{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:41:28Z","timestamp":1790808088536,"version":"4.1.0"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T00:00:00Z","timestamp":1571702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010198","name":"Ministerio de Econom\u00eda, Industria y Competitividad, Gobierno de Espa\u00f1a","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010198","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008431","name":"Consejer\u00eda de Educaci\u00f3n, Junta de Castilla y Le\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008431","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal for Parasitology: Drugs and Drug Resistance"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.ijpddr.2019.10.004","type":"journal-article","created":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T20:52:14Z","timestamp":1571777534000},"page":"70-79","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["Antileishmanial activity of terpenylquinones on Leishmania infantum and their effects on Leishmania topoisomerase IB"],"prefix":"10.1016","volume":"11","author":[{"given":"Yolanda","family":"P\u00e9rez-Pertejo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M.","family":"Escudero-Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa M.","family":"Reguera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Bala\u00f1a-Fouce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo A.","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo G.","family":"Jambrina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo","family":"San Feliciano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda-\u00c1ngeles","family":"Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijpddr.2019.10.004_bib1","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1007\/s00436-011-2555-5","article-title":"Leishmania antimony resistance: what we know what we can learn from the field","volume":"109","author":"A\u00eft-Oudhia","year":"2011","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.ijpddr.2019.10.004_bib2","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1055\/s-0031-1280092","article-title":"Structure\/antileishmanial activity relationship study of naphthoquinones and dependency of the mode of action on the substitution patterns","volume":"77","author":"Ali","year":"2011","journal-title":"Planta Med."},{"key":"10.1016\/j.ijpddr.2019.10.004_bib3","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.exppara.2019.02.013","article-title":"Efficacy of lapachol on treatment of cutaneous and visceral leishmaniasis","volume":"199","author":"Ara\u00fajo","year":"2019","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.ijpddr.2019.10.004_bib4","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.exppara.2017.02.004","article-title":"Evaluation on the leishmanicidal activity of 2-N,N'-dialkylamino-1,4-naphthoquinone derivatives","volume":"176","author":"Ara\u00fajo","year":"2017","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.ijpddr.2019.10.004_bib5","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1007\/s10495-016-1259-9","article-title":"Plumbagin, a plant-derived naphthoquinone metabolite induces mitochondria mediated apoptosis-like cell death in Leishmania donovani: an ultrastructural and physiological study","volume":"21","author":"Awasthi","year":"2016","journal-title":"Apoptosis"},{"key":"10.1016\/j.ijpddr.2019.10.004_bib6","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.ijpddr.2014.07.006","article-title":"Trypanosomatids topoisomerase re-visited. New structural findings and role in drug discovery","volume":"4","author":"Bala\u00f1a-Fouce","year":"2014","journal-title":"Int. J. Parasitol. Drugs Drug Resist."},{"key":"10.1016\/j.ijpddr.2019.10.004_bib7","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/j.drudis.2019.03.007","article-title":"Walking a tightrope: drug discovery in visceral leishmaniasis","volume":"24","author":"Bala\u00f1a-Fouce","year":"2019","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.ijpddr.2019.10.004_bib8","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1093\/bmb\/lds031","article-title":"Management of trypanosomiasis and leishmaniasis","volume":"104","author":"Barrett","year":"2012","journal-title":"Br. Med. Bull."},{"key":"10.1016\/j.ijpddr.2019.10.004_bib9","doi-asserted-by":"crossref","DOI":"10.1002\/ardp.201600286","article-title":"Synthesis and evaluation of new naphthalene and naphthoquinone derivatives as anticancer agents","volume":"350","author":"Beretta","year":"2017","journal-title":"Arch. Pharm. (Weinheim)"},{"key":"10.1016\/j.ijpddr.2019.10.004_bib10","doi-asserted-by":"crossref","first-page":"3257","DOI":"10.1021\/ct300400x","article-title":"Optimization of the additive CHARMM all-atom protein force field targeting improved sampling of the backbone \u03c6, \u03c8 and side-chain \u03c71 and \u03c72 dihedral angles","volume":"8","author":"Best","year":"2012","journal-title":"J. Chem. Theory Comput."