{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:54:20Z","timestamp":1787727260153,"version":"build-2784847793"},"reference-count":41,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Pharmaceutics"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1016\/j.ijpharm.2012.12.044","type":"journal-article","created":{"date-parts":[[2013,1,8]],"date-time":"2013-01-08T21:45:11Z","timestamp":1357681511000},"page":"39-49","source":"Crossref","is-referenced-by-count":69,"title":["Red blood cells as innovative antigen carrier to induce specific immune tolerance"],"prefix":"10.1016","volume":"443","author":[{"given":"Magali","family":"Cremel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Gu\u00e9rin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Horand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Banz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yann","family":"Godfrin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijpharm.2012.12.044_bib0005","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.4049\/jimmunol.161.7.3347","article-title":"Expression and function of CTLA-4 in Th1 and Th2 cells","volume":"161","author":"Alegre","year":"1998","journal-title":"J. Immunol."},{"issue":"Suppl. 1","key":"10.1016\/j.ijpharm.2012.12.044_bib0010","first-page":"S6","article-title":"Immune tolerance induction in patients with hemophilia A","volume":"127","author":"Astermark","year":"2010","journal-title":"Thromb. Res."},{"key":"10.1016\/j.ijpharm.2012.12.044_bib0015","doi-asserted-by":"crossref","first-page":"2965","DOI":"10.1016\/j.vaccine.2010.02.013","article-title":"In situ targeting of dendritic cells by antigen-loaded red blood cells: a novel approach to cancer immunotherapy","volume":"28","author":"Banz","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.ijpharm.2012.12.044_bib0020","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/S0764-4469(97)85017-2","article-title":"Molecular mechanisms of erythrophagocytosis. Characterization of the senescent erythrocytes that are phagocytized by macrophages","volume":"320","author":"Bratosin","year":"1997","journal-title":"C. R. Acad. Sci. III"},{"key":"10.1016\/j.ijpharm.2012.12.044_bib0025","doi-asserted-by":"crossref","first-page":"327","DOI":"10.4049\/jimmunol.180.1.327","article-title":"Antigen-driven interactions with dendritic cells and expansion of Foxp3+ regulatory T cells occur in the absence of inflammatory signals","volume":"180","author":"Chappert","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijpharm.2012.12.044_bib0030","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/BF00926740","article-title":"Modulated red blood cell survival by membrane protein clustering","volume":"144","author":"Chiarantini","year":"1995","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.ijpharm.2012.12.044_bib0035","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.yexcr.2005.07.002","article-title":"A physiological model to study iron recycling in macrophages","volume":"310","author":"Delaby","year":"2005","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.ijpharm.2012.12.044_bib0040","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jneuroim.2012.03.021","article-title":"Intravenous tolerance effectively overcomes enhanced pro-inflammatory responses and experimental autoimmune encephalomyelitis severity in the absence of IL-12 receptor signaling","volume":"247","author":"Fitzgerald","year":"2012","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.ijpharm.2012.12.044_bib0045","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1182\/blood-2009-10-250472","article-title":"Crucial roles of B7-H1 and B7-DC expressed on mesenteric lymph node dendritic cells in the generation of antigen-specific CD4+Foxp3+ regulatory T cells in the establishment of oral tolerance","volume":"116","author":"Fukaya","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.ijpharm.2012.12.044_bib0050","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1517\/14712598.2012.631909","article-title":"Meeting highlights: international seminar on the red blood cells as vehicles for drugs","volume":"12","author":"Godfrin","year":"2012","journal-title":"Expert Opin. Biol. Ther."