{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T07:52:23Z","timestamp":1777535543432,"version":"3.51.4"},"reference-count":42,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,5,11]],"date-time":"2016-05-11T00:00:00Z","timestamp":1462924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["AI125821"],"award-info":[{"award-number":["AI125821"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal for Parasitology: Drugs and Drug Resistance"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.ijpddr.2016.06.002","type":"journal-article","created":{"date-parts":[[2016,6,24]],"date-time":"2016-06-24T01:26:09Z","timestamp":1466731569000},"page":"356-363","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Kinetic profiling an abundantly expressed planarian serotonergic GPCR identifies bromocriptine as a perdurant antagonist"],"prefix":"10.1016","volume":"6","author":[{"given":"John D.","family":"Chan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Grab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan S.","family":"Marchant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijpddr.2016.06.002_bib1","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.celrep.2015.06.052","article-title":"Large-scale combinatorial deorphanization of platynereis neuropeptide GPCRs","volume":"12","author":"Bauknecht","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.ijpddr.2016.06.002_bib2","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/nature11691","article-title":"Automated design of ligands to polypharmacological profiles","volume":"492","author":"Besnard","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.ijpddr.2016.06.002_bib3","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1021\/cb200248h","article-title":"A\u00a0luminescent biosensor with increased dynamic range for intracellular cAMP","volume":"6","author":"Binkowski","year":"2011","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.ijpddr.2016.06.002_bib4","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/978-1-61779-160-4_14","article-title":"Luminescent biosensors for real-time monitoring of intracellular cAMP","volume":"756","author":"Binkowski","year":"2011","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.ijpddr.2016.06.002_bib5","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/nmeth.1328","article-title":"High-throughput ethomics in large groups of Drosophila","volume":"6","author":"Branson","year":"2009","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ijpddr.2016.06.002_bib6","doi-asserted-by":"crossref","first-page":"4853","DOI":"10.1073\/pnas.1518377113","article-title":"Neural correlates of the LSD experience revealed by multimodal neuroimaging","volume":"113","author":"Carhart-Harris","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ijpddr.2016.06.002_bib7","article-title":"Pharmacological and functional genetic assays to manipulate regeneration of the planarian Dugesia japonica","volume":"54","author":"Chan","year":"2011","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.ijpddr.2016.06.002_bib8","doi-asserted-by":"crossref","first-page":"e1003942","DOI":"10.1371\/journal.ppat.1003942","article-title":"\u2019Death and axes\u2019; unexpected Ca2+ entry phenologs predict new anti-schistosomal agents","volume":"10","author":"Chan","year":"2014","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ijpddr.2016.06.002_bib9","doi-asserted-by":"crossref","first-page":"e0004063","DOI":"10.1371\/journal.pntd.0004063","article-title":"Ergot alkaloids (Re)generate new leads as antiparasitics","volume":"9","author":"Chan","year":"2015","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.ijpddr.2016.06.002_bib10","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.ijpddr.2016.06.001","article-title":"Pharmacological profiling an abundantly expressed schistosome serotonergic GPCR identifies nuciferine as a potent antagonist","volume":"6","author":"Chan","year":"2016","journal-title":"Int. J. Parasitol. Drugs Drug Resist."},{"key":"10.1016\/j.ijpddr.2016.06.002_bib11","doi-asserted-by":"crossref","first-page":"e1005651","DOI":"10.1371\/journal.ppat.1005651","article-title":"A\u00a0miniaturized screen of a schistosoma mansoni serotonergic G protein-coupled receptor identifies novel classes of parasite-selective inhibitors","volume":"12","author":"Chan","year":"2016","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ijpddr.2016.06.002_bib12","doi-asserted-by":"crossref","first-page":"6681","DOI":"10.1074\/jbc.R114.616391","article-title":"Single-cell analysis of G-protein signal transduction","volume":"290","author":"Clister","year":"2015","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.ijpddr.2016.06.002_bib13","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1016\/S0140-6736(13)61949-2","article-title":"Human schistosomiasis","volume":"383","author":"Colley","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.ijpddr.2016.06.002_bib14","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1021\/cb8000414","article-title":"Novel genetically encoded biosensors using firefly luciferase","volume":"3","author":"Fan","year":"2008","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.ijpddr.2016.06.002_bib15","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1387\/ijdb.113428sf","article-title":"Regeneration of neuronal cell types in Schmidtea mediterranea: an immunohistochemical and expression study","volume":"56","author":"Fraguas","year":"2012","journal-title":"Int. J. Dev. Biol."