},{"key":"10.1016\/j.ijpddr.2019.10.004_bib11","doi-asserted-by":"crossref","first-page":"D313","DOI":"10.1093\/nar\/gkw1132","article-title":"The SWISS-MODEL Repository\u2014new features and functionality","volume":"45","author":"Bienert","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ijpddr.2019.10.004_bib12","doi-asserted-by":"crossref","first-page":"7539","DOI":"10.1073\/pnas.1330762100","article-title":"An unusual type IB topoisomerase from African trypanosomes","volume":"100","author":"Bodley","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ijpddr.2019.10.004_bib13","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1021\/tx9902082","article-title":"Role of quinones in toxicology","volume":"13","author":"Bolton","year":"2000","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.ijpddr.2019.10.004_bib14","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1002\/jcc.21287","article-title":"CHARMM: the biomolecular simulation program","volume":"30","author":"Brooks","year":"2009","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.ijpddr.2019.10.004_bib15","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/S0140-6736(18)31204-2","article-title":"Leishmaniasis","volume":"392","author":"Burza","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.ijpddr.2019.10.004_bib16","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.drudis.2014.09.012","article-title":"Trypanosomatids see the light: recent advances in bioimaging research","volume":"20","author":"Calvo-\u00c1lvarez","year":"2015","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.ijpddr.2019.10.004_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0003666","article-title":"Infrared fluorescent imaging as a potent tool for in vitro, ex vivo and in vivo models of visceral leishmaniasis","volume":"9","author":"Calvo-\u00c1lvarez","year":"2015","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.ijpddr.2019.10.004_bib18","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1039\/C4RA11726C","article-title":"New 1,4-anthracenedione derivatives with fused heterocyclic rings: synthesis and biological evaluation","volume":"5","author":"Castro","year":"2015","journal-title":"RSC Adv."},{"key":"10.1016\/j.ijpddr.2019.10.004_bib19","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ejmech.2013.06.018","article-title":"Synthesis and antifungal activity of terpenyl-1,4-naphthoquinone and 1,4-anthracenedione derivatives","volume":"67","author":"Castro","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ijpddr.2019.10.004_bib20","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.ejmech.2013.07.057","article-title":"Synthesis of quinoidal molecules: strategies towards bioactive compounds with an emphasis on lapachones","volume":"69","author":"Castro","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ijpddr.2019.10.004_bib21","series-title":"S\u00edntesis, reordenamiento y evaluaci\u00f3n citot\u00f3xica de nuevas diterpenyl-1,4-naftohidroquinonas","author":"Chamorro","year":"2002"},{"key":"10.1016\/j.ijpddr.2019.10.004_bib22","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ejps.2013.02.003","article-title":"Shikonin, a natural product from the root of Lithospermum erythrorhizon, is a cytotoxic DNA-binding agent","volume":"49","author":"Chen","year":"2013","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ijpddr.2019.10.004_bib23","doi-asserted-by":"crossref","first-page":"10089","DOI":"10.1063\/1.464397","article-title":"Particle mesh Ewald: an N\u00b7log(N) method for Ewald sums in large systems","volume":"98","author":"Darden","year":"1993","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.ijpddr.2019.10.004_bib24","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1590\/S0103-50532001000300003","article-title":"Trypanocidal activity of isolated naphthoquinones from Tabebuia and some heterocyclic derivatives: a review from an interdisciplinary study","volume":"12","author":"De Moura","year":"2001","journal-title":"J. Braz. Chem. Soc."},{"key":"10.1016\/j.ijpddr.2019.10.004_bib25","doi-asserted-by":"crossref","first-page":"3131","DOI":"10.1093\/jac\/dkx283","article-title":"Visceral leishmaniasis relapse hazard is linked to reduced miltefosine exposure in patients from Eastern Africa: a population pharmacokinetic\/pharmacodynamic study","volume":"72","author":"Dorlo","year":"2017","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.ijpddr.2019.10.004_bib26","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.ijpddr.2017.06.003","article-title":"Antileishmanial activity and tubulin polymerization inhibition of podophyllotoxin derivatives on Leishmania infantum","volume":"7","author":"Escudero-Mart\u00ednez","year":"2017","journal-title":"Int. J. Parasit. Drugs Drug Resist."