{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T02:53:44Z","timestamp":1789700024174,"version":"4.0.1"},"reference-count":132,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001215","name":"La Trobe University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001215","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal for Parasitology: Drugs and Drug Resistance"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.ijpddr.2025.100602","type":"journal-article","created":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T11:19:21Z","timestamp":1751973561000},"page":"100602","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Antimalarial drug resistance and drug discovery: learning from the past to innovate the future"],"prefix":"10.1016","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8271-8689","authenticated-orcid":false,"given":"Liana","family":"Theodoridis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4947-371X","authenticated-orcid":false,"given":"Teresa G.","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.ijpddr.2025.100602_bib1","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/S0006-2952(02)01299-6","article-title":"Haem polymerase as a novel target of antimalarial action of cyproheptadine","volume":"64","author":"Agrawal","year":"2002","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.ijpddr.2025.100602_bib2","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1038\/s41467-017-01345-2","article-title":"Identifying host regulators and inhibitors of liver stage malaria infection using kinase activity profiles","volume":"8","author":"Arang","year":"2017","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.ijpddr.2025.100602_bib3","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s12906-023-04324-x","article-title":"Betulinic and ursolic acids from Nauclea latifolia roots mediate their antimalarial activities through docking with PfEMP-1 and PfPKG proteins","volume":"24","author":"Asanga","year":"2024","journal-title":"BMC Complement. Med. Therap."},{"key":"10.1016\/j.ijpddr.2025.100602_bib4","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1007\/s11418-008-0259-7","article-title":"Alkaloids from the seeds of Peganum harmala showing antiplasmodial and vasorelaxant activities","volume":"62","author":"Astulla","year":"2008","journal-title":"J. Nat. Med."},{"issue":"15","key":"10.1016\/j.ijpddr.2025.100602_bib5","doi-asserted-by":"crossref","first-page":"9465","DOI":"10.1021\/la201040c","article-title":"The potent antimalarial peptide cyclosporin a induces the aggregation and permeabilization of sphingomyelin-rich membranes","volume":"27","author":"Azouzi","year":"2011","journal-title":"Langmuir"},{"issue":"3","key":"10.1016\/j.ijpddr.2025.100602_bib6","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.drudis.2018.01.018","article-title":"A bibliometric review of drug repurposing","volume":"23","author":"Baker","year":"2018","journal-title":"Drug Discov. Today"},{"issue":"4","key":"10.1016\/j.ijpddr.2025.100602_bib7","doi-asserted-by":"crossref","first-page":"415","DOI":"10.3347\/kjp.2016.54.4.415","article-title":"Antiplasmodial and cytotoxic activities of toad venoms from Southern Amazon, Brazil","volume":"54","author":"Banfi","year":"2016","journal-title":"Kor. J. Parasitol."},{"issue":"5","key":"10.1016\/j.ijpddr.2025.100602_bib8","article-title":"Prevention of malaria in travellers","volume":"36","author":"Batchelor","year":"2007","journal-title":"Aust. Fam. Physician"},{"issue":"3","key":"10.1016\/j.ijpddr.2025.100602_bib9","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/0006-2952(94)90279-8","article-title":"Roles of peptidyl-prolyl cis-trans isomerase and calcineurin in the mechanisms of antimalarial action of cyclosporin A, FK506, and rapamycin","volume":"48","author":"Bell","year":"1994","journal-title":"Biochem. Pharmacol."},{"issue":"52","key":"10.1016\/j.ijpddr.2025.100602_bib10","doi-asserted-by":"crossref","first-page":"36336","DOI":"10.1074\/jbc.M114.614206","article-title":"Multiple drugs compete for transport via the Plasmodium falciparum chloroquine resistance transporter at distinct but interdependent sites","volume":"289","author":"Bellanca","year":"2014","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.ijpddr.2025.100602_bib11","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1021\/acsinfecdis.3c00025","article-title":"Human polo-like kinase inhibitors as antiplasmodials","volume":"9","author":"Bohmer","year":"2023","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.ijpddr.2025.100602_bib12","doi-asserted-by":"crossref","first-page":"419","DOI":"10.3389\/fcimb.2018.00419","article-title":"Manipulating eryptosis of human red blood cells: a novel antimalarial strategy?","volume":"8","author":"Boulet","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"4","key":"10.1016\/j.ijpddr.2025.100602_bib13","doi-asserted-by":"crossref","first-page":"824","DOI":"10.3390\/microorganisms10040824","article-title":"Red blood cell BCL-xL is required for Plasmodium falciparum survival: insights into host-directed malaria therapies","volume":"10","author":"Boulet","year":"2022","journal-title":"Microorganisms"},{"issue":"1","key":"10.1016\/j.ijpddr.2025.100602_bib14","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1186\/s12915-022-01374-4","article-title":"The protein aggregation inhibitor YAT2150 has potent antimalarial activity in Plasmodium falciparum in vitro cultures","volume":"20","author":"Bouz\u00f3n-Arn\u00e1iz","year":"2022","journal-title":"BMC Biol."