},{"key":"10.1016\/j.ijpharm.2012.12.044_bib0055","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1046\/j.1365-2567.1999.00778.x","article-title":"Intravenous tolerization with type II collagen induces interleukin-4-and interleukin-10-producing CD4+ T cells","volume":"97","author":"Gumanovskaya","year":"1999","journal-title":"Immunology"},{"key":"10.1016\/j.ijpharm.2012.12.044_bib0060","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.0105-2896.2004.00142.x","article-title":"Cross-presentation, dendritic cell subsets, and the generation of immunity to cellular antigens","volume":"199","author":"Heath","year":"2004","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.ijpharm.2012.12.044_bib0065","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1006\/exmp.1999.2290","article-title":"Mechanisms of suppression of experimental autoimmune encephalomyelitis by intravenous administration of myelin basic protein: role of regulatory spleen cells","volume":"68","author":"Hilliard","year":"2000","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.ijpharm.2012.12.044_bib0070","doi-asserted-by":"crossref","first-page":"441","DOI":"10.4049\/jimmunol.176.1.441","article-title":"Interaction of mouse dendritic cells and malaria-infected erythrocytes: uptake, maturation, and antigen presentation","volume":"176","author":"Ing","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijpharm.2012.12.044_bib0075","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1042\/BA20010045","article-title":"In vitro phagocytosis of carrier mouse red blood cells is increased by Band 3 cross-linking or diamide treatment","volume":"34","author":"Jordan","year":"2001","journal-title":"Biotechnol. Appl. Biochem."},{"key":"10.1016\/j.ijpharm.2012.12.044_bib0080","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0304-4165(96)00040-2","article-title":"Targeting of mouse erythrocytes by band 3 crosslinkers","volume":"1291","author":"Jordan","year":"1996","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ijpharm.2012.12.044_bib0085","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0300-9084(97)87625-0","article-title":"In vitro properties and organ uptake of rat band 3 cross-linked erythrocytes","volume":"79","author":"Jordan","year":"1997","journal-title":"Biochimie"},{"key":"10.1016\/j.ijpharm.2012.12.044_bib0090","doi-asserted-by":"crossref","first-page":"3521","DOI":"10.1073\/pnas.72.9.3521","article-title":"Mechanism of removal of senescent cells by human macrophages in situ","volume":"72","author":"Kay","year":"1975","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ijpharm.2012.12.044_bib0095","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1111\/j.1537-2995.2007.01348.x","article-title":"Reduced expression of CD47 during murine red blood cell (RBC) senescence and its role in RBC clearance from the circulation","volume":"47","author":"Khandelwal","year":"2007","journal-title":"Transfusion (Paris)"},{"key":"10.1016\/j.ijpharm.2012.12.044_bib0100","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/j.1365-2567.2011.03457.x","article-title":"Complexity of dendritic cell subsets and their function in the host immune system","volume":"133","author":"Kushwah","year":"2011","journal-title":"Immunology"},{"key":"10.1016\/j.ijpharm.2012.12.044_bib0105","doi-asserted-by":"crossref","first-page":"5215","DOI":"10.1182\/blood-2010-10-313239","article-title":"Mechanism for phosphatidylserine-dependent erythrophagocytosis in mouse liver","volume":"117","author":"Lee","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.ijpharm.2012.12.044_bib0110","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.4049\/jimmunol.181.4.2483","article-title":"CD11c+CD11b+ dendritic cells play an important role in intravenous tolerance and the suppression of experimental autoimmune encephalomyelitis","volume":"181","author":"Li","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijpharm.2012.12.044_bib0115","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.1073\/pnas.93.7.3031","article-title":"Intravenous injection of soluble antigen induces thymic and peripheral T-cells apoptosis","volume":"93","author":"Liblau","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ijpharm.2012.12.044_bib0120","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1046\/j.1440-1711.2002.01115.x","article-title":"Immature, but not inactive: the tolerogenic function of immature dendritic cells","volume":"80","author":"Mahnke","year":"2002","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.ijpharm.2012.12.044_bib0125","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jaut.2009.03.010","article-title":"Naturally-existing CD4(+)CD25(+)Foxp3(+) regulatory T cells are required for tolerance to experimental autoimmune thyroiditis induced by either exogenous or endogenous autoantigen","volume":"33","author":"Morris","year":"2009","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.ijpharm.2012.12.044_bib0130","doi-asserted-by":"crossref","first-page":"6129","DOI":"10.1016\/j.vaccine.2006.05.013","article-title":"The mouse immune response to carrier erythrocyte entrapped antigens","volume":"24","author":"Murray","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.ijpharm.2012.12.044_bib0135","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/j.0105-2896.2006.00419.x","article-title":"The role of CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA-4) in regulatory T-cell biology","volume":"212","author":"Sansom","year":"2006","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.ijpharm.2012.12.044_bib0140","first-page":"2641","article-title":"Immunomodulation of experimental autoimmune uveoretinitis by intravenous injection of uveitogenic peptides","volume":"33","author":"Sasamoto","year":"1992","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.ijpharm.2012.12.044_bib0145","first-page":"560","article-title":"The immunogenicity of therapeutic proteins","volume":"9","author":"Schellekens","year":"2010","journal-title":"Discov. Med."