},{"key":"10.1016\/j.ijpddr.2016.06.002_bib16","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0022-3565(25)29779-8","article-title":"Effect of methysergide and dihydroergotamine on Schistosoma mansoni","volume":"188","author":"Hillman","year":"1974","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ijpddr.2016.06.002_bib17","doi-asserted-by":"crossref","first-page":"e1321","DOI":"10.1371\/journal.pntd.0001321","article-title":"Utility of repeated praziquantel dosing in the treatment of schistosomiasis in high-risk communities in Africa: a systematic review","volume":"5","author":"King","year":"2011","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.ijpddr.2016.06.002_bib18","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1124\/mol.108.052084","article-title":"Pharmacological analysis of the novel, rapid, and potent inactivation of the human 5-Hydroxytryptamine7 receptor by risperidone, 9-OH-Risperidone, and other inactivating antagonists","volume":"75","author":"Knight","year":"2009","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ijpddr.2016.06.002_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molbiopara.2004.05.010","article-title":"Biogenic amine receptors in parasitic nematodes: what can be learned from Caenorhabditis elegans?","volume":"137","author":"Komuniecki","year":"2004","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.ijpddr.2016.06.002_bib20","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1113\/jphysiol.2006.120212","article-title":"Genetically encoded Ca2+ indicators: using genetics and molecular design to understand complex physiology","volume":"578","author":"Kotlikoff","year":"2007","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.ijpddr.2016.06.002_bib21","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.molbiopara.2015.09.001","article-title":"A\u00a0constitutively active G protein-coupled acetylcholine receptor regulates motility of larval Schistosoma mansoni","volume":"202","author":"MacDonald","year":"2015","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.ijpddr.2016.06.002_bib22","doi-asserted-by":"crossref","first-page":"83","DOI":"10.4269\/ajtmh.1983.32.83","article-title":"Neuropharmacology of the parasitic trematode, Schistosoma mansoni","volume":"32","author":"Mellin","year":"1983","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.ijpddr.2016.06.002_bib23","doi-asserted-by":"crossref","first-page":"e464","DOI":"10.1371\/journal.pntd.0000464","article-title":"A\u00a0novel biological activity of praziquantel requiring voltage-operated Ca2+ channel \u03b2 subunits: subversion of flatworm regenerative polarity","volume":"3","author":"Nogi","year":"2009","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.ijpddr.2016.06.002_bib24","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1093\/jac\/dkt491","article-title":"The little we know about the pharmacokinetics and pharmacodynamics of praziquantel (racemate and R-enantiomer)","volume":"69","author":"Olliaro","year":"2014","journal-title":"J.\u00a0Antimicrob. Chemother."},{"key":"10.1016\/j.ijpddr.2016.06.002_bib25","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.ijpara.2006.12.019","article-title":"Identification of a platyhelminth neuropeptide receptor","volume":"37","author":"Omar","year":"2007","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.ijpddr.2016.06.002_bib26","doi-asserted-by":"crossref","first-page":"e1003878","DOI":"10.1371\/journal.ppat.1003878","article-title":"Serotonin signaling in Schistosoma mansoni: a serotonin-activated G protein-coupled receptor controls parasite movement","volume":"10","author":"Patocka","year":"2014","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ijpddr.2016.06.002_bib27","doi-asserted-by":"crossref","first-page":"19471","DOI":"10.1074\/jbc.R115.654764","article-title":"Integrated approaches for genome-wide interrogation of the druggable non-olfactory G protein-coupled receptor superfamily","volume":"290","author":"Roth","year":"2015","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.ijpddr.2016.06.002_bib28","doi-asserted-by":"crossref","first-page":"e1002457","DOI":"10.1371\/journal.pbio.1002457","article-title":"GPCRs direct germline development and somatic gonad function in planarians","volume":"14","author":"Saberi","year":"2016","journal-title":"PLoS Biol."