{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T06:19:06Z","timestamp":1773901146921,"version":"3.50.1"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T00:00:00Z","timestamp":1605484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005668","name":"Funda\u00e7\u00e3o de Apoio \u00e0 Pesquisa do Distrito Federal","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005668","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal for Parasitology: Drugs and Drug Resistance"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.ijpddr.2020.11.002","type":"journal-article","created":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T22:53:11Z","timestamp":1605826391000},"page":"257-263","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["A retrospective cohort study of the effectiveness and adverse events of intralesional pentavalent antimonials in the treatment of cutaneous leishmaniasis"],"prefix":"10.1016","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1567-0288","authenticated-orcid":false,"given":"Bruna C\u00f4rtes","family":"Rodrigues","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina Freitas","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4128-1593","authenticated-orcid":false,"given":"Daniel Holanda","family":"Barroso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorgeth Oliveira Carneiro da","family":"Motta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen D\u00e9a Ribeiro de","family":"Paula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e1udia","family":"Porto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofia Sales","family":"Martins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ciro Martins","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raimunda Nonata Ribeiro","family":"Sampaio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijpddr.2020.11.002_bib1","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1111\/tmi.13130","article-title":"Plasma antimony determination during cutaneous leishmaniasis treatment with intralesional infiltration of meglumine antimoniate","volume":"23","author":"Aguiar","year":"2018","journal-title":"Trop. Med. Int. Health"},{"key":"10.1016\/j.ijpddr.2020.11.002_bib2","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1046\/j.1365-2133.1998.02105.x","article-title":"Intralesional treatment of cutaneous leishmaniasis with meglumine antimoniate","volume":"138","author":"Aste","year":"1998","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.ijpddr.2020.11.002_bib3","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.bbi.2010.12.009","article-title":"Hormone levels are associated with clinical markers and cytokine levels in human localized cutaneous leishmaniasis","volume":"25","author":"Baccan","year":"2011","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.ijpddr.2020.11.002_bib4","doi-asserted-by":"crossref","first-page":"601","DOI":"10.2174\/1566524043360285","article-title":"New insights into the developmental biology and transmission mechanisms of Leishmania","volume":"4","author":"Bates","year":"2004","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.ijpddr.2020.11.002_bib5","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1590\/0074-02760160478","article-title":"Low dose systemic or intralesional meglumine antimoniate treatment for American tegumentary leishmaniasis results in low lethality, low incidence of relapse, and low late mucosal involvement in a referral centre in Rio de Janeiro, Brazil (2001-2013)","volume":"112","author":"Brahim","year":"2017","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.ijpddr.2020.11.002_bib6","series-title":"Manual de vigil\u00e2ncia da leishmaniose tegumentar","year":"2017"},{"key":"10.1016\/j.ijpddr.2020.11.002_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0184777","article-title":"Efficacy of pentavalent antimoniate intralesional infiltration therapy for cutaneous leishmaniasis: a systematic review","volume":"12","author":"Brito","year":"2017","journal-title":"PloS One"},{"key":"10.1016\/j.ijpddr.2020.11.002_bib8","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/tmi.13210","article-title":"American tegumentary leishmaniasis in Brazil: a critical review of the current therapeutic approach with systemic meglumine antimoniate and short-term possibilities for an alternative treatment","volume":"24","author":"Carvalho","year":"2019","journal-title":"Trop. Med. Int. Health"},{"key":"10.1016\/j.ijpddr.2020.11.002_bib9","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.3389\/fmicb.2018.01308","article-title":"The binomial parasite-host immunity in the healing process and in reactivation of human tegumentary