{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T06:26:59Z","timestamp":1784010419489,"version":"3.55.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T00:00:00Z","timestamp":1704240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010801","name":"Xunta de Galicia","doi-asserted-by":"publisher","award":["ED431C 2020\/17"],"award-info":[{"award-number":["ED431C 2020\/17"]}],"id":[{"id":"10.13039\/501100010801","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Gobierno de Espana Ministerio de Ciencia e Innovacion","doi-asserted-by":"publisher","award":["PID 2020-113881RB-I00"],"award-info":[{"award-number":["PID 2020-113881RB-I00"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002924","name":"Federaci\u00f3n Espa\u00f1ola de Enfermedades Raras","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008425","name":"Xunta de Galicia Conseller\u00eda de Educacion e Ordenaci\u00f3n Universitaria","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008425","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Pharmaceutics"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.ijpharm.2024.123779","type":"journal-article","created":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T19:39:29Z","timestamp":1704310769000},"page":"123779","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Multifunctional polymeric guanidine and hydantoin halamines with broad biocidal activity"],"prefix":"10.1016","volume":"651","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2326-8803","authenticated-orcid":false,"given":"Lev","family":"Bromberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Magari\u00f1os","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz S.","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ysabel","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0507-049X","authenticated-orcid":false,"given":"Angel","family":"Concheiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. Alan","family":"Hatton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8546-7085","authenticated-orcid":false,"given":"Carmen","family":"Alvarez-Lorenzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijpharm.2024.123779_b0005","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1021\/acsbiomaterials.7b00996","article-title":"Novel N-Br bond-containing N-halamine nanofibers with antibacterial activities","volume":"4","author":"Bai","year":"2018","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"1","key":"10.1016\/j.ijpharm.2024.123779_b0010","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1021\/acsptsci.0c00174","article-title":"Antibacterial and antiviral functional materials: chemistry and biological activity toward tackling COVID-19-like pandemics","volume":"4","author":"Balasubramaniam","year":"2021","journal-title":"ACS Pharmacol. Transl. Sci."},{"issue":"9","key":"10.1016\/j.ijpharm.2024.123779_b0015","doi-asserted-by":"crossref","first-page":"4548","DOI":"10.1021\/la205127x","article-title":"Antiviral properties of polymeric aziridine- and biguanide-modified core-shell magnetic nanoparticles","volume":"28","author":"Bromberg","year":"2012","journal-title":"Langmuir."},{"issue":"39","key":"10.1016\/j.ijpharm.2024.123779_b0020","doi-asserted-by":"crossref","first-page":"22001","DOI":"10.1021\/acsami.5b06905","article-title":"Nucleophilic polymers and gels in hydrolytic degradation of chemical warfare agents","volume":"7","author":"Bromberg","year":"2015","journal-title":"ACS Appl. Mater. Interfaces."},{"key":"10.1016\/j.ijpharm.2024.123779_b0025","doi-asserted-by":"crossref","first-page":"7490","DOI":"10.1016\/j.polymer.2007.10.040","article-title":"Poly(N-vinylguanidine): Characterization, and catalytic and bactericidal properties","volume":"48","author":"Bromberg","year":"2007","journal-title":"Polymer."},{"key":"10.1016\/j.ijpharm.2024.123779_b0030","doi-asserted-by":"crossref","first-page":"17555","DOI":"10.1021\/acsami.6b05241","article-title":"Self-decontaminating fibrous materials reactive toward chemical threats","volume":"8","author":"Bromberg","year":"2016","journal-title":"ACS Appl. Mater. Interfaces."},{"key":"10.1016\/j.ijpharm.2024.123779_b0035","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4028\/www.scientific.net\/KEM.893.3","article-title":"Reactive fibrous materials for decontamination of chemical and biological threats","volume":"893","author":"Bromberg","year":"2021","journal-title":"Key Eng. Mater."},{"key":"10.1016\/j.ijpharm.2024.123779_b0040","first-page":"357","article-title":"Chiral polymeric halogen adducts synthesis and reactivity","volume":"3","author":"Chiellini","year":"1985","journal-title":"React. Polym."