{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T19:20:48Z","timestamp":1758396048593,"version":"3.37.3"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T00:00:00Z","timestamp":1728604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007319","name":"Albert Einstein College of Medicine, Yeshiva University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["T32-GM007288","T32-GM149364"],"award-info":[{"award-number":["T32-GM007288","T32-GM149364"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal for Parasitology: Drugs and Drug Resistance"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.ijpddr.2024.100567","type":"journal-article","created":{"date-parts":[[2024,10,13]],"date-time":"2024-10-13T05:32:42Z","timestamp":1728797562000},"page":"100567","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Yeast-based assay to identify inhibitors of the malaria parasite sodium phosphate uptake transporter as potential novel antimalarial drugs"],"prefix":"10.1016","volume":"26","author":[{"given":"Joseph M.","family":"Sweeney","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian M.","family":"Willis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8781-7846","authenticated-orcid":false,"given":"Myles H.","family":"Akabas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijpddr.2024.100567_bib1","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/S0006-291X(03)01068-4","article-title":"Transcriptional regulation of phosphate-responsive genes in low-affinity phosphate-transporter-defective mutants in Saccharomyces cerevisiae","volume":"306","author":"Auesukaree","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ijpddr.2024.100567_bib2","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1056\/NEJMoa2101746","article-title":"Evidence of artemisinin-resistant malaria in Africa","volume":"385","author":"Balikagala","year":"2021","journal-title":"N. Engl. J. Med."},{"year":"2023","series-title":"Goodman & Gilman's the Pharmacological Basis of Therapeutics","author":"Brunton","key":"10.1016\/j.ijpddr.2024.100567_bib3"},{"key":"10.1016\/j.ijpddr.2024.100567_bib4","first-page":"3229","article-title":"The PHO84 gene of Saccharomyces cerevisiae encodes an inorganic phosphate transporter","volume":"11","author":"Bun-Ya","year":"1991","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.ijpddr.2024.100567_bib5","doi-asserted-by":"crossref","first-page":"22323","DOI":"10.1016\/S0021-9258(18)41673-0","article-title":"Phosphate transport by capillaries of the blood-brain barrier","volume":"267","author":"Dallaire","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijpddr.2024.100567_bib6","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1111\/j.1365-2958.2006.05125.x","article-title":"Transport of nucleosides across the Plasmodium falciparum parasite plasma membrane has characteristics of PfENT1","volume":"60","author":"Downie","year":"2006","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.ijpddr.2024.100567_bib7","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.3389\/fmicb.2017.02554","article-title":"The impact of single amino acids on growth and volatile aroma production by Saccharomyces cerevisiae strains","volume":"8","author":"Fairbairn","year":"2017","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.ijpddr.2024.100567_bib8","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.mam.2012.07.007","article-title":"Phosphate transporters of the SLC20 and SLC34 families","volume":"34","author":"Forster","year":"2013","journal-title":"Mol. Aspect. Med."},{"key":"10.1016\/j.ijpddr.2024.100567_bib9","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1021\/cb500981y","article-title":"Yeast-based high-throughput screen identifies Plasmodium falciparum equilibrative nucleoside transporter 1 inhibitors that kill malaria parasites","volume":"10","author":"Frame","year":"2015","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.ijpddr.2024.100567_bib10","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1042\/BJ20101118","article-title":"Differential roles for the low-affinity phosphate transporters Pho87 and Pho90 in Saccharomyces cerevisiae","volume":"434","author":"Ghillebert","year":"2011","journal-title":"Biochem. J."},{"key":"10.1016\/j.ijpddr.2024.100567_bib11","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1046\/j.1365-2958.2003.03365.x","article-title":"Inorganic phosphate is sensed by specific phosphate carriers and acts in concert with glucose as a nutrient signal for activation of the protein kinase A pathway in the yeast Saccharomyces cerevisiae","volume":"47","author":"Giots","year":"2003","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.ijpddr.2024.100567_bib12","first-page":"1030","article-title":"Artemisinin resistance increasing","volume":"330","author":"Harris","year":"2023","journal-title":"JAMA"},{"key":"10.1016\/j.ijpddr.2024.100567_bib13","doi-asserted-by":"crossref","first-page":"H448","DOI":"10.1152\/ajpheart.00433.2019","article-title":"Several phosphate transport processes are present in vascular smooth muscle cells","volume":"318","author":"Hortells","year":"2020","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ijpddr.2024.100567_bib14","doi-asserted-by":"crossref","first-page":"5076","DOI":"10.1128\/MCB.22.14.5076-5088.2002","article-title":"Dissection of a complex phenotype by functional genomics reveals roles for