{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T11:04:48Z","timestamp":1786791888162,"version":"build-2736575974"},"reference-count":37,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,6,3]],"date-time":"2018-06-03T00:00:00Z","timestamp":1527984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council (ARC) of Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004167","name":"Medicines for Malaria Venture (MMV)","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004167","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Yourgene Bioscience"},{"DOI":"10.13039\/501100001782","name":"The University of Melbourne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001782","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001782","name":"University of Melbourne","doi-asserted-by":"publisher","award":["0707258"],"award-info":[{"award-number":["0707258"]}],"id":[{"id":"10.13039\/501100001782","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Australian Government's Education Investment Fund"},{"DOI":"10.13039\/501100004224","name":"Peter MacCallum Cancer Centre Foundation (KJS)","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004224","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal for Parasitology: Drugs and Drug Resistance"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.ijpddr.2018.06.002","type":"journal-article","created":{"date-parts":[[2018,6,4]],"date-time":"2018-06-04T17:49:39Z","timestamp":1528134579000},"page":"379-385","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Arylpyrrole and fipronil analogues that inhibit the motility and\/or development of Haemonchus contortus in vitro"],"prefix":"10.1016","volume":"8","author":[{"given":"H.M.P.","family":"Dilrukshi Herath","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjian","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Preston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul","family":"Jabbar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean L.","family":"McGee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4408-5467","authenticated-orcid":false,"given":"Andreas","family":"Hofmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6310-796X","authenticated-orcid":false,"given":"Jose","family":"Garcia-Bustos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bill C.H.","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8330-6416","authenticated-orcid":false,"given":"Anson V.","family":"Koehler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxiu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoqiao","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengxiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiqi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingmin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin B.","family":"Gasser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijpddr.2018.06.002_bib1","series-title":"Synthesis and Chemistry of Agrochemicals III","isbn-type":"print","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1021\/bk-1992-0504.ch025","article-title":"Insecticidal pyrroles: discovery and overview","author":"Addor","year":"1992","ISBN":"https:\/\/id.crossref.org\/isbn\/9780841224735"},{"key":"10.1016\/j.ijpddr.2018.06.002_bib2","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ijpddr.2014.02.002","article-title":"Drug repurposing and human parasitic protozoan diseases","volume":"4","author":"Andrews","year":"2014","journal-title":"Int. J. Parasitol. Drugs Drug Resist"},{"key":"10.1016\/j.ijpddr.2018.06.002_bib3","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/bs.apar.2016.02.024","article-title":"Diagnosis, treatment and management of Haemonchus contortus in small ruminants","volume":"93","author":"Besier","year":"2016","journal-title":"Adv. Parasitol."},{"key":"10.1016\/j.ijpddr.2018.06.002_bib4","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1006\/pest.1994.1064","article-title":"Insecticidal action and mitochondrial uncoupling activity of AC-303,630 and related halogenated pyrroles","volume":"50","author":"Black","year":"1994","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.ijpddr.2018.06.002_bib5","doi-asserted-by":"crossref","first-page":"233","DOI":"10.7164\/antibiotics.40.233","article-title":"LL-F42248\u03b1, a novel chlorinated pyrrole antibiotic","volume":"40","author":"Carter","year":"1987","journal-title":"J. Antibiot."},{"key":"10.1016\/j.ijpddr.2018.06.002_bib6","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1007\/s00894-009-0477-2","article-title":"Homology modeling of human \u03b11\u03b22\u03b32 and house fly \u03b23 GABA receptor channels and surflex-docking of fipronil","volume":"15","author":"Cheng","year":"2009","journal-title":"J. Mol. Model."