},{"issue":"1","key":"10.1016\/j.ijpddr.2025.100602_bib15","doi-asserted-by":"crossref","first-page":"3500","DOI":"10.1038\/s41598-020-60549-7","article-title":"Detection of mutations associated with artemisinin resistance at k13-propeller gene and a near complete return of chloroquine susceptible falciparum malaria in Southeast of Tanzania","volume":"10","author":"Bwire","year":"2020","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.ijpddr.2025.100602_bib16","doi-asserted-by":"crossref","first-page":"339","DOI":"10.3347\/kjp.2022.60.5.339","article-title":"Antimalarial efficacy of aqueous extract of strychnos ligustrina and its combination with dihydroartemisinin and piperaquine phosphate (DHP) against Plasmodium berghei Infection","volume":"60","author":"Cahyaningsih","year":"2022","journal-title":"Kor. J. Parasitol."},{"key":"10.1016\/j.ijpddr.2025.100602_bib17","series-title":"Halofantrine Resistance in African Countries","author":"Carme","year":"1993"},{"issue":"11","key":"10.1016\/j.ijpddr.2025.100602_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003790","article-title":"Killer bee molecules: antimicrobial peptides as effector molecules to target sporogonic stages of Plasmodium","volume":"9","author":"Carter","year":"2013","journal-title":"PLoS Pathog."},{"issue":"10","key":"10.1016\/j.ijpddr.2025.100602_bib19","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2011.97","article-title":"Drug-induced permeabilization of parasite's digestive vacuole is a key trigger of programmed cell death in Plasmodium falciparum","volume":"2","author":"Ch'Ng","year":"2011","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.ijpddr.2025.100602_bib20","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s12906-021-03317-y","article-title":"Antimalarial properties and molecular docking analysis of compounds from Dioscorea bulbifera L. as new antimalarial agent candidates","volume":"21","author":"Chaniad","year":"2021","journal-title":"BMC Complement. Med. Therap."},{"issue":"1","key":"10.1016\/j.ijpddr.2025.100602_bib21","article-title":"Repurposing drugs to target the malaria parasite unfolding protein response","volume":"8","author":"Chen","year":"2018","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.ijpddr.2025.100602_bib22","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1021\/acschembio.1c00512","article-title":"High-content phenotypic screen of a focused TCAMS drug library identifies novel disruptors of the malaria parasite calcium dynamics","volume":"16","author":"Chia","year":"2021","journal-title":"ACS Chem. Biol."},{"issue":"1\u20133","key":"10.1016\/j.ijpddr.2025.100602_bib23","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.febslet.2004.07.019","article-title":"Isolation and characterization of Psalmopeotoxin I and II: two novel antimalarial peptides from the venom of the tarantula Psalmopoeus cambridgei","volume":"572","author":"Choi","year":"2004","journal-title":"FEBS Lett."},{"issue":"8","key":"10.1016\/j.ijpddr.2025.100602_bib24","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nchembio806","article-title":"A clinical drug library screen identifies astemizole as an antimalarial agent","volume":"2","author":"Chong","year":"2006","journal-title":"Nat. Chem. Biol."},{"issue":"1","key":"10.1016\/j.ijpddr.2025.100602_bib25","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1006\/bbrc.1993.2060","article-title":"Control of heme polymerase by chloroquine and other quinoline derivatives","volume":"195","author":"Chou","year":"1993","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"14","key":"10.1016\/j.ijpddr.2025.100602_bib26","doi-asserted-by":"crossref","first-page":"5392","DOI":"10.1073\/pnas.1218412110","article-title":"Protein complex directs hemoglobin-to-hemozoin formation in Plasmodium falciparum","volume":"110","author":"Chugh","year":"2013","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"Suppl. l_3","key":"10.1016\/j.ijpddr.2025.100602_bib27","first-page":"s57","article-title":"Expert recommendations for antimalarial prophylaxis","volume":"8","author":"Connor","year":"2001","journal-title":"J. Trav. Med."},{"key":"10.1016\/j.ijpddr.2025.100602_bib28","first-page":"121","article-title":"Fighting Plasmodium chloroquine resistance with acetylenic chloroquine analogues","volume":"20","author":"Cortopassi","year":"2022","journal-title":"Int. J. Parasitol.: Drugs Drug Resist."},{"issue":"3","key":"10.1016\/j.ijpddr.2025.100602_bib29","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1073\/pnas.91.3.1143","article-title":"Selection for mefloquine resistance in Plasmodium falciparum is linked to amplification of the pfmdr1 gene and cross-resistance to halofantrine and quinine","volume":"91","author":"Cowman","year":"1994","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"3","key":"10.1016\/j.ijpddr.2025.100602_bib30","doi-asserted-by":"crossref","first-page":"467","DOI":"10.3390\/foods14030467","article-title":"From traditional Amazon use to food applications: Tapirira guianensis seed extracts as a triad of antiproliferative effect, oxidative defense, and antimalarial activity","volume":"14","author":"Crispim","year":"2025","journal-title":"Foods"},{"issue":"8","key":"10.1016\/j.ijpddr.2025.100602_bib31","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1586\/eri.09.68","article-title":"Discovery, mechanisms of action and combination therapy of artemisinin","volume":"7","author":"Cui","year":"2009","journal-title":"Expert Rev. Anti-infect. Ther."},{"issue":"10","key":"10.1016\/j.ijpddr.2025.100602_bib32","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1248\/bpb.33.1728","article-title":"Anti-hepatitis B virus activities of cinobufacini and its active components bufalin and cinobufagin in HepG2. 