{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:57:18Z","timestamp":1761922638647,"version":"build-2065373602"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T00:00:00Z","timestamp":1666656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["NRF-2015R1A6A1A03032236","NRF-2021R1A2C2007346"],"award-info":[{"award-number":["NRF-2015R1A6A1A03032236","NRF-2021R1A2C2007346"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal for Parasitology: Drugs and Drug Resistance"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.ijpddr.2022.10.006","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T12:30:06Z","timestamp":1667910606000},"page":"113-120","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Anti-malarial activity of HCl salt of SKM13 (SKM13-2HCl)"],"prefix":"10.1016","volume":"20","author":[{"given":"Thuy-Tien Thi","family":"Trinh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su-Yeon","family":"Yun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gum-Ju","family":"Bae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwonmo","family":"Moon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyelee","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4434-4003","authenticated-orcid":false,"given":"Tae Hui","family":"Eum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-ah","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soon-Ai","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hak Sung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seon-Ju","family":"Yeo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijpddr.2022.10.006_bib1","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1002\/jps.2600650533","article-title":"Enhancement of solubility of drug salts by hydrophilic counterions: properties of organic salts of an antimalarial drug","volume":"65","author":"Agharkar","year":"1976","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.ijpddr.2022.10.006_bib2","doi-asserted-by":"crossref","first-page":"3801","DOI":"10.1038\/s41467-018-06221-1","article-title":"Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome","volume":"9","author":"Bridgford","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ijpddr.2022.10.006_bib3","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.addr.2007.04.009","article-title":"Parasitic diseases: liposomes and polymeric nanoparticles versus lipid nanoparticles","volume":"59","author":"Date","year":"2007","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ijpddr.2022.10.006_bib4","first-page":"255","article-title":"The use of truncated area under the curves in the bioequivalence evaluation of long half-life drugs. Studies with donepezil and memantine","volume":"58","author":"Erkent","year":"2008","journal-title":"Arzneimittelforschung"},{"key":"10.1016\/j.ijpddr.2022.10.006_bib5","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1016\/j.xphs.2017.01.023","article-title":"Measurement and accurate interpretation of the solubility of pharmaceutical salts","volume":"106","author":"He","year":"2017","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.ijpddr.2022.10.006_bib7","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1073\/pnas.1600459113","article-title":"Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7","volume":"113","author":"Ismail","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ijpddr.2022.10.006_bib8","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.apsb.2015.07.003","article-title":"Insoluble drug delivery strategies: review of recent advances and business prospects","volume":"5","author":"Kalepu","year":"2015","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.ijpddr.2022.10.006_bib9","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.ejps.2013.08.040","article-title":"Compound selection for development - is salt formation the ultimate answer? Experiences with an extended concept of the \"100mg approach","volume":"57","author":"Korn","year":"2014","journal-title":"Eur. J. Pharmaceut. Sci."},{"key":"10.1016\/j.ijpddr.2022.10.006_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0121057","article-title":"Effects of malaria parasite density on blood cell parameters","volume":"10","author":"Kotepui","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ijpddr.2022.10.006_bib11","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.4155\/tde.14.67","article-title":"Pathways and progress in improving drug delivery through the intestinal mucosa and blood-brain barriers","volume":"5","author":"Laksitorini","year":"2014","journal-title":"Ther. Deliv."},{"key":"10.1016\/j.ijpddr.2022.10.006_bib12","doi-asserted-by":"crossref","first-page":"7193","DOI":"10.1021\/acs.jmedchem.2c00144","article-title":"Discovery of a highly selective and H435r-sensitive thyroid hormone receptor \u03b2 agonist","volume":"65","author":"Li","year":"2022","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ijpddr.2022.10.006_bib13","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1080\/14787210.2016.1192462","article-title":"Single dose treatment of malaria - current status and perspectives","volume":"14","author":"Mischlinger","year":"2016","journal-title":"Expert Rev. Anti Infect. Ther."},{"key":"10.1016\/j.ijpddr.2022.10.006_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/molecules22122268","article-title":"Quinoline-based hybrid compounds with antimalarial activity","volume":"22","author":"Nqoro","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.ijpddr.2022.10.006_bib15","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/35005132","article-title":"The structure of malaria pigment beta-haematin","volume":"404","author":"Pagola","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.ijpddr.2022.10.006_bib16","doi-asserted-by":"crossref","first-page":"6665","DOI":"10.1021\/jm701032y","article-title":"Trends in active pharmaceutical ingredient salt selection based on analysis of the Orange Book database","volume":"50","author":"Paulekuhn","year":"2007","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ijpddr.2022.10.006_bib17","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.actatropica.2019.04.020","article-title":"Nano-facilitated drug delivery strategies in the treatment of plasmodium infection","volume":"195","author":"Puttappa","year":"2019","journal-title":"Acta Trop."},{"key":"10.1016\/j.ijpddr.2022.10.006_bib18","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/jps.21399","article-title":"Solubility enhancement of a poorly water-soluble anti-malarial drug: experimental design and use of a modified multifluid nozzle pilot spray drier","volume":"98","author":"Sahoo","year":"2009","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.ijpddr.2022.10.006_bib19","doi-asserted-by":"crossref","first-page":"4047","DOI":"10.2147\/IDR.S279433","article-title":"Antimalarial drug resistance and novel targets for antimalarial drug discovery","volume":"13","author":"Shibeshi","year":"2020","journal-title":"Infect. Drug Resist."},{"key":"10.1016\/j.ijpddr.2022.10.006_bib20","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1021\/jm070201e","article-title":"Synthesis and antimalarial property of orally active phenoxazinium salts","volume":"50","author":"Takasu","year":"2007","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ijpddr.2022.10.006_bib21","doi-asserted-by":"crossref","first-page":"205","DOI":"10.3389\/fphar.2015.00205","article-title":"Multi-target pharmacology: possibilities and limitations of the \"skeleton key approach\" from a medicinal chemist perspective","volume":"6","author":"Talevi","year":"2015","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ijpddr.2022.10.006_bib22","doi-asserted-by":"crossref","first-page":"5792","DOI":"10.1128\/AAC.00287-13","article-title":"Pharmacokinetic and pharmacodynamic considerations in antimalarial dose optimization","volume":"57","author":"White","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ijpddr.2022.10.006_bib23","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s12936-017-1725-z","article-title":"Anti-malarial effect of novel chloroquine derivatives as agents for the treatment of malaria","volume":"16","author":"Yeo","year":"2017","journal-title":"Malar. J."},{"key":"10.1016\/j.ijpddr.2022.10.006_bib24","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.cmpb.2010.01.007","article-title":"PKSolver: an add-in program for pharmacokinetic and pharmacodynamic data analysis in Microsoft Excel","volume":"99","author":"Zhang","year":"2010","journal-title":"Comput. Methods Progr. Biomed."}],"container-title":["International Journal for Parasitology: Drugs and Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211320722000276?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211320722000276?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:52:38Z","timestamp":1761922358000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211320722000276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":23,"alternative-id":["S2211320722000276"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpddr.2022.10.006","relation":{},"ISSN":["2211-3207"],"issn-type":[{"type":"print","value":"2211-3207"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-malarial activity of HCl salt of SKM13 (SKM13-2HCl)","name":"articletitle","label":"Article Title"},{"value":"International Journal for Parasitology: Drugs and Drug Resistance","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijpddr.2022.10.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Ltd on behalf of Australian Society for Parasitology.","name":"copyright","label":"Copyright"}]}}