},{"key":"10.1016\/j.ijpddr.2018.06.002_bib7","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0048-3575(80)90064-4","article-title":"Inhibition of Tribolium gut chitin synthetase","volume":"13","author":"Cohen","year":"1980","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.ijpddr.2018.06.002_bib8","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/nm.4306","article-title":"The drug repurposing hub: a next-generation drug library and information resource","volume":"23","author":"Corsello","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.ijpddr.2018.06.002_bib9","series-title":"Pesticides and the Future: Minimizing Chronic Exposure of Humans and the Environment","first-page":"147","article-title":"Fipronil: action at the GABA receptor","author":"Gant","year":"1998"},{"key":"10.1016\/j.ijpddr.2018.06.002_bib10","first-page":"1622","article-title":"Antofine analogues can inhibit tobacco mosaic virus assembly through small-molecule-RNA interactions","volume":"13","author":"Gao","year":"2012","journal-title":"Chem. Biochem"},{"key":"10.1016\/j.ijpddr.2018.06.002_bib11","series-title":"Haemonchus contortus and Haemonchosis - Past, Present and Future Trends. Advances in Parasitology","isbn-type":"print","author":"Gasser","year":"2016","ISBN":"https:\/\/id.crossref.org\/isbn\/9780128103951"},{"key":"10.1016\/j.ijpddr.2018.06.002_bib12","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1645\/14-703.1","article-title":"Anthelmintic drug discovery: into the future","volume":"101","author":"Geary","year":"2015","journal-title":"J. Parasitol."},{"key":"10.1016\/j.ijpddr.2018.06.002_bib13","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/bs.apar.2016.02.010","article-title":"The biochemistry of Haemonchus contortus and other parasitic nematodes","volume":"93","author":"Harder","year":"2016","journal-title":"Adv. Parasitol."},{"key":"10.1016\/j.ijpddr.2018.06.002_bib14","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.vetpar.2017.07.005","article-title":"Screening of a small, well-curated natural product-based library identifies two rotenoids with potent nematocidal activity against Haemonchus contortus","volume":"244","author":"Herath","year":"2017","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.ijpddr.2018.06.002_bib15","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1186\/s13071-017-2191-8","article-title":"Assessing the anthelmintic activity of pyrazole-5-carboxamide derivatives against Haemonchus contortus","volume":"10","author":"Jiao","year":"2017","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.ijpddr.2018.06.002_bib16","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/nature06722","article-title":"A new class of anthelmintics effective against drug-resistant nematodes","volume":"452","author":"Kaminsky","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.ijpddr.2018.06.002_bib17","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.vetpar.2011.11.048","article-title":"An inconvenient truth: global worming and anthelmintic resistance","volume":"186","author":"Kaplan","year":"2012","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.ijpddr.2018.06.002_bib18","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/bs.apar.2016.02.012","article-title":"Anthelmintic resistance in Haemonchus contortus: history, mechanisms and diagnosis","volume":"93","author":"Kotze","year":"2016","journal-title":"Adv. Parasitol."},{"key":"10.1016\/j.ijpddr.2018.06.002_bib19","series-title":"Pytochemicals for Pest Control","first-page":"195","article-title":"Structure-activity relationships for insecticidal pyrroles","author":"Kuhn","year":"1997"},{"key":"10.1016\/j.ijpddr.2018.06.002_bib20","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1186\/s13071-016-1458-9","article-title":"Anthelmintic activity of selected ethno-medicinal plant extracts on parasitic stages of Haemonchus contortus","volume":"9","author":"Kumarasingha","year":"2016","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.ijpddr.2018.06.002_bib21","doi-asserted-by":"crossref","first-page":"6858","DOI":"10.1016\/j.bmcl.2012.09.036","article-title":"The trifluoromethyl transformation synthesis, crystal structure and insecticidal activities of novel 2-pyrrolecarboxamide and 2-pyrrolecarboxlate","volume":"22","author":"Li","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ijpddr.2018.06.002_bib22","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s11030-014-9515-9","article-title":"Design, synthesis, and biological evaluation of 2-benzylpyrroles and 2-benzoylpyrroles based on structures of insecticidal chlorfenapyr and natural pyrrolomycins","volume":"18","author":"Liu","year":"2014","journal-title":"Mol. Divers."},{"key":"10.1016\/j.ijpddr.2018.06.002_bib23","doi-asserted-by":"crossref","first-page":"6072","DOI":"10.1021\/jf501377t","article-title":"Design, synthesis, and biological evaluation of various \u03b1-substituted benzylpyrroles based on the structures of insecticidal chlorfenapyr and natural pyrrolomycins","volume":"62","author":"Ma","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ijpddr.2018.06.002_bib24","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1159\/000331724","article-title":"DHA protects against zinc mediated alterations in neuronal cellular bioenergetics","volume":"28","author":"McGee","year":"2011","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.ijpddr.2018.06.002_bib25","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1002\/ps.1192","article-title":"Mode of action of etoxazole","volume":"62","author":"Nauen","year":"2006","journal-title":"Pest Manag. Sci."