{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:44:58Z","timestamp":1790779498069,"version":"4.1.0"},"reference-count":54,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,6,25]],"date-time":"2016-06-25T00:00:00Z","timestamp":1466812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005363","name":"Universidad de Buenos Aires","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005363","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT-2014-1798"],"award-info":[{"award-number":["PICT-2014-1798"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008056","name":"Fundaci\u00f3n Florencio Fiorini","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008056","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal for Parasitology: Drugs and Drug Resistance"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.ijpddr.2016.12.003","type":"journal-article","created":{"date-parts":[[2016,12,22]],"date-time":"2016-12-22T03:19:05Z","timestamp":1482376745000},"page":"23-33","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["Comparative effects of histone deacetylases inhibitors and resveratrol on Trypanosoma cruzi replication, differentiation, infectivity and gene expression"],"prefix":"10.1016","volume":"7","author":[{"given":"Vanina A.","family":"Campo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"20","key":"10.1016\/j.ijpddr.2016.12.003_bib1","doi-asserted-by":"crossref","first-page":"10150","DOI":"10.1093\/nar\/gks813","article-title":"Cell-cycle-regulated control of VSG expression site silencing by histones and histone chaperones ASF1A and CAF-1b in Trypanosoma brucei","volume":"40","author":"Alsford","year":"2012","journal-title":"Nucleic Acids Res."},{"issue":"2","key":"10.1016\/j.ijpddr.2016.12.003_bib2","doi-asserted-by":"crossref","first-page":"e31847","DOI":"10.1371\/journal.pone.0031847","article-title":"Comparative gene expression profiling of P.\u00a0falciparum malaria parasites exposed to three different histone deacetylase inhibitors","volume":"7","author":"Andrews","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.ijpddr.2016.12.003_bib3","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/icb.2011.97","article-title":"HDAC inhibitors in parasitic diseases","volume":"90","author":"Andrews","year":"2012","journal-title":"Immunol. Cell Biol."},{"issue":"6","key":"10.1016\/j.ijpddr.2016.12.003_bib4","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/S0020-7519(00)00043-6","article-title":"Anti-malarial effect of histone deacetylation inhibitors and mammalian tumour cytodifferentiating agents","volume":"30","author":"Andrews","year":"2000","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.ijpddr.2016.12.003_bib5","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1158\/1055-9965.EPI-07-0022","article-title":"Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent","volume":"6","author":"Boocock","year":"2007","journal-title":"Cancer Epidemiol. Biomark. Prev"},{"issue":"4","key":"10.1016\/j.ijpddr.2016.12.003_bib6","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1084\/jem.20082826","article-title":"Drug inhibition of HDAC3 and epigenetic control of differentiation in Apicomplexa parasites","volume":"206","author":"Bougdour","year":"2009","journal-title":"J.\u00a0Exp. Med."},{"issue":"16","key":"10.1016\/j.ijpddr.2016.12.003_bib7","doi-asserted-by":"crossref","first-page":"15860","DOI":"10.1074\/jbc.M314051200","article-title":"The surface coat of the mammal-dwelling infective trypomastigote stage of Trypanosoma cruzi is formed by highly diverse immunogenic mucins","volume":"279","author":"Buscaglia","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"issue":"1","key":"10.1016\/j.ijpddr.2016.12.003_bib8","doi-asserted-by":"crossref","first-page":"e1002474","DOI":"10.1371\/journal.ppat.1002474","article-title":"Trypanosoma cruzi trans-sialidase in complex with a neutralizing antibody: structure\/function studies towards the rational design of inhibitors","volume":"8","author":"Buschiazzo","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ijpddr.2016.12.003_bib9","doi-asserted-by":"crossref","first-page":"5151","DOI":"10.1016\/j.bmc.2014.12.066","article-title":"Evaluation of histone deacetylase inhibitors (HDACi) as therapeutic leads for human African trypanosomiasis (HAT)","volume":"23","author":"Carrillo","year":"2015","journal-title":"Bioorg. Med. Chem."},{"issue":"1","key":"10.1016\/j.ijpddr.2016.12.003_bib10","doi-asserted-by":"crossref","first-page":"e1000737","DOI":"10.1371\/journal.ppat.1000737","article-title":"Histone deacetylases play a major role in the transcriptional regulation of the Plasmodium falciparum life cycle","volume":"6","author":"Chaal","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ijpddr.2016.12.003_bib11","doi-asserted-by":"crossref","first-page":"e884","DOI":"10.1038\/cddis.2013.416","article-title":"The epigenetic modifier trichostatin A, a histone deacetylase inhibitor, suppresses proliferation and epithelial-mesenchymal transition of lens epithelial cells","volume":"4","author":"Chen","year":"2013","journal-title":"Cell Death Dis."