},{"key":"10.1016\/j.ijpharm.2024.123779_b0045","doi-asserted-by":"crossref","first-page":"6847","DOI":"10.1007\/s00253-016-7507-7","article-title":"Sensing and inactivation of bacillus anthracis sterne by polymer-bromine complexes","volume":"100","author":"D\u2019Angelo","year":"2016","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.ijpharm.2024.123779_b0050","doi-asserted-by":"crossref","first-page":"928","DOI":"10.3390\/polym3020928","article-title":"Physical and chemical characterization of Poly(hexamethylene biguanide) hydrochloride","volume":"3","author":"de Paula","year":"2011","journal-title":"Polymers."},{"issue":"6","key":"10.1016\/j.ijpharm.2024.123779_b0055","doi-asserted-by":"crossref","first-page":"4806","DOI":"10.1021\/acs.chemrev.6b00687","article-title":"Chemical insights into antibacterial N-halamines","volume":"117","author":"Dong","year":"2017","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ijpharm.2024.123779_b0060","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1002\/pola.27894","article-title":"N-bromo-hydantoin grafted polystyrene beads: Synthesis and nano-micro beads characteristics for achieving controlled release of active oxidative bromine and extended microbial inactivation efficiency","volume":"54","author":"Farah","year":"2016","journal-title":"J. Polym. Sci., Part A: Polym. Chem."},{"key":"10.1016\/j.ijpharm.2024.123779_b0065","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.eurpolymj.2018.06.014","article-title":"New guanidine-containing polyelectrolytes as advanced antibacterial materials","volume":"105","author":"Gorbunova","year":"2018","journal-title":"Eur. Polym. J."},{"key":"10.1016\/j.ijpharm.2024.123779_b0070","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.acthis.2018.03.007","article-title":"Current methodology of MTT assay in bacteria - A review","volume":"120","author":"Grela","year":"2018","journal-title":"Acta Histochem."},{"issue":"3","key":"10.1016\/j.ijpharm.2024.123779_b0075","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1021\/bm301980q","article-title":"Antimicrobial N-halamine polymers and coatings: A review of their synthesis, characterization, and applications","volume":"14","author":"Hui","year":"2013","journal-title":"Biomacromolecules."},{"key":"10.1016\/j.ijpharm.2024.123779_b0080","doi-asserted-by":"crossref","first-page":"5626-","DOI":"10.1038\/s41598-021-84842-1","article-title":"Microbicidal actives with virucidal efficacy against SARS-CoV-2 and other beta- and alpha-coronaviruses and implications for future emerging coronaviruses and other enveloped viruses","volume":"11","author":"Ijaz","year":"2021","journal-title":"Sci Rep."},{"key":"10.1016\/j.ijpharm.2024.123779_b0085","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1093\/jac\/dkv474","article-title":"Bactericidal effects of polyhexamethylene biguanide against intracellular Staphylococcus aureus EMRSA-15 and USA 300","volume":"71","author":"Kamaruzzaman","year":"2016","journal-title":"J Antimicrob Chemother."},{"key":"10.1016\/j.ijpharm.2024.123779_b0090","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.biopha.2005.07.007","article-title":"Polybiguanides, particularly polyethylene hexamethylene biguanide, have activity against human immunodeficiency virus type 1","volume":"59","author":"Krebs","year":"2005","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ijpharm.2024.123779_b0095","doi-asserted-by":"crossref","first-page":"2101113","DOI":"10.1002\/adhm.202101113","article-title":"Broad-spectrum antiviral peptides and polymers","volume":"10","author":"Kuroki","year":"2021","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.ijpharm.2024.123779_b0100","doi-asserted-by":"crossref","first-page":"6477","DOI":"10.1021\/ie060253m","article-title":"Durable and regenerable biocidal polymers: Acyclic N-halamine cotton cellulose","volume":"45","author":"Liu","year":"2006","journal-title":"Ind. Eng. Chem. Res."},{"issue":"6","key":"10.1016\/j.ijpharm.2024.123779_b0105","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1021\/acsbiomaterials.1c00117","article-title":"N-halamine polypropylene nonwoven fabrics with rechargeable antibacterial and antiviral functions for medical applications","volume":"7","author":"Ma","year":"2021","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"34","key":"10.1016\/j.ijpharm.2024.123779_b0110","doi-asserted-by":"crossref","first-page":"41056","DOI":"10.1021\/acsami.1c10133","article-title":"A novel N-halamine biocidal nanofibrous membrane for chlorine rechargeable rapid water disinfection applications","volume":"13","author":"Ma","year":"2021","journal-title":"ACS Appl. Mater. Interfaces."},{"key":"10.1016\/j.ijpharm.2024.123779_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2022.111543","article-title":"Strategies and perspectives of developing anti-biofilm materials for improved food safety","volume":"159","author":"Ma","year":"2022","journal-title":"Food Res Int."