{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T13:40:45Z","timestamp":1770558045085,"version":"3.49.0"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T00:00:00Z","timestamp":1545177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"National Science & Technological Pillar Program","award":["2015BAD1101"],"award-info":[{"award-number":["2015BAD1101"]}]},{"name":"China Agriculture Research System"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal for Parasitology: Drugs and Drug Resistance"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.ijpddr.2018.12.004","type":"journal-article","created":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T21:26:20Z","timestamp":1545341180000},"page":"27-34","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["New life for an old drug: In vitro and in vivo effects of the anthelmintic drug niclosamide against Toxoplasma gondii RH strain"],"prefix":"10.1016","volume":"9","author":[{"given":"Ji Li","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong Fei","family":"Si","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao Fei","family":"Shang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu Kun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu Zheng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijpddr.2018.12.004_bib1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0163-7258(82)90064-X","article-title":"The biology and toxicology of molluscicides, bayluscide","volume":"19","author":"Andrews","year":"1982","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ijpddr.2018.12.004_bib2","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/S0002-9394(02)01537-4","article-title":"A prospective, randomized trial of pyrimethamine and azithromycin vs pyrimethamine and sulfadiazine for the treatment of ocular toxoplasmosis","volume":"134","author":"Bosch-Driessen","year":"2002","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.ijpddr.2018.12.004_bib3","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.cellsig.2017.04.001","article-title":"Niclosamide: beyond an antihelminthic drug","volume":"41","author":"Chen","year":"2018","journal-title":"Cell. Signal."},{"key":"10.1016\/j.ijpddr.2018.12.004_bib4","doi-asserted-by":"crossref","first-page":"314","DOI":"10.3109\/09273948.2011.608915","article-title":"Therapy for ocular toxoplasmosis","volume":"19","author":"de la Torre","year":"2011","journal-title":"Ocul. Immunol. Inflamm."},{"key":"10.1016\/j.ijpddr.2018.12.004_bib5","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.vetpar.2004.09.005","article-title":"Toxoplasmosis - a waterborne zoonosis","volume":"126","author":"Dubey","year":"2004","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.ijpddr.2018.12.004_bib6","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/j.ijpara.2008.03.007","article-title":"Toxoplasma gondii infection in humans and animals in the United States","volume":"38","author":"Dubey","year":"2008","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.ijpddr.2018.12.004_bib7","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jogoh.2017.12.003","article-title":"An updated literature review on maternal-fetal and reproductive disorders of Toxoplasma gondii infection","volume":"47","author":"Fallahi","year":"2018","journal-title":"J. Gynecol. Obstet. Hum. Reprod."},{"key":"10.1016\/j.ijpddr.2018.12.004_bib8","doi-asserted-by":"crossref","first-page":"8375","DOI":"10.1021\/jm3007596","article-title":"Salicylanilide inhibitors of Toxoplasma gondii","volume":"55","author":"Fomovska","year":"2012","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ijpddr.2018.12.004_bib9","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0306-3623(96)00149-8","article-title":"The mechanisms of action of antiprotozoal and anthelmintic drugs in man","volume":"28","author":"Frayha","year":"1997","journal-title":"Gen. Pharmacol."},{"key":"10.1016\/j.ijpddr.2018.12.004_bib10","first-page":"483","article-title":"Results of laboratory and field trials with the molluscicide Bayer 73","volume":"25","author":"Goennert","year":"1961","journal-title":"Bull. World Health Organ."},{"key":"10.1016\/j.ijpddr.2018.12.004_bib11","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1093\/trstmh\/try040","article-title":"Ocular toxoplasmosis: adverse reactions to treatment in a Brazilian cohort","volume":"112s","author":"Guaraldo","year":"2018","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.ijpddr.2018.12.004_bib12","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1177\/106002809302701215","article-title":"Atovaquone: a review","volume":"27","author":"Haile","year":"1993","journal-title":"Ann. Pharmacother."