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Dumbarton Oaks Research Library and Collection, Washington, D.C., pp. 279\u2013329."},{"key":"10.1016\/j.ijpp.2021.01.002_bib0385","first-page":"62","article-title":"Enfermedades en el arte prehispanico Colombiano","volume":"29","author":"Sotomayor Trib\u00edn","year":"1990","journal-title":"Bolet\u00edn Museo del Oro"},{"key":"10.1016\/j.ijpp.2021.01.002_bib0390","series-title":"Congenital Malformations: A Report of a Study of Series of Consecutive Births in 24 Centres","author":"Stevenson","year":"1966"},{"key":"10.1016\/j.ijpp.2021.01.002_bib0395","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ijpp.2019.07.001","article-title":"Developmental anomalies and South American paleopathology: a comparison of block vertebrae and co-occurring axial anomalies among three skeletal samples from the El Brujo archaeological complex of northern coastal Peru","volume":"29","author":"Titelbaum","year":"2020","journal-title":"Int. J. Paleopathol."},{"key":"10.1016\/j.ijpp.2021.01.002_bib0400","series-title":"Reconstruction of Life from the Skeleton.","first-page":"109","article-title":"Congenital abnormalities in skeletal populations","author":"Turkel","year":"1989"},{"key":"10.1016\/j.ijpp.2021.01.002_bib0405","unstructured":"TVN, 2016. En Panam\u00e1 175 personas padecen Osteog\u00e9nesis Imperfecta. TVN Noticias. 6 May. <https:\/\/www.tvn-2.com\/nacionales\/Panama-personas-padecen-Osteogenesis-Impmerfecta_0_4477052315.html>. Accessed 11 September 2020."},{"key":"10.1016\/j.ijpp.2021.01.002_bib0410","unstructured":"TVN, 2020. Hospital del Ni\u00f1o recibe 860 pacientes nuevos al a\u00f1o con enfermedades raras. TVN Noticias. 29 February. <https:\/\/www.tvn-2.com\/nacionales\/salud\/Hospital-Nino-recibe-pacientes-enfermedades-raras_0_5522447713.html>. Accessed 28 April 2020."},{"key":"10.1016\/j.ijpp.2021.01.002_bib0415","series-title":"A New Voyage and Description of the Isthmus of America","author":"Wafer","year":"1729"},{"key":"10.1016\/j.ijpp.2021.01.002_bib0420","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1002\/ajpa.20357","article-title":"Albinism (OCA2) in amerindians","volume":"48","author":"Woolf","year":"2005","journal-title":"Yearb. Phys. 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