{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T23:21:37Z","timestamp":1785799297357,"version":"3.56.0"},"reference-count":95,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012131","name":"Department of Science and Technology of Liaoning Province","doi-asserted-by":"publisher","award":["2021JH2\/10300067"],"award-info":[{"award-number":["2021JH2\/10300067"]}],"id":[{"id":"10.13039\/501100012131","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013099","name":"Scientific Research Fund of Liaoning Provincial Education Department","doi-asserted-by":"publisher","award":["LJKZ0099"],"award-info":[{"award-number":["LJKZ0099"]}],"id":[{"id":"10.13039\/501100013099","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007620","name":"Department of Education of Liaoning Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007620","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010018","name":"Doctoral Start-up Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["2023-BS-086"],"award-info":[{"award-number":["2023-BS-086"]}],"id":[{"id":"10.13039\/501100010018","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Pharmaceutics"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.ijpharm.2023.123729","type":"journal-article","created":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T21:44:56Z","timestamp":1703195096000},"page":"123729","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Repolarizing Tumor-Associated Macrophages and inducing immunogenic cell Death: A targeted liposomal strategy to boost cancer immunotherapy"],"prefix":"10.1016","volume":"651","author":[{"given":"Cong","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianrui","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijpharm.2023.123729_b0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.soncn.2019.08.002","article-title":"Cancer and the Immune System: The History and Background of Immunotherapy","volume":"35","author":"Abbott","year":"2019","journal-title":"Semin. Oncol. Nurs."},{"key":"10.1016\/j.ijpharm.2023.123729_b0010","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics15010294","article-title":"Insights into Asymmetric Liposomes as a Potential Intervention for Drug Delivery Including Pulmonary Nanotherapeutics","volume":"15","author":"Al Badri","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ijpharm.2023.123729_b0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2022.114482","article-title":"Engineering nanosystems to overcome barriers to cancer diagnosis and treatment","volume":"189","author":"Alhaj-Suliman","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ijpharm.2023.123729_b0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.critrevonc.2007.07.004","article-title":"The inflammatory micro-environment in tumor progression: the role of tumor-associated macrophages","volume":"66","author":"Allavena","year":"2008","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.ijpharm.2023.123729_b0025","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s12929-018-0426-4","article-title":"Cancer stem cells as key drivers of tumour progression","volume":"25","author":"Ayob","year":"2018","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.ijpharm.2023.123729_b0030","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22136995","article-title":"Macrophage Polarization States in the Tumor Microenvironment","volume":"22","author":"Boutilier","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ijpharm.2023.123729_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106556","article-title":"Induction of immunogenic cell death by novel platinum-based anticancer agents","volume":"187","author":"Chang","year":"2023","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ijpharm.2023.123729_b0040","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/S0005-2736(02)00661-2","article-title":"Rate of biodistribution of STEALTH liposomes to tumor and skin: influence of liposome diameter and implications for toxicity and therapeutic activity","volume":"1609","author":"Charrois","year":"2003","journal-title":"BBA"},{"key":"10.1016\/j.ijpharm.2023.123729_b0045","doi-asserted-by":"crossref","first-page":"5506","DOI":"10.1039\/C9CS00271E","article-title":"Local biomaterials-assisted cancer immunotherapy to trigger systemic antitumor responses","volume":"48","author":"Chen","year":"2019","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.ijpharm.2023.123729_b0050","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s12929-019-0568-z","article-title":"Tumor-associated macrophages: an accomplice in solid tumor progression","volume":"26","author":"Chen","year":"2019","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.ijpharm.2023.123729_b0055","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s12032-022-01670-7","article-title":"Tumor-associated macrophages of the M1\/M2 phenotype are involved in the regulation of malignant biological behavior of breast cancer cells through the EMT pathway","volume":"39","author":"Chen","year":"2022","journal-title":"Med. Oncol."