2.15 cells","volume":"33","author":"Cui","year":"2010","journal-title":"Biol. Pharm. Bull."},{"issue":"6","key":"10.1016\/j.ijpddr.2025.100602_bib33","doi-asserted-by":"crossref","first-page":"931","DOI":"10.4269\/ajtmh.2012.11-0552","article-title":"Use of a rhesus Plasmodium cynomolgi model to screen for anti-hypnozoite activity of pharmaceutical substances","volume":"86","author":"Deye","year":"2012","journal-title":"Am. J. Trop. Med. Hyg."},{"issue":"10","key":"10.1016\/j.ijpddr.2025.100602_bib34","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/j.drudis.2015.06.009","article-title":"Supporting malaria elimination with 21st century antimalarial agent drug discovery","volume":"20","author":"Diagana","year":"2015","journal-title":"Drug Discov. Today"},{"issue":"8","key":"10.1016\/j.ijpddr.2025.100602_bib35","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1128\/AAC.32.8.1182","article-title":"Activity of fluoroquinolone antibiotics against Plasmodium falciparum in vitro","volume":"32","author":"Divo","year":"1988","journal-title":"Antimicrob. Agents Chemother."},{"issue":"4","key":"10.1016\/j.ijpddr.2025.100602_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1002132","article-title":"Targeting the cell stress response of Plasmodium falciparum to overcome artemisinin resistance","volume":"13","author":"Dogovski","year":"2015","journal-title":"PLoS Biol."},{"issue":"12","key":"10.1016\/j.ijpddr.2025.100602_bib37","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1056\/NEJMp1108322","article-title":"The threat of artemisinin-resistant malaria","volume":"365","author":"Dondorp","year":"2011","journal-title":"N. Engl. J. Med."},{"issue":"5","key":"10.1016\/j.ijpddr.2025.100602_bib38","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1056\/NEJMoa0808859","article-title":"Artemisinin resistance in Plasmodium falciparum malaria","volume":"361","author":"Dondorp","year":"2009","journal-title":"N. Engl. J. Med."},{"issue":"19","key":"10.1016\/j.ijpddr.2025.100602_bib39","doi-asserted-by":"crossref","first-page":"10070","DOI":"10.1080\/07391102.2022.2152871","article-title":"High-throughput virtual screening approach of natural compounds as target inhibitors of plasmepsin-II","volume":"41","author":"En-Nahli","year":"2023","journal-title":"J. Biomol. Struct. Dyn."},{"issue":"4","key":"10.1016\/j.ijpddr.2025.100602_bib40","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.chom.2020.02.005","article-title":"Dual plasmepsin-targeting antimalarial agents disrupt multiple stages of the malaria parasite life cycle","volume":"27","author":"Favuzza","year":"2020","journal-title":"Cell Host Microbe"},{"issue":"10203","key":"10.1016\/j.ijpddr.2025.100602_bib41","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/S0140-6736(19)31139-0","article-title":"Malaria eradication within a generation: ambitious, achievable, and necessary","volume":"394","author":"Feachem","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.ijpddr.2025.100602_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1475-2875-10-351","article-title":"Primaquine in vivax malaria: an update and review on management issues","volume":"10","author":"Fernando","year":"2011","journal-title":"Malar. J."},{"issue":"1","key":"10.1016\/j.ijpddr.2025.100602_bib43","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0026-895X(25)14644-0","article-title":"Plasmodium berghei dihydrofolate reductase isolation, properties, and inhibition by antifolates","volume":"5","author":"Ferone","year":"1969","journal-title":"Mol. Pharmacol."},{"issue":"12","key":"10.1016\/j.ijpddr.2025.100602_bib44","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/nrmicro3138","article-title":"Antimalarial drug discovery\u2014approaches and progress towards new medicines","volume":"11","author":"Flannery","year":"2013","journal-title":"Nat. Rev. Microbiol."},{"issue":"6","key":"10.1016\/j.ijpddr.2025.100602_bib45","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1093\/jac\/dki099","article-title":"In vitro antiplasmodial activity of prenylated chalcone derivatives of hops (Humulus lupulus) and their interaction with haemin","volume":"55","author":"Fr\u00f6lich","year":"2005","journal-title":"J. Antimicrob. Chemother."},{"issue":"6","key":"10.1016\/j.ijpddr.2025.100602_bib46","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1128\/AAC.48.6.2116-2123.2004","article-title":"Evolution of resistance to sulfadoxine-pyrimethamine in Plasmodium falciparum","volume":"48","author":"Gatton","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"issue":"5","key":"10.1016\/j.ijpddr.2025.100602_bib47","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1128\/AAC.01342-07","article-title":"The antimicrobial peptide NK-2, the core region of mammalian NK-lysin, kills intraerythrocytic Plasmodium falciparum","volume":"52","author":"Gelhaus","year":"2008","journal-title":"Antimicrob. Agents Chemother."},{"issue":"6","key":"10.1016\/j.ijpddr.2025.100602_bib48","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1080\/14787210.2017.1313703","article-title":"pfmdr1 (Plasmodium falciparum multidrug drug resistance gene 1): a pivotal factor in malaria resistance to artemisinin combination therapies","volume":"15","author":"Gil","year":"2017","journal-title":"Expert Rev. Anti-infect. Ther."},{"issue":"1","key":"10.1016\/j.ijpddr.2025.100602_bib49","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.actatropica.2005.06.021","article-title":"Should chloroquine be laid to rest?","volume":"96","author":"Ginsburg","year":"2005","journal-title":"Acta Trop."