{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T01:35:25Z","timestamp":1774661725273,"version":"3.50.1"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,4,26]],"date-time":"2019-04-26T00:00:00Z","timestamp":1556236800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004326","name":"Bayer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004326","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal for Parasitology: Drugs and Drug Resistance"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.ijpddr.2019.04.004","type":"journal-article","created":{"date-parts":[[2019,4,26]],"date-time":"2019-04-26T12:33:18Z","timestamp":1556281998000},"page":"45-50","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Macrocyclic lactone anthelmintic-induced leukocyte binding to Dirofilaria immitis microfilariae: Influence of the drug resistance status of the parasite"],"prefix":"10.1016","volume":"10","author":[{"given":"Tessa","family":"Berrafato","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruby","family":"Coates","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara J.","family":"Reaves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Kulke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian J.","family":"Wolstenholme","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijpddr.2019.04.004_bib1","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1186\/s13071-016-1476-7","article-title":"Efficacy of four commercially available heartworm preventive products against the JYD-34 laboratory strain of Dirofilaria immitis","volume":"9","author":"Blagburn","year":"2016","journal-title":"Parasites Vectors"},{"key":"10.1016\/j.ijpddr.2019.04.004_bib2","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.vetpar.2011.01.024","article-title":"Correlation between loss of efficacy of macrocyclic lactone heartworm anthelmintics and P-glycoprotein genotype","volume":"176","author":"Bourguinat","year":"2011","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.ijpddr.2019.04.004_bib3","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.vetpar.2015.04.002","article-title":"Macrocyclic lactone resistance in Dirofilaria immitis: failure of heartworm preventives and investigation of genetic markers for resistance","volume":"210","author":"Bourguinat","year":"2015","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.ijpddr.2019.04.004_bib4","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1186\/s13071-017-2437-5","article-title":"Dirofilaria immitis JYD-34 isolate: whole genome analysis","volume":"10","author":"Bourguinat","year":"2017","journal-title":"Parasites Vectors"},{"key":"10.1016\/j.ijpddr.2019.04.004_bib5","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13071-016-1293-z","article-title":"Protection of dogs against canine heartworm infection 28 days after four monthly treatments with Advantage Multi (R) for Dogs","volume":"9","author":"Bowman","year":"2016","journal-title":"Parasites Vectors"},{"key":"10.1016\/j.ijpddr.2019.04.004_bib6","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1053\/j.tcam.2011.07.001","article-title":"Macrocyclic lactones and Dirofilaria immitis microfilariae","volume":"26","author":"Bowman","year":"2011","journal-title":"Top. Companion Anim. Med."},{"key":"10.1016\/j.ijpddr.2019.04.004_bib7","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1186\/s13071-017-2116-6","article-title":"Examining the role of macrolides and host immunity in combatting filarial parasites","volume":"10","author":"Carithers","year":"2017","journal-title":"Parasites Vectors"},{"key":"10.1016\/j.ijpddr.2019.04.004_bib8","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.vetpar.2017.09.003","article-title":"Evaluation of the larval migration inhibition assay for detecting macrocyclic lactone resistance in Dirofilaria immitis","volume":"246","author":"Evans","year":"2017","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.ijpddr.2019.04.004_bib9","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.ijpddr.2013.05.001","article-title":"Development of an in vitro bioassay for measuring susceptibility to macrocyclic lactone anthelmintics in Dirofilaria immitis","volume":"3","author":"Evans","year":"2013","journal-title":"Int. J. Parasitol. - Drugs Drug Res."},{"key":"10.1016\/j.ijpddr.2019.04.004_bib10","doi-asserted-by":"crossref","first-page":"158","DOI":"10.2307\/3272537","article-title":"The isolation of microfilariae from blood for use as antigen","volume":"31","author":"Franks","year":"1945","journal-title":"J. Parasitol."},{"key":"10.1016\/j.ijpddr.2019.04.004_bib11","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1053\/j.tcam.2011.09.004","article-title":"Evidence for macrocyclic lactone anthelmintic resistance in Dirofilaria immitis","volume":"26","author":"Geary","year":"2011","journal-title":"Top. Companion Anim. Med."},{"key":"10.1016\/j.ijpddr.2019.04.004_bib12","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.vetpar.2005.10.002","article-title":"Comparative plasma dispositions of ivermectin and doramectin following subcutaneous and oral administration in dogs","volume":"135","author":"Gokbulut","year":"2006","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.ijpddr.2019.04.004_bib13","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.vetpar.2005.04.004","article-title":"Evaluation of efficacy of heartworm preventive products at the FDA","volume":"133","author":"Hampshire","year":"2005","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.ijpddr.2019.04.004_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0006438","article-title":"Profiling extracellular vesicle release by the filarial nematode Brugia malayi reveals sex-specific differences in cargo and a sensitivity to ivermectin","volume":"12","author":"Harischandra","year":"2018","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.ijpddr.2019.04.004_bib15","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.ijpara.2007.01.001","article-title":"A novel approach for combining the use of in vitro and in vivo data to measure and detect emerging moxidectin resistance in gastrointestinal nematodes of goats","volume":"37","author":"Kaplan","year":"2007","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.ijpddr.2019.04.004_bib16","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.dci.2011.03.021","article-title":"Expression and function of triggering receptor expressed on myeloid cells-1 (TREM-1) on canine PMNs","volume":"35","author":"Li","year":"2011","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.ijpddr.2019.04.004_bib17","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1186\/s13071-017-2436-6","article-title":"Does evaluation of in vitro microfilarial motility reflect the resistance status of Dirofilaria immitis isolates to macrocyclic lactones?","volume":"10","author":"Maclean","year":"2017","journal-title":"Parasites Vectors"},{"key":"10.1016\/j.ijpddr.2019.04.004_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0005279","article-title":"Human leukocytes kill Brugia malayi microfilariae independently of DNA-based extracellular trap release","volume":"11","author":"McCoy","year":"2017","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.ijpddr.2019.04.004_bib19","doi-asserted-by":"crossref","first-page":"888","DOI":"10.2174\/138920112800399194","article-title":"Pharmacokinetic features of the antiparasitic macrocyclic lactones","volume":"13","author":"McKellar","year":"2012","journal-title":"Curr. Pharmaceut. Biotechnol."