},{"key":"10.1016\/j.ijpharm.2024.123779_b0120","first-page":"49","article-title":"Polyhexamethylene biguanide hydrochloride: Features and applications","volume":"4","author":"Mashat","year":"2016","journal-title":"Brit. J. Environ. Sci."},{"key":"10.1016\/j.ijpharm.2024.123779_b0125","first-page":"132","article-title":"Antimicrobial effectiveness of polyhexamethylene biguanide on enterococcus faecalis, staphylococcus epidermidis and candida albicans","volume":"15","author":"Medvedec","year":"2018","journal-title":"Med Glas (Zenica)."},{"key":"10.1016\/j.ijpharm.2024.123779_b0130","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1093\/jac\/dkn125","article-title":"Biocompatibility index of antiseptic agents by parallel assessment of antimicrobial activity and cellular cytotoxicity","volume":"61","author":"Muller","year":"2008","journal-title":"J. Antimicrob Chemother."},{"key":"10.1016\/j.ijpharm.2024.123779_b0135","doi-asserted-by":"crossref","first-page":"4357031","DOI":"10.1155\/2017\/4357031","article-title":"Fungicidal, corrosive, and mutational effects of polyhexamethylene biguanide combined with 1-Bromo-3-chloro-5,5-dimethylimidazolidine-2,4-dione","volume":"2017","author":"Niu","year":"2017","journal-title":"Biomed Res Int."},{"issue":"51","key":"10.1016\/j.ijpharm.2024.123779_b0140","doi-asserted-by":"crossref","first-page":"15373","DOI":"10.1021\/la5017214","article-title":"Polyvinylamine: A tool for engineering interfaces","volume":"30","author":"Pelton","year":"2014","journal-title":"Langmuir."},{"key":"10.1016\/j.ijpharm.2024.123779_b0145","doi-asserted-by":"crossref","first-page":"638","DOI":"10.3390\/antibiotics10060638","article-title":"Bioactive coatings with Ag-camphorimine complexes to prevent surface colonization by the pathogenic yeast candida albicans","volume":"10","author":"Pinheiro","year":"2021","journal-title":"Antibiotics (basel)."},{"key":"10.1016\/j.ijpharm.2024.123779_b0150","doi-asserted-by":"crossref","first-page":"4343","DOI":"10.1016\/S0043-1354(00)00216-5","article-title":"Methods for the photometric determination of reactive bromine and chlorine species with ABTS","volume":"34","author":"Pinkernell","year":"2000","journal-title":"Water Res."},{"key":"10.1016\/j.ijpharm.2024.123779_b0155","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.ajic.2009.08.012","article-title":"Effect of surfactants, temperature, and sonication on the virucidal activity of polyhexamethylene biguanide against the bacteriophage MS2 Am","volume":"38","author":"Pinto","year":"2010","journal-title":"J. Infect. Control."},{"key":"10.1016\/j.ijpharm.2024.123779_b0160","first-page":"1880","article-title":"Polyhexamethylene biguanide exposure leads to viral aggregation","volume":"108","author":"Pinto","year":"2010","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.ijpharm.2024.123779_b0165","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.3390\/microorganisms10071375","article-title":"The activity of PHMB and other guanidino containing compounds against acanthamoeba and other ocular pathogens","volume":"10","author":"Ratnayake","year":"2022","journal-title":"Microorganisms."},{"key":"10.1016\/j.ijpharm.2024.123779_b0170","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1001\/jamaophthalmol.2013.2498","article-title":"The evaluation of polyhexamethylene biguanide (PHMB) as a disinfectant for adenovirus","volume":"131","author":"Romanowski","year":"2013","journal-title":"JAMA Ophthalmol."},{"key":"10.1016\/j.ijpharm.2024.123779_b0175","doi-asserted-by":"crossref","first-page":"4392","DOI":"10.1039\/D2BM00472K","article-title":"Antimicrobial mechanisms of biomaterials: from macro to nano","volume":"10","author":"Roy","year":"2022","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.ijpharm.2024.123779_b0180","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1002\/jmv.26722","article-title":"Overinterpretation of the antiviral results for human coronavirus strain 229E (HCoV-229E) relative to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)","volume":"93","author":"Shewale","year":"2020","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.ijpharm.2024.123779_b0185","first-page":"5267","article-title":"In-vitro antifungal susceptibility reveals occurrence of azole and allylamine resistance among clinical isolates of candida albicans and candida non albicans from central India","volume":"5","author":"Singh","year":"2014","journal-title":"Int. J. Pharm. Sci. Res."},{"issue":"22","key":"10.1016\/j.ijpharm.2024.123779_b0190","doi-asserted-by":"crossref","first-page":"4487","DOI":"10.1021\/acs.jpcb.0c02609","article-title":"Insights into the polyhexamethylene biguanide (PHMB) mechanism of action on bacterial membrane and DNA: A molecular dynamics study","volume":"124","author":"Sowlati-Hashjin","year":"2020","journal-title":"J. Phys. Chem. B."