{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T11:30:57Z","timestamp":1774438257046,"version":"3.50.1"},"reference-count":37,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Pediatric Otorhinolaryngology"],"published-print":{"date-parts":[[2011,5]]},"DOI":"10.1016\/j.ijporl.2011.02.021","type":"journal-article","created":{"date-parts":[[2011,4,14]],"date-time":"2011-04-14T22:15:26Z","timestamp":1302819326000},"page":"708-712","source":"Crossref","is-referenced-by-count":24,"title":["Acute otitis media severity: Association with cytokine gene polymorphisms and other risk factors"],"prefix":"10.1016","volume":"75","author":[{"given":"David P.","family":"McCormick","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James J.","family":"Grady","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Diego","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reuben","family":"Matalon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krystal","family":"Revai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janak A.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yimei","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tasnee","family":"Chonmaitree","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijporl.2011.02.021_bib0005","series-title":"Textbook of Pediatric Infectious Diseases","first-page":"215","article-title":"Otitis media","author":"Kline","year":"2004"},{"key":"10.1016\/j.ijporl.2011.02.021_bib0010","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0140-6736(04)15495-0","article-title":"Otitis media","volume":"363","author":"Rovers","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.ijporl.2011.02.021_bib0015","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1093\/infdis\/160.1.83","article-title":"Epidemiology of otitis media during the first seven years of life in children in greater Boston: a prospective, cohort study","volume":"160","author":"Teele","year":"1989","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ijporl.2011.02.021_bib0020","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/00006454-200003000-00003","article-title":"Efficacy, safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in children Northern California Kaiser Permanente Vaccine Study Center Group","volume":"19","author":"Black","year":"2000","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/j.ijporl.2011.02.021_bib0025","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1177\/000348949710600802","article-title":"Distribution and heritability of recurrent ear infections","volume":"106","author":"Kvaerner","year":"1997","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"10.1016\/j.ijporl.2011.02.021_bib0030","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1001\/jama.282.22.2125","article-title":"The heritability of otitis media: a twin and triplet study","volume":"282","author":"Casselbrant","year":"1999","journal-title":"JAMA"},{"key":"10.1016\/j.ijporl.2011.02.021_bib0035","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1093\/aje\/155.10.958","article-title":"Heritability of symptom domains in otitis media: a longitudinal study of 1373 twin pairs","volume":"155","author":"Rovers","year":"2002","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.ijporl.2011.02.021_bib0040","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/1471-2350-10-85","article-title":"Otitis media: a genome-wide linkage scan with evidence of susceptibility loci within the 17q12 and 10q22.3 regions","volume":"10","author":"Casselbrant","year":"2009","journal-title":"BMC Med. Genet."},{"key":"10.1016\/j.ijporl.2011.02.021_bib0045","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1086\/426061","article-title":"Chronic and recurrent otitis media: a genome scan for susceptibility","volume":"75","author":"Daly","year":"2004","journal-title":"Am. J. Hum. Gen."},{"key":"10.1016\/j.ijporl.2011.02.021_bib0050","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/sj.gene.6364301","article-title":"Cytokine gene polymporphism in human disease: on-line databases supplement 3","volume":"7","author":"Hollegaard","year":"2006","journal-title":"Genes Immun."},{"key":"10.1016\/j.ijporl.2011.02.021_bib0055","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1097\/INF.0b013e3181aa5b13","article-title":"Nasopharyngeal acute phase cytokines in viral upper respiratory infection: impact on acute otitis media in children","volume":"28","author":"Patel","year":"2009","journal-title":"Pediatr. Infect. Dis. J"},{"key":"10.1016\/j.ijporl.2011.02.021_bib0060","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1086\/599833","article-title":"Association between cytokine gene polymorphisms and risk for upper respiratory tract infection and acute otitis media","volume":"49","author":"Revai","year":"2009","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.ijporl.2011.02.021_bib0065","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1542\/peds.2006-0764","article-title":"Association of proinflammatory cytokinegene polymorphisms with susceptibility to otitis media","volume":"118","author":"Patel","year":"2006","journal-title":"Pediatrics"},{"key":"10.1016\/j.ijporl.2011.02.021_bib0070","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1542\/peds.113.5.1451","article-title":"Subcommittee on management of acute otitis media. Diagnosis and management of acute otitis media","volume":"113","author":"American Academy of Pediatrics","year":"2004","journal-title":"Pediatrics"},{"key":"10.1016\/j.ijporl.2011.02.021_bib0075","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1086\/528685","article-title":"Viral upper respiratory tract infection and otitis media complication in young children","volume":"46","author":"Chonmaitree","year":"2008","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.ijporl.2011.02.021_bib0080","article-title":"Clinical spectrum of acute otitis media complicating upper respiratory tract viral infection","author":"Kalu","year":"2010","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/j.ijporl.2011.02.021_bib0085","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1097\/00006454-200003000-00019","article-title":"Otitis media: can clinical findings predict bacterial or viral etiology?","volume":"19","author":"McCormick","year":"2000","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/j.ijporl.2011.02.021_bib0090","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1097\/01.inf.0000199290.73333.89","article-title":"Development of a practical tool for assessing the severity of otitis media","volume":"25","author":"Friedman","year":"2006","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/j.ijporl.2011.02.021_bib0095","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/INF.0b013e318185a3a0","article-title":"Responsiveness