},{"issue":"2","key":"10.1016\/j.ijpddr.2016.12.003_bib12","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.molbiopara.2007.07.007","article-title":"Post-transcriptional regulation of gene expression in trypanosomes and leishmanias","volume":"156","author":"Clayton","year":"2007","journal-title":"Mol. Biochem. Parasitol."},{"issue":"4","key":"10.1016\/j.ijpddr.2016.12.003_bib13","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1084\/jem.20011433","article-title":"A\u00a0Trypanosoma cruzi small surface molecule provides the first immunological evidence that Chagas' disease is due to a single parasite lineage","volume":"195","author":"Di Noia","year":"2002","journal-title":"J.\u00a0Exp. Med."},{"issue":"1","key":"10.1016\/j.ijpddr.2016.12.003_bib14","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.molbiopara.2009.06.001","article-title":"Histone deacetylase inhibitors induce apoptosis, histone hyperacetylation and up-regulation of gene transcription in Schistosoma mansoni","volume":"168","author":"Dubois","year":"2009","journal-title":"Mol. Biochem. Parasitol."},{"issue":"3","key":"10.1016\/j.ijpddr.2016.12.003_bib15","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1093\/embo-reports\/kvf053","article-title":"Histone acetylation: a switch between repressive and permissive chromatin. Second in review series on chromatin dynamics","volume":"3","author":"Eberharter","year":"2002","journal-title":"EMBO Rep."},{"key":"10.1016\/j.ijpddr.2016.12.003_bib16","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1186\/1471-2164-8-216","article-title":"Trichostatin A: effects on gene expression in the protozoan parasite Entamoeba histolytica","volume":"8","author":"Ehrenkaufer","year":"2007","journal-title":"BMC Genom."},{"issue":"5733","key":"10.1016\/j.ijpddr.2016.12.003_bib17","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1126\/science.1112631","article-title":"The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease","volume":"309","author":"El-Sayed","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.ijpddr.2016.12.003_bib18","doi-asserted-by":"crossref","first-page":"117e126","DOI":"10.1016\/j.ijpddr.2015.05.004","article-title":"Profiling the anti-protozoal activity of anti-cancer HDAC inhibitors against Plasmodium and Trypanosoma parasites","volume":"5","author":"Engel","year":"2015","journal-title":"Int. J. Parasitol. Drugs Drug Resist."},{"issue":"Suppl.\u00a0l","key":"10.1016\/j.ijpddr.2016.12.003_bib19","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.1017\/S0031182000075703","article-title":"Trans-sialidase, SAPA amino acid repeats and the relationship between Trypanosoma cruzi and the mammalian host","volume":"108","author":"Frasch","year":"1994","journal-title":"Parasitology"},{"issue":"2","key":"10.1016\/j.ijpddr.2016.12.003_bib20","first-page":"151","article-title":"Gene expression profiling of multiple histone deacetylase (HDAC) inhibitors: defining a common gene set produced by HDAC inhibition in T24 and MDA carcinoma cell lines","volume":"2","author":"Glaser","year":"2003","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.ijpddr.2016.12.003_bib21","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.gene.2005.09.010","article-title":"Acetylation and deacetylation of non-histone proteins","volume":"363","author":"Glozak","year":"2005","journal-title":"Gene"},{"issue":"2","key":"10.1016\/j.ijpddr.2016.12.003_bib22","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1006\/excr.2000.5080","article-title":"The human histone deacetylase family","volume":"262","author":"Gray","year":"2001","journal-title":"Exp. Cell Res."},{"issue":"8","key":"10.1016\/j.ijpddr.2016.12.003_bib23","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.4161\/cc.7.8.5740","article-title":"Resveratrol: a multitargeted agent for age-associated chronic diseases","volume":"7","author":"Harikumar","year":"2008","journal-title":"Cell Cycle"},{"key":"10.1016\/j.ijpddr.2016.12.003_bib24","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1021\/acs.jmedchem.5b01478","article-title":"Structure-based design and synthesis of novel inhibitors targeting HDAC8 from Schistosoma mansoni for the treatment of schistosomiasis","volume":"59","author":"Heimburg","year":"2016","journal-title":"J.\u00a0Med. Chem."},{"issue":"6954","key":"10.1016\/j.ijpddr.2016.12.003_bib25","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nature01960","article-title":"Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan","volume":"425","author":"Howitz","year":"2003","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.ijpddr.2016.12.003_bib26","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.tips.2013.12.004","article-title":"Small molecule SIRT1 activators for the treatment of aging and age-related diseases","volume":"35","author":"Hubbard","year":"2014","journal-title":"Trends Pharmacol. Sci."