},{"issue":"10","key":"10.1016\/j.ijpharm.2024.123779_b0195","doi-asserted-by":"crossref","first-page":"4357","DOI":"10.1021\/acs.biomac.1c00920","article-title":"Antiviral polymers based on N-halamine polyurea","volume":"22","author":"Steinman","year":"2021","journal-title":"Biomacromolecules."},{"key":"10.1016\/j.ijpharm.2024.123779_b0200","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1128\/AAC.00866-08","article-title":"Specific interactions between the viral coreceptor CXCR4 and the biguanide-based compound NB325 mediate inhibition of human immunodeficiency virus type 1 infection","volume":"53","author":"Thakkar","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ijpharm.2024.123779_b0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.coco.2021.100668","article-title":"Antibacterial and antiviral N-halamine nanofibrous membranes with nanonet structure for bioprotective applications","volume":"24","author":"Tian","year":"2021","journal-title":"Composites Commun."},{"issue":"6","key":"10.1016\/j.ijpharm.2024.123779_b0210","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01697-15","article-title":"Human coronavirus 229E remains infectious on common touch surface materials","volume":"6","author":"Warnes","year":"2015","journal-title":"MBio."},{"key":"10.1016\/j.ijpharm.2024.123779_b0215","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/nprot.2007.521","article-title":"Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances","volume":"3","author":"Wiegand","year":"2008","journal-title":"Nat. Protoc."},{"issue":"2","key":"10.1016\/j.ijpharm.2024.123779_b0220","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1080\/10643388809388345","article-title":"Halamine water disinfectants","volume":"18","author":"Worley","year":"1988","journal-title":"Crit. Rev. in Environ. Control."},{"key":"10.1016\/j.ijpharm.2024.123779_b0225","doi-asserted-by":"crossref","first-page":"915","DOI":"10.3390\/polym11050915","article-title":"Polyhexamethylene biguanide: Polyurethane blend nanofibrous membranes for wound infection control","volume":"22","author":"Worsley","year":"2019","journal-title":"Polymers (basel)."},{"key":"10.1016\/j.ijpharm.2024.123779_b0230","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.3390\/v14081721","article-title":"Disinfectants against SARS-CoV-2: A review","volume":"14","author":"Xiao","year":"2022","journal-title":"Viruses."},{"key":"10.1016\/j.ijpharm.2024.123779_b0235","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1002\/pat.4911","article-title":"Surface antimicrobial modification of polyamide by Poly(hexamethylene guanidine) hydrochloride","volume":"31","author":"Ye","year":"2020","journal-title":"Polym. Adv. Technol."},{"key":"10.1016\/j.ijpharm.2024.123779_b0240","doi-asserted-by":"crossref","first-page":"47426","DOI":"10.1002\/app.47426","article-title":"Synthesis of antibacterial N-halamine acryl acid copolymers and their application onto cotton","volume":"136","author":"Zhang","year":"2019","journal-title":"J. Appl. Polym. Sci."},{"key":"10.1016\/j.ijpharm.2024.123779_b0245","doi-asserted-by":"crossref","first-page":"6189","DOI":"10.1016\/S0032-3861(98)00828-3","article-title":"Synthesis and antimicrobial activity of polymeric guanidine and biguanidine salts","volume":"40","author":"Zhang","year":"1999","journal-title":"Polymer."},{"key":"10.1016\/j.ijpharm.2024.123779_b0250","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1021\/mp800121f","article-title":"Endocytosis and membrane potential are required for hela cell uptake of R.I.-CKTat9, a retro inverso tat cell penetrating peptide","volume":"6","author":"Zhang","year":"2009","journal-title":"Mol Pharm."},{"key":"10.1016\/j.ijpharm.2024.123779_b0255","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/j.ijbiomac.2020.06.053","article-title":"N-halamine modified multiporous bacterial cellulose with enhanced antibacterial and hemostatic properties","volume":"161","author":"Zhang","year":"2020","journal-title":"Int. J. Biol. Macromol."}],"container-title":["International Journal of Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378517324000139?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378517324000139?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:42:01Z","timestamp":1759920121000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378517324000139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":51,"alternative-id":["S0378517324000139"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpharm.2024.123779","relation":{},"ISSN":["0378-5173"],"issn-type":[{"value":"0378-5173","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multifunctional polymeric guanidine and hydantoin halamines with broad biocidal activity","name":"articletitle","label":"Article Title"},{"value":"International Journal of Pharmaceutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijpharm.2024.123779","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"123779"}}