and construct validity of a symptom scale for acute otitis media","volume":"28","author":"Shaikh","year":"2009","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/j.ijporl.2011.02.021_bib0100","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1097\/INF.0b013e318185a387","article-title":"Development and preliminary evaluation of a parent-reported outcome instrument for clinical trials in acute otitis media","volume":"28","author":"Shaikh","year":"2009","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/j.ijporl.2011.02.021_bib0105","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1542\/peds.2009-2689","article-title":"Symptoms or symptom-based scores cannot predict acute otitis media at otitis-prone age","volume":"125","author":"Laine","year":"2010","journal-title":"Pediatrics"},{"key":"10.1016\/j.ijporl.2011.02.021_bib0110","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1542\/peds.2004-1665","article-title":"Nonsevere acute otitis media: a clinical trial comparing outcomes of watchful waiting versus immediate antibiotic treatment","volume":"119","author":"McCormick","year":"2005","journal-title":"Pediatrics"},{"key":"10.1016\/j.ijporl.2011.02.021_bib0115","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1542\/peds.112.3.527","article-title":"Treatment of otitis media with observation and a safety-net antibiotic prescription","volume":"112","author":"Siegel","year":"2003","journal-title":"Pediatrics"},{"key":"10.1016\/j.ijporl.2011.02.021_bib0120","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1136\/bmj.322.7282.336","article-title":"Pragmatic randomized controlled trial of two prescribing strategies for childhood acute otitis media","volume":"322","author":"Little","year":"2001","journal-title":"BMJ"},{"key":"10.1016\/j.ijporl.2011.02.021_bib0125","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1093\/clinids\/22.6.1079","article-title":"A metaanalytic review of the risk factors for acute otitis media","volume":"22","author":"Uhari","year":"1996","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.ijporl.2011.02.021_bib0130","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1097\/00006454-200005001-00004","article-title":"Role of viruses in the pathogenesis of acute otitis media","volume":"19","author":"Heikkinen","year":"2000","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/j.ijporl.2011.02.021_bib0135","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1016\/j.ijporl.2006.05.011","article-title":"A high prevalence of new onset otitis media during parent diagnosed common colds","volume":"70","author":"Winther","year":"2006","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"10.1016\/j.ijporl.2011.02.021_bib0140","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1086\/500942","article-title":"Otitis media bacterial colonization, and the smoking parent","volume":"42","author":"Murphy","year":"2006","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.ijporl.2011.02.021_bib0145","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1465-9921-6-38","article-title":"Association of current smoking with airway inflammation in chronic obstructive pulmonary disease and asymptomatic smokers","volume":"6","author":"Willemse","year":"2005","journal-title":"Respir. Res."},{"key":"10.1016\/j.ijporl.2011.02.021_bib0150","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1086\/500935","article-title":"The contribution of smoking and exposure to tobacco smoke to Streptococcus pneumoniae and Haemophilus influenzae carriage in children and their mothers","volume":"42","author":"Greenberg","year":"2006","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.ijporl.2011.02.021_bib0155","doi-asserted-by":"crossref","first-page":"e34","DOI":"10.1086\/525856","article-title":"Association of nasopharyngeal bacterial colonization during upper respiratory tract infection and the development of acute otitis media","volume":"46","author":"Revai","year":"2008","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.ijporl.2011.02.021_bib0160","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1086\/516477","article-title":"Relationship between nasopharyngeal colonization and the development of otitis media in children","volume":"175","author":"Faden","year":"1997","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ijporl.2011.02.021_bib0165","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1651-2227.2009.01506.x","article-title":"Prenatal and postnatal smoking and acute otitis media in early childhood","volume":"99","author":"Haberg","year":"2010","journal-title":"Acta Paediatr."},{"key":"10.1016\/j.ijporl.2011.02.021_bib0170","doi-asserted-by":"crossref","first-page":"e16","DOI":"10.1542\/peds.104.2.e16","article-title":"Maternal cigarette smoking during pregnancy is an independent predictor for symptoms of middle ear disease five years\u2019 postdelivery","volume":"104","author":"Stathis","year":"1999","journal-title":"Pediatrics"},{"key":"10.1016\/j.ijporl.2011.02.021_bib0175","doi-asserted-by":"crossref","first-page":"94","DOI":"10.3109\/00016488809107375","article-title":"The Bayesian approach to the evaluation of risk factors in acute and recurrent acute otitis media","volume":"106","author":"Sipila","year":"1988","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.ijporl.2011.02.021_bib0180","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0165-5876(93)90193-7","article-title":"The impact of familial factors and day-care center attendance","volume":"26","author":"Rasmussen","year":"1993","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"10.1016\/j.ijporl.2011.02.021_bib0185","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1542\/peds.2007-0524","article-title":"Genetic polymorphisms in immunoresponse genes TNFA, IL6 IL10, and TLR4 are associated with recurrent acute otitis media","volume":"120","author":"Emonts","year":"2007","journal-title":"Pediatrics"}],"container-title":["International Journal of Pediatric Otorhinolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165587611000887?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165587611000887?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,6]],"date-time":"2024-04-06T04:45:53Z","timestamp":1712378753000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165587611000887"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,5]]}},"alternative-id":["S0165587611000887"],"URL":"https:\/\/doi.org\/10.1016\/j.ijporl.2011.02.021","relation":{},"ISSN":["0165-5876"],"issn-type":[{"value":"0165-5876","type":"print"}],"subject":[],"published":{"date-parts":[[2011,5]]}}}