},{"key":"10.1016\/j.ijpddr.2018.12.004_bib13","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.molonc.2012.02.004","article-title":"Discovery of small molecule cancer drugs: successes, challenges and opportunities","volume":"6","author":"Hoelder","year":"2012","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.ijpddr.2018.12.004_bib14","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0020-7519(99)00170-8","article-title":"Identification of a 200- to 300-fold repetitive 529 bp DNA fragment in Toxoplasma gondii, and its use for diagnostic and quantitative PCR1","volume":"30","author":"Homan","year":"2000","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.ijpddr.2018.12.004_bib15","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1128\/AAC.01952-12","article-title":"New life for an old drug: the anthelmintic drug niclosamide inhibits Pseudomonas aeruginosa quorum sensing","volume":"57","author":"Imperi","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ijpddr.2018.12.004_bib16","doi-asserted-by":"crossref","first-page":"358","DOI":"10.2165\/00003495-198632040-00004","article-title":"Anthelmintics. Current concepts in the treatment of helminthic infections","volume":"32","author":"Katz","year":"1986","journal-title":"Drugs"},{"key":"10.1016\/j.ijpddr.2018.12.004_bib17","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.bcp.2017.08.009","article-title":"Antihelminthic drug niclosamide inhibits CIP2A and reactivates tumor suppressor protein phosphatase 2A in non-small cell lung cancer cells","volume":"144","author":"Kim","year":"2017","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ijpddr.2018.12.004_bib18","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.phrs.2016.11.008","article-title":"Niclosamide ethanolamine inhibits artery constriction","volume":"115","author":"Li","year":"2017","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ijpddr.2018.12.004_bib19","first-page":"59","article-title":"Toxoplasmosis in immunocompromised patients","volume":"64","author":"Machala","year":"2015","journal-title":"Epidemiol. Mikrobiol. Imunol."},{"key":"10.1016\/j.ijpddr.2018.12.004_bib20","doi-asserted-by":"crossref","first-page":"4172","DOI":"10.1158\/0008-5472.CAN-10-3978","article-title":"Antihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutations","volume":"71","author":"Osada","year":"2011","journal-title":"Cancer Res."},{"key":"10.1016\/j.ijpddr.2018.12.004_bib21","doi-asserted-by":"crossref","first-page":"550","DOI":"10.7326\/0003-4819-102-4-550","article-title":"Niclosamide therapy for tapeworm infections","volume":"102","author":"Pearson","year":"1985","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.ijpddr.2018.12.004_bib22","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1111\/j.1751-0813.1987.tb06060.x","article-title":"Chemotherapy of paramphistomosis in cattle","volume":"64","author":"Rolfe","year":"1987","journal-title":"Aust. Vet. J."},{"key":"10.1016\/j.ijpddr.2018.12.004_bib23","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0002-9394(14)74456-3","article-title":"Therapy for ocular toxoplasmosis","volume":"115","author":"Rothova","year":"1993","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.ijpddr.2018.12.004_bib24","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.ijpddr.2018.02.006","article-title":"Licochalcone A: an effective and low-toxicity compound against Toxoplasma gondii in vitro and in vivo","volume":"2","author":"Si","year":"2018","journal-title":"Int. J. Parasitol. Drugs Drug Resist."},{"key":"10.1016\/j.ijpddr.2018.12.004_bib25","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1038\/nm.3699","article-title":"Niclosamide ethanolamine-induced mild mitochondrial uncoupling improves diabetic symptoms in mice","volume":"20","author":"Tao","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.ijpddr.2018.12.004_bib26","series-title":"Toxoplasma Gondii: the Model Apicomplexan - Perspectives and Methods","author":"Weiss","year":"2013"},{"key":"10.1016\/j.ijpddr.2018.12.004_bib27","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nm.4184","article-title":"Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen","volume":"22","author":"Xu","year":"2016","journal-title":"Nat. Med."}],"container-title":["International Journal for Parasitology: Drugs and Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211320718301258?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211320718301258?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:48:18Z","timestamp":1761922098000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211320718301258"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":27,"alternative-id":["S2211320718301258"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpddr.2018.12.004","relation":{},"ISSN":["2211-3207"],"issn-type":[{"value":"2211-3207","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"New life for an old drug: In vitro and in vivo effects of the anthelmintic drug niclosamide against Toxoplasma gondii RH strain","name":"articletitle","label":"Article Title"},{"value":"International Journal for Parasitology: Drugs and Drug Resistance","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijpddr.2018.12.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier Ltd on behalf of Australian Society for Parasitology.","name":"copyright","label":"Copyright"}]}}