leishmaniasis","volume":"9","author":"Concei\u00e7\u00e3o-Silva","year":"2018","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.ijpddr.2020.11.002_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0149697","article-title":"The cure rate after placebo or No therapy in American cutaneous leishmaniasis: a systematic review and meta-analysis","volume":"11","author":"Cota","year":"2016","journal-title":"PloS One"},{"key":"10.1016\/j.ijpddr.2020.11.002_bib11","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.actatropica.2019.03.007","article-title":"Comparison between systemic and intralesional meglumine antimoniate therapy in a primary health care unit","volume":"193","author":"Duque","year":"2019","journal-title":"Acta Trop."},{"key":"10.1016\/j.ijpddr.2020.11.002_bib12","first-page":"201","article-title":"Tratamento da leishmaniose tegumentar americana com inje\u00e7\u00f5es intralesionadas de n-metil-glucamina","volume":"65","author":"Gadelha","year":"1990","journal-title":"An. Bras. Dermatol."},{"key":"10.1016\/j.ijpddr.2020.11.002_bib13","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1590\/abd1806-4841.20142389","article-title":"Complementary exams in the diagnosis of American tegumentary leishmaniasis","volume":"89","author":"Gomes","year":"2014","journal-title":"An. Bras. Dermatol."},{"key":"10.1016\/j.ijpddr.2020.11.002_bib14","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/jdv.12473","article-title":"The influence of treatment on the development of leishmaniasis recidiva cutis: a 17-year case-control study in Midwestern Brazil","volume":"29","author":"Gomes","year":"2015","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"10.1016\/j.ijpddr.2020.11.002_bib15","series-title":"Applied Logistic Regression","author":"Hosmer","year":"2013"},{"key":"10.1016\/j.ijpddr.2020.11.002_bib16","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1590\/S0365-05962007000200002","article-title":"Tratamento da leishmaniose tegumentar americana","volume":"82","author":"Lima","year":"2007","journal-title":"An. Bras. Dermatol."},{"key":"10.1016\/j.ijpddr.2020.11.002_bib17","doi-asserted-by":"crossref","first-page":"18","DOI":"10.47993\/gmb.v43i1.13","article-title":"El tratamiento intralesional de Leishmaniasis cut\u00e1nea es seguro frente al riesgo de complicaciones mucosas? Gaceta M\u00e9dica Boliviana","volume":"43","author":"Limachi-Choque","year":"2020","journal-title":"Gac Med Bol"},{"key":"10.1016\/j.ijpddr.2020.11.002_bib18","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1590\/S1678-9946201658068","article-title":"Pancreatic toxicity as an adverse effect induced by meglumine antimoniate therapy in a clinical trial for cutaneous leishmaniasis","volume":"58","author":"Lyra","year":"2016","journal-title":"Rev. Inst. Med. Trop. Sao Paulo"},{"key":"10.1016\/j.ijpddr.2020.11.002_bib19","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1590\/S0037-86821985000300011","article-title":"Pentavalent antimonials: old drugs for new diseases","volume":"18","author":"Marsden","year":"1985","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"10.1016\/j.ijpddr.2020.11.002_bib20","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.jaad.2009.06.088","article-title":"New World cutaneous leishmaniasis: updated review of current and future diagnosis and treatment","volume":"63","author":"Mitropoulos","year":"2010","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.ijpddr.2020.11.002_bib21","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1111\/j.1365-3156.2009.02408.x","article-title":"Antimony in plasma and skin of patients with cutaneous leishmaniasis--relationship with side effects after treatment with meglumine antimoniate","volume":"14","author":"Neves","year":"2009","journal-title":"Trop. Med. Int. Health"},{"key":"10.1016\/j.ijpddr.2020.11.002_bib22","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.actatropica.2011.02.007","article-title":"Systematic review of the adverse effects of cutaneous leishmaniasis treatment in the New World","volume":"118","author":"Oliveira","year":"2011","journal-title":"Acta Trop."},{"key":"10.1016\/j.ijpddr.2020.11.002_bib23","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1046\/j.1365-4362.1997.00188.x","article-title":"Intralesional therapy of American cutaneous leishmaniasis with pentavalent antimony in Rio de Janeiro, Brazil--an area of Leishmania (V.) braziliensis transmission","volume":"36","author":"Oliveira-Neto","year":"1997","journal-title":"Int. J. Dermatol."