{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:00:55Z","timestamp":1761156055780},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Ministry of Science, ICT & Future Planning","award":["NRF-2012R1A1A1013003"],"award-info":[{"award-number":["NRF-2012R1A1A1013003"]}]}],"content-domain":{"domain":["ijporlonline.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Pediatric Otorhinolaryngology"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.ijporl.2016.01.014","type":"journal-article","created":{"date-parts":[[2016,1,25]],"date-time":"2016-01-25T18:00:17Z","timestamp":1453744817000},"page":"31-36","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Protective effects of the seaweed phlorotannin polyphenolic compound dieckol on gentamicin-induced damage in auditory hair cells"],"prefix":"10.1016","volume":"83","author":[{"given":"Mun Young","family":"Chang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seon-Hee","family":"Byon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyeon-Cheol","family":"Shin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song Ee","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju Yeon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jang Yul","family":"Byun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Dae","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moo Kyun","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.ijporl.2016.01.014_bib0165","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.tips.2013.05.006","article-title":"Understanding platinum-induced ototoxicity","volume":"34","author":"Langer","year":"2013","journal-title":"Trends. Pharmacol. Sci."},{"issue":"11","key":"10.1016\/j.ijporl.2016.01.014_bib0170","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1002\/ar.22578","article-title":"Cisplatin and aminoglycoside antibiotics: hearing loss and its prevention","volume":"295","author":"Schacht","year":"2012","journal-title":"Anat. Rec. (Hoboken)"},{"issue":"6","key":"10.1016\/j.ijporl.2016.01.014_bib0175","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1002\/lary.23336","article-title":"Effect of cisplatin on distortion product otoacoustic emissions in Japanese patients","volume":"122","author":"Eiamprapai","year":"2012","journal-title":"Laryngoscope"},{"issue":"10","key":"10.1016\/j.ijporl.2016.01.014_bib0180","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1200\/JCO.2006.07.9723","article-title":"Early changes in auditory function as a result of platinum chemotherapy: use of extended high-frequency audiometry and evoked distortion product otoacoustic emissions","volume":"25","author":"Knight","year":"2007","journal-title":"J. Clin. Oncol."},{"issue":"16","key":"10.1016\/j.ijporl.2016.01.014_bib0185","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1016\/j.ejca.2003.08.009","article-title":"Predicting cisplatin ototoxicity in children: the influence of age and the cumulative dose","volume":"40","author":"Li","year":"2004","journal-title":"Eur. J. Cancer"},{"issue":"1","key":"10.1016\/j.ijporl.2016.01.014_bib0190","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3892\/ol.2012.997","article-title":"Prospective evaluation of cisplatin- and carboplatin-mediated ototoxicity in paediatric and adult soft tissue and osteosarcoma patients","volume":"5","author":"Nitz","year":"2013","journal-title":"Oncol. Lett."},{"issue":"2","key":"10.1016\/j.ijporl.2016.01.014_bib0195","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/jat.2852","article-title":"Novel synthetic protective compound, KR-22335, against cisplatin-induced auditory cell death","volume":"34","author":"Shin","year":"2014","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.ijporl.2016.01.014_bib0200","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2012.12.008","article-title":"A novel synthetic compound, 3-amino-3-(4-fluoro-phenyl)-1H-quinoline-2,4-dione, inhibits cisplatin-induced hearing loss by the suppression of reactive oxygen species: in vitro and in vivo study","volume":"232","author":"Shin","year":"2013","journal-title":"Neuroscience"},{"issue":"9","key":"10.1016\/j.ijporl.2016.01.014_bib0205","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.jnutbio.2010.08.009","article-title":"EGb 761 (Ginkgo biloba) protects cochlear hair cells against ototoxicity induced by gentamicin via reducing reactive oxygen species and nitric oxide-related apoptosis","volume":"22","author":"Yang","year":"2011","journal-title":"J. Nutr. Biochem."