},{"key":"10.1016\/j.ijpharm.2023.123729_b0060","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1186\/s12951-021-01202-x","article-title":"Cancer cell membrane-coated nanoparticles for bimodal imaging-guided photothermal therapy and docetaxel-enhanced immunotherapy against cancer","volume":"19","author":"Chen","year":"2021","journal-title":"J Nanobiotechnology"},{"key":"10.1016\/j.ijpharm.2023.123729_b0065","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.semcancer.2022.01.006","article-title":"Surgery-mediated tumor-promoting effects on the immune microenvironment","volume":"86","author":"Cheng","year":"2022","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.ijpharm.2023.123729_b0070","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1634\/theoncologist.8-6-514","article-title":"Goals and objectives in the management of metastatic breast cancer","volume":"8","author":"Chung","year":"2003","journal-title":"Oncologist"},{"key":"10.1016\/j.ijpharm.2023.123729_b0075","doi-asserted-by":"crossref","first-page":"381","DOI":"10.3109\/21691401.2014.953633","article-title":"Application of liposomes in medicine and drug delivery","volume":"44","author":"Daraee","year":"2016","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"10.1016\/j.ijpharm.2023.123729_b0080","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1021\/acsami.6b13738","article-title":"Coadministration of Oligomeric Hyaluronic Acid-Modified Liposomes with Tumor-Penetrating Peptide-iRGD Enhances the Antitumor Efficacy of Doxorubicin against Melanoma","volume":"9","author":"Deng","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.ijpharm.2023.123729_b0085","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1002\/anie.201804882","article-title":"Nanoparticle-Mediated Immunogenic Cell Death Enables and Potentiates Cancer Immunotherapy","volume":"58","author":"Duan","year":"2019","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.ijpharm.2023.123729_b0090","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.canlet.2014.05.008","article-title":"Tumor-associated macrophages promote cancer stem cell-like properties via transforming growth factor-beta1-induced epithelial-mesenchymal transition in hepatocellular carcinoma","volume":"352","author":"Fan","year":"2014","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ijpharm.2023.123729_b0095","doi-asserted-by":"crossref","first-page":"8509","DOI":"10.1002\/jcp.27782","article-title":"CD8(+) cytotoxic T lymphocytes in cancer immunotherapy: A review","volume":"234","author":"Farhood","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ijpharm.2023.123729_b0100","doi-asserted-by":"crossref","DOI":"10.3390\/polym15061490","article-title":"Metal-Organic Frameworks Applications in Synergistic Cancer Photo-Immunotherapy","volume":"15","author":"Fernandes","year":"2023","journal-title":"Polymers (basel)"},{"key":"10.1016\/j.ijpharm.2023.123729_b0105","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1016\/j.cclet.2021.10.074","article-title":"Applying nanotechnology to boost cancer immunotherapy by promoting immunogenic cell death","volume":"33","author":"Fu","year":"2022","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.ijpharm.2023.123729_b0110","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1002\/cam4.4979","article-title":"The role of tumor neogenesis pipelines in tumor progression and their therapeutic potential","volume":"12","author":"Fu","year":"2023","journal-title":"Cancer Med."},{"key":"10.1016\/j.ijpharm.2023.123729_b0115","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jdermsci.2016.05.004","article-title":"Tumor-associated M2 macrophages in mycosis fungoides acquire immunomodulatory function by interferon alpha and interferon gamma","volume":"83","author":"Furudate","year":"2016","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.ijpharm.2023.123729_b0120","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2020.590941","article-title":"The Crosstalk Between Tumor-Associated Macrophages (TAMs) and Tumor Cells and the Corresponding Targeted Therapy","volume":"10","author":"Ge","year":"2020","journal-title":"Front. Oncol."