{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T07:42:34Z","timestamp":1791099754567,"version":"4.1.0"},"reference-count":6,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":227,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal for Parasitology: Drugs and Drug Resistance"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1016\/j.ijpddr.2012.05.002","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T03:15:39Z","timestamp":1339470939000},"page":"230-235","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Recent highlights in anti-protozoan drug development and resistance research"],"prefix":"10.1016","volume":"2","author":[{"given":"Frederick S.","family":"Buckner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman C.","family":"Waters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicky M.","family":"Avery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijpddr.2012.05.002_b0005","doi-asserted-by":"crossref","first-page":"4400","DOI":"10.1073\/pnas.1015762108","article-title":"Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria","volume":"108","author":"Charman","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ijpddr.2012.05.002_b0010","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1128\/AAC.50.3.1045-1053.2006","article-title":"Mefloquine induces dose-related neurological effects in a rat model","volume":"50","author":"Dow","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ijpddr.2012.05.002_b0015","first-page":"13","article-title":"Artemisinin antimalarials: mechanisms of action and resistance","volume":"58","author":"Meshnick","year":"1998","journal-title":"Med. Trop. (Mars.)"},{"key":"10.1016\/j.ijpddr.2012.05.002_b0020","doi-asserted-by":"crossref","first-page":"6277","DOI":"10.1021\/jm200647u","article-title":"Structure\u2013activity relationships of 4-position diamine quinoline methanols as intermittent preventative treatment (IPT) against Plasmodium falciparum","volume":"54","author":"Milner","year":"2011","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ijpddr.2012.05.002_b0025","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1016\/j.febslet.2011.04.042","article-title":"Drug-resistant malaria: molecular mechanisms and implications for public health","volume":"585","author":"Petersen","year":"2011","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ijpddr.2012.05.002_b0030","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1126\/science.1193225","article-title":"Spiroindolones, a potent compound class for the treatment of malaria","volume":"329","author":"Rottmann","year":"2010","journal-title":"Science"}],"container-title":["International Journal for Parasitology: Drugs and Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221132071200019X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221132071200019X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:45:16Z","timestamp":1761921916000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S221132071200019X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":6,"alternative-id":["S221132071200019X"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpddr.2012.05.002","relation":{},"ISSN":["2211-3207"],"issn-type":[{"value":"2211-3207","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Recent highlights in anti-protozoan drug development and resistance research","name":"articletitle","label":"Article Title"},{"value":"International Journal for Parasitology: Drugs and Drug Resistance","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijpddr.2012.05.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Australian Society for Parasitology. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}