{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:02:35Z","timestamp":1791252155669,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T00:00:00Z","timestamp":1714435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal for Parasitology: Drugs and Drug Resistance"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.ijpddr.2024.100545","type":"journal-article","created":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T21:53:05Z","timestamp":1715032385000},"page":"100545","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Exploring therapeutic approaches against Naegleria fowleri infections through the COVID box"],"prefix":"10.1016","volume":"25","author":[{"given":"Javier","family":"Chao-Pellicer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I\u00f1igo","family":"Arberas-Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines","family":"Sifaoui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6233-8224","authenticated-orcid":false,"given":"Jos\u00e9 E.","family":"Pi\u00f1ero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Lorenzo-Morales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijpddr.2024.100545_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23010068","article-title":"Systematic analysis of clemastine, a candidate apicomplexan parasite-selective tubulin-targeting agent","volume":"23","author":"Abbaali","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ijpddr.2024.100545_bib2","doi-asserted-by":"crossref","DOI":"10.1590\/0074-02760210207","article-title":"Medicines for Malaria Venture COVID Box: a source for repurposing drugs with antifungal activity against human pathogenic fungi","volume":"116","author":"Almeida-Paes","year":"2021","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.ijpddr.2024.100545_bib3","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.00515-22","article-title":"A Fluorometric assay for the in vitro evaluation of activity against naegleria fowleri cysts","volume":"10","author":"Arberas-Jim\u00e9nez","year":"2022","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.ijpddr.2024.100545_bib4","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1021\/acschemneuro.6b00197","article-title":"Primary amoebic meningoencephalitis: Neurochemotaxis and Neurotropic preferences of naegleria fowleri","volume":"7","author":"Baig","year":"2016","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.ijpddr.2024.100545_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.exppara.2018.02.010","article-title":"The therapeutic strategies against Naegleria fowleri","volume":"187","author":"Bellini","year":"2018","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.ijpddr.2024.100545_bib6","doi-asserted-by":"crossref","first-page":"39806","DOI":"10.18632\/oncotarget.5655","article-title":"Repurposing of nitroxoline as a potential anticancer agent against human prostate cancer: a crucial role on AMPK\/mTOR signaling pathway and the interplay with Chk2 activation","volume":"6","author":"Chang","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.ijpddr.2024.100545_bib7","doi-asserted-by":"crossref","first-page":"e36","DOI":"10.1093\/cid\/civ017","article-title":"The first association of a primary amebic meningoencephalitis death with culturable Naegleria fowleri in tap water from a US treated public drinking water system","volume":"60","author":"Cope","year":"2015","journal-title":"Clin. Infect. Dis. an Off. Publ. Infect. Dis. Soc. Am."},{"key":"10.1016\/j.ijpddr.2024.100545_bib8","first-page":"1520","article-title":"Origin and evolution of the worldwide distributed pathogenic amoeboflagellate Naegleria fowleri","volume":"11","author":"De Jonckheere","year":"2011","journal-title":"Infect. Genet. Evol. J. Mol. Epidemiol. Evol. Genet. Infect. Dis."},{"key":"10.1016\/j.ijpddr.2024.100545_bib9","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/labmed\/lmw008","article-title":"Naegleria fowleri that induces primary amoebic meningoencephalitis: rapid diagnosis and rare case of survival in a 12-Year-Old Caucasian Girl","volume":"47","author":"Dunn","year":"2016","journal-title":"Lab. Med."},{"key":"10.1016\/j.ijpddr.2024.100545_bib10","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1099\/mic.0.27218-0","article-title":"Balamuthia mandrillaris from soil samples","volume":"150","author":"Dunnebacke","year":"2004","journal-title":"Microbiology"},{"key":"10.1016\/j.ijpddr.2024.100545_bib11","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.17084","article-title":"Malaria: biochemical, physiological, diagnostic, and therapeutic updates","volume":"12","author":"El Saftawy","year":"2024","journal-title":"PeerJ"},{"key":"10.1016\/j.ijpddr.2024.100545_bib12","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1038\/bjp.2008.147","article-title":"The histamine H3 receptor: an attractive target for the treatment of cognitive disorders","volume":"154","author":"Esbenshade","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ijpddr.2024.100545_bib13","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1124\/jpet.104.078402","article-title":"Pharmacological properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: II. Neurophysiological characterization and broad preclinical efficacy in cognition and schizophrenia of a potent and selective histamine H3 r","volume":"313","author":"Fox","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ijpddr.2024.100545_bib14","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/s41586-020-2286-9","article-title":"A SARS-CoV-2 protein interaction map reveals targets for drug repurposing","volume":"583","author":"Gordon","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.ijpddr.2024.100545_bib15","doi-asserted-by":"crossref","first-page":"6677","DOI":"10.1128\/AAC.01293-15","article-title":"Naegleria fowleri: pathogenesis, diagnosis, and treatment options","volume":"59","author":"Grace","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ijpddr.2024.100545_bib16","doi-asserted-by":"crossref","first-page":"172","DOI":"10.3389\/fgene.2020.00172","article-title":"The molecular Chaperone CCT\/TRiC: an essential component of Proteostasis and a potential Modulator of protein aggregation","volume":"11","author":"Grantham","year":"2020","journal-title":"Front. Genet."