{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:18:01Z","timestamp":1792034281711,"version":"4.4.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Psychophysiology"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.ijpsycho.2021.09.004","type":"journal-article","created":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T06:18:15Z","timestamp":1632118695000},"page":"1-5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Acute social and somatic stress alters cortical metaplasticity probed with non-invasive brain stimulation in humans"],"prefix":"10.1016","volume":"170","author":[{"given":"Carmenrita","family":"Infortuna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovico","family":"Mineo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Buffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian P.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Rosaria Anna","family":"Muscatello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenio","family":"Aguglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Bruno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocco Antonio","family":"Zoccali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asad","family":"Sheikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen","family":"Chusid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhyiong","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fortunato","family":"Battaglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl","key":"10.1016\/j.ijpsycho.2021.09.004_bb0005","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1038\/81453","article-title":"Synaptic plasticity: taming the beast","volume":"3","author":"Abbott","year":"2000","journal-title":"Nat. Neurosci."},{"issue":"4","key":"10.1016\/j.ijpsycho.2021.09.004_bb0010","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/S0166-2236(96)80018-X","article-title":"Metaplasticity: the plasticity of synaptic plasticity","volume":"19","author":"Abraham","year":"1996","journal-title":"Trends Neurosci."},{"issue":"2","key":"10.1016\/j.ijpsycho.2021.09.004_bb0015","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1080\/08990220.2018.1460263","article-title":"Variations in corticomotor excitability in response to distal focal thermal stimulation","volume":"35","author":"Ansari","year":"2018","journal-title":"Somatosens. Mot. Res."},{"issue":"1","key":"10.1016\/j.ijpsycho.2021.09.004_bb0020","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1460-9568.2005.04552.x","article-title":"Long-lasting modulation of the induction of LTD and LTP in rat hippocampal CA1 by behavioural stress and environmental enrichment","volume":"23","author":"Artola","year":"2006","journal-title":"Eur. J. Neurosci."},{"issue":"Suppl. 2","key":"10.1016\/j.ijpsycho.2021.09.004_bb0025","doi-asserted-by":"crossref","first-page":"17200","DOI":"10.1073\/pnas.1204599109","article-title":"Variations in postnatal maternal care and the epigenetic regulation of metabotropic glutamate receptor 1 expression and hippocampal function in the rat","volume":"2","author":"Bagot","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U S A, 109 Suppl"},{"key":"10.1016\/j.ijpsycho.2021.09.004_bb0030","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.7521","article-title":"Evaluation of the socially evaluated cold-pressor group test (SECPT-G) in the general population","volume":"7","author":"Becker","year":"2019","journal-title":"PeerJ"},{"issue":"1","key":"10.1016\/j.ijpsycho.2021.09.004_bb0035","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1523\/JNEUROSCI.02-01-00032.1982","article-title":"Theory for the development of neuron selectivity: orientation specificity and binocular interaction in visual cortex","volume":"2","author":"Bienenstock","year":"1982","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.ijpsycho.2021.09.004_bb0040","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/sj.npp.1301559","article-title":"Synaptic plasticity: multiple forms, functions, and mechanisms","volume":"33","author":"Citri","year":"2008","journal-title":"Neuropsychopharmacology"},{"issue":"2","key":"10.1016\/j.ijpsycho.2021.09.004_bb0045","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1080\/10253890.2017.1301424","article-title":"Academic stress disrupts cortical plasticity in graduate students","volume":"20","author":"Concerto","year":"2017","journal-title":"Stress"},{"issue":"1","key":"10.1016\/j.ijpsycho.2021.09.004_bb0050","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s00213-017-4751-1","article-title":"Hypericum perforatum extract modulates cortical plasticity in humans","volume":"235","author":"Concerto","year":"2018","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.ijpsycho.2021.09.004_bb0055","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.ctim.2018.09.013","article-title":"Exploring the effect of adaptogenic Rhodiola Rosea extract on neuroplasticity in humans","volume":"41","author":"Concerto","year":"2018","journal-title":"Complement. Ther. Med."