},{"key":"10.1016\/j.ijpharm.2023.123729_b0125","doi-asserted-by":"crossref","first-page":"6520","DOI":"10.1039\/C6CS00409A","article-title":"Lipid-based nanovesicles for nanomedicine","volume":"45","author":"Grimaldi","year":"2016","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.ijpharm.2023.123729_b0130","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1530\/ERC-18-0284","article-title":"Inhibition of TAMs improves the response to docetaxel in castration-resistant prostate cancer","volume":"26","author":"Guan","year":"2019","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.ijpharm.2023.123729_b0135","article-title":"Immunologically modified enzyme-responsive micelles regulate the tumor microenvironment for cancer immunotherapy","volume":"13","author":"Han","year":"2022","journal-title":"Mater Today Bio"},{"key":"10.1016\/j.ijpharm.2023.123729_b0140","doi-asserted-by":"crossref","first-page":"20206","DOI":"10.1039\/C9NR03353J","article-title":"Multifunctional biomimetic nanoparticles loading baicalin for polarizing tumor-associated macrophages","volume":"11","author":"Han","year":"2019","journal-title":"Nanoscale"},{"key":"10.1016\/j.ijpharm.2023.123729_b0145","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/948098","article-title":"Macrophages in tumor microenvironments and the progression of tumors","volume":"2012","author":"Hao","year":"2012","journal-title":"Clin. Dev. Immunol."},{"key":"10.1016\/j.ijpharm.2023.123729_b0150","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.actbio.2018.05.024","article-title":"Self-stabilized silk sericin-based nanoparticles: In vivo biocompatibility and reduced doxorubicin-induced toxicity","volume":"74","author":"Hu","year":"2018","journal-title":"Acta Biomater."},{"key":"10.1016\/j.ijpharm.2023.123729_b0155","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jcyt.2022.10.008","article-title":"Adjuvant cytokine-induced killer cell immunotherapy improves long-term survival in patients with stage I-II non-small cell lung cancer after curative surgery","volume":"25","author":"Huang","year":"2023","journal-title":"Cytotherapy"},{"key":"10.1016\/j.ijpharm.2023.123729_b0160","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.1158\/0008-5472.CAN-14-3587","article-title":"Perivascular M2 Macrophages Stimulate Tumor Relapse after Chemotherapy","volume":"75","author":"Hughes","year":"2015","journal-title":"Cancer Res."},{"key":"10.1016\/j.ijpharm.2023.123729_b0165","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics13091374","article-title":"Engineering Therapeutic Strategies in Cancer Immunotherapy via Exogenous Delivery of Toll-like Receptor Agonists","volume":"13","author":"Jeong","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ijpharm.2023.123729_b0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119310","article-title":"Multi-functional nanocomplex codelivery of Trp2 and R837 to activate melanoma-specific immunity","volume":"582","author":"Ji","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijpharm.2023.123729_b0175","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.actbio.2021.12.014","article-title":"Tumor microcalcification-mediated relay drug delivery for photodynamic immunotherapy of breast cancer","volume":"140","author":"Jian","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.ijpharm.2023.123729_b0180","doi-asserted-by":"crossref","first-page":"17218","DOI":"10.1039\/D1NR05512G","article-title":"Chemotherapeutic drug-induced immunogenic cell death for nanomedicine-based cancer chemo-immunotherapy","volume":"13","author":"Jiang","year":"2021","journal-title":"Nanoscale"},{"key":"10.1016\/j.ijpharm.2023.123729_b0185","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.2174\/1871520620666200804103714","article-title":"A Mini-Review on Nano Technology in the Tumour Targeting Strategies: Drug Delivery to Cancer Cells","volume":"20","author":"Kaur","year":"2020","journal-title":"Anticancer Agents Med Chem."},{"key":"10.1016\/j.ijpharm.2023.123729_b0190","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1021\/acs.molpharmaceut.8b00042","article-title":"Use of Dual-Ligand Modification in Kupffer Cell-Targeted Liposomes To Examine the Contribution of Kupffer Cells to Accelerated Blood Clearance Phenomenon","volume":"15","author":"Lai","year":"2018","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ijpharm.2023.123729_b0195","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1208\/s12249-019-1385-0","article-title":"Dual-Ligand Modification of PEGylated Liposomes Used for Targeted Doxorubicin Delivery to Enhance Anticancer Efficacy","volume":"20","author":"Li","year":"2019","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.ijpharm.2023.123729_b0200","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/s41392-021-00670-9","article-title":"Myeloid-derived suppressor cells as immunosuppressive regulators and therapeutic targets in cancer","volume":"6","author":"Li","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.ijpharm.2023.123729_b0205","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.nano.2014.11.006","article-title":"Recent advances in targeted nanoparticles drug delivery to melanoma","volume":"11","author":"Li","year":"2015","journal-title":"Nanomed."