177.12.8785","article-title":"Gram-negative bacteria aggravate murine small intestinal Th1-type immunopathology following oral infection with Toxoplasma gondii","volume":"177","author":"Heimesaat","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijpara.2026.104847_b0075","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3389\/fvets.2020.00113","article-title":"Cystoisospora suis control in Europe is not always effective","volume":"7","author":"Hinney","year":"2020","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.ijpara.2026.104847_b0080","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s40813-018-0097-2","article-title":"Detection of Cystoisospora suis in faeces of suckling piglets - when and how? A comparison of methods","volume":"4","author":"Joachim","year":"2018","journal-title":"Porcine Health Manage."},{"key":"10.1016\/j.ijpara.2026.104847_b0085","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1126\/science.1201711","article-title":"A family of IFN-\u03b3-inducible 65-kD GTPases protects against bacterial infection","volume":"332","author":"Kim","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.ijpara.2026.104847_b0090","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3390\/vaccines10020215","article-title":"Coccidiosis: recent progress in host immunity and alternatives to antibiotic strategies","volume":"10","author":"Lee","year":"2022","journal-title":"Vaccines (Basel)"},{"key":"10.1016\/j.ijpara.2026.104847_b0095","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/S0020-7519(98)00075-7","article-title":"Role of T lymphocytes and cytokines in coccidiosis","volume":"28","author":"Lillehoj","year":"1998","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.ijpara.2026.104847_b0100","doi-asserted-by":"crossref","first-page":"419","DOI":"10.2460\/javma.1984.185.04.419","article-title":"Prevalence of oocysts of Isospora suis and Eimeria spp from sows on farms with and without a history of neonatal coccidiosis","volume":"185","author":"Lindsay","year":"1984","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"10.1016\/j.ijpara.2026.104847_b0105","doi-asserted-by":"crossref","first-page":"15630","DOI":"10.1038\/s41598-022-20082-1","article-title":"On the influence of the source of porcine colostrum in the development of early immune ontogeny in piglets","volume":"12","author":"Maciag","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ijpara.2026.104847_b0110","doi-asserted-by":"crossref","DOI":"10.1099\/ijsem.0.005153","article-title":"Turicibacter bilis sp. nov., a novel bacterium isolated from the chicken eggshell and swine ileum","volume":"72","author":"Maki","year":"2022","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"10.1016\/j.ijpara.2026.104847_b0115","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.cimid.2017.04.002","article-title":"Humoral immune responses of experimentally Eimeria ninakholyakimovae-infected goat kids","volume":"51","author":"Matos","year":"2017","journal-title":"Comp. Immunol. Microbiol. Infect. Dis."},{"key":"10.1016\/j.ijpara.2026.104847_b0120","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1007\/s00436-011-2633-8","article-title":"Necrotic enteritis due to simultaneous infection with Isospora suis and clostridia in newborn piglets and its prevention by early treatment with toltrazuril","volume":"110","author":"Mengel","year":"2012","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.ijpara.2026.104847_b0125","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1439-0450.2005.00824.x","article-title":"Occurrence of Isospora suis in Germany, Switzerland and Austria","volume":"52","author":"Mundt","year":"2005","journal-title":"J. Vet. Med. B Infect. Dis. Vet. Public Health"},{"key":"10.1016\/j.ijpara.2026.104847_b0130","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s00436-005-0030-x","article-title":"Isospora suis: an experimental model for mammalian intestinal coccidiosis","volume":"98","author":"Mundt","year":"2006","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.ijpara.2026.104847_b0135","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s00436-006-0314-9","article-title":"Efficacy of various anticoccidials against experimental porcine neonatal isosporosis","volume":"100","author":"Mundt","year":"2007","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.ijpara.2026.104847_b0140","article-title":"Parasite-probiotic interactions in the gut: bacillus sp. and Enterococcus faecium regulate type-2 inflammatory responses and modify the gut microbiota of pigs during helminth infection","volume":"12","author":"Myhill","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ijpara.2026.104847_b0145","doi-asserted-by":"crossref","first-page":"7936","DOI":"10.1038\/srep07936","article-title":"Transcriptome and histopathological changes in mouse brain infected with Neospora caninum","volume":"5","author":"Nishimura","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ijpara.2026.104847_b0150","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.ijpara.2016.11.007","article-title":"The genome of the protozoan parasite Cystoisospora suis and a reverse vaccinology approach to identify vaccine candidates","volume":"47","author":"Palmieri","year":"2017","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.ijpara.2026.104847_b0155","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.femsle.2005.08.046","article-title":"Shigella spp. and enteroinvasive Escherichia coli pathogenicity factors","volume":"252","author":"Parsot","year":"2005","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.ijpara.2026.104847_b0160","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1186\/1471-2164-15-806","article-title":"Dual