{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T22:50:03Z","timestamp":1769813403683,"version":"3.49.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,5,28]],"date-time":"2015-05-28T00:00:00Z","timestamp":1432771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004916","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["FAPESP, 2011\/20484-7"],"award-info":[{"award-number":["FAPESP, 2011\/20484-7"]}],"id":[{"id":"10.13039\/501100004916","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["CNPq, 473343\/2012-6"],"award-info":[{"award-number":["CNPq, 473343\/2012-6"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal for Parasitology: Drugs and Drug Resistance"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.ijpddr.2015.05.006","type":"journal-article","created":{"date-parts":[[2015,6,17]],"date-time":"2015-06-17T08:31:52Z","timestamp":1434529912000},"page":"77-83","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Leishmania is not prone to develop resistance to tamoxifen"],"prefix":"10.1016","volume":"5","author":[{"given":"Adriano C.","family":"Coelho","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiana T.","family":"Trinconi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa","family":"Senra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenicer K.U.","family":"Yokoyama-Yasunaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia R.B.","family":"Uliana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijpddr.2015.05.006_bib1","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1017\/S003118201300022X","article-title":"Genetic dissection of drug resistance in trypanosomes","volume":"140","author":"Alsford","year":"2013","journal-title":"Parasitology"},{"key":"10.1016\/j.ijpddr.2015.05.006_bib2","doi-asserted-by":"crossref","first-page":"e35671","DOI":"10.1371\/journal.pone.0035671","article-title":"Leishmaniasis worldwide and global estimates of its incidence","volume":"7","author":"Alvar","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ijpddr.2015.05.006_bib3","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.exppara.2007.11.009","article-title":"Leishmania amazonensis: biosynthesis of polyprenols of 9 isoprene units by amastigotes","volume":"118","author":"Arruda","year":"2008","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.ijpddr.2015.05.006_bib4","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1017\/S0031182013000140","article-title":"Genomic approaches to tackle drug resistance in Leishmania","volume":"140","author":"Berg","year":"2013","journal-title":"Parasitology"},{"key":"10.1016\/j.ijpddr.2015.05.006_bib5","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/0092-8674(84)90498-7","article-title":"Unstable DNA amplifications in methotrexate-resistant Leishmania consist of extrachromosomal circles which relocalize during stabilization","volume":"38","author":"Beverley","year":"1984","journal-title":"Cell"},{"key":"10.1016\/j.ijpddr.2015.05.006_bib6","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1073\/pnas.83.8.2584","article-title":"Primary structure of the gene encoding the bifunctional dihydrofolate reductase-thymidylate synthase of Leishmania major","volume":"83","author":"Beverley","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ijpddr.2015.05.006_bib7","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/cbdd.12239","article-title":"Discovery of synthetic Leishmania inhibitors by screening of a 2-arylbenzothiophene library","volume":"83","author":"Bonano","year":"2014","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.ijpddr.2015.05.006_bib8","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1046\/j.1365-3156.2001.00795.x","article-title":"A\u00a0policy for leishmaniasis with respect to the prevention and control of drug resistance","volume":"6","author":"Bryceson","year":"2001","journal-title":"Trop. Med. Int. Health"},{"key":"10.1016\/j.ijpddr.2015.05.006_bib9","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0014-5793(96)00942-8","article-title":"Tamoxifen retards glycosphingolipid metabolism in human cancer cells","volume":"394","author":"Cabot","year":"1996","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ijpddr.2015.05.006_bib10","doi-asserted-by":"crossref","first-page":"18427","DOI":"10.1016\/S0021-9258(18)55077-8","article-title":"Heavy metal resistance: a new role for P-glycoproteins in Leishmania","volume":"266","author":"Callahan","year":"1991","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.ijpddr.2015.05.006_bib11","doi-asserted-by":"crossref","first-page":"7316","DOI":"10.1038\/sj.onc.1206937","article-title":"Antiestrogen resistance in breast cancer and the role of estrogen receptor signaling","volume":"22","author":"Clarke","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.ijpddr.2015.05.006_bib12","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1073\/pnas.80.8.2132","article-title":"Overproduction of a bifunctional thymidylate synthetase-dihydrofolate reductase and DNA amplification in methotrexate-resistant Leishmania tropica","volume":"80","author":"Coderre","year":"1983","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ijpddr.2015.05.006_bib43","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.exppara.2008.03.018","article-title":"Characterization of Leishmania (Leishmania) amazonensis