},{"issue":"10","key":"10.1016\/j.ijpddr.2025.100602_bib50","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.pt.2018.07.011","article-title":"Opportunities for host-targeted therapies for malaria","volume":"34","author":"Glennon","year":"2018","journal-title":"Trends Parasitol."},{"issue":"2","key":"10.1016\/j.ijpddr.2025.100602_bib51","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/j.1365-2125.1987.tb03165.x","article-title":"Chloroquine excretion following malaria prophylaxis","volume":"24","author":"Gustafsson","year":"1987","journal-title":"Br. J. Clin. Pharmacol."},{"issue":"11","key":"10.1016\/j.ijpddr.2025.100602_bib52","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1093\/infdis\/jis602","article-title":"HIV nonnucleoside reverse transcriptase inhibitors and trimethoprim-sulfamethoxazole inhibit plasmodium liver stages","volume":"206","author":"Hobbs","year":"2012","journal-title":"J. Infect. Dis."},{"issue":"10","key":"10.1016\/j.ijpddr.2025.100602_bib53","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1021\/np200399t","article-title":"Antimalarial \u03b2-carboline and indolactam alkaloids from Marinactinospora thermotolerans, a deep sea isolate","volume":"74","author":"Huang","year":"2011","journal-title":"J. Nat. Prod."},{"issue":"18","key":"10.1016\/j.ijpddr.2025.100602_bib54","doi-asserted-by":"crossref","first-page":"4688","DOI":"10.1111\/j.1742-4658.2007.05999.x","article-title":"Drug\u2010resistant malaria\u2212 an insight","volume":"274","author":"Hyde","year":"2007","journal-title":"FEBS J."},{"issue":"1","key":"10.1016\/j.ijpddr.2025.100602_bib55","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1080\/10286020.2017.1320989","article-title":"Fusaripeptide A: new antifungal and anti-malarial cyclodepsipeptide from the endophytic fungus Fusarium sp","volume":"20","author":"Ibrahim","year":"2018","journal-title":"J. Asian Nat. Prod. Res."},{"issue":"1","key":"10.1016\/j.ijpddr.2025.100602_bib56","doi-asserted-by":"crossref","DOI":"10.1146\/annurev.mi.38.100184.002415","article-title":"Deep-sea microbiology","volume":"38","author":"Jannasch","year":"1984","journal-title":"Annu. Rev. Microbiol."},{"issue":"2","key":"10.1016\/j.ijpddr.2025.100602_bib57","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/s40203-024-00232-1","article-title":"Repurposing of drug bank compounds against Plasmodium falciparum dihydroorotate dehydrogenase as novel anti malarial drug candidates by computational approaches","volume":"12","author":"Joshi","year":"2024","journal-title":"Silico Pharmacol."},{"issue":"1","key":"10.1016\/j.ijpddr.2025.100602_bib58","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/s41418-019-0338-1","article-title":"Liver stage malaria infection is controlled by host regulators of lipid peroxidation","volume":"27","author":"Kain","year":"2020","journal-title":"Cell Death Differ."},{"issue":"1","key":"10.1016\/j.ijpddr.2025.100602_bib59","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01220-16","article-title":"Caged Garcinia xanthones, a novel chemical scaffold with potent antimalarial activity","volume":"61","author":"Ke","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"issue":"1","key":"10.1016\/j.ijpddr.2025.100602_bib60","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0035-9203(87)90311-7","article-title":"Amodiaquine fails to cure chloroquine resistant Plasmodium falciparum in the Punjab","volume":"81","author":"Khaliq","year":"1987","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"issue":"4","key":"10.1016\/j.ijpddr.2025.100602_bib61","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1021\/acs.jnatprod.9b00647","article-title":"Antimalarial 9-methoxystrobilurins, oudemansins, and related polyketides from cultures of basidiomycete Favolaschia species","volume":"83","author":"Kornsakulkarn","year":"2020","journal-title":"J. Nat. Prod."},{"issue":"6","key":"10.1016\/j.ijpddr.2025.100602_bib62","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1093\/infdis\/158.6.1368","article-title":"A comparative trial of three regimens for treating uncomplicated falciparum malaria in Acre, Brazil","volume":"158","author":"Kremsner","year":"1988","journal-title":"J. Infect. Dis."},{"issue":"1","key":"10.1016\/j.ijpddr.2025.100602_bib63","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.exppara.2009.05.002","article-title":"Antiplasmodial and antileishmanial activities of phylloseptin-1, an antimicrobial peptide from the skin secretion of Phyllomedusa azurea (Amphibia)","volume":"123","author":"K\u00fcckelhaus","year":"2009","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.ijpddr.2025.100602_bib64","first-page":"503","volume":"403","author":"Lancet","year":"2024"},{"issue":"5","key":"10.1016\/j.ijpddr.2025.100602_bib65","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1021\/acs.jmedchem.0c02022","article-title":"Novel antimalarial tetrazoles and amides active against the hemoglobin degradation pathway in Plasmodium falciparum","volume":"64","author":"Lawong","year":"2021","journal-title":"J. Med. Chem."},{"issue":"14","key":"10.1016\/j.ijpddr.2025.100602_bib66","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1002\/cmdc.202100176","article-title":"Repurposing anticancer drugs to tackle malaria","volume":"16","author":"Le Govic","year":"2021","journal-title":"ChemMedChem"},{"issue":"1","key":"10.1016\/j.ijpddr.2025.100602_bib67","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1128\/AAC.00263-07","article-title":"In vitro monitoring of Plasmodium falciparum drug resistance in French Guiana: a synopsis of continuous assessment from 1994 to 2005","volume":"52","author":"Legrand","year":"2008","journal-title":"Antimicrob. Agents Chemother."