},{"issue":"1","key":"10.1016\/j.ijpddr.2016.12.003_bib27","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1046\/j.1365-2958.2002.03018.x","article-title":"Histone deacetylases in Trypanosoma brucei: two are essential and another is required for normal cell cycle progression","volume":"45","author":"Ingram","year":"2002","journal-title":"Mol. Microbiol."},{"issue":"5733","key":"10.1016\/j.ijpddr.2016.12.003_bib28","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1126\/science.1112680","article-title":"The genome of the kinetoplastid parasite, Leishmania major","volume":"309","author":"Ivens","year":"2005","journal-title":"Science"},{"issue":"5297","key":"10.1016\/j.ijpddr.2016.12.003_bib29","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1126\/science.275.5297.218","article-title":"Cancer chemopreventive activity of resveratrol, a natural product derived from grapes","volume":"275","author":"Jang","year":"1997","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.ijpddr.2016.12.003_bib30","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s00436-007-0729-y","article-title":"In\u00a0vitro antileishmanial activity of resveratrol and its hydroxylated analogues against Leishmania major promastigotes and amastigotes","volume":"102","author":"Kedzierski","year":"2007","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.ijpddr.2016.12.003_bib31","first-page":"525241","article-title":"Gene expression in trypanosomatid parasites","volume":"2010","author":"Martinez-Calvillo","year":"2010","journal-title":"J.\u00a0Biomed. Biotechnol."},{"issue":"8","key":"10.1016\/j.ijpddr.2016.12.003_bib32","doi-asserted-by":"crossref","first-page":"4669","DOI":"10.1128\/AAC.04694-14","article-title":"Characterization of trypanosoma cruzi sirtuins as possible drug targets for Chagas disease","volume":"59","author":"Moretti","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"issue":"6","key":"10.1016\/j.ijpddr.2016.12.003_bib33","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S0960-894X(01)00049-X","article-title":"The synthesis of cyclic tetrapeptoid analogues of the antiprotozoal natural product apicidin","volume":"11","author":"Murray","year":"2001","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"4","key":"10.1016\/j.ijpddr.2016.12.003_bib34","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s00412-009-0213-9","article-title":"Distinct acetylation of Trypanosoma cruzi histone H4 during cell cycle, parasite differentiation, and after DNA damage","volume":"118","author":"Nardelli","year":"2009","journal-title":"Chromosoma"},{"issue":"1","key":"10.1016\/j.ijpddr.2016.12.003_bib35","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.bmc.2009.10.042","article-title":"Antimalarial and antileishmanial activities of histone deacetylase inhibitors with triazole-linked cap group","volume":"18","author":"Patil","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ijpddr.2016.12.003_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molbiopara.2015.11.001","article-title":"Expression of non-acetylatable lysines 10 and 14 of histone H4 impairs transcription and replication in Trypanosoma cruzi","volume":"204","author":"Prata Ramos","year":"2015","journal-title":"Mol. Biochem. Parasitol."},{"issue":"23","key":"10.1016\/j.ijpddr.2016.12.003_bib37","doi-asserted-by":"crossref","first-page":"15884","DOI":"10.1074\/jbc.M802081200","article-title":"Histone acetylation and methylation at sites initiating divergent polycistronic transcription in Trypanosoma cruzi","volume":"283","author":"Respuela","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.ijpddr.2016.12.003_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0003725","article-title":"Overexpression of cytoplasmic TcSIR2RP1and mitochondrial TcSIR2RP3 impacts on Trypanosoma cruzi growth and cell invasion","author":"Ritagliati","year":"2015","journal-title":"PLoS Negl. Trop. Dis."},{"issue":"8","key":"10.1016\/j.ijpddr.2016.12.003_bib39","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1590\/0074-0276130565","article-title":"Chagas disease: control, elimination and eradication. Is it possible?","volume":"108","author":"Rodrigues Coura","year":"2013","journal-title":"Mem. Inst. Oswaldo Cruz"},{"issue":"2","key":"10.1016\/j.ijpddr.2016.12.003_bib40","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1128\/AAC.49.2.808-812.2005","article-title":"In\u00a0vitro antileishmanial activity of nicotinamide","volume":"49","author":"Sereno","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ijpddr.2016.12.003_bib41","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1146\/annurev.biochem.76.052705.162114","article-title":"Functions of site-specific histone acetylation and deacetylation","volume":"76","author":"Shahbazian","year":"2007","journal-title":"Annu. Rev. Biochem."},{"issue":"9","key":"10.1016\/j.ijpddr.2016.12.003_bib42","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1101\/gad.1790409","article-title":"Four histone variants mark the boundaries of polycistronic transcription units in Trypanosoma brucei","volume":"23","author":"Siegel","year":"2009","journal-title":"Genes Dev."