},{"issue":"6","key":"10.1016\/j.ijpsycho.2021.09.004_bb0060","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/j.pain.2014.02.024","article-title":"Cyclical changes of cortical excitability and metaplasticity in migraine: evidence from a repetitive transcranial magnetic stimulation study","volume":"155","author":"Cosentino","year":"2014","journal-title":"Pain"},{"issue":"7","key":"10.1016\/j.ijpsycho.2021.09.004_bb0065","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1016\/j.neubiorev.2010.12.016","article-title":"Epigenetic mechanisms mediating vulnerability and resilience to psychiatric disorders","volume":"35","author":"Dudley","year":"2011","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.ijpsycho.2021.09.004_bb0070","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.psyneuen.2019.05.028","article-title":"Clinical characterization of allostatic overload","volume":"108","author":"Fava","year":"2019","journal-title":"Psychoneuroendocrinology"},{"issue":"1","key":"10.1016\/j.ijpsycho.2021.09.004_bb0075","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1159\/000331393","article-title":"Post-weaning to pre-pubertal (\u2019juvenile\u2019) stress: a model of induced predisposition to stress-related disorders","volume":"95","author":"Horovitz","year":"2012","journal-title":"Neuroendocrinology"},{"issue":"5045","key":"10.1016\/j.ijpsycho.2021.09.004_bb0080","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1126\/science.1346729","article-title":"The influence of prior synaptic activity on the induction of long-term potentiation","volume":"255","author":"Huang","year":"1992","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.ijpsycho.2021.09.004_bb0085","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.tins.2013.03.007","article-title":"Emerging roles of metaplasticity in behaviour and disease","volume":"36","author":"Hulme","year":"2013","journal-title":"Trends Neurosci."},{"issue":"18","key":"10.1016\/j.ijpsycho.2021.09.004_bb0090","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph17186647","article-title":"Exploring the gender difference and predictors of perceived stress among students enrolled in different medical programs: a cross-sectional study","volume":"17","author":"Infortuna","year":"2020","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"13","key":"10.1016\/j.ijpsycho.2021.09.004_bb0095","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph17134836","article-title":"Affective temperament traits and age-predicted recreational Cannabis use in medical students: a cross-sectional study","volume":"17","author":"Infortuna","year":"2020","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"5","key":"10.1016\/j.ijpsycho.2021.09.004_bb0100","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.brs.2015.06.017","article-title":"Consensus paper: probing homeostatic plasticity of human cortex with non-invasive transcranial brain stimulation","volume":"8","author":"Karabanov","year":"2015","journal-title":"Brain Stimul."},{"key":"10.1016\/j.ijpsycho.2021.09.004_bb0105","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.nlm.2018.02.011","article-title":"Different mechanisms underlie stress-induced changes in plasticity and metaplasticity in the prefrontal cortex of juvenile and adult animals: emotional-induced metaplasticity in the prefrontal cortex","volume":"154","author":"Khazen","year":"2018","journal-title":"Neurobiol. Learn. Mem."},{"issue":"6","key":"10.1016\/j.ijpsycho.2021.09.004_bb0110","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nrn849","article-title":"The stressed hippocampus, synaptic plasticity and lost memories","volume":"3","author":"Kim","year":"2002","journal-title":"Nat. Rev. Neurosci."