},{"key":"10.1016\/j.ijpddr.2019.10.004_bib27","doi-asserted-by":"crossref","first-page":"3071","DOI":"10.1016\/j.ejmech.2011.03.012","article-title":"Synthesis and anti-Trypanosoma cruzi activity of \u03b2-lapachone analogues","volume":"46","author":"Ferreira","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ijpddr.2019.10.004_bib28","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.ejmech.2013.10.011","article-title":"Synthesis and biological evaluation of novel ferrocene-naphthoquinones as antiplasmodial agents","volume":"70","author":"Garc\u00eda-Barrantes","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ijpddr.2019.10.004_bib29","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1021\/ct200723y","article-title":"Optimization of the CHARMM additive force field for DNA: improved treatment of the BI\/BII conformational equilibrium","volume":"8","author":"Hart","year":"2012","journal-title":"J. Chem. Theory Comput."},{"key":"10.1016\/j.ijpddr.2019.10.004_bib30","doi-asserted-by":"crossref","first-page":"4803","DOI":"10.1021\/jm050076b","article-title":"Synthesis and mechanism of action studies of a series of norindenoisoquinoline topoisomerase I poisons reveal an inhibitor with a flipped orientation in the ternary DNA-enzyme-inhibitor complex as determined by X-ray crystallographic analysis","volume":"48","author":"Ioanoviciu","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ijpddr.2019.10.004_bib31","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/nrd4683","article-title":"Hit and lead criteria in drug discovery for infectious diseases of the developing world","volume":"14","author":"Katsuno","year":"2015","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ijpddr.2019.10.004_bib32","doi-asserted-by":"crossref","first-page":"22463","DOI":"10.1016\/S0021-9258(18)41552-9","article-title":"Beta-lapachone, a novel DNA topoisomerase I inhibitor with a mode of action different from camptothecin","volume":"268","author":"Li","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijpddr.2019.10.004_bib33","doi-asserted-by":"crossref","first-page":"5760","DOI":"10.1016\/j.bmc.2007.06.005","article-title":"New cytotoxic diterpenylnaphthohydroquinone derivatives obtained from a natural diterpenoid","volume":"15","author":"Miguel del Corral","year":"2007","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ijpddr.2019.10.004_bib34","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0968-0896(97)10007-4","article-title":"Further antineoplastic terpenylquinones and terpenylhydroquinones","volume":"6","author":"Miguel del Corral","year":"1998","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ijpddr.2019.10.004_bib35","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1021\/jm001048q","article-title":"New selective cytotoxic diterpenylquinones and diterpenylhydroquinones","volume":"44","author":"Miguel del Corral","year":"2001","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ijpddr.2019.10.004_bib36","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1007\/s40265-013-0133-0","article-title":"Therapeutic options for visceral leishmaniasis","volume":"73","author":"Monge-Maillo","year":"2013","journal-title":"Drugs"},{"key":"10.1016\/j.ijpddr.2019.10.004_bib37","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1002\/jcc.20289","article-title":"Scalable molecular dynamics with NAMD","volume":"26","author":"Phillips","year":"2005","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.ijpddr.2019.10.004_bib38","doi-asserted-by":"crossref","first-page":"4570","DOI":"10.3390\/molecules14114570","article-title":"The trypanocidal activity of naphthoquinones: a review","volume":"14","author":"Pinto","year":"2009","journal-title":"Molecules"},{"key":"10.1016\/j.ijpddr.2019.10.004_bib39","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.chembiol.2010.04.012","article-title":"DNA topoisomerases and their poisoning by anticancer and antibacterial drugs","volume":"17","author":"Pommier","year":"2010","journal-title":"Chem. Biol."},{"key":"10.1016\/j.ijpddr.2019.10.004_bib40","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.ijpddr.2014.05.001","article-title":"Target-based vs. phenotypic screenings in Leishmania drug discovery: a marriage of convenience or a dialogue of the deaf?","volume":"4","author":"Reguera","year":"2014","journal-title":"Int. J. Parasitol. Drugs Drug Resist."},{"key":"10.1016\/j.ijpddr.2019.10.004_bib41","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.bbaexp.2006.03.006","article-title":"DNA topoisomerase I from parasitic protozoa: a potential target for chemotherapy","volume":"1759","author":"Reguera","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ijpddr.2019.10.004_bib42","series-title":"S\u00edntesis de nuevas naftoquinonas citot\u00f3xicas a partir de diterpenoides naturales","author":"Rodr\u00edguez","year":"2006"},{"key":"10.1016\/j.ijpddr.2019.10.004_bib43","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1042\/BJ20071286","article-title":"An insight into the mechanism of inhibition of unusual bi-subunit topoisomerase I from Leishmania donovani by 3,3'-di-indolylmethane, a novel DNA topoisomerase I poison with a strong binding affinity to the enzyme","volume":"409","author":"Roy","year":"2008","journal-title":"Biochem. J."