the yeast cyclin-dependent protein kinase Pho85 in stress adaptation and cell integrity","volume":"22","author":"Huang","year":"2002","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.ijpddr.2024.100567_bib15","series-title":"Assay Guidance Manual","article-title":"HTS assay validation","author":"Iversen","year":"2004"},{"key":"10.1016\/j.ijpddr.2024.100567_bib16","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1146\/annurev-micro-091014-104506","article-title":"Ion regulation in the malaria parasite","volume":"69","author":"Kirk","year":"2015","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.ijpddr.2024.100567_bib17","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1534\/genetics.111.133306","article-title":"Regulation of amino acid, nucleotide, and phosphate metabolism in Saccharomyces cerevisiae","volume":"190","author":"Ljungdahl","year":"2012","journal-title":"Genetics"},{"key":"10.1016\/j.ijpddr.2024.100567_bib18","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3389\/fchem.2018.00088","article-title":"Targeting channels and transporters in Protozoan parasite infections","volume":"6","author":"Meier","year":"2018","journal-title":"Front. Chem."},{"key":"10.1016\/j.ijpddr.2024.100567_bib19","doi-asserted-by":"crossref","first-page":"4309","DOI":"10.1091\/mbc.11.12.4309","article-title":"New components of a system for phosphate accumulation and polyphosphate metabolism in Saccharomyces cerevisiae revealed by genomic expression analysis","volume":"11","author":"Ogawa","year":"2000","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.ijpddr.2024.100567_bib20","doi-asserted-by":"crossref","DOI":"10.1093\/femsyr\/fou005","article-title":"Effects of high medium pH on growth, metabolism and transport in Saccharomyces cerevisiae","volume":"15","author":"Pe\u00f1a","year":"2015","journal-title":"FEMS Yeast Res."},{"key":"10.1016\/j.ijpddr.2024.100567_bib21","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/mmi.12159","article-title":"Malaria parasites tolerate a broad range of ionic environments and do not require host cation remodelling","volume":"88","author":"Pillai","year":"2013","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.ijpddr.2024.100567_bib22","doi-asserted-by":"crossref","first-page":"35273","DOI":"10.1074\/jbc.M405398200","article-title":"Low affinity orthophosphate carriers regulate PHO gene expression independently of internal orthophosphate concentration in Saccharomyces cerevisiae","volume":"279","author":"Pinson","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijpddr.2024.100567_bib23","doi-asserted-by":"crossref","first-page":"5746","DOI":"10.1038\/s41467-022-33403-9","article-title":"A G358S mutation in the Plasmodium falciparum Na(+) pump PfATP4 confers clinically-relevant resistance to cipargamin","volume":"13","author":"Qiu","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ijpddr.2024.100567_bib24","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1056\/NEJMc1705789","article-title":"Artemisinin-resistant Plasmodium falciparum in Africa","volume":"377","author":"Rasmussen","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijpddr.2024.100567_bib25","doi-asserted-by":"crossref","first-page":"C606","DOI":"10.1152\/ajpcell.00064.2007","article-title":"Deciphering PiT transport kinetics and substrate specificity using electrophysiology and flux measurements","volume":"293","author":"Ravera","year":"2007","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.ijpddr.2024.100567_bib26","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.4269\/ajtmh.18-0845","article-title":"Artemisinin resistance outside of Southeast Asia","volume":"99","author":"Rosenthal","year":"2018","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.ijpddr.2024.100567_bib27","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1126\/science.1193225","article-title":"Spiroindolones, a potent compound class for the treatment of malaria","volume":"329","author":"Rottmann","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.ijpddr.2024.100567_bib28","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1016\/S0020-7519(01)00258-2","article-title":"Nutrient acquisition by intracellular apicomplexan parasites: staying in for dinner","volume":"31","author":"Saliba","year":"2001","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.ijpddr.2024.100567_bib29","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/nature05149","article-title":"Sodium-dependent uptake of inorganic phosphate by the intracellular malaria parasite","volume":"443","author":"Saliba","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.ijpddr.2024.100567_bib30","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1042\/BJ20112086","article-title":"Mutational analysis of putative phosphate- and proton-binding sites in the Saccharomyces cerevisiae Pho84 phosphate:H(+) transceptor and its effect on signalling to the PKA and PHO pathways","volume":"445","author":"Samyn","year":"2012","journal-title":"Biochem. J."},{"key":"10.1016\/j.ijpddr.2024.100567_bib31","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1093\/cid\/ciab716","article-title":"Efficacy of cipargamin (KAE609) in a randomized, phase II dose-escalation study in adults in sub-saharan Africa with uncomplicated Plasmodium falciparum malaria","volume":"74","author":"Schmitt","year":"2022","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.ijpddr.2024.100567_bib32","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1101\/gad.7.7a.1160","article-title":"CLB5 and CLB6, a new pair of B cyclins involved in DNA replication in Saccharomyces cerevisiae","volume":"7","author":"Schwob","year":"1993","journal-title":"Genes Dev."