},{"issue":"2","key":"10.1016\/j.ijpddr.2016.12.003_bib43","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.actatropica.2012.01.001","article-title":"Anti-Trypanosoma cruzi activity of nicotinamide","volume":"122","author":"Soares","year":"2012","journal-title":"Acta Trop."},{"issue":"1","key":"10.1016\/j.ijpddr.2016.12.003_bib44","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.1365-2958.2010.07062.x","article-title":"Epigenetic mechanisms regulate stage differentiation in the minimized protozoan Giardia lamblia","volume":"76","author":"Sonda","year":"2010","journal-title":"Mol. Microbiol."},{"issue":"3","key":"10.1016\/j.ijpddr.2016.12.003_bib45","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1645\/GE-1043R.1","article-title":"Scriptaid and suberoylanilide hydroxamic acid are histone deacetylase inhibitors with potent anti-Toxoplasma gondii activity in\u00a0vitro","volume":"93","author":"Strobl","year":"2007","journal-title":"J.\u00a0Parasitol."},{"key":"10.1016\/j.ijpddr.2016.12.003_bib46","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1186\/1471-2164-10-152","article-title":"Histone acetylations mark origins of polycistronic transcription in Leishmania major","volume":"10","author":"Thomas","year":"2009","journal-title":"BMC Genom."},{"issue":"9","key":"10.1016\/j.ijpddr.2016.12.003_bib47","doi-asserted-by":"crossref","first-page":"e73785","DOI":"10.1371\/journal.pone.0073785","article-title":"HDAC1 and HDAC2 restrain the intestinal inflammatory response by regulating intestinal epithelial cell differentiation","volume":"8","author":"Turgeon","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ijpddr.2016.12.003_bib48","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.ijbiomac.2016.03.014","article-title":"Resveratrol inhibits Trypanosoma cruzi arginine kinase and exerts atrypanocidal activity","volume":"87","author":"Valera Vera","year":"2016","journal-title":"Int. J. Biol. Macromol"},{"key":"10.1016\/j.ijpddr.2016.12.003_bib49","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1017\/S0031182013001704","article-title":"Inhibition of NAD+-dependent histone deacetylases (sirtuins) causes growth arrest and activates both apoptosis and autophagy in the pathogenic protozoan Trypanosoma cruzi","volume":"141","author":"Veiga-Santos","year":"2014","journal-title":"Parasitology"},{"issue":"8","key":"10.1016\/j.ijpddr.2016.12.003_bib50","doi-asserted-by":"crossref","first-page":"e73097","DOI":"10.1371\/journal.pone.0073097","article-title":"Resveratrol as a Pan-HDAC inhibitor alters the acetylation status of histone proteins in human-derived hepatoblastoma cells","volume":"8","author":"Venturelli","year":"2013","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.ijpddr.2016.12.003_bib51","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.actatropica.2005.03.004","article-title":"Stage-specific antileishmanial activity of an inhibitor of SIR2 histone deacetylase","volume":"94","author":"Vergnes","year":"2005","journal-title":"Acta Trop."},{"issue":"5","key":"10.1016\/j.ijpddr.2016.12.003_bib52","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/biof.1032","article-title":"Sirtuin activators and inhibitors","volume":"38","author":"Villalba","year":"2012","journal-title":"Biofactors"},{"issue":"6","key":"10.1016\/j.ijpddr.2016.12.003_bib53","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.ijpara.2008.11.013","article-title":"Trypanosoma cruzi bromodomain factor 2 (BDF2) binds to acetylated histones and is accumulated after UV irradiation","volume":"39","author":"Villanova","year":"2009","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.ijpddr.2016.12.003_bib54","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0004026","article-title":"Targeting lysine Deacetylases (KDACs) in parasites","author":"Wang","year":"2015","journal-title":"PLoS Negl. Trop. Dis."}],"container-title":["International Journal for Parasitology: Drugs and Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211320716300574?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211320716300574?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:46:42Z","timestamp":1761922002000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211320716300574"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["S2211320716300574"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpddr.2016.12.003","relation":{},"ISSN":["2211-3207"],"issn-type":[{"value":"2211-3207","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparative effects of histone deacetylases inhibitors and resveratrol on Trypanosoma cruzi replication, differentiation, infectivity and gene expression","name":"articletitle","label":"Article Title"},{"value":"International Journal for Parasitology: Drugs and Drug Resistance","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijpddr.2016.12.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Author. Published by Elsevier Ltd on behalf of Australian Society for Parasitology.","name":"copyright","label":"Copyright"}]}}