transcriptional profiling of mice and Toxoplasma gondii during acute and chronic infection","volume":"15","author":"Pittman","year":"2014","journal-title":"BMC Genomics"},{"key":"10.1016\/j.ijpara.2026.104847_b0165","doi-asserted-by":"crossref","first-page":"8604","DOI":"10.3168\/jds.2018-15786","article-title":"Effect of milk protein composition and amount of \u03b2-casein on growth performance, gut hormones, and inflammatory cytokines in an in vivo piglet model","volume":"102","author":"Rafiee-Tari","year":"2019","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.ijpara.2026.104847_b0170","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.vetpar.2004.10.018","article-title":"Coccidial infections in housed lambs: oocyst excretion, antibody levels and genetic influences on the infection","volume":"127","author":"Reeg","year":"2005","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.ijpara.2026.104847_b0175","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1590\/S0074-02761998000600028","article-title":"Experimental infection of swine by Isospora suis Biester 1934 for species confirmation","volume":"93","author":"Sayd","year":"1998","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.ijpara.2026.104847_b0180","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.vetpar.2013.07.007","article-title":"Transfer of Cystoisospora suis-specific colostral antibodies and their correlation with the course of neonatal porcine cystoisosporosis","volume":"197","author":"Schwarz","year":"2013","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.ijpara.2026.104847_b0185","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.vetpar.2014.04.026","article-title":"Superinfection of sows with Cystoisospora suis ante partum leads to a milder course of cystoisosporosis in suckling piglets","volume":"204","author":"Schwarz","year":"2014","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.ijpara.2026.104847_b0190","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3389\/fvets.2015.00068","article-title":"Cystoisospora suis \u2013 a model of mammalian cystoisosporosis","volume":"2","author":"Shrestha","year":"2015","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.ijpara.2026.104847_b0195","doi-asserted-by":"crossref","first-page":"983","DOI":"10.3389\/fmicb.2020.00983","article-title":"Shifts in the fecal microbial community of Cystoisospora suis infected piglets in response to toltrazuril","volume":"11","author":"Shrestha","year":"2020","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.ijpara.2026.104847_b0200","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1186\/s12864-025-11909-y","article-title":"The effects of formula milk on development, nutrient absorption, and immune characteristics of piglets","volume":"26","author":"Tang","year":"2025","journal-title":"BMC Genomics"},{"issue":"Suppl 1","key":"10.1016\/j.ijpara.2026.104847_b0205","doi-asserted-by":"crossref","first-page":"S157","DOI":"10.1007\/s00436-009-1507-9","article-title":"Age, not infection dose, determines the outcome of Isospora suis infections in suckling piglets","volume":"105","author":"Worliczek","year":"2009","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.ijpara.2026.104847_b0210","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1111\/j.1365-3024.2009.01184.x","article-title":"Changes in lymphocyte populations in suckling piglets during primary infections with Isospora suis","volume":"32","author":"Worliczek","year":"2010","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.ijpara.2026.104847_b0215","doi-asserted-by":"crossref","first-page":"5827","DOI":"10.1016\/j.psj.2020.07.042","article-title":"Dietary corn-resistant starch suppresses broiler abdominal fat deposition associated with the reduced cecal Firmicutes","volume":"99","author":"Zhang","year":"2020","journal-title":"Poult. Sci."},{"key":"10.1016\/j.ijpara.2026.104847_b0220","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2021.693412","article-title":"Therapeutic and improving function of lactobacilli in the prevention and treatment of cardiovascular-related diseases: a novel perspective from gut microbiota","volume":"8","author":"Zhao","year":"2021","journal-title":"Front. Nutr."},{"key":"10.1016\/j.ijpara.2026.104847_b0225","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.aninu.2020.08.010","article-title":"Dietary supplementation with betaine or glycine improves the carcass trait, meat quality and lipid metabolism of finishing mini-pigs","volume":"7","author":"Zhong","year":"2021","journal-title":"Anim. Nutr."}],"container-title":["International Journal for Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020751926000780?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020751926000780?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T05:49:47Z","timestamp":1793944187000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0020751926000780"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":45,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S0020751926000780"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpara.2026.104847","relation":{},"ISSN":["0020-7519"],"issn-type":[{"value":"0020-7519","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Primary infection with Cystoisospora suis modulates systemic immunity and the gut microbiota during secondary infection in piglets","name":"articletitle","label":"Article Title"},{"value":"International Journal for Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijpara.2026.104847","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Australian Society for Parasitology. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104847"}}