promastigotes resistant to pentamidine","volume":"120","author":"Coelho","year":"2008","journal-title":"Exp Parasitol"},{"key":"10.1016\/j.ijpddr.2015.05.006_bib13","doi-asserted-by":"crossref","first-page":"e1512","DOI":"10.1371\/journal.pntd.0001512","article-title":"Multiple mutations in heterogeneous miltefosine-resistant Leishmania major population as determined by whole genome sequencing","volume":"6","author":"Coelho","year":"2012","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.ijpddr.2015.05.006_bib14","doi-asserted-by":"crossref","first-page":"e2999","DOI":"10.1371\/journal.pntd.0002999","article-title":"In\u00a0vitro and in\u00a0vivo miltefosine susceptibility of a Leishmania amazonensis isolate from a patient with diffuse cutaneous leishmaniasis","volume":"8","author":"Coelho","year":"2014","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.ijpddr.2015.05.006_bib15","doi-asserted-by":"crossref","first-page":"704","DOI":"10.3201\/eid1804.110841","article-title":"Leishmania resistance to miltefosine associated with genetic marker","volume":"18","author":"Cojean","year":"2012","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.ijpddr.2015.05.006_bib16","doi-asserted-by":"crossref","first-page":"14536","DOI":"10.1073\/pnas.0907560106","article-title":"Antiestrogen-resistant subclones of MCF-7 human breast cancer cells are derived from a common monoclonal drug-resistant progenitor","volume":"106","author":"Coser","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ijpddr.2015.05.006_bib17","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1046\/j.1365-3156.2001.00754.x","article-title":"Monitoring drug resistance in leishmaniasis","volume":"6","author":"Croft","year":"2001","journal-title":"Trop. Med. Int. Health"},{"key":"10.1016\/j.ijpddr.2015.05.006_bib18","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1016\/0006-2952(94)90073-6","article-title":"Tamoxifen and hydroxytamoxifen as intramembraneous inhibitors of lipid peroxidation. Evidence for peroxyl radical scavenging activity","volume":"47","author":"Custodio","year":"1994","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ijpddr.2015.05.006_bib19","doi-asserted-by":"crossref","first-page":"e1167","DOI":"10.1371\/journal.pntd.0001167","article-title":"Gene expression profiling and molecular characterization of antimony resistance in Leishmania amazonensis","volume":"5","author":"do Monte-Neto","year":"2011","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.ijpddr.2015.05.006_bib20","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1007\/s00436-014-3835-7","article-title":"Experimental selection of paromomycin and miltefosine resistance in intracellular amastigotes of Leishmania donovani and L.\u00a0infantum","volume":"113","author":"Hendrickx","year":"2014","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.ijpddr.2015.05.006_bib21","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0166-6851(84)90131-2","article-title":"Characterization of a mutant Leishmania donovani deficient in adenosine kinase activity","volume":"12","author":"Iovannisci","year":"1984","journal-title":"Mol. Biochem. Parasitol."},{"issue":"Suppl.\u00a0A","key":"10.1016\/j.ijpddr.2015.05.006_bib22","doi-asserted-by":"crossref","first-page":"A3","DOI":"10.1016\/S0149-2918(02)85031-7","article-title":"Historical perspective on hormonal therapy of advanced breast cancer","volume":"24","author":"Jordan","year":"2002","journal-title":"Clin. Ther."},{"key":"10.1016\/j.ijpddr.2015.05.006_bib23","first-page":"129","article-title":"The role of tamoxifen in the treatment and prevention of breast cancer","volume":"16","author":"Jordan","year":"1992","journal-title":"Curr. Probl. Cancer"},{"key":"10.1016\/j.ijpddr.2015.05.006_bib24","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1073\/pnas.84.5.1253","article-title":"Tunicamycin-resistant Leishmania mexicana amazonensis: expression of virulence associated with an increased activity of N-acetylglucosaminyltransferase and amplification of its presumptive gene","volume":"84","author":"Kink","year":"1987","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ijpddr.2015.05.006_bib25","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0006-291X(84)91062-3","article-title":"Tamoxifen is a calmodulin antagonist in the activation of cAMP phosphodiesterase","volume":"118","author":"Lam","year":"1984","journal-title":"Biochem.. Biophys. Res. Commun."},{"key":"10.1016\/j.ijpddr.2015.05.006_bib26","first-page":"1879","article-title":"Role of PKC-ERK signaling in tamoxifen-induced apoptosis and tamoxifen resistance in human breast cancer cells","volume":"27","author":"Li","year":"2012","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.ijpddr.2015.05.006_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0166-6851(00)00184-5","article-title":"Characterization of cytochrome b from Toxoplasma gondii and Q(o) domain mutations as a mechanism of atovaquone-resistance","volume":"108","author":"McFadden","year":"2000","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.ijpddr.2015.05.006_bib28","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1093\/jac\/dkm219","article-title":"Tamoxifen is effective against Leishmania and induces a rapid alkalinization of parasitophorous vacuoles harbouring Leishmania (Leishmania) amazonensis amastigotes","volume":"60","author":"Miguel","year":"2007","journal-title":"J.