},{"key":"10.1016\/j.ijpddr.2019.10.004_bib44","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/0021-9991(77)90098-5","article-title":"Numerical integration of the cartesian equations of motion of a system with constraints: molecular dynamics of n-alkanes","volume":"23","author":"Ryckaert","year":"1977","journal-title":"J. Comput. Phys."},{"key":"10.1016\/j.ijpddr.2019.10.004_bib45","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1007\/s12639-011-0040-9","article-title":"Therapeutic switching in leishmania chemotherapy: a distinct approach towards unsatisfied treatment needs","volume":"35","author":"Shakya","year":"2011","journal-title":"J. Parasit. Dis."},{"key":"10.1016\/j.ijpddr.2019.10.004_bib46","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1021\/jm049146p","article-title":"Structures of three classes of anticancer agents bound to the human topoisomerase I\u2212DNA covalent complex","volume":"48","author":"Staker","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ijpddr.2019.10.004_bib47","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1056\/NEJMoa0903627","article-title":"Single-dose liposomal amphotericin B for visceral leishmaniasis in India","volume":"362","author":"Sundar","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijpddr.2019.10.004_bib48","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/1099-1573(200102)15:1<44::AID-PTR685>3.0.CO;2-1","article-title":"In vitro and in vivo leishmanicidal activity of 2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone (lapachol)","volume":"15","author":"Teixeira","year":"2001","journal-title":"Phytother Res."},{"key":"10.1016\/j.ijpddr.2019.10.004_bib49","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.ijpddr.2019.10.004_bib50","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1002\/jcc.21367","article-title":"CHARMM general force field: a force field for drug-like molecules compatible with the CHARMM all-atom additive biological force fields","volume":"31","author":"Vanommeslaeghe","year":"2010","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.ijpddr.2019.10.004_bib51","doi-asserted-by":"crossref","first-page":"3521","DOI":"10.1074\/jbc.M203991200","article-title":"A novel active DNA topoisomerase I in Leishmania donovani","volume":"278","author":"Villa","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijpddr.2019.10.004_bib52","doi-asserted-by":"crossref","first-page":"W296","DOI":"10.1093\/nar\/gky427","article-title":"SWISS-MODEL: homology modelling of protein structures and complexes","volume":"46","author":"Waterhouse","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ijpddr.2019.10.004_bib53","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1186\/s13046-016-0455-3","article-title":"Inhibitory effects of lapachol on rat C6 glioma in vitro and in vivo by targeting DNA topoisomerase I and topoisomerase II","volume":"35","author":"Xu","year":"2016","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.ijpddr.2019.10.004_bib54","doi-asserted-by":"crossref","first-page":"5781","DOI":"10.1016\/j.bmc.2016.09.034","article-title":"Design, synthesis and biological evaluation of lapachol derivatives possessing indole scaffolds as topoisomerase I inhibitors","volume":"24","author":"Zhang","year":"2016","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ijpddr.2019.10.004_bib55","article-title":"Topoisomerase I inhibitors, shikonin and topotecan, inhibit growth and induce apoptosis of glioma cells and glioma stem cells","volume":"8","author":"Zhang","year":"2013","journal-title":"PLoS One"}],"container-title":["International Journal for Parasitology: Drugs and Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211320719301095?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211320719301095?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:50:57Z","timestamp":1761922257000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211320719301095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":55,"alternative-id":["S2211320719301095"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpddr.2019.10.004","relation":{},"ISSN":["2211-3207"],"issn-type":[{"value":"2211-3207","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antileishmanial activity of terpenylquinones on Leishmania infantum and their effects on Leishmania topoisomerase IB","name":"articletitle","label":"Article Title"},{"value":"International Journal for Parasitology: Drugs and Drug Resistance","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijpddr.2019.10.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Ltd on behalf of Australian Society for Parasitology.","name":"copyright","label":"Copyright"}]}}