},{"key":"10.1016\/j.ijpharm.2023.123729_b0210","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.cytogfr.2022.07.004","article-title":"Correlation between PD-1\/PD-L1 expression and polarization in tumor-associated macrophages: A key player in tumor immunotherapy","volume":"67","author":"Li","year":"2022","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.ijpharm.2023.123729_b0215","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s12943-019-0961-y","article-title":"Reactive oxygen species: a volatile driver of field cancerization and metastasis","volume":"18","author":"Liao","year":"2019","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.ijpharm.2023.123729_b0220","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s13045-019-0760-3","article-title":"Tumor-associated macrophages in tumor metastasis: biological roles and clinical therapeutic applications","volume":"12","author":"Lin","year":"2019","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.ijpharm.2023.123729_b0225","doi-asserted-by":"crossref","first-page":"38506","DOI":"10.1021\/acsami.2c09462","article-title":"Self-Assembled Immunostimulatory Tetrahedral Framework Nucleic Acid Vehicles for Tumor Chemo-immunotherapy","volume":"14","author":"Liu","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.ijpharm.2023.123729_b0230","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1186\/s12967-022-03813-w","article-title":"Targeting macrophages: a novel treatment strategy in solid tumors","volume":"20","author":"Liu","year":"2022","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.ijpharm.2023.123729_b0235","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/s41571-019-0308-z","article-title":"Improving cancer immunotherapy using nanomedicines: progress, opportunities and challenges","volume":"17","author":"Martin","year":"2020","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.ijpharm.2023.123729_b0240","doi-asserted-by":"crossref","first-page":"e58","DOI":"10.1016\/S1470-2045(15)70017-3","article-title":"Immunotherapy improves overall survival in pancreatic cancer","volume":"16","author":"Mayor","year":"2015","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.ijpharm.2023.123729_b0245","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.jconrel.2022.09.009","article-title":"Tumor immunotherapy boosted by R837 nanocrystals through combining chemotherapy and mild hyperthermia","volume":"350","author":"Meng","year":"2022","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ijpharm.2023.123729_b0250","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s00262-020-02676-8","article-title":"Therapeutic potential of anti-VEGF receptor 2 therapy targeting for M2-tumor-associated macrophages in colorectal cancer","volume":"70","author":"Min","year":"2021","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.ijpharm.2023.123729_b0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.107198","article-title":"Exosome-mediated miR-33 transfer induces M1 polarization in mouse macrophages and exerts antitumor effect in 4T1 breast cancer cell line","volume":"90","author":"Moradi-Chaleshtori","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ijpharm.2023.123729_b0260","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2021-002614","article-title":"Metformin reduces PD-L1 on tumor cells and enhances the anti-tumor immune response generated by vaccine immunotherapy","volume":"9","author":"Munoz","year":"2021","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.ijpharm.2023.123729_b0265","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.583084","article-title":"Tumor-Associated Macrophages in Tumor Immunity","volume":"11","author":"Pan","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ijpharm.2023.123729_b0270","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.semcancer.2019.05.002","article-title":"Toll-like receptor-induced cytokines as immunotherapeutic targets in cancers and autoimmune