{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T07:34:40Z","timestamp":1780990480254,"version":"3.54.1"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Pharmaceutics"],"published-print":{"date-parts":[[2011,7]]},"DOI":"10.1016\/j.ijpharm.2011.06.051","type":"journal-article","created":{"date-parts":[[2011,7,8]],"date-time":"2011-07-08T19:17:07Z","timestamp":1310152627000},"source":"Crossref","is-referenced-by-count":3,"title":["Combining formulation and process aspects for optimizing the high-shear wet granulation of common drugs"],"prefix":"10.1016","author":[{"given":"Mauro","family":"Cavinato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Andreato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Bresciani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Pignatone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Bellazzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Franceschinis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Realdon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Canu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea C.","family":"Santomaso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijpharm.2011.06.051_bib0130","series-title":"Particle size measurement. Volume 1","author":"Allen","year":"1997"},{"key":"10.1016\/j.ijpharm.2011.06.051_bib0005","first-page":"196","article-title":"Granulation of powders","volume":"220","author":"Barlow","year":"1968","journal-title":"Chem. Eng. (Lond.)"},{"key":"10.1016\/j.ijpharm.2011.06.051_bib0010","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.ijpharm.2003.12.005","article-title":"Power consumption measurement and temperature recording during granulation","volume":"272","author":"Betz","year":"2004","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijpharm.2011.06.051_bib0015","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1205\/cherd06205","article-title":"Effect of drug active substance particles on wet granulation process","volume":"85","author":"Belohlav","year":"2007","journal-title":"Chem. Eng. Res. Des."},{"key":"10.1016\/j.ijpharm.2011.06.051_bib0020","first-page":"375","article-title":"Determination of the uncritical quantity of granulating liquid by power measurements on planetary mixers","volume":"41","author":"Bier","year":"1979","journal-title":"Pharm. Ind."},{"key":"10.1016\/j.ijpharm.2011.06.051_bib0025","article-title":"Closing the gap in series scale up of high shear wet granulation process using impeller power and blade design","author":"Campbell","year":"2010","journal-title":"Powder Technol."},{"key":"10.1016\/j.ijpharm.2011.06.051_bib0030","first-page":"116","article-title":"Granule formation by the agglomeration of damp powders: part I. The mechanism of granule growth","volume":"43","author":"Capes","year":"1965","journal-title":"Trans. Inst. Chem. Eng."},{"key":"10.1016\/j.ijpharm.2011.06.051_bib0035","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ijpharm.2009.11.032","article-title":"Formulation design for optimal high-shear wet granulation using on-line torque measurements","volume":"387","author":"Cavinato","year":"2010","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijpharm.2011.06.051_bib0040","series-title":"Handbook of Pharmaceutical Granulation Technology","article-title":"High-shear granulation","author":"Gokhale","year":"2006"},{"key":"10.1016\/j.ijpharm.2011.06.051_bib0045","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1006\/jcis.2002.8527","article-title":"Drop penetration into porous powder beds","volume":"253","author":"Hapgood","year":"2002","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.ijpharm.2011.06.051_bib0050","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1002\/aic.690490207","article-title":"Nucleation regime map for liquid bound granules","volume":"49","author":"Hapgood","year":"2003","journal-title":"AIChE J."},{"key":"10.1016\/j.ijpharm.2011.06.051_bib0055","unstructured":"Imanidis, G., 1986. Untersuchungen \u00fcber die Agglomerierkinetik und die elektrische Leistungsaufnahme beim Granulierprozess im Schnellmischer. Doctoral Thesis. University of Basel, Switzerland."},{"key":"10.1016\/j.ijpharm.2011.06.051_bib0060","article-title":"Bestimmung der optimalen Menge Granulierfl\u00fcssigkeit durch Messung der elektrischen Leistungsaufnahme eines Planetenmischers","volume":"41\u201344","author":"Leuenberger","year":"1979","journal-title":"Acta Pharm. Technol."},{"key":"10.1016\/j.ijpharm.2011.06.051_bib0065","first-page":"13","article-title":"Determination of the liquid requirement for a conventional granulation process","volume":"4","author":"Leuenberger","year":"1981","journal-title":"Ger. Chem. Eng."},{"key":"10.1016\/j.ijpharm.2011.06.051_bib0070","first-page":"72","article-title":"Granulation, newtechniques","volume":"57","author":"Leuenberger","year":"1982","journal-title":"Pharm. Acta Helv."},{"key":"10.1016\/j.ijpharm.2011.06.051_bib0075","first-page":"281","article-title":"Steuerung der Granulatherstellung im Mischer durch Leistungsmessung","volume":"XXXVI","author":"Leuenberger","year":"1984","journal-title":"Chem. Ind."},{"key":"10.1016\/j.ijpharm.2011.06.051_bib0085","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S0032-5910(00)00259-X","article-title":"Liquid distribution in wet granulation: dimensionless spray flux","volume":"114","author":"Litster","year":"2001","journal-title":"Powder Technol."},{"key":"10.1016\/j.ijpharm.2011.06.051_bib0090","series-title":"The Science and Engineering of Granulation Processes","author":"Litster","year":"2004"},{"key":"10.1016\/j.ijpharm.2011.06.051_bib0095","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S0032-5910(99)00203-X","article-title":"Effect of primary particle size on granule growth and endpoint determination in high-shear wet granulation","volume":"108","author":"Mackaplow","year":"2000","journal-title":"Powder Technol."},{"key":"10.1016\/j.ijpharm.2011.06.051_bib0100","first-page":"422","article-title":"A contribution to the theory and practice of granulation","volume":"36","author":"Newitt","year":"1958","journal-title":"Chem. Eng. Res. Des."},{"key":"10.1016\/j.ijpharm.2011.06.051_bib0135","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.cej.2010.05.008","article-title":"Effect of formulation hydrophobicity on drug distribution in wet granulation","volume":"164","author":"Nguyen","year":"2010","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.ijpharm.2011.06.051_bib0110","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.powtec.2008.04.034","article-title":"Influence of material properties on the agglomeration of water-soluble amorphous particles","volume":"189","author":"Palzer","year":"2009","journal-title":"Powder Technol."},{"key":"10.1016\/j.ijpharm.2011.06.051_bib0115","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.tifs.2009.08.005","article-title":"The relation between material properties and supra-molecular structure of water-soluble food solids","volume":"21","author":"Palzer","year":"2010","journal-title":"Trends Food Sci. Technol."},{"key":"10.1016\/j.ijpharm.2011.06.051_bib0120","article-title":"Agglomeration of pharmaceutical, detergent, chemical and food powders\u2014similarities and differences of materials and processes","author":"Palzer","year":"2010","journal-title":"Powder Technol."},{"key":"10.1016\/j.ijpharm.2011.06.051_bib0125","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1016\/j.ces.2007.11.018","article-title":"Growth kinetics and mechanism of wet granulation in a laboratory-scale high shear mixer: effect of initial polydispersity of particle size","volume":"63","author":"Realpe","year":"2008","journal-title":"Chem. Eng. Sci."}],"container-title":["International Journal of Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378517311006296?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378517311006296?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T16:22:10Z","timestamp":1543681330000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378517311006296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7]]},"references-count":25,"alternative-id":["S0378517311006296"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpharm.2011.06.051","relation":{},"ISSN":["0378-5173"],"issn-type":[{"value":"0378-5173","type":"print"}],"subject":[],"published":{"date-parts":[[2011,7]]}}}