},{"key":"10.1016\/j.ijpddr.2024.100545_bib17","doi-asserted-by":"crossref","DOI":"10.3390\/biom11091320","article-title":"Primary amoebic meningoencephalitis by naegleria fowleri: pathogenesis and treatments","volume":"11","author":"G\u00fc\u00e9mez","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.ijpddr.2024.100545_bib18","doi-asserted-by":"crossref","first-page":"3089","DOI":"10.1021\/acschemneuro.0c00428","article-title":"HMG-CoA Reductase Inhibitors as drug leads against naegleria fowleri","volume":"11","author":"Hahn","year":"2020","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.ijpddr.2024.100545_bib19","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.tmaid.2016.12.005","article-title":"Surviving Naegleria fowleri infections: a successful case report and novel therapeutic approach","volume":"16","author":"Heggie","year":"2017","journal-title":"Trav. Med. Infect. Dis."},{"key":"10.1016\/j.ijpddr.2024.100545_bib20","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1177\/120347540300700608","article-title":"Antihistamines in the treatment of dermatitis","volume":"7","author":"Herman","year":"2003","journal-title":"J. Cutan. Med. Surg."},{"key":"10.1016\/j.ijpddr.2024.100545_bib21","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/1440-1681.13192","article-title":"Naegleria fowleri: Sources of infection, pathophysiology, diagnosis, and management; a review","volume":"47","author":"Jahangeer","year":"2020","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.ijpddr.2024.100545_bib22","first-page":"470","article-title":"Naegleria meningitis: a rare survival","volume":"50","author":"Jain","year":"2002","journal-title":"Neurol. India"},{"key":"10.1016\/j.ijpddr.2024.100545_bib23","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1093\/cid\/cir961","article-title":"Fatal Naegleria fowleri infection acquired in Minnesota: possible expanded range of a deadly thermophilic organism","volume":"54","author":"Kemble","year":"2012","journal-title":"Clin. Infect. Dis. an Off. Publ. Infect. Dis. Soc. Am."},{"key":"10.1016\/j.ijpddr.2024.100545_bib24","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.riam.2009.06.003","article-title":"Amphotericin B: side effects and toxicity","volume":"26","author":"Laniado-Labor\u00edn","year":"2009","journal-title":"Rev. Iberoam. De. Micol."},{"key":"10.1016\/j.ijpddr.2024.100545_bib25","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1007\/s00436-014-3936-3","article-title":"Novel cathepsin B and cathepsin B-like cysteine protease of Naegleria fowleri excretory-secretory proteins and their biochemical properties","volume":"113","author":"Lee","year":"2014","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.ijpddr.2024.100545_bib26","doi-asserted-by":"crossref","first-page":"e744","DOI":"10.1542\/peds.2014-2292","article-title":"Successful treatment of an adolescent with Naegleria fowleri primary amebic meningoencephalitis","volume":"135","author":"Linam","year":"2015","journal-title":"Pediatrics"},{"key":"10.1016\/j.ijpddr.2024.100545_bib27","doi-asserted-by":"crossref","first-page":"5810","DOI":"10.1073\/pnas.1913525117","article-title":"Plasmodium chaperonin TRiC\/CCT identified as a target of the antihistamine clemastine using parallel chemoproteomic strategy","volume":"117","author":"Lu","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ijpddr.2024.100545_bib28","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1007\/s11686-022-00591-9","article-title":"Successful treatment of primary amoebic meningoencephalitis using a novel therapeutic Regimen including miltefosine and voriconazole","volume":"67","author":"Mart\u00ednez","year":"2022","journal-title":"Acta Parasitol."},{"key":"10.1016\/j.ijpddr.2024.100545_bib29","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1128\/JCM.43.2.629-634.2005","article-title":"Development of colorimetric microtiter plate assay for assessment of antimicrobials against Acanthamoeba","volume":"43","author":"McBride","year":"2005","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.ijpddr.2024.100545_bib30","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.pt.2019.06.011","article-title":"Naegleria fowleri","volume":"35","author":"Pi\u00f1ero","year":"2019","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.ijpddr.2024.100545_bib31","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1021\/acschemneuro.6b00232","article-title":"Naegleria fowleri: diagnosis, pathophysiology of brain inflammation, and Antimicrobial treatments","volume":"7","author":"Pugh","year":"2016","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.ijpddr.2024.100545_bib32","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nrd.2018.168","article-title":"Drug