},{"key":"10.1016\/j.ijpddr.2016.06.002_bib29","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0378-1119(97)00152-2","article-title":"Molecular identification of a G protein-coupled receptor family which is expressed in planarians","volume":"195","author":"Saitoh","year":"1997","journal-title":"Gene"},{"key":"10.1016\/j.ijpddr.2016.06.002_bib30","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1124\/mol.106.024612","article-title":"Risperidone irreversibly binds to and inactivates the h5-HT7 serotonin receptor","volume":"70","author":"Smith","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ijpddr.2016.06.002_bib31","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.molbiopara.2009.06.003","article-title":"Investigation of a dopamine receptor in Schistosoma mansoni: functional studies and immunolocalization","volume":"168","author":"Taman","year":"2009","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.ijpddr.2016.06.002_bib32","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.pharmthera.2011.10.007","article-title":"A\u00a0new approach for studying GPCR dimers: drug-induced inactivation and reactivation to reveal GPCR dimer function in\u00a0vitro, in primary culture, and in\u00a0vivo","volume":"133","author":"Teitler","year":"2012","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ijpddr.2016.06.002_bib33","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S0022-3565(25)29917-7","article-title":"Tryptaminergic and dopaminergic responses of Schistosoma mansoni","volume":"190","author":"Tomosky","year":"1974","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ijpddr.2016.06.002_bib34","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1124\/mol.109.056283","article-title":"Human 5-HT7 receptor-induced inactivation of forskolin-stimulated adenylate cyclase by risperidone, 9-OH-risperidone and other \u201cinactivating antagonists\u201d","volume":"76","author":"Toohey","year":"2009","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ijpddr.2016.06.002_bib35","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature12031","article-title":"The genomes of four tapeworm species reveal adaptations to parasitism","volume":"496","author":"Tsai","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.ijpddr.2016.06.002_bib36","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1124\/jpet.113.207670","article-title":"Kinetics of 5-HT2B receptor signaling: profound agonist-dependent effects on signaling onset and duration","volume":"347","author":"Unett","year":"2013","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ijpddr.2016.06.002_bib37","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1126\/science.1232808","article-title":"Structural features for functional selectivity at serotonin receptors","volume":"340","author":"Wacker","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.ijpddr.2016.06.002_bib38","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1126\/science.1232807","article-title":"Structural basis for molecular recognition at serotonin receptors","volume":"340","author":"Wang","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.ijpddr.2016.06.002_bib39","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0742-8413(84)90151-8","article-title":"Drug effects on the 5-HT response of Schistosoma mansoni","volume":"77","author":"Willcockson","year":"1984","journal-title":"Comp. Biochem. Physiol. C"},{"key":"10.1016\/j.ijpddr.2016.06.002_bib40","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1186\/1471-2164-12-596","article-title":"The repertoire of G protein-coupled receptors in the human parasite Schistosoma mansoni and the model organism Schmidtea mediterranea","volume":"12","author":"Zamanian","year":"2011","journal-title":"BMC Genomics"},{"key":"10.1016\/j.ijpddr.2016.06.002_bib41","doi-asserted-by":"crossref","first-page":"e40787","DOI":"10.1371\/journal.pone.0040787","article-title":"Novel RNAi-mediated approach to G protein-coupled receptor deorphanization: proof of principle and characterization of a planarian 5-HT receptor","volume":"7","author":"Zamanian","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ijpddr.2016.06.002_bib42","doi-asserted-by":"crossref","first-page":"15983","DOI":"10.1523\/JNEUROSCI.3029-11.2011","article-title":"Opposing roles of voltage-gated Ca2+ channels in neuronal control of stem cell differentiation in\u00a0vivo","volume":"31","author":"Zhang","year":"2011","journal-title":"J.\u00a0Neurosci."}],"container-title":["International Journal for Parasitology: Drugs and Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211320716300367?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211320716300367?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:46:38Z","timestamp":1761921998000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211320716300367"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S2211320716300367"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpddr.2016.06.002","relation":{},"ISSN":["2211-3207"],"issn-type":[{"value":"2211-3207","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Kinetic profiling an abundantly expressed planarian serotonergic GPCR identifies bromocriptine as a perdurant antagonist","name":"articletitle","label":"Article Title"},{"value":"International Journal for Parasitology: Drugs and Drug Resistance","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijpddr.2016.06.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Authors. Published by Elsevier Ltd on behalf of Australian Society for Parasitology.","name":"copyright","label":"Copyright"}]}}