{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T07:18:02Z","timestamp":1770275882634,"version":"3.49.0"},"reference-count":18,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,8,19]],"date-time":"2016-08-19T00:00:00Z","timestamp":1471564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal for Parasitology: Drugs and Drug Resistance"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.ijpddr.2016.09.003","type":"journal-article","created":{"date-parts":[[2016,9,23]],"date-time":"2016-09-23T09:11:06Z","timestamp":1474621866000},"page":"179-183","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Human dihydrofolate reductase influences the sensitivity of the malaria parasite Plasmodium falciparum to ketotifen \u2013 A cautionary tale in screening transgenic parasites"],"prefix":"10.1016","volume":"6","author":[{"given":"Phuong N.","family":"Tran","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cameron J.","family":"Tate","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie C.","family":"Ridgway","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin J.","family":"Saliba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiaran","family":"Kirk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7369-1058","authenticated-orcid":false,"given":"Alexander G.","family":"Maier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijpddr.2016.09.003_bib1","doi-asserted-by":"crossref","first-page":"15424","DOI":"10.1073\/pnas.0902072106","article-title":"The extremely slow and variable activity of dihydrofolate reductase in human liver and its implications for high folic acid intake","volume":"106","author":"Bailey","year":"2009","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ijpddr.2016.09.003_bib2","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1080\/00034983.1991.11812549","article-title":"Chloroquine-potentiating action of antihistaminics in Plasmodium falciparum in\u00a0vitro","volume":"85","author":"Basco","year":"1991","journal-title":"Ann. Trop. Med. Parasitol."},{"key":"10.1016\/j.ijpddr.2016.09.003_bib3","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1128\/AEM.02745-14","article-title":"An In planta-expressed polyketide synthase produces (R)-mellein in the wheat pathogen Parastagonospora nodorum","volume":"81","author":"Chooi","year":"2015","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.ijpddr.2016.09.003_bib4","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0166-6851(99)00189-9","article-title":"The selectable marker human dihydrofolate reductase enables sequential genetic manipulation of the Plasmodium berghei genome","volume":"106","author":"De Koning-Ward","year":"2000","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.ijpddr.2016.09.003_bib5","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1128\/AAC.00920-12","article-title":"A\u00a0class of tricyclic compounds blocking malaria parasite oocyst development and transmission","volume":"57","author":"Eastman","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ijpddr.2016.09.003_bib6","doi-asserted-by":"crossref","first-page":"10931","DOI":"10.1073\/pnas.94.20.10931","article-title":"Transformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanil","volume":"94","author":"Fidock","year":"1997","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ijpddr.2016.09.003_bib7","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.actatropica.2005.04.002","article-title":"Exploring the folate pathway in Plasmodium falciparum","volume":"94","author":"Hyde","year":"2005","journal-title":"Acta Trop."},{"key":"10.1016\/j.ijpddr.2016.09.003_bib8","doi-asserted-by":"crossref","first-page":"943","DOI":"10.4269\/ajtmh.1999.60.943","article-title":"The antimalarial triazine WR99210 and the prodrug PS-15: folate reversal of in\u00a0vitro activity against Plasmodium falciparum and a non-antifolate mode of action of the prodrug","volume":"60","author":"Kinyanjui","year":"1999","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.ijpddr.2016.09.003_bib9","doi-asserted-by":"crossref","first-page":"418","DOI":"10.2307\/3280287","article-title":"Synchronization of Plasmodium falciparum erythrocytic stages in culture","volume":"65","author":"Lambros","year":"1979","journal-title":"J.\u00a0Parasitol."},{"key":"10.1016\/j.ijpddr.2016.09.003_bib10","doi-asserted-by":"crossref","first-page":"5922","DOI":"10.1021\/bi900411a","article-title":"Effect of dimerization on the stability and catalytic activity of dihydrofolate reductase from the hyperthermophile Thermotoga maritima","volume":"48","author":"Loveridge","year":"2009","journal-title":"Biochemistry"},{"key":"10.1016\/j.ijpddr.2016.09.003_bib11","series-title":"Malaria : Methods and Protocols","first-page":"3","article-title":"In\u00a0vitro culturing Plasmodium falciparum erythrocytic stages","author":"Maier","year":"2013"},{"key":"10.1016\/j.ijpddr.2016.09.003_bib12","doi-asserted-by":"crossref","first-page":"8716","DOI":"10.1073\/pnas.96.15.8716","article-title":"A\u00a0set of independent selectable markers for transfection of the human malaria parasite Plasmodium falciparum","volume":"96","author":"Mamoun","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ijpddr.2016.09.003_bib13","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s13318-012-0080-2","article-title":"Ketotifen is an antimalarial prodrug of norketotifen with blood schizonticidal and liver-stage efficacy","volume":"37","author":"Milner","year":"2012","journal-title":"Eur. J. Drug Metabolism Pharmacokinet."},{"key":"10.1016\/j.ijpddr.2016.09.003_bib14","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/978-1-62703-026-7_6","article-title":"Transfection of Plasmodium falciparum","volume":"923","author":"Rug","year":"2013","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.ijpddr.2016.09.003_bib15","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0001-706X(00)00133-9","article-title":"Interaction between chloroquine and diverse pharmacological agents in chloroquine resistant Plasmodium yoelii nigeriensis","volume":"77","author":"Singh","year":"2000","journal-title":"Acta Trop."},{"key":"10.1016\/j.ijpddr.2016.09.003_bib16","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1126\/science.781840","article-title":"Human malaria parasites in continuous culture","volume":"193","author":"Trager","year":"1976","journal-title":"Science"},{"key":"10.1016\/j.ijpddr.2016.09.003_bib17","doi-asserted-by":"crossref","first-page":"4773","DOI":"10.1038\/ncomms5773","article-title":"A\u00a0female gametocyte-specific ABC transporter plays a role in lipid metabolism in the malaria parasite","volume":"5","author":"Tran","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ijpddr.2016.09.003_bib18","first-page":"667","article-title":"Inhibition of protein synthesis by blasticidin S: I. studies with cell-free systems from bacterial and mammalian cells","volume":"57","author":"Yamaguchi","year":"1965","journal-title":"J.\u00a0Biochem."}],"container-title":["International Journal for Parasitology: Drugs and Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211320716300756?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211320716300756?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:48:27Z","timestamp":1761922107000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211320716300756"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S2211320716300756"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpddr.2016.09.003","relation":{},"ISSN":["2211-3207"],"issn-type":[{"value":"2211-3207","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Human dihydrofolate reductase influences the sensitivity of the malaria parasite Plasmodium falciparum to ketotifen \u2013 A cautionary tale in screening transgenic parasites","name":"articletitle","label":"Article Title"},{"value":"International Journal for Parasitology: Drugs and Drug Resistance","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijpddr.2016.09.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Authors. Published by Elsevier Ltd on behalf of Australian Society for Parasitology.","name":"copyright","label":"Copyright"}]}}