\u00a0Antimicrob. Chemother."},{"key":"10.1016\/j.ijpddr.2015.05.006_bib29","doi-asserted-by":"crossref","first-page":"e249","DOI":"10.1371\/journal.pntd.0000249","article-title":"Tamoxifen is effective in the treatment of Leishmania amazonensis infections in mice","volume":"2","author":"Miguel","year":"2008","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.ijpddr.2015.05.006_bib30","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/jac\/dkn509","article-title":"Tamoxifen as a potential antileishmanial agent: efficacy in the treatment of Leishmania braziliensis and Leishmania chagasi infections","volume":"63","author":"Miguel","year":"2009","journal-title":"J.\u00a0Antimicrob. Chemother."},{"key":"10.1016\/j.ijpddr.2015.05.006_bib31","doi-asserted-by":"crossref","first-page":"R114","DOI":"10.1186\/bcr3581","article-title":"GPR30 as an initiator of tamoxifen resistance in hormone-dependent breast cancer","volume":"15","author":"Mo","year":"2013","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.ijpddr.2015.05.006_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molbiopara.2005.08.016","article-title":"Roles for mitochondria in pentamidine susceptibility and resistance in Leishmania donovani","volume":"145","author":"Mukherjee","year":"2006","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.ijpddr.2015.05.006_bib33","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.2174\/156802611796575876","article-title":"Drug target identification in intracellular and extracellular protozoan parasites","volume":"11","author":"Muller","year":"2011","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.ijpddr.2015.05.006_bib34","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/nrc2713","article-title":"Biological determinants of endocrine resistance in breast cancer","volume":"9","author":"Musgrove","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.ijpddr.2015.05.006_bib35","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.drup.2004.07.002","article-title":"Leishmaniasis: drugs in the clinic, resistance and new developments","volume":"7","author":"Ouellette","year":"2004","journal-title":"Drug Resist. Updat"},{"key":"10.1016\/j.ijpddr.2015.05.006_bib36","first-page":"49965","article-title":"Functional cloning of the miltefosine transporter. A novel P-type phospholipid translocase from Leishmania involved in drug resistance","volume":"278","author":"Perez-Victoria","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.ijpddr.2015.05.006_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2007.03.016","article-title":"Pathways to tamoxifen resistance","volume":"256","author":"Riggins","year":"2007","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ijpddr.2015.05.006_bib38","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1093\/cid\/cit102","article-title":"Increasing failure of miltefosine in the treatment of Kala-azar in Nepal and the potential role of parasite drug resistance, reinfection, or noncompliance","volume":"56","author":"Rijal","year":"2013","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.ijpddr.2015.05.006_bib39","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1046\/j.1365-3156.2001.00778.x","article-title":"Drug resistance in Indian visceral leishmaniasis","volume":"6","author":"Sundar","year":"2001","journal-title":"Trop. Med. Int. Health"},{"key":"10.1016\/j.ijpddr.2015.05.006_bib40","doi-asserted-by":"crossref","first-page":"193","DOI":"10.4269\/ajtmh.2001.65.193","article-title":"Resistance to treatment in Kala-azar: speciation of isolates from northeast India","volume":"65","author":"Sundar","year":"2001","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.ijpddr.2015.05.006_bib41","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/1574-6976.12032","article-title":"Drug resistance in vectorborne parasites: multiple actors and scenarios for an evolutionary arms race","volume":"38","author":"Vanaerschot","year":"2013","journal-title":"FEMS Microbiol. Ver."},{"key":"10.1016\/j.ijpddr.2015.05.006_bib42","first-page":"68","article-title":"In\u00a0vitro sensitivity of Leishmania (Viannia) braziliensis and Leishmania (Leishmania) amazonensis Brazilian isolates to meglumine antimoniate and amphotericin B","volume":"15","author":"Zauli-Nascimento","year":"2010","journal-title":"Trop. Med. Int. Health"}],"container-title":["International Journal for Parasitology: Drugs and Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211320715300026?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211320715300026?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:45:13Z","timestamp":1761921913000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211320715300026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["S2211320715300026"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpddr.2015.05.006","relation":{},"ISSN":["2211-3207"],"issn-type":[{"value":"2211-3207","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Leishmania is not prone to develop resistance to tamoxifen","name":"articletitle","label":"Article Title"},{"value":"International Journal for Parasitology: Drugs and Drug Resistance","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijpddr.2015.05.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}