},{"issue":"7","key":"10.1016\/j.ijpddr.2025.100602_bib68","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1021\/acsinfecdis.0c00910","article-title":"Benzimidazole derivatives are potent against multiple life cycle stages of Plasmodium falciparum malaria parasites","volume":"7","author":"Leshabane","year":"2021","journal-title":"ACS Infect. Dis."},{"issue":"12","key":"10.1016\/j.ijpddr.2025.100602_bib69","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1021\/acs.jnatprod.4c00740","article-title":"Cyclopeptide avellanins D\u2013O with antimalarial activity from the mariana trench anemone-derived Hamigera ingelheimensis MSC5","volume":"87","author":"Li","year":"2024","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.ijpddr.2025.100602_bib70","article-title":"Evaluation of antimalarial properties from Azores deep-sea invertebrate extracts: a first contribution","author":"Lino","year":"2015","journal-title":"bioRxiv"},{"issue":"1","key":"10.1016\/j.ijpddr.2025.100602_bib71","doi-asserted-by":"crossref","first-page":"62","DOI":"10.4269\/ajtmh.1996.54.62","article-title":"Clinical studies of atovaquone, alone or in combination with other antimalarial drugs, for treatment of acute uncomplicated malaria in Thailand","volume":"54","author":"Looareesuwan","year":"1996","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.ijpddr.2025.100602_bib72","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.peptides.2016.01.013","article-title":"Inhibition of malaria parasite Plasmodium falciparum development by crotamine, a cell penetrating peptide from the snake venom","volume":"78","author":"Maluf","year":"2016","journal-title":"Peptides"},{"issue":"5948","key":"10.1016\/j.ijpddr.2025.100602_bib73","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1126\/science.1175667","article-title":"Chloroquine transport via the malaria parasite's chloroquine resistance transporter","volume":"325","author":"Martin","year":"2009","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.ijpddr.2025.100602_bib74","doi-asserted-by":"crossref","first-page":"245","DOI":"10.4269\/ajtmh.2007.76.245","article-title":"In vitro antimalarial drug susceptibility and pfcrt mutation among fresh Plasmodium falciparum isolates from the Lao PDR (Laos)","volume":"76","author":"Mayxay","year":"2007","journal-title":"Am. J. Trop. Med. Hyg."},{"issue":"39","key":"10.1016\/j.ijpddr.2025.100602_bib75","doi-asserted-by":"crossref","first-page":"35580","DOI":"10.1021\/acsomega.3c01309","article-title":"In silico and in vitro potential of FDA-approved drugs for antimalarial drug repurposing against plasmodium serine hydroxymethyltransferases","volume":"8","author":"Mee-Udorn","year":"2023","journal-title":"ACS Omega"},{"issue":"1","key":"10.1016\/j.ijpddr.2025.100602_bib76","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0035-9203(94)90484-7","article-title":"Diagnosis of Plasmodium falciparum infections in mummies using the rapid manual ParaSight\u2122-F test","volume":"88","author":"Miller","year":"1994","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"issue":"12","key":"10.1016\/j.ijpddr.2025.100602_bib77","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1093\/infdis\/jir664","article-title":"Limited geographical origin and global spread of sulfadoxine-resistant dhps alleles in Plasmodium falciparum populations","volume":"204","author":"Mita","year":"2011","journal-title":"J. Infect. Dis."},{"issue":"5","key":"10.1016\/j.ijpddr.2025.100602_bib78","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.chembiol.2023.04.011","article-title":"Human nuclear hormone receptor activity contributes to malaria parasite liver stage development","volume":"30","author":"Mittal","year":"2023","journal-title":"Cell Chem. Biol."},{"issue":"6220","key":"10.1016\/j.ijpddr.2025.100602_bib79","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1126\/science.1260403","article-title":"Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance","volume":"347","author":"Mok","year":"2015","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.ijpddr.2025.100602_bib80","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.chembiol.2025.05.001","article-title":"The critical role of PSAC channel in malaria parasite survival is driven home by phenotypic screening under relevant nutrient levels","volume":"32","author":"Molina","year":"2025","journal-title":"Cell Chem. Biol."},{"issue":"9469","key":"10.1016\/j.ijpddr.2025.100602_bib81","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1016\/S0140-6736(05)66417-3","article-title":"Amodiaquine alone, amodiaquine+ sulfadoxine-pyrimethamine, amodiaquine+ artesunate, and artemether-lumefantrine for outpatient treatment of malaria in Tanzanian children: a four-arm randomised effectiveness trial","volume":"365","author":"Mutabingwa","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.ijpddr.2025.100602_bib82","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.jep.2015.09.017","article-title":"Antiplasmodial potential of traditional phytotherapy of some remedies used in treatment of malaria in Meru\u2013Tharaka Nithi County of Kenya","volume":"175","author":"Muthaura","year":"2015","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.ijpddr.2025.100602_bib83","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1021\/acs.jnatprod.9b01285","article-title":"Natural products as sources of new drugs over the nearly four decades from 01\/1981 to 09\/2019","volume":"83","author":"Newman","year":"2020","journal-title":"J. Nat. Prod."