},{"key":"10.1016\/j.ijpddr.2020.11.002_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0006141","article-title":"Harmonized clinical trial methodologies for localized cutaneous leishmaniasis and potential for extensive network with capacities for clinical evaluation","volume":"12","author":"Olliaro","year":"2018","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.ijpddr.2020.11.002_bib25","series-title":"Leishmaniasis en las Americas. Recomedaciones para el tratamiento","year":"2013"},{"key":"10.1016\/j.ijpddr.2020.11.002_bib26","series-title":"Manual de procedimientos para vigilancia y control de las leishmaniasis en las Am\u00e9ricas","year":"2019"},{"issue":"2","key":"10.1016\/j.ijpddr.2020.11.002_bib27","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1590\/0037-8682-0323-2016","article-title":"Intralesional treatment with meglumine antimoniate in three patients with New World cutaneous leishmaniasis and large periarticular lesions with comorbidities","volume":"50","author":"Pimentel","year":"2017","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"10.1016\/j.ijpddr.2020.11.002_bib28","series-title":"The Case of Leishmaniasis in the Bolivian Rainforest (Doctoral Dissertation)","article-title":"The rough journey to access health care","author":"Rodr\u00edguez","year":"2019"},{"key":"10.1016\/j.ijpddr.2020.11.002_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0178592","article-title":"Low versus high dose of antimony for American cutaneous leishmaniasis: a randomized controlled blind non-inferiority trial in Rio de Janeiro, Brazil","volume":"12","author":"Saheki","year":"2017","journal-title":"PloS One"},{"key":"10.1016\/j.ijpddr.2020.11.002_bib30","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1590\/S0037-86822005000300001","article-title":"Retrospective study of 151 patients with cutaneous leishmaniasis treated with meglumine antimoniate","volume":"38","author":"Schubach","year":"2005","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"10.1016\/j.ijpddr.2020.11.002_bib31","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1590\/0074-02760160183","article-title":"Intralesional meglumine antimoniate for the treatment of localized cutaneous leishmaniasis: a retrospective review of a Brazilian referral centre","volume":"111","author":"Silva","year":"2016","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.ijpddr.2020.11.002_bib32","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1590\/0074-027601700125","article-title":"Towards a standard protocol for antimony intralesional infiltration technique for cutaneous leishmaniasis treatment","volume":"113","author":"Silva","year":"2018","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.ijpddr.2020.11.002_bib33","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1365-4632.2008.03417.x","article-title":"Treatment of New World cutaneous leishmaniasis-a systematic review with a meta-analysis","volume":"47","author":"Tuon","year":"2008","journal-title":"Int. J. Dermatol."},{"key":"10.1016\/j.ijpddr.2020.11.002_bib34","series-title":"Tratamento intralesional da leishmaniose cut\u00e2nea com antimoniato de meglumina no Instituto de Pesquisa Cl\u00ednica Evandro Chagas, Fiocruz, Rio de Janeiro (2002 a julho 2011)","first-page":"92","author":"Vasconcellos","year":"2013"},{"key":"10.1016\/j.ijpddr.2020.11.002_bib35","doi-asserted-by":"crossref","first-page":"257","DOI":"10.4269\/ajtmh.2012.11-0612","article-title":"Intralesional meglumine antimoniate for treatment of cutaneous leishmaniasis patients with contraindication to systemic therapy from Rio de Janeiro (2000 to 2006)","volume":"87","author":"Vasconcellos","year":"2012","journal-title":"Am. J. Trop. Med. Hyg."}],"container-title":["International Journal for Parasitology: Drugs and Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211320720300440?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211320720300440?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:51:32Z","timestamp":1761922292000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211320720300440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":35,"alternative-id":["S2211320720300440"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpddr.2020.11.002","relation":{},"ISSN":["2211-3207"],"issn-type":[{"value":"2211-3207","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A retrospective cohort study of the effectiveness and adverse events of intralesional pentavalent antimonials in the treatment of cutaneous leishmaniasis","name":"articletitle","label":"Article Title"},{"value":"International Journal for Parasitology: Drugs and Drug Resistance","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijpddr.2020.11.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Ltd on behalf of Australian Society for Parasitology.","name":"copyright","label":"Copyright"}]}}