{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T16:06:00Z","timestamp":1776701160731,"version":"3.51.2"},"reference-count":18,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T00:00:00Z","timestamp":1628208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006181","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado da Bahia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006181","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal for Parasitology: Drugs and Drug Resistance"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.ijpddr.2021.08.002","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T02:15:10Z","timestamp":1628648110000},"page":"80-83","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Potent and selective antiplasmodial activity of marine sponges from Bahia state, Brazil"],"prefix":"10.1016","volume":"17","author":[{"given":"Uesley Vieira","family":"Alves","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eujeane","family":"Jardim e Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jailciele Gonzaga","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8851-3438","authenticated-orcid":false,"given":"Luisa Oliveira","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio","family":"Lanna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Claudia","family":"de Souza Pinto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Luisa da Fonseca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2939-7780","authenticated-orcid":false,"given":"Fernando","family":"de Pilla Varotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3401-6054","authenticated-orcid":false,"given":"Ronan","family":"Batista","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"MAY","key":"10.1016\/j.ijpddr.2021.08.002_bib1","first-page":"1","article-title":"How do antimalarial drugs reach their intracellular targets?","volume":"6","author":"Basore","year":"2015","journal-title":"Front. Pharmacol."},{"issue":"8","key":"10.1016\/j.ijpddr.2021.08.002_bib2","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.3390\/molecules14083037","article-title":"Plant-derived antimalarial agents: new leads and efficient phytomedicines. part II. non-alkaloidal natural products","volume":"14","author":"Batista","year":"2009","journal-title":"Molecules"},{"issue":"7","key":"10.1016\/j.ijpddr.2021.08.002_bib3","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1128\/AAC.34.7.1381","article-title":"Structure-activity relationships of analogs of pentamidine against Plasmodium falciparum and Leishmania mexicana amazonensis","volume":"34","author":"Bell","year":"1990","journal-title":"Antimicrob. Agents Chemother."},{"issue":"11","key":"10.1016\/j.ijpddr.2021.08.002_bib4","first-page":"1113","article-title":"Antimalarial activity of crude extracts from Brazilian plants studied in\u00a0vivo in Plasmodium berghei-infected mice and in\u00a0vitro against Plasmodium falciparum in culture","volume":"24","author":"Carvalho","year":"1991","journal-title":"Brazilian Journal of Medical and Biological Research\u00a0= Revista Brasileira de Pesquisas Medicas e Biologicas"},{"issue":"1","key":"10.1016\/j.ijpddr.2021.08.002_bib5","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0378-8741(02)00005-3","article-title":"Antimalarial activity of medicinal plants used in traditional medicine in S. Tom\u00e9 and Pr\u00edncipe islands","volume":"81","author":"C\u00e9u de Madureira","year":"2002","journal-title":"J.\u00a0Ethnopharmacol."},{"issue":"4","key":"10.1016\/j.ijpddr.2021.08.002_bib6","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.3390\/molecules26041081","article-title":"Chemical strategies towards the synthesis of betulinic acid and its more potent antiprotozoal analogues","volume":"26","author":"Cunha","year":"2021","journal-title":"Molecules"},{"issue":"2","key":"10.1016\/j.ijpddr.2021.08.002_bib7","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0022-1759(86)90368-6","article-title":"Rapid colorimetric assay for cell growth and survival: modifications to the tetrazolium dye procedure giving improved sensitivity and reliability","volume":"89","author":"Denizot","year":"1986","journal-title":"J.\u00a0Immunol. Methods"},{"issue":"9","key":"10.1016\/j.ijpddr.2021.08.002_bib8","first-page":"3378","article-title":"Identification of novel antiplasmodial compound by hierarquical virtual screening and in\u00a0vitro assays","volume":"39","author":"J\u00fanior","year":"2021","journal-title":"J.\u00a0Biomol. Struct. Dyn."},{"issue":"11","key":"10.1016\/j.ijpddr.2021.08.002_bib9","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/nrd4683","article-title":"Hit and lead criteria in drug discovery for infectious diseases of the developing world","volume":"14","author":"Katsuno","year":"2015","journal-title":"Nat. Rev. Drug Discov."},{"issue":"3","key":"10.1016\/j.ijpddr.2021.08.002_bib10","doi-asserted-by":"crossref","first-page":"418","DOI":"10.2307\/3280287","article-title":"Synchronization of Plasmodium falciparum erythrocytic stages in culture","volume":"65","author":"Lambros","year":"1979","journal-title":"J.\u00a0Parasitol."},{"key":"10.1016\/j.ijpddr.2021.08.002_bib11","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1002\/cbdv.201100309","article-title":"New antiplasmodial bromotyrosine derivatives from Suberea ianthelliformis Lendenfeld, 1888","volume":"9","author":"Mani","year":"2012","journal-title":"Chem. Biodivers."},{"issue":"6","key":"10.1016\/j.ijpddr.2021.08.002_bib12","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.cell.2011.08.024","article-title":"Artemisinin: discovery from the Chinese herbal garden","volume":"146","author":"Miller","year":"2011","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.ijpddr.2021.08.002_bib13","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.bse.2007.09.008","article-title":"Chemical variability within the marine sponge Aplysina fulva","volume":"36","author":"Nu\u00f1ez","year":"2008","journal-title":"Biochem. Systemat. Ecol."},{"issue":"119","key":"10.1016\/j.ijpddr.2021.08.002_bib14","first-page":"1","article-title":"Deploying triple artemisinin-based combination therapy (TACT) for malaria treatment in Africa: ethical and practical considerations","volume":"20","author":"Tindana","year":"2021","journal-title":"Malar. J."},{"issue":"4254","key":"10.1016\/j.ijpddr.2021.08.002_bib15","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1126\/science.781840","article-title":"Human malaria parasites in continuous culture","volume":"193","author":"Trager","year":"1976","journal-title":"Science"},{"issue":"9","key":"10.1016\/j.ijpddr.2021.08.002_bib16","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/S1473-3099(19)30391-3","article-title":"Determinants of dihydroartemisinin-piperaquine treatment failure in Plasmodium falciparum malaria in Cambodia, Thailand, and Vietnam: a prospective clinical, pharmacological, and genetic study","volume":"19","author":"van der Pluijm","year":"2019","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.ijpddr.2021.08.002_bib17","series-title":"World Malaria Report 2020","year":"2020"},{"issue":"98","key":"10.1016\/j.ijpddr.2021.08.002_bib18","article-title":"China declared malaria-free: a milestone in the world malaria eradication and Chinese public health","volume":"10","author":"Zhou","year":"2021","journal-title":"Infectious Diseases of Poverty"}],"container-title":["International Journal for Parasitology: Drugs and Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211320721000385?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211320721000385?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:51:25Z","timestamp":1761922285000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211320721000385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":18,"alternative-id":["S2211320721000385"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpddr.2021.08.002","relation":{},"ISSN":["2211-3207"],"issn-type":[{"value":"2211-3207","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Potent and selective antiplasmodial activity of marine sponges from Bahia state, Brazil","name":"articletitle","label":"Article Title"},{"value":"International Journal for Parasitology: Drugs and Drug Resistance","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijpddr.2021.08.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Ltd on behalf of Australian Society for Parasitology.","name":"copyright","label":"Copyright"}]}}