},{"key":"10.1016\/j.ijpddr.2018.06.002_bib26","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1208\/s12248-012-9390-1","article-title":"Drug repurposing: far beyond new targets for old drugs","volume":"14","author":"Oprea","year":"2012","journal-title":"AAPS J."},{"key":"10.1016\/j.ijpddr.2018.06.002_bib27","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/BF00623561","article-title":"A new insecticide inhibits chitin synthesis","volume":"60","author":"Post","year":"1973","journal-title":"Naturwissenschaften"},{"key":"10.1016\/j.ijpddr.2018.06.002_bib28","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ijpddr.2014.07.002","article-title":"Repurposing drugs for the treatment and control of helminth infections","volume":"4","author":"Panic","year":"2014","journal-title":"Int. J. Parasitol. Drugs Drug Resist."},{"key":"10.1016\/j.ijpddr.2018.06.002_bib29","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.ijpara.2015.01.007","article-title":"Low cost whole-organism screening of compounds for anthelmintic activity","volume":"45","author":"Preston","year":"2015","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.ijpddr.2018.06.002_bib30","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.ijpddr.2016.07.004","article-title":"Screening of the \u2018Pathogen Box\u2019 identifies an approved pesticide with major anthelmintic activity against the barber's pole worm","volume":"6","author":"Preston","year":"2016","journal-title":"Int. J. Parasitol. Drugs Drug Resist."},{"key":"10.1016\/j.ijpddr.2018.06.002_bib31","doi-asserted-by":"crossref","first-page":"4515","DOI":"10.1096\/fj.201700288R","article-title":"Deguelin exerts potent nematocidal activity via the mitochondrial respiratory chain","volume":"31","author":"Preston","year":"2017","journal-title":"FASEB J."},{"key":"10.1016\/j.ijpddr.2018.06.002_bib32","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/452157a","article-title":"Drug discovery: fresh hope to can the worms","volume":"452","author":"Prichard","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.ijpddr.2018.06.002_bib33","doi-asserted-by":"crossref","first-page":"R89","DOI":"10.1186\/gb-2013-14-8-r89","article-title":"The genome and developmental transcriptome of the strongylid nematode Haemonchus contortus","volume":"14","author":"Schwarz","year":"2013","journal-title":"Genome Biol."},{"key":"10.1016\/j.ijpddr.2018.06.002_bib34","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1289\/ehp.9087213","article-title":"Uncouplers of oxidative phosphorylation","volume":"87","author":"Terada","year":"1990","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ijpddr.2018.06.002_bib35","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/ps.1698","article-title":"Genetic and biochemical analysis of a laboratory-selected spirodiclofen-resistant strain of Tetranychus urticae Koch (Acari: Tetranychidae)","volume":"65","author":"Van Pottelberge","year":"2009","journal-title":"Pest Manag. Sci."},{"key":"10.1016\/j.ijpddr.2018.06.002_bib36","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1124\/jpet.103.051839","article-title":"Differential actions of fipronil and dieldrin insecticides on GABA-gated chloride channels in cockroach neurons","volume":"306","author":"Zhao","year":"2003","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.ijpddr.2018.06.002_bib37","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1124\/jpet.104.065516","article-title":"Fipronil is a potent open channel blocker of glutamate-activated chloride channels in cockroach neurons","volume":"310","author":"Zhao","year":"2004","journal-title":"J. Pharmacol. Exp. Therapeut."}],"container-title":["International Journal for Parasitology: Drugs and Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211320718300496?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211320718300496?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:50:01Z","timestamp":1761922201000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211320718300496"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["S2211320718300496"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpddr.2018.06.002","relation":{},"ISSN":["2211-3207"],"issn-type":[{"value":"2211-3207","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Arylpyrrole and fipronil analogues that inhibit the motility and\/or development of Haemonchus contortus in vitro","name":"articletitle","label":"Article Title"},{"value":"International Journal for Parasitology: Drugs and Drug Resistance","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijpddr.2018.06.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier Ltd on behalf of Australian Society for Parasitology.","name":"copyright","label":"Copyright"}]}}