},{"key":"10.1016\/j.ijpddr.2019.04.004_bib20","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1186\/s13071-017-2429-5","article-title":"Efficacy of oral moxidectin against susceptible and resistant isolates of Dirofilaria immitis in dogs","volume":"10","author":"McTier","year":"2017","journal-title":"Parasites Vectors"},{"key":"10.1016\/j.ijpddr.2019.04.004_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0001261","article-title":"The NIH-NIAID Filariasis Research reagent Resource center","volume":"5","author":"Michalski","year":"2011","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.ijpddr.2019.04.004_bib22","doi-asserted-by":"crossref","first-page":"20120","DOI":"10.1073\/pnas.1011983107","article-title":"Ivermectin disrupts the function of the excretory-secretory apparatus in microfilariae of Brugia malayi","volume":"107","author":"Moreno","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.ijpddr.2019.04.004_bib23","doi-asserted-by":"crossref","first-page":"968","DOI":"10.3389\/fimmu.2018.00968","article-title":"Dirofilaria immitis microfilariae and third-stage larvae induce canine NETosis resulting in different types of PMN extracellular traps","volume":"9","author":"Munoz-Caro","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ijpddr.2019.04.004_bib24","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.ijpddr.2012.04.001","article-title":"Moxidectin and the avermectins: consanguinity but not identity","volume":"2","author":"Prichard","year":"2012","journal-title":"Int. J. Parasitol.-Drugs Drug Res."},{"key":"10.1016\/j.ijpddr.2019.04.004_bib25","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1186\/s13071-014-0494-6","article-title":"Establishment of macrocylic lactone resistant Dirofilaria immitis isolates in experimentally infected laboratory dogs","volume":"7","author":"Pulaski","year":"2014","journal-title":"Parasites Vectors"},{"key":"10.1016\/j.ijpddr.2019.04.004_bib26","first-page":"123","article-title":"Effect of ivermectin on serum dependent cellular interactions to Dipetalonema viteae microfilariae","volume":"38","author":"Rao","year":"1987","journal-title":"Trop. Med. Parasitol."},{"key":"10.1016\/j.ijpddr.2019.04.004_bib27","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.ijpddr.2018.09.002","article-title":"Recognition and killing of Brugia malayi microfilariae by human immune cells is dependent on the parasite sample and is not altered by ivermectin treatment","volume":"8","author":"Reaves","year":"2018","journal-title":"Int. J. Parasitol.-Drugs Drug Resist."},{"key":"10.1016\/j.ijpddr.2019.04.004_bib28","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ijpddr.2014.08.003","article-title":"Utilization of computer processed high definition video imaging for measuring motility of microscopic nematode stages on a quantitative scale: \"The Worminator''","volume":"4","author":"Storey","year":"2014","journal-title":"Int. J. Parasitol.-Drugs Drug Res."},{"key":"10.1016\/j.ijpddr.2019.04.004_bib29","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.vetpar.2014.02.004","article-title":"Ivermectin-dependent attachment of PMNs and peripheral blood mononuclear cells to Dirofilaria immitis microfilariae in vitro","volume":"206","author":"Vatta","year":"2014","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.ijpddr.2019.04.004_bib1a","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1017\/S003118201500061X","article-title":"The emergence of macrocyclic lactone resistance in the canine heartworm, Dirofilaria immitis","volume":"142","author":"Wolstenholme","year":"2015","journal-title":"Parasitology"},{"key":"10.1016\/j.ijpddr.2019.04.004_bib30","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s10158-016-0190-7","article-title":"How do the macrocyclic lactones kill filarial nematode larvae?","volume":"16","author":"Wolstenholme","year":"2016","journal-title":"Invertebr. Neurosci."},{"key":"10.1016\/j.ijpddr.2019.04.004_bib31","doi-asserted-by":"crossref","first-page":"S85","DOI":"10.1017\/S0031182005008218","article-title":"Glutamate-gated chloride channels and the mode of action of the avermectin\/milbemycin anthelmintics","volume":"131","author":"Wolstenholme","year":"2005","journal-title":"Parasitology"},{"key":"10.1016\/j.ijpddr.2019.04.004_bib32","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1006\/expr.1997.4160","article-title":"Ivermectin-induced killing of microfilariae in vitro by PMNs mediated by NO","volume":"86","author":"Zahner","year":"1997","journal-title":"Exp. Parasitol."}],"container-title":["International Journal for Parasitology: Drugs and Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211320719300399?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211320719300399?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:49:12Z","timestamp":1761922152000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211320719300399"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":33,"alternative-id":["S2211320719300399"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpddr.2019.04.004","relation":{},"ISSN":["2211-3207"],"issn-type":[{"value":"2211-3207","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Macrocyclic lactone anthelmintic-induced leukocyte binding to Dirofilaria immitis microfilariae: Influence of the drug resistance status of the parasite","name":"articletitle","label":"Article Title"},{"value":"International Journal for Parasitology: Drugs and Drug Resistance","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijpddr.2019.04.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Ltd on behalf of Australian Society for Parasitology.","name":"copyright","label":"Copyright"}]}}