},{"issue":"1","key":"10.1016\/j.ijpddr.2025.100602_bib84","doi-asserted-by":"crossref","first-page":"4568","DOI":"10.1038\/s41467-023-39914-3","article-title":"Preventing antimalarial drug resistance with triple artemisinin-based combination therapies","volume":"14","author":"Nguyen","year":"2023","journal-title":"Nat. Commun."},{"issue":"11","key":"10.1016\/j.ijpddr.2025.100602_bib85","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1086\/320707","article-title":"Evidence for different mechanisms of chloroquine resistance in 2 Plasmodium species that cause human malaria","volume":"183","author":"Nomura","year":"2001","journal-title":"J. Infect. Dis."},{"issue":"1","key":"10.1016\/j.ijpddr.2025.100602_bib86","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s11418-023-01746-2","article-title":"Ceramicines U\u2013Z from Chisocheton ceramicus and structure\u2013antimalarial activity relationship study","volume":"78","author":"Nugroho","year":"2024","journal-title":"J. Nat. Med."},{"key":"10.1016\/j.ijpddr.2025.100602_bib87","series-title":"Guidelines for the Treatment of Malaria","author":"Organization","year":"2015"},{"key":"10.1016\/j.ijpddr.2025.100602_bib88","doi-asserted-by":"crossref","DOI":"10.1051\/parasite\/2018021","article-title":"Plasmodium falciparum resistance to artemisinin-based combination therapies: a sword of Damocles in the path toward malaria elimination","volume":"25","author":"Ouji","year":"2018","journal-title":"Parasite"},{"issue":"7131","key":"10.1016\/j.ijpddr.2025.100602_bib89","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nature05572","article-title":"Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum","volume":"446","author":"Painter","year":"2007","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.ijpddr.2025.100602_bib90","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01498-21","article-title":"In vitro antimalarial activity of inhibitors of the human GTPase Rac1","volume":"66","author":"Parapini","year":"2022","journal-title":"Antimicrob. Agents Chemother."},{"issue":"5","key":"10.1016\/j.ijpddr.2025.100602_bib91","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01802-19","article-title":"Whole-cell phenotypic screening of medicines for malaria venture pathogen box identifies specific inhibitors of Plasmodium falciparum late-stage development and egress","volume":"64","author":"Patra","year":"2020","journal-title":"Antimicrob. Agents Chemother."},{"issue":"5","key":"10.1016\/j.ijpddr.2025.100602_bib92","doi-asserted-by":"crossref","first-page":"648","DOI":"10.4269\/ajtmh.1994.51.648","article-title":"A strong association between mefloquine and halofantrine resistance and amplification, overexpression, and mutation in the P-glycoprotein gene homolog (pfmdr) of Plasmodium falciparum in vitro","volume":"51","author":"Peel","year":"1994","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.ijpddr.2025.100602_bib93","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114408","article-title":"Design and synthesis of harmiquins, harmine and chloroquine hybrids as potent antiplasmodial agents","volume":"238","author":"Poje","year":"2022","journal-title":"Eur. J. Med. Chem."},{"issue":"8","key":"10.1016\/j.ijpddr.2025.100602_bib94","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.03339-23","article-title":"Bioactivity of synthetic peptides from Ecuadorian frog skin secretions against Leishmania mexicana, Plasmodium falciparum, and Trypanosoma cruzi","volume":"12","author":"Proa\u00f1o-Bola\u00f1os","year":"2024","journal-title":"Microbiol. Spectr."},{"issue":"2","key":"10.1016\/j.ijpddr.2025.100602_bib95","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.actatropica.2012.07.003","article-title":"Antiplasmodial effect of the venom of Crotalus durissus cumanensis, crotoxin complex and Crotoxin B","volume":"124","author":"Quintana","year":"2012","journal-title":"Acta Trop."},{"key":"10.1016\/j.ijpddr.2025.100602_bib96","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s10787-015-0239-y","article-title":"Therapy and pharmacological properties of hydroxychloroquine and chloroquine in treatment of systemic lupus erythematosus, rheumatoid arthritis and related diseases","volume":"23","author":"Rainsford","year":"2015","journal-title":"Inflammopharmacology"},{"issue":"5","key":"10.1016\/j.ijpddr.2025.100602_bib97","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0041-0101(00)00154-9","article-title":"Plants as source of drugs","volume":"39","author":"Rates","year":"2001","journal-title":"Toxicon"},{"issue":"6772","key":"10.1016\/j.ijpddr.2025.100602_bib98","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1038\/35002615","article-title":"Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum","volume":"403","author":"Reed","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.ijpddr.2025.100602_bib99","first-page":"1","article-title":"Emergence, transmission dynamics and mechanisms of artemisinin partial resistance in malaria parasites in Africa","author":"Rosenthal","year":"2024","journal-title":"Nat. Rev. Microbiol."},{"issue":"1","key":"10.1016\/j.ijpddr.2025.100602_bib100","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.36922\/itps.1313","article-title":"Drug repurposing approach for identifying Pfmrk inhibitors as potential antimalarial agents: an in silico analysis","volume":"7","author":"Sahu","year":"2023","journal-title":"INNOSC Theranost. Pharmacol. Sci."