},{"issue":"5","key":"10.1016\/j.ijpsycho.2021.09.004_bb0115","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1097\/00006842-199509000-00009","article-title":"Persistent high cortisol responses to repeated psychological stress in a subpopulation of healthy men","volume":"57","author":"Kirschbaum","year":"1995","journal-title":"Psychosom. Med."},{"issue":"Pt B","key":"10.1016\/j.ijpsycho.2021.09.004_bb0120","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.neubiorev.2016.05.001","article-title":"A meta-analysis of non-invasive brain stimulation and autonomic functioning: implications for brain-heart pathways to cardiovascular disease","volume":"74","author":"Makovac","year":"2017","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.ijpsycho.2021.09.004_bb0125","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1146\/annurev.neuro.22.1.105","article-title":"Stress and hippocampal plasticity","volume":"22","author":"McEwen","year":"1999","journal-title":"Annu. Rev. Neurosci."},{"issue":"1","key":"10.1016\/j.ijpsycho.2021.09.004_bb0130","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1523\/JNEUROSCI.0733-19.2019","article-title":"Revisiting the stress concept: implications for affective disorders","volume":"40","author":"McEwen","year":"2020","journal-title":"J. Neurosci."},{"issue":"14","key":"10.1016\/j.ijpsycho.2021.09.004_bb0135","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.19-14-j0004.1999","article-title":"Exposing rats to a predator blocks primed burst potentiation in the hippocampus in vitro","volume":"19","author":"Mesches","year":"1999","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.ijpsycho.2021.09.004_bb0140","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0028-3932(71)90067-4","article-title":"The assessment and analysis of handedness: the Edinburgh inventory","volume":"9","author":"Oldfield","year":"1971","journal-title":"Neuropsychologia"},{"issue":"Pt 20","key":"10.1016\/j.ijpsycho.2021.09.004_bb0145","doi-asserted-by":"crossref","first-page":"4811","DOI":"10.1113\/jphysiol.2011.210179","article-title":"Neuronal homeostasis: time for a change?","volume":"589","author":"O\u2019Leary","year":"2011","journal-title":"J. Physiol."},{"key":"10.1016\/j.ijpsycho.2021.09.004_bb0150","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1146\/annurev-pharmtox-010617-052735","article-title":"Convergent neuronal plasticity and metaplasticity mechanisms of stress, nicotine, and alcohol","volume":"58","author":"Ostroumov","year":"2018","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"issue":"Pt 8","key":"10.1016\/j.ijpsycho.2021.09.004_bb0155","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1093\/brain\/awh527","article-title":"Homeostatic-like plasticity of the primary motor hand area is impaired in focal hand dystonia","volume":"128","author":"Quartarone","year":"2005","journal-title":"Brain"},{"issue":"3","key":"10.1016\/j.ijpsycho.2021.09.004_bb0160","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s100720100002","article-title":"Modification of cortical excitability induced by gabapentin: a study by transcranial magnetic stimulation","volume":"22","author":"Rizzo","year":"2001","journal-title":"Neurol. Sci."},{"issue":"2","key":"10.1016\/j.ijpsycho.2021.09.004_bb0165","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1093\/cercor\/bhg122","article-title":"Acute stress-induced changes in hippocampal\/prefrontal circuits in rats: effects of antidepressants","volume":"14","author":"Rocher","year":"2004","journal-title":"Cereb. Cortex"},{"issue":"33","key":"10.1016\/j.ijpsycho.2021.09.004_bb0170","doi-asserted-by":"crossref","first-page":"8285","DOI":"10.1523\/JNEUROSCI.1963-08.2008","article-title":"Cortisol inhibits neuroplasticity induction in human motor cortex","volume":"28","author":"Sale","year":"2008","journal-title":"J. Neurosci."},{"issue":"6","key":"10.1016\/j.ijpsycho.2021.09.004_bb0175","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.psyneuen.2008.03.001","article-title":"HPA axis activation by a socially evaluated cold-pressor test","volume":"33","author":"Schwabe","year":"2008","journal-title":"Psychoneuroendocrinology"},{"issue":"13","key":"10.1016\/j.ijpsycho.2021.09.004_bb0180","doi-asserted-by":"crossref","first-page":"3379","DOI":"10.1523\/JNEUROSCI.5316-03.2004","article-title":"Preconditioning of low-frequency repetitive transcranial magnetic stimulation with transcranial direct current stimulation: evidence for homeostatic plasticity in the human motor cortex","volume":"24","author":"Siebner","year":"2004","journal-title":"J. Neurosci."