},{"issue":"4","key":"10.1016\/j.ijporl.2016.01.014_bib0210","first-page":"513","article-title":"Effect of protective agents against cisplatin ototoxicity","volume":"21","author":"Rybak","year":"2000","journal-title":"Am. J. Otol."},{"issue":"1","key":"10.1016\/j.ijporl.2016.01.014_bib0215","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1471-4159.2006.04117.x","article-title":"Kanamycin alters cytoplasmic and nuclear phosphoinositide signaling in the organ of Corti in vivo","volume":"99","author":"Jiang","year":"2006","journal-title":"J. Neurochem."},{"issue":"3","key":"10.1016\/j.ijporl.2016.01.014_bib0220","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.etap.2013.02.013","article-title":"Protective effect of a marine polyphenol, dieckol against carbon tetrachloride-induced acute liver damage in mouse, Environ","volume":"35","author":"Kang","year":"2013","journal-title":"Toxicol. Pharmacol."},{"issue":"3","key":"10.1016\/j.ijporl.2016.01.014_bib0225","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/j.etap.2013.09.018","article-title":"Protective effect of dieckol isolated from Ecklonia cava against ethanol caused damage in vitro and in zebrafish model","volume":"36","author":"Kang","year":"2013","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"2","key":"10.1016\/j.ijporl.2016.01.014_bib0230","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.tiv.2009.11.002","article-title":"Protective effects of dieckol isolated from Ecklonia cava against high glucose-induced oxidative stress in human umbilical vein endothelial cells","volume":"24","author":"Lee","year":"2010","journal-title":"Toxicol. In Vitro."},{"issue":"6-7","key":"10.1016\/j.ijporl.2016.01.014_bib0235","doi-asserted-by":"crossref","first-page":"526","DOI":"10.3109\/10715762.2013.797080","article-title":"Cytoprotective effect of dieckol on human endothelial progenitor cells (hEPCs) from oxidative stress-induced apoptosis","volume":"47","author":"Lee","year":"2013","journal-title":"Free Radic. Res."},{"issue":"19","key":"10.1016\/j.ijporl.2016.01.014_bib0240","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/S1359-6446(05)03552-X","article-title":"Ototoxicity: therapeutic opportunities","volume":"10","author":"Rybak","year":"2005","journal-title":"Drug Discov. Today"},{"issue":"24","key":"10.1016\/j.ijporl.2016.01.014_bib0245","doi-asserted-by":"crossref","first-page":"9217","DOI":"10.1158\/0008-5472.CAN-04-1581","article-title":"Caspase inhibitors, but not c-Jun NH2-terminal kinase inhibitor treatment, prevent cisplatin-induced hearing loss","volume":"64","author":"Wang","year":"2004","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.ijporl.2016.01.014_bib0250","first-page":"159","article-title":"Protective effect of l-N-acetylcysteine against gentamycin ototoxicity in the organ cultures of the rat cochlea","volume":"52","author":"Maniu","year":"2011","journal-title":"Rom. J. Morphol. Embryol."},{"issue":"4","key":"10.1016\/j.ijporl.2016.01.014_bib0255","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1007\/BF02976957","article-title":"Antioxidative properties of brown algae polyphenolics and their perspectives as chemopreventive agents against vascular risk factors","volume":"26","author":"Kang","year":"2003","journal-title":"Arch. Pharm. Res."},{"issue":"5","key":"10.1016\/j.ijporl.2016.01.014_bib0260","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1016\/j.bmc.2009.01.031","article-title":"Chemical components and its antioxidant properties in vitro: an edible marine brown alga, Ecklonia cava","volume":"17","author":"Li","year":"2009","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ijporl.2016.01.014_bib0265","series-title":"Schuknecht's Pathology of the Ear","author":"Merchant","year":"2010"},{"issue":"1-2","key":"10.1016\/j.ijporl.2016.01.014_bib0270","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/0378-5955(96)00075-5","article-title":"Direct detection of ototoxicant-induced reactive oxygen species generation in cochlear explants","volume":"98","author":"Clerici","year":"1996","journal-title":"Hear. Res."