},{"issue":"3","key":"10.1016\/j.ijpddr.2025.100602_bib101","first-page":"316","article-title":"Identification of \u03b2-hematin inhibitors in a high-throughput screening effort reveals scaffolds with in vitro antimalarial activity","volume":"4","author":"Sandlin","year":"2014","journal-title":"Int. J. Parasitol.: Drugs Drug Resist."},{"issue":"4","key":"10.1016\/j.ijpddr.2025.100602_bib102","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1086\/507115","article-title":"Decreasing pfmdr1 copy number in Plasmodium falciparum malaria heightens susceptibility to mefloquine, lumefantrine, halofantrine, quinine, and artemisinin","volume":"194","author":"Sidhu","year":"2006","journal-title":"J. Infect. Dis."},{"issue":"5591","key":"10.1016\/j.ijpddr.2025.100602_bib103","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1126\/science.1074045","article-title":"Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations","volume":"298","author":"Sidhu","year":"2002","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.ijpddr.2025.100602_bib104","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1039\/D4MD00007B","article-title":"\u201cSeasoning\u201d antimalarial drugs' action: chloroquine bile salts as novel triple-stage antiplasmodial hits","volume":"15","author":"Silva","year":"2024","journal-title":"RSC Med. Chem."},{"issue":"10","key":"10.1016\/j.ijpddr.2025.100602_bib105","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/s41573-023-00772-9","article-title":"Antimalarial drug discovery: progress and approaches","volume":"22","author":"Siqueira-Neto","year":"2023","journal-title":"Nat. Rev. Drug Discov."},{"issue":"1","key":"10.1016\/j.ijpddr.2025.100602_bib106","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/s42003-019-0397-3","article-title":"Cyclization-blocked proguanil as a strategy to improve the antimalarial activity of atovaquone","volume":"2","author":"Skinner-Adams","year":"2019","journal-title":"Commun. Biol."},{"issue":"8","key":"10.1016\/j.ijpddr.2025.100602_bib107","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1039\/C3NP70118B","article-title":"Recent advances in deep-sea natural products","volume":"31","author":"Skropeta","year":"2014","journal-title":"Nat. Prod. Rep."},{"issue":"3","key":"10.1016\/j.ijpddr.2025.100602_bib108","first-page":"534","article-title":"Red cells from ferrochelatase-deficient erythropoietic protoporphyria patients are resistant to growth of malarial parasites","volume":"125","author":"Smith","year":"2015","journal-title":"Blood,J. Am. Soc. Hematol."},{"issue":"6220","key":"10.1016\/j.ijpddr.2025.100602_bib109","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1126\/science.1260867","article-title":"K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates","volume":"347","author":"Straimer","year":"2015","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.ijpddr.2025.100602_bib110","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/clpt.2012.236","article-title":"Phenotypic vs. target\u2010based drug discovery for first\u2010in\u2010class medicines","volume":"93","author":"Swinney","year":"2013","journal-title":"Clin. Pharmacol. Therapeut."},{"key":"10.1016\/j.ijpddr.2025.100602_bib111","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12936-020-03269-7","article-title":"In silico and in vivo anti-malarial investigation on 1-(heteroaryl)-2-((5-nitroheteroaryl) methylene) hydrazine derivatives","volume":"19","author":"Tahghighi","year":"2020","journal-title":"Malar. J."},{"issue":"10","key":"10.1016\/j.ijpddr.2025.100602_bib112","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1021\/np0701069","article-title":"Antimalarial benzoquinones from an endophytic fungus, Xylaria sp","volume":"70","author":"Tansuwan","year":"2007","journal-title":"J. Nat. Prod."},{"issue":"1","key":"10.1016\/j.ijpddr.2025.100602_bib113","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.toxicon.2008.05.008","article-title":"Antileishmanial and antitrypanosomal activity of bufadienolides isolated from the toad Rhinella jimi parotoid macrogland secretion","volume":"52","author":"Tempone","year":"2008","journal-title":"Toxicon"},{"issue":"9","key":"10.1016\/j.ijpddr.2025.100602_bib114","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.pt.2016.05.010","article-title":"Artemisinin action and resistance in Plasmodium falciparum","volume":"32","author":"Tilley","year":"2016","journal-title":"Trends Parasitol."},{"issue":"5529","key":"10.1016\/j.ijpddr.2025.100602_bib115","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1126\/science.1061573","article-title":"Haplotype diversity and linkage disequilibrium at human G6PD: recent origin of alleles that confer malarial resistance","volume":"293","author":"Tishkoff","year":"2001","journal-title":"Science"},{"issue":"14","key":"10.1016\/j.ijpddr.2025.100602_bib116","doi-asserted-by":"crossref","first-page":"3807","DOI":"10.1093\/emboj\/17.14.3807","article-title":"Allelic exchange at the endogenous genomic locus in Plasmodium falciparum proves the role of dihydropteroate synthase in sulfadoxine-resistant malaria","volume":"17","author":"Triglia","year":"1998","journal-title":"EMBO J."