},{"issue":"5","key":"10.1016\/j.ijpsycho.2021.09.004_bb0185","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.clinph.2018.01.060","article-title":"Disruption of cortical synaptic homeostasis in individuals with chronic low back pain","volume":"129","author":"Thapa","year":"2018","journal-title":"Clin. Neurophysiol."},{"issue":"45","key":"10.1016\/j.ijpsycho.2021.09.004_bb0190","doi-asserted-by":"crossref","first-page":"10848","DOI":"10.1523\/JNEUROSCI.1833-17.2017","article-title":"Central network dynamics regulating visceral and humoral functions","volume":"37","author":"Valentino","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ijpsycho.2021.09.004_bb0195","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.neuroimage.2019.04.075","article-title":"The central autonomic network at rest: uncovering functional MRI correlates of time-varying autonomic outflow","volume":"197","author":"Valenza","year":"2019","journal-title":"Neuroimage"},{"issue":"18","key":"10.1016\/j.ijpsycho.2021.09.004_bb0200","doi-asserted-by":"crossref","first-page":"6197","DOI":"10.1523\/JNEUROSCI.4673-09.2010","article-title":"L-type voltage-gated Ca2+ channels: a single molecular switch for long-term potentiation\/long-term depression-like plasticity and activity-dependent metaplasticity in humans","volume":"30","author":"Wankerl","year":"2010","journal-title":"J. Neurosci."},{"issue":"5","key":"10.1016\/j.ijpsycho.2021.09.004_bb0205","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1097\/00001756-199305000-00034","article-title":"Priming of homosynaptic long-term depression in hippocampus by previous synaptic activity","volume":"4","author":"Wexler","year":"1993","journal-title":"Neuroreport"},{"issue":"7","key":"10.1016\/j.ijpsycho.2021.09.004_bb0210","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1162\/jocn_a_00174","article-title":"Stress sensitizes the brain: increased processing of unpleasant pictures after exposure to acute stress","volume":"24","author":"Weymar","year":"2012","journal-title":"J. Cogn. Neurosci."},{"issue":"2","key":"10.1016\/j.ijpsycho.2021.09.004_bb0215","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.psyneuen.2004.07.002","article-title":"Habituation of cortisol responses to repeated psychosocial stress-further characterization and impact of genetic factors","volume":"30","author":"W\u00fcst","year":"2005","journal-title":"Psychoneuroendocrinology"},{"issue":"6632","key":"10.1016\/j.ijpsycho.2021.09.004_bb0220","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/387497a0","article-title":"Behavioural stress facilitates the induction of long-term depression in the hippocampus","volume":"387","author":"Xu","year":"1997","journal-title":"Nature"},{"issue":"17","key":"10.1016\/j.ijpsycho.2021.09.004_bb0225","doi-asserted-by":"crossref","first-page":"4288","DOI":"10.1523\/JNEUROSCI.0406-05.2005","article-title":"Behavioral stress enhances hippocampal CA1 long-term depression through the blockade of the glutamate uptake","volume":"25","author":"Yang","year":"2005","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.ijpsycho.2021.09.004_bb0230","doi-asserted-by":"crossref","first-page":"11","DOI":"10.5114\/aoms.2010.13500","article-title":"Methods of evaluation of autonomic nervous system function","volume":"6","author":"Zygmunt","year":"2010","journal-title":"Arch. Med. Sci."}],"container-title":["International Journal of Psychophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167876021008825?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167876021008825?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T18:33:42Z","timestamp":1673289222000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167876021008825"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":46,"alternative-id":["S0167876021008825"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpsycho.2021.09.004","relation":{},"ISSN":["0167-8760"],"issn-type":[{"value":"0167-8760","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acute social and somatic stress alters cortical metaplasticity probed with non-invasive brain stimulation in humans","name":"articletitle","label":"Article Title"},{"value":"International Journal of Psychophysiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijpsycho.2021.09.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}