},{"issue":"1-2","key":"10.1016\/j.ijporl.2016.01.014_bib0275","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-5955(96)00169-4","article-title":"Reactive oxygen species in chick hair cells after gentamicin exposure in vitro","volume":"104","author":"Hirose","year":"1997","journal-title":"Hear. Res."},{"issue":"1","key":"10.1016\/j.ijporl.2016.01.014_bib0280","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1159\/000013861","article-title":"Aminoglycoside antibiotics","volume":"5","author":"Forge","year":"2000","journal-title":"Audiol. Neurootol."},{"issue":"1","key":"10.1016\/j.ijporl.2016.01.014_bib0285","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.neuroscience.2005.05.055","article-title":"Inhibition of the calcium- and voltage-dependent big conductance potassium channel ameliorates cisplatin-induced apoptosis in spiral ligament fibrocytes of the cochlea","volume":"135","author":"Liang","year":"2005","journal-title":"Neuroscience"},{"issue":"3","key":"10.1016\/j.ijporl.2016.01.014_bib0290","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0385-8146(03)00049-X","article-title":"Expression of caspase-activated deoxyribonuclease (CAD) and caspase 3 (CPP32) in the cochlea of cisplatin (CDDP)-treated guinea pigs","volume":"30","author":"Watanabe","year":"2003","journal-title":"Auris Nasus Larynx"},{"issue":"1-2","key":"10.1016\/j.ijporl.2016.01.014_bib0295","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0378-5955(01)00380-X","article-title":"Blockade of c-Jun N-terminal kinase pathway attenuates gentamicin-induced cochlear and vestibular hair cell death","volume":"163","author":"Ylikoski","year":"2002","journal-title":"Hear. Res."},{"issue":"4","key":"10.1016\/j.ijporl.2016.01.014_bib0300","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.neuroscience.2003.08.041","article-title":"Involvement of ras activation in toxic hair cell damage of the mammalian cochlea","volume":"122","author":"Battaglia","year":"2003","journal-title":"Neuroscience"},{"issue":"12","key":"10.1016\/j.ijporl.2016.01.014_bib0305","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1055\/s-2002-36100","article-title":"Rescue of auditory hair cells from ototoxicity by CEP-11 004, an inhibitor of the JNK signaling pathway","volume":"81","author":"Bodmer","year":"2002","journal-title":"Laryngorhinootologie"},{"issue":"1\u20132","key":"10.1016\/j.ijporl.2016.01.014_bib0310","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.heares.2006.09.008","article-title":"Blocking c-Jun-N-terminal kinase signaling can prevent hearing loss induced by both electrode insertion trauma and neomycin ototoxicity","volume":"226","author":"Eshraghi","year":"2007","journal-title":"Hear. Res."},{"issue":"1","key":"10.1016\/j.ijporl.2016.01.014_bib0315","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cne.20129","article-title":"Progression of hair cell ejection and molecular markers of apoptosis in the avian cochlea following gentamicin treatment","volume":"475","author":"Mangiardi","year":"2004","journal-title":"J. Comp. Neurol."},{"issue":"6","key":"10.1016\/j.ijporl.2016.01.014_bib0320","doi-asserted-by":"crossref","first-page":"670","DOI":"10.3109\/00016480903428200","article-title":"Gentamicin-induced spiral ganglion cell death: apoptosis mediated by ROS and the JNK signaling pathway","volume":"130","author":"Jeong","year":"2010","journal-title":"Acta Otolaryngol."}],"container-title":["International Journal of Pediatric Otorhinolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165587616000276?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165587616000276?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T00:22:04Z","timestamp":1567556524000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165587616000276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":32,"alternative-id":["S0165587616000276"],"URL":"https:\/\/doi.org\/10.1016\/j.ijporl.2016.01.014","relation":{},"ISSN":["0165-5876"],"issn-type":[{"value":"0165-5876","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective effects of the seaweed phlorotannin polyphenolic compound dieckol on gentamicin-induced damage in auditory hair cells","name":"articletitle","label":"Article Title"},{"value":"International Journal of Pediatric Otorhinolaryngology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijporl.2016.01.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}