},{"issue":"1","key":"10.1016\/j.ijpddr.2025.100602_bib117","doi-asserted-by":"crossref","first-page":"7485","DOI":"10.1038\/s41467-024-51846-0","article-title":"The artemisinin-induced dormant stages of Plasmodium falciparum exhibit hallmarks of cellular quiescence\/senescence and drug resilience","volume":"15","author":"Tripathi","year":"2024","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.ijpddr.2025.100602_bib118","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1128\/AAC.05540-11","article-title":"Phenotypic and genotypic analysis of in vitro-selected artemisinin-resistant progeny of Plasmodium falciparum","volume":"56","author":"Tucker","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ijpddr.2025.100602_bib119","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.850176","article-title":"Target-based virtual screening of natural compounds identifies a potent antimalarial with selective falcipain-2 inhibitory activity","volume":"13","author":"Uddin","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.ijpddr.2025.100602_bib120","article-title":"Study of the antimalarial activity of the leaf extracts and fractions of Persea americana and Dacryodes edulis and their HPLC analysis","volume":"2021","author":"Uzor","year":"2021","journal-title":"Evid. base Compl. Alternative Med."},{"issue":"5","key":"10.1016\/j.ijpddr.2025.100602_bib121","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1054\/drup.2000.0157","article-title":"Atovaquone resistance in malaria parasites","volume":"3","author":"Vaidya","year":"2000","journal-title":"Drug Resist. Updates"},{"issue":"7","key":"10.1016\/j.ijpddr.2025.100602_bib122","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.chembiol.2020.04.001","article-title":"Inhibition of resistance-refractory P. falciparum kinase PKG delivers prophylactic, blood stage, and transmission-blocking antiplasmodial activity","volume":"27","author":"Vanaerschot","year":"2020","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.ijpddr.2025.100602_bib123","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12936-018-2195-7","article-title":"Adjunctive therapy for severe malaria: a review and critical appraisal","volume":"17","author":"Varo","year":"2018","journal-title":"Malar. J."},{"issue":"4","key":"10.1016\/j.ijpddr.2025.100602_bib124","doi-asserted-by":"crossref","first-page":"833","DOI":"10.4269\/ajtmh.14-0031","article-title":"Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine","volume":"91","author":"Venkatesan","year":"2014","journal-title":"Am. J. Trop. Med. Hyg."},{"issue":"24","key":"10.1016\/j.ijpddr.2025.100602_bib125","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.127441","article-title":"Targeting liver stage malaria with metformin","volume":"4","author":"Vera","year":"2019","journal-title":"JCI insight"},{"issue":"10","key":"10.1016\/j.ijpddr.2025.100602_bib126","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1002\/jcb.29954","article-title":"An integrated virtual screening and drug repurposing strategy for the discovery of new antimalarial drugs against Plasmodium falciparum phosphatidylinositol 3\u2010kinase","volume":"122","author":"Verma","year":"2021","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.ijpddr.2025.100602_bib127","first-page":"1383","article-title":"Chemotherapy of malaria","volume":"12","author":"Vinetz","year":"2011","journal-title":"Pharmacol. Basis Therapeut."},{"issue":"11","key":"10.1016\/j.ijpddr.2025.100602_bib128","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110923","article-title":"Human peroxiredoxin 6 is essential for malaria parasites and provides a host-based drug target","volume":"39","author":"Wagner","year":"2022","journal-title":"Cell Rep."},{"issue":"5","key":"10.1016\/j.ijpddr.2025.100602_bib129","doi-asserted-by":"crossref","first-page":"4156","DOI":"10.1021\/acs.jmedchem.1c01993","article-title":"Drug repurposing of quisinostat to discover novel Plasmodium falciparum HDAC1 inhibitors with enhanced triple-stage antimalarial activity and improved safety","volume":"65","author":"Wang","year":"2022","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ijpddr.2025.100602_bib130","first-page":"1","article-title":"Macrolides rapidly inhibit red blood cell invasion by the human malaria parasite","volume":"13","author":"Wilson","year":"2015","journal-title":"Plasmod. Falcipar. BMC Biol."},{"issue":"2","key":"10.1016\/j.ijpddr.2025.100602_bib131","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1128\/AAC.01868-12","article-title":"Reduced artemisinin susceptibility of Plasmodium falciparum ring stages in western Cambodia","volume":"57","author":"Witkowski","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ijpddr.2025.100602_bib132","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111275","article-title":"Repurposing of existing therapeutics to combat drug-resistant malaria","volume":"136","author":"Yadav","year":"2021","journal-title":"Biomed. Pharmacother."}],"container-title":["International Journal for Parasitology: Drugs and Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211320725000259?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211320725000259?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T07:56:30Z","timestamp":1754985390000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211320725000259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":132,"alternative-id":["S2211320725000259"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpddr.2025.100602","relation":{},"ISSN":["2211-3207"],"issn-type":[{"value":"2211-3207","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antimalarial drug resistance and drug discovery: learning from the past to innovate the future","name":"articletitle","label":"Article Title"},{"value":"International Journal for Parasitology: Drugs and Drug Resistance","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijpddr.2025.100602","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd on behalf of Australian Society for Parasitology.","name":"copyright","label":"Copyright"}],"article-number":"100602"}}