{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:13:04Z","timestamp":1785715984577,"version":"3.56.0"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T00:00:00Z","timestamp":1554249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["LP110200770"],"award-info":[{"award-number":["LP110200770"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["16632"],"award-info":[{"award-number":["16632"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["17159"],"award-info":[{"award-number":["17159"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001786","name":"University of Adelaide","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001786","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001801","name":"University of Western Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001801","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal for Parasitology: Drugs and Drug Resistance"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.ijpddr.2019.04.003","type":"journal-article","created":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T11:58:29Z","timestamp":1554724709000},"page":"38-44","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Aminoguanidines: New leads for treatment of Giardia duodenalis infection"],"prefix":"10.1016","volume":"10","author":[{"given":"Rebecca J.","family":"Abraham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Abraham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Stevens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen W.","family":"Page","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7125-863X","authenticated-orcid":false,"given":"Adam","family":"McCluskey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8297-5770","authenticated-orcid":false,"given":"Darren J.","family":"Trott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan M.","family":"O'Handley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijpddr.2019.04.003_bib1","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1021\/acs.jmedchem.5b01797","article-title":"Robenidine analogues as gram-positive antibacterial agents","volume":"59","author":"Abraham","year":"2016","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ijpddr.2019.04.003_bib2","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S1383-5742(02)00007-8","article-title":"Is metronidazole carcinogenic?","volume":"511","author":"Bendesky","year":"2002","journal-title":"Mutat. Res."},{"key":"10.1016\/j.ijpddr.2019.04.003_bib3","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.mimet.2007.07.014","article-title":"A new quantitative in vitro microculture method for Giardia duodenalis trophozoites","volume":"71","author":"Benere","year":"2007","journal-title":"J. Microbiol. Methods"},{"key":"10.1016\/j.ijpddr.2019.04.003_bib4","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1051\/parasite\/2008153261","article-title":"Pathophysiology of enteric infections with Giardia duodenalius","volume":"15","author":"Buret","year":"2008","journal-title":"Parasite"},{"key":"10.1016\/j.ijpddr.2019.04.003_bib5","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1128\/CMR.15.3.329-341.2002","article-title":"Methods for cultivation of luminal parasitic protists of clinical importance","volume":"15","author":"Clark","year":"2002","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.ijpddr.2019.04.003_bib6","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/0035-9203(86)90249-X","article-title":"Effect of twenty-three chemotherapeutic agents on the adherence and growth inhibition of Giardia lamblia in vitro","volume":"80","author":"Crouch","year":"1986","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.ijpddr.2019.04.003_bib8","doi-asserted-by":"crossref","first-page":"8974","DOI":"10.3748\/wjg.v19.i47.8974","article-title":"Extra-intestinal and long term consequences of Giardia duodenalis infections","volume":"19","author":"Halliez","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.ijpddr.2019.04.003_bib10","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1093\/infdis\/140.6.984","article-title":"Single-dose metronidazole and tinidazole as therapy for giardiasis: success rates, side effects, and drug absorption and elimination","volume":"140","author":"Jokipii","year":"1979","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ijpddr.2019.04.003_bib11","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1126\/science.168.3929.373","article-title":"1,3-Bis(p-chlorobenzylideneamino)guanidine hydrochloride (robenzidene): new poultry anticoccidial agent","volume":"168","author":"Kantor","year":"1970","journal-title":"Science"},{"key":"10.1016\/j.ijpddr.2019.04.003_bib12","first-page":"1","article-title":"World Health Organization estimates of the global and regional disease burden of 22 foodborne bacterial, Protozoal, and viral diseases, 2010: a data synthesis","volume":"12","author":"Kirk","year":"2015","journal-title":"PLoS Med."},{"key":"10.1016\/j.ijpddr.2019.04.003_bib13","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1017\/S0031182000045091","article-title":"Fine-structural changes in eimeria-tenella, from infections in chick-embryos and chickens, after exposure to anticoccidial drug robenidene","volume":"65","author":"Lee","year":"1972","journal-title":"Parasitology"},{"key":"10.1016\/j.ijpddr.2019.04.003_bib15","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1128\/AAC.50.1.162-170.2006","article-title":"In vitro effects of thiazolides on Giardia lamblia WB clone C6 cultured axenically and in coculture with Caco2 cells","volume":"50","author":"Muller","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ijpddr.2019.04.003_bib16","series-title":"Metronidazole. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases","author":"Nagel","year":"2015"},{"key":"10.1016\/j.ijpddr.2019.04.003_bib17","doi-asserted-by":"crossref","first-page":"13680","DOI":"10.1021\/ja027953c","article-title":"Strong binding in the DNA minor groove by an aromatic diamidine with a shape that does not match the curvature of the groove","volume":"124","author":"Nguyen","year":"2002","journal-title":"J. Am. Chem. Soc."},{"issue":"9","key":"10.1016\/j.ijpddr.2019.04.003_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0183457","article-title":"Evaluation of robenidine analog NCL195 as a novel broad-spectrum antibacterial agent","volume":"12","author":"Ogunniyi","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.ijpddr.2019.04.003_bib19","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.pt.2006.02.015","article-title":"Giardia and cryptosporidium join the \u2018neglected diseases initiative\u2019","volume":"22","author":"Savioli","year":"2006","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.ijpddr.2019.04.003_bib21","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/S0020-7519(00)00127-2","article-title":"Giardiasis as a re-emerging infectious disease and its zoonotic potential","volume":"30","author":"Thompson","year":"2000","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.ijpddr.2019.04.003_bib22","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1002\/(SICI)1521-1878(199803)20:3<256::AID-BIES9>3.0.CO;2-P","article-title":"My favorite cell: Giardia","volume":"20","author":"Upcroft","year":"1998","journal-title":"Bioessays : News Rev. Mol. Cell. Dev. Biol."},{"key":"10.1016\/j.ijpddr.2019.04.003_bib23","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1128\/CMR.14.1.150-164.2001","article-title":"Drug targets and mechanisms of resistance in the anaerobic protozoa","volume":"14","author":"Upcroft","year":"2001","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.ijpddr.2019.04.003_bib24","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/S0006-291X(72)80185-2","article-title":"Robenzidene, an inhibitor of oxidative phosphorylation","volume":"46","author":"Wong","year":"1972","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ijpddr.2019.04.003_bib25","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1517\/14740338.2.6.529","article-title":"Efficacy of antigiardial drugs","volume":"2","author":"Wright","year":"2003","journal-title":"Expert Opin. Drug Saf."}],"container-title":["International Journal for Parasitology: Drugs and Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211320718301325?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211320718301325?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T11:40:09Z","timestamp":1778845209000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211320718301325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":21,"alternative-id":["S2211320718301325"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpddr.2019.04.003","relation":{},"ISSN":["2211-3207"],"issn-type":[{"value":"2211-3207","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aminoguanidines: New leads for treatment of Giardia duodenalis infection","name":"articletitle","label":"Article Title"},{"value":"International Journal for Parasitology: Drugs and Drug Resistance","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijpddr.2019.04.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Ltd on behalf of Australian Society for Parasitology.","name":"copyright","label":"Copyright"}]}}