},{"key":"10.1016\/j.ijpddr.2024.100567_bib33","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1021\/acsinfecdis.9b00168","article-title":"Identification via a parallel hit progression strategy of improved small molecule inhibitors of the malaria purine uptake transporter that inhibit Plasmodium falciparum parasite proliferation","volume":"5","author":"Sosa","year":"2019","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.ijpddr.2024.100567_bib34","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.chom.2012.12.006","article-title":"Na(+) regulation in the malaria parasite Plasmodium falciparum involves the cation ATPase PfATP4 and is a target of the spiroindolone antimalarials","volume":"13","author":"Spillman","year":"2013","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.ijpddr.2024.100567_bib35","doi-asserted-by":"crossref","first-page":"6375","DOI":"10.1016\/S0021-9258(19)84572-6","article-title":"Phosphonocarboxylic acids as specific inhibitors of Na+-dependent transport of phosphate across renal brush border membrane","volume":"261","author":"Szczepanska-Konkel","year":"1986","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijpddr.2024.100567_bib36","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1128\/jb.164.2.964-968.1985","article-title":"Regulation of inorganic phosphate transport systems in Saccharomyces cerevisiae","volume":"164","author":"Tamai","year":"1985","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ijpddr.2024.100567_bib37","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abb4024","article-title":"Structure of the sodium-dependent phosphate transporter reveals insights into human solute carrier SLC20","volume":"6","author":"Tsai","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.ijpddr.2024.100567_bib38","doi-asserted-by":"crossref","first-page":"F643","DOI":"10.1152\/ajprenal.00228.2007","article-title":"Phosphate transporters: a tale of two solute carrier families","volume":"293","author":"Virkki","year":"2007","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.ijpddr.2024.100567_bib39","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1152\/physrev.1969.49.2.285","article-title":"Intracellular pH","volume":"49","author":"Waddell","year":"1969","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ijpddr.2024.100567_bib40","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1038\/s41467-023-37411-1","article-title":"Structural basis of the substrate recognition and inhibition mechanism of Plasmodium falciparum nucleoside transporter PfENT1","volume":"14","author":"Wang","year":"2023","journal-title":"Nat. Commun."},{"first-page":"283","year":"2023","series-title":"World Malaria Report 2023","key":"10.1016\/j.ijpddr.2024.100567_bib41"},{"key":"10.1016\/j.ijpddr.2024.100567_bib42","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.926541","article-title":"Updated list of transport proteins in Plasmodium falciparum","volume":"12","author":"Wunderlich","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.ijpddr.2024.100567_bib43","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1093\/genetics\/159.4.1491","article-title":"Phosphate transport and sensing in Saccharomyces cerevisiae","volume":"159","author":"Wykoff","year":"2001","journal-title":"Genetics"},{"key":"10.1016\/j.ijpddr.2024.100567_bib44","doi-asserted-by":"crossref","first-page":"4465","DOI":"10.1128\/MCB.00104-07","article-title":"Osteoblast autonomous Pi regulation via Pit1 plays a role in bone mineralization","volume":"27","author":"Yoshiko","year":"2007","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.ijpddr.2024.100567_bib45","doi-asserted-by":"crossref","DOI":"10.1126\/science.aap7847","article-title":"Uncovering the essential genes of the human malaria parasite Plasmodium falciparum by saturation mutagenesis","volume":"360","author":"Zhang","year":"2018","journal-title":"Science"}],"container-title":["International Journal for Parasitology: Drugs and Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211320724000484?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211320724000484?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T23:15:06Z","timestamp":1733958906000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211320724000484"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":45,"alternative-id":["S2211320724000484"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpddr.2024.100567","relation":{},"ISSN":["2211-3207"],"issn-type":[{"type":"print","value":"2211-3207"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Yeast-based assay to identify inhibitors of the malaria parasite sodium phosphate uptake transporter as potential novel antimalarial drugs","name":"articletitle","label":"Article Title"},{"value":"International Journal for Parasitology: Drugs and Drug Resistance","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijpddr.2024.100567","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Ltd on behalf of Australian Society for Parasitology.","name":"copyright","label":"Copyright"}],"article-number":"100567"}}