repurposing: progress, challenges and recommendations","volume":"18","author":"Pushpakom","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ijpddr.2024.100545_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2019.e01947","article-title":"Repurposing of terconazole as an anti Trypanosoma cruzi agent","volume":"5","author":"Reigada","year":"2019","journal-title":"Heliyon"},{"key":"10.1016\/j.ijpddr.2024.100545_bib34","author":"Rizo-Liendo","year":"2019"},{"key":"10.1016\/j.ijpddr.2024.100545_bib35","doi-asserted-by":"crossref","first-page":"3287","DOI":"10.1007\/s00436-022-07660-y","article-title":"Role of cathepsin B of Naegleria fowleri during primary amebic meningoencephalitis","volume":"121","author":"Rodr\u00edguez-Mera","year":"2022","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.ijpddr.2024.100545_bib36","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/s41419-020-02842-x","article-title":"On-target versus off-target effects of drugs inhibiting the replication of SARS-CoV-2","volume":"11","author":"Sauvat","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ijpddr.2024.100545_bib37","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/164_2016_12","article-title":"Role of the histamine H(3) receptor in the central nervous system","volume":"241","author":"Schlicker","year":"2017","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.ijpddr.2024.100545_bib38","first-page":"930","article-title":"Neuroimaging findings in rare amebic infections of the central nervous system","volume":"16","author":"Schumacher","year":"1995","journal-title":"AJNR. Am. J. Neuroradiol."},{"key":"10.1016\/j.ijpddr.2024.100545_bib39","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1550-7408.2005.00082.x","article-title":"In-vitro activity of miltefosine and voriconazole on clinical isolates of free-living amebas: Balamuthia mandrillaris, Acanthamoeba spp., and Naegleria fowleri","volume":"53","author":"Schuster","year":"2006","journal-title":"J. Eukaryot. Microbiol."},{"key":"10.1016\/j.ijpddr.2024.100545_bib40","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/j.1550-7408.2007.00280.x","article-title":"A biochemical comparison of proteases from pathogenic naegleria fowleri and non-pathogenic Naegleria gruberi","volume":"54","author":"Serrano-Luna","year":"2007","journal-title":"J. Eukaryot. Microbiol."},{"key":"10.1016\/j.ijpddr.2024.100545_bib41","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1021\/acsinfecdis.9b00227","article-title":"Identification of four amoebicidal Nontoxic compounds by a molecular Docking screen of naegleria fowleri sterol \u03948-\u03947-Isomerase and Phenotypic assays","volume":"5","author":"Shi","year":"2019","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.ijpddr.2024.100545_bib42","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1002\/1098-0997(2000)8:5<240::AID-IDOG1026>3.0.CO;2-4","article-title":"Terconazole cream for non-Candida albicans fungal vaginitis: results of a retrospective analysis","volume":"8","author":"Sood","year":"2000","journal-title":"Infect. Dis. Obstet. Gynecol."},{"key":"10.1016\/j.ijpddr.2024.100545_bib43","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1097\/LGT.0000000000000383","article-title":"Reduced antifungal Susceptibility of Vulvovaginal Candida species at normal Vaginal pH levels: clinical Implications","volume":"22","author":"Spitzer","year":"2018","journal-title":"J. Low. Genit. Tract Dis."},{"key":"10.1016\/j.ijpddr.2024.100545_bib44","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/978-3-030-40204-4_2","article-title":"The TRiC\/CCT chaperonin and its role in Uncontrolled Proliferation","volume":"1243","author":"Wang","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.ijpddr.2024.100545_bib45","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1289\/ehp.5785","article-title":"Azole fungicides affect mammalian steroidogenesis by inhibiting sterol 14 alpha-demethylase and aromatase","volume":"111","author":"Zarn","year":"2003","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ijpddr.2024.100545_bib46","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007245","article-title":"Enzymatic chokepoints and synergistic drug targets in the sterol biosynthesis pathway of Naegleria fowleri","volume":"14","author":"Zhou","year":"2018","journal-title":"PLoS Pathog."}],"container-title":["International Journal for Parasitology: Drugs and Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211320724000265?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211320724000265?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T02:15:18Z","timestamp":1722996918000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211320724000265"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":46,"alternative-id":["S2211320724000265"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpddr.2024.100545","relation":{},"ISSN":["2211-3207"],"issn-type":[{"value":"2211-3207","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploring therapeutic approaches against Naegleria fowleri infections through the COVID box","name":"articletitle","label":"Article Title"},{"value":"International Journal for Parasitology: Drugs and Drug Resistance","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijpddr.2024.100545","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Ltd on behalf of Australian Society for Parasitology.","name":"copyright","label":"Copyright"}],"article-number":"100545"}}