diseases","volume":"64","author":"Patra","year":"2020","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.ijpharm.2023.123729_b0275","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.2147\/IJN.S285999","article-title":"Combination Cancer Immunotherapy of Nanoparticle-Based Immunogenic Cell Death Inducers and Immune Checkpoint Inhibitors","volume":"16","author":"Qi","year":"2021","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.ijpharm.2023.123729_b0280","doi-asserted-by":"crossref","first-page":"e2200027","DOI":"10.1002\/advs.202200027","article-title":"Advanced Biomaterials for Cell-Specific Modulation and Restore of Cancer Immunotherapy","volume":"9","author":"Ruan","year":"2022","journal-title":"Adv Sci (weinh)"},{"key":"10.1016\/j.ijpharm.2023.123729_b0285","doi-asserted-by":"crossref","first-page":"9050","DOI":"10.1158\/0008-5472.CAN-08-1327","article-title":"Macrophage-derived SPARC bridges tumor cell-extracellular matrix interactions toward metastasis","volume":"68","author":"Sangaletti","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.ijpharm.2023.123729_b0290","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/s41551-019-0436-x","article-title":"Engineering patient-specific cancer immunotherapies","volume":"3","author":"Scheetz","year":"2019","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.ijpharm.2023.123729_b0295","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.cyto.2017.05.024","article-title":"Cytokines in immunogenic cell death: Applications for cancer immunotherapy","volume":"97","author":"Showalter","year":"2017","journal-title":"Cytokine"},{"key":"10.1016\/j.ijpharm.2023.123729_b0300","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/ijc.30424","article-title":"Lipoxin A(4) selectively programs the profile of M2 tumor-associated macrophages which favour control of tumor progression","volume":"140","author":"Simoes","year":"2017","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.ijpharm.2023.123729_b0305","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.114955","article-title":"Specific targeting of cancer stem cells by immunotherapy: A possible stratagem to restrain cancer recurrence and metastasis","volume":"198","author":"Singh","year":"2022","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ijpharm.2023.123729_b0310","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1038\/s41467-020-15532-1","article-title":"Author Correction: A next-generation tumor-targeting IL-2 preferentially promotes tumor-infiltrating CD8(+) T-cell response and effective tumor control","volume":"11","author":"Sun","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ijpharm.2023.123729_b0315","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0168-3659(01)00368-6","article-title":"Evaluation of circulation profiles of liposomes coated with hydrophilic polymers having different molecular weights in rats","volume":"75","author":"Takeuchi","year":"2001","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ijpharm.2023.123729_b0320","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.109821","article-title":"Cancer immunotherapy: Pros, cons and beyond","volume":"124","author":"Tan","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ijpharm.2023.123729_b0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119929","article-title":"Targeted delivery of zoledronic acid through the sialic acid - Siglec axis for killing and reversal of M2 phenotypic tumor-associated macrophages - A promising cancer immunotherapy","volume":"590","author":"Tang","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijpharm.2023.123729_b0330","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121706","article-title":"MnO(2)-melittin nanoparticles serve as an effective anti-tumor immunotherapy by enhancing systemic immune response","volume":"288","author":"Tang","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.ijpharm.2023.123729_b0335","doi-asserted-by":"crossref","first-page":"e2203973","DOI":"10.1002\/advs.202203973","article-title":"Targeted xCT-mediated Ferroptosis and Protumoral Polarization of Macrophages Is Effective against HCC and Enhances the Efficacy of the Anti-PD-1\/L1 Response","volume":"10","author":"Tang","year":"2023","journal-title":"Adv. Sci. (weinh)"},{"key":"10.1016\/j.ijpharm.2023.123729_b0340","doi-asserted-by":"crossref","first-page":"3469","DOI":"10.1007\/s11033-022-07184-9","article-title":"MMP-9 secreted by M2-type macrophages promotes Wilms' tumour metastasis through the PI3K\/AKT pathway","volume":"49","author":"Tian","year":"2022","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.ijpharm.2023.123729_b0345","first-page":"92","article-title":"Peptide-based