},{"key":"10.1016\/j.ijpharm.2012.12.044_bib0150","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1073\/pnas.0910620107","article-title":"FoxP3+ regulatory T cells essentially contribute to peripheral CD8+ T-cell tolerance induced by steady-state dendritic cells","volume":"107","author":"Schildknecht","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ijpharm.2012.12.044_bib0155","doi-asserted-by":"crossref","first-page":"5131","DOI":"10.1016\/S0021-9258(18)89189-X","article-title":"In vivo recognition and clearance of red blood cells containing phosphatidylserine in their plasma membranes","volume":"260","author":"Schroit","year":"1985","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijpharm.2012.12.044_bib0160","doi-asserted-by":"crossref","first-page":"5498","DOI":"10.1073\/pnas.83.15.5498","article-title":"Erythrocyte homeostasis: antibody-mediated recognition of the senescent state by macrophages","volume":"83","author":"Singer","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ijpharm.2012.12.044_bib0165","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1046\/j.1365-2567.1998.00554.x","article-title":"Bolus injection of aqueous antigen leads to a high density of T-cell-receptor ligand in the spleen, transient T-cell activation and anergy induction","volume":"94","author":"Switzer","year":"1998","journal-title":"Immunology"},{"key":"10.1016\/j.ijpharm.2012.12.044_bib0170","doi-asserted-by":"crossref","first-page":"23611","DOI":"10.1016\/S0021-9258(18)54327-1","article-title":"Clustering of integral membrane proteins of the human erythrocyte membrane stimulates autologous IgG binding, complement deposition, and phagocytosis","volume":"266","author":"Turrini","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijpharm.2012.12.044_bib0175","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.4049\/jimmunol.178.4.2579","article-title":"Deficient CD4+CD25high T regulatory cell function in patients with active systemic lupus erythematosus","volume":"178","author":"Valencia","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijpharm.2012.12.044_bib0180","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1111\/j.1365-2567.2007.02592.x","article-title":"Tolerization of an established alphaB-crystallin-reactive T-cell response by intravenous antigen","volume":"121","author":"Verbeek","year":"2007","journal-title":"Immunology"},{"key":"10.1016\/j.ijpharm.2012.12.044_bib0185","first-page":"183","article-title":"Induction of immunological tolerance by oral, but not intravenous and intraportal,administration of ovalbumin and the difference between young and old mice","volume":"10","author":"Wakabayashi","year":"2006","journal-title":"J. Nutr. Health Aging"},{"key":"10.1016\/j.ijpharm.2012.12.044_bib0190","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1126\/science.1160062","article-title":"CTLA-4 control over Foxp3+ regulatory T cell function","volume":"322","author":"Wing","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.ijpharm.2012.12.044_bib0195","doi-asserted-by":"crossref","first-page":"6923","DOI":"10.4049\/jimmunol.181.10.6923","article-title":"CD8+ CD205+ splenic dendritic cells are specialized to induce Foxp3+ regulatory T cells","volume":"181","author":"Yamazaki","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijpharm.2012.12.044_bib0200","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1002\/hep.22395","article-title":"Mechanism of T cell tolerance induction by murine hepatic Kupffer cells","volume":"48","author":"You","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.ijpharm.2012.12.044_bib0205","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1073\/pnas.86.6.2040","article-title":"Encapsulation of doxorubicin in liver-targeted erythrocytes increases the therapeutic index of the drug in a murine metastatic model","volume":"86","author":"Zocchi","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U.S.A."}],"container-title":["International Journal of Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378517313000082?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378517313000082?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T14:25:58Z","timestamp":1687962358000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378517313000082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":41,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["S0378517313000082"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpharm.2012.12.044","relation":{},"ISSN":["0378-5173"],"issn-type":[{"value":"0378-5173","type":"print"}],"subject":[],"published":{"date-parts":[[2013,2]]}}}