targeting of immunosuppressive cells in cancer","volume":"5","author":"Trac","year":"2020","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.ijpharm.2023.123729_b0350","doi-asserted-by":"crossref","DOI":"10.3390\/molecules24010009","article-title":"Molecular Repolarisation of Tumour-Associated Macrophages","volume":"24","author":"van Dalen","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.ijpharm.2023.123729_b0355","doi-asserted-by":"crossref","first-page":"3468","DOI":"10.1002\/jcp.25808","article-title":"M2-like macrophages induce colon cancer cell invasion via matrix metalloproteinases","volume":"232","author":"Vinnakota","year":"2017","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ijpharm.2023.123729_b0360","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1021\/mp200028w","article-title":"Bisphosphonate-derivatized liposomes to control drug release from collagen\/hydroxyapatite scaffolds","volume":"8","author":"Wang","year":"2011","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ijpharm.2023.123729_b0365","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.intimp.2014.05.011","article-title":"The novel role of thymopentin in induction of maturation of bone marrow dendritic cells (BMDCs)","volume":"21","author":"Wang","year":"2014","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ijpharm.2023.123729_b0370","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120208","article-title":"Lymph node-targeted immune-activation mediated by imiquimod-loaded mesoporous polydopamine based-nanocarriers","volume":"255","author":"Wang","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.ijpharm.2023.123729_b0375","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110978","article-title":"Reactive oxygen species in immune cells: A new antitumor target","volume":"133","author":"Wang","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ijpharm.2023.123729_b0380","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.3389\/fphar.2019.01371","article-title":"XIAOPI Formula Inhibits Breast Cancer Stem Cells via Suppressing Tumor-Associated Macrophages\/C-X-C Motif Chemokine Ligand 1 Pathway","volume":"10","author":"Wang","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ijpharm.2023.123729_b0385","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1038\/s41467-018-03915-4","article-title":"A cancer vaccine-mediated postoperative immunotherapy for recurrent and metastatic tumors","volume":"9","author":"Wang","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ijpharm.2023.123729_b0390","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s00018-020-03581-0","article-title":"Metabolic crosstalk in the tumor microenvironment regulates antitumor immunosuppression and immunotherapy resisitance","volume":"78","author":"Wei","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.ijpharm.2023.123729_b0395","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/s41467-020-20723-x","article-title":"Boosting anti-PD-1 therapy with metformin-loaded macrophage-derived microparticles","volume":"12","author":"Wei","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ijpharm.2023.123729_b0400","doi-asserted-by":"crossref","first-page":"e2002054","DOI":"10.1002\/adma.202002054","article-title":"Engineering Macrophages for Cancer Immunotherapy and Drug Delivery","volume":"32","author":"Xia","year":"2020","journal-title":"Adv. Mater."},{"key":"10.1016\/j.ijpharm.2023.123729_b0405","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.bbrc.2018.03.224","article-title":"Celastrol inhibits cancer metastasis by suppressing M2-like polarization of macrophages","volume":"503","author":"Yang","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ijpharm.2023.123729_b0410","doi-asserted-by":"crossref","first-page":"5121","DOI":"10.1021\/acsnano.7b09041","article-title":"Cancer Cell Membrane-Coated Adjuvant Nanoparticles with Mannose Modification for Effective Anticancer Vaccination","volume":"12","author":"Yang","year":"2018","journal-title":"ACS Nano"},{"key":"10.1016\/j.ijpharm.2023.123729_b0415","doi-asserted-by":"crossref","first-page":"e1612","DOI":"10.1002\/wnan.1612","article-title":"Regulation of cancer-immunity cycle and tumor microenvironment by nanobiomaterials to enhance tumor immunotherapy","volume":"12","author":"Yang","year":"2020","journal-title":"Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol."},{"key":"10.1016\/j.ijpharm.2023.123729_b0420","first-page":"694","article-title":"Targeted delivery of chlorogenic acid by mannosylated liposomes to effectively promote the polarization of TAMs for the treatment of glioblastoma","volume":"5","author":"Ye","year":"2020","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.ijpharm.2023.123729_b0425","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173090","article-title":"Macrophage M1\/M2 polarization","volume":"877","author":"Yunna","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ijpharm.2023.123729_b0430","doi-asserted-by":"crossref","first-page":"50475","DOI":"10.1021\/acsami.2c11534","article-title":"Leveraging Nanodrug Delivery System for Simultaneously Targeting Tumor Cells and M2 Tumor-Associated Macrophages for Efficient Colon Cancer Therapy","volume":"14","author":"Zeng","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.ijpharm.2023.123729_b0435","doi-asserted-by":"crossref","first-page":"11049","DOI":"10.1002\/cam4.5489","article-title":"Antitumor therapy for breast cancer: Focus on tumor-associated macrophages and nanosized drug delivery systems","volume":"12","author":"Zhan","year":"2023","journal-title":"Cancer Med."},{"key":"10.1016\/j.ijpharm.2023.123729_b0440","first-page":"359","article-title":"Polarization of tumor-associated macrophages by TLR7\/8 conjugated radiosensitive peptide hydrogel for overcoming tumor radioresistance","volume":"16","author":"Zhang","year":"2022","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.ijpharm.2023.123729_b0445","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.109890","article-title":"Effects of Aire on perforin expression in BMDCs via TLR7\/8 and its therapeutic effect on type 1 diabetes","volume":"117","author":"Zhang","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ijpharm.2023.123729_b0450","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.jconrel.2021.05.036","article-title":"Charge-switchable nanoparticles enhance Cancer immunotherapy based on mitochondrial dynamic regulation and immunogenic cell death induction","volume":"335","author":"Zhao","year":"2021","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ijpharm.2023.123729_b0455","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.jconrel.2021.11.028","article-title":"Nanomaterials targeting tumor associated macrophages for cancer immunotherapy","volume":"341","author":"Zhao","year":"2022","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ijpharm.2023.123729_b0460","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2021-004219","article-title":"Tumor-associated macrophage-specific CD155 contributes to M2-phenotype transition, immunosuppression, and tumor progression in colorectal cancer","volume":"10","author":"Zhu","year":"2022","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.ijpharm.2023.123729_b0465","doi-asserted-by":"crossref","first-page":"54","DOI":"10.7150\/jca.49692","article-title":"Tumor-associated macrophages: role in tumorigenesis and immunotherapy implications","volume":"12","author":"Zhu","year":"2021","journal-title":"J. Cancer"},{"key":"10.1016\/j.ijpharm.2023.123729_b0470","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s40164-021-00252-z","article-title":"Roles of tumor-associated macrophages in tumor progression: implications on therapeutic strategies","volume":"10","author":"Zhu","year":"2021","journal-title":"Exp. Hematol. Oncol."},{"key":"10.1016\/j.ijpharm.2023.123729_b0475","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s13402-022-00741-1","article-title":"Immunosuppression, immune escape, and immunotherapy in pancreatic cancer: focused on the tumor microenvironment","volume":"46","author":"Zhu","year":"2023","journal-title":"Cell. Oncol. (Dordr.)"}],"container-title":["International Journal of Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378517323011511?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378517323011511?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:38:15Z","timestamp":1759919895000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378517323011511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":95,"alternative-id":["S0378517323011511"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpharm.2023.123729","relation":{},"ISSN":["0378-5173"],"issn-type":[{"value":"0378-5173","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Repolarizing Tumor-Associated Macrophages and inducing immunogenic cell Death: A targeted liposomal strategy to boost cancer immunotherapy","name":"articletitle","label":"Article Title"},{"value":"International Journal of Pharmaceutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijpharm.2023.123729","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"123729"}}