{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T08:47:23Z","timestamp":1789202843565,"version":"build-2803163510"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T00:00:00Z","timestamp":1712707200000},"content-version":"vor","delay-in-days":40,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014237","name":"Florida Breast Cancer Foundation","doi-asserted-by":"publisher","award":["3UL1TR001427-07S1"],"award-info":[{"award-number":["3UL1TR001427-07S1"]}],"id":[{"id":"10.13039\/100014237","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100029611","name":"Association of Schools and Colleges of Optometry","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100029611","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006827","name":"Florida Department of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006827","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Particle Therapy"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.ijpt.2024.02.001","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T15:36:27Z","timestamp":1713800187000},"page":"100006","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Effects on Lung Tissue After Breast Cancer Radiation: Comparing Photon and Proton Therapies"],"prefix":"10.1016","volume":"11","author":[{"given":"Shruti","family":"Siva Kumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Bradley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy P.","family":"Mendenhall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond B.","family":"Mailhot Vega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric D.","family":"Brooks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul G.","family":"Okunieff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fantine","family":"Giap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teena","family":"Burchianti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Daily","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coy D.","family":"Heldermon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanna","family":"Galochkina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Hyun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Swarts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter G.","family":"O\u2019Dell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ijpt.2024.02.001_bib1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3322\/caac.21763","article-title":"Cancer statistics, 2023","volume":"73","author":"Siegel","year":"2023","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.ijpt.2024.02.001_bib2","unstructured":"SEERCancer statistics review, 1975\u20132017. SEER. Accessed March 31, 2021. https:\/\/seer.cancer.gov\/csr\/1975_2017\/index.html."},{"key":"10.1016\/j.ijpt.2024.02.001_bib3","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1186\/1748-717X-8-268","article-title":"Meta-analysis of incidence of early lung toxicity in 3-dimensional conformal irradiation of breast carcinomas","volume":"8","author":"Gokula","year":"2013","journal-title":"Radiat Oncol"},{"issue":"6","key":"10.1016\/j.ijpt.2024.02.001_bib4","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1097\/COC.0b013e318280d614","article-title":"Can proton therapy improve the therapeutic ratio in breast cancer patients at risk for nodal disease?","volume":"37","author":"Xu","year":"2014","journal-title":"Am J Clin Oncol"},{"issue":"3","key":"10.1016\/j.ijpt.2024.02.001_bib5","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.ijrobp.2009.02.062","article-title":"Postoperative proton radiotherapy for localized and locoregional breast cancer: potential for clinically relevant improvements?","volume":"76","author":"Ares","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"3","key":"10.1016\/j.ijpt.2024.02.001_bib6","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.ijrobp.2013.01.038","article-title":"Proton therapy for breast cancer after mastectomy: early outcomes of a prospective clinical trial","volume":"86","author":"MacDonald","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"10.1016\/j.ijpt.2024.02.001_bib7","doi-asserted-by":"crossref","first-page":"26","DOI":"10.14338\/IJPT-19-00070.1","article-title":"Insurance coverage for adjuvant proton therapy in the definitive treatment of breast cancer","volume":"6","author":"Mendenhall","year":"2019","journal-title":"Int J Part Ther"},{"issue":"4","key":"10.1016\/j.ijpt.2024.02.001_bib8","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1056\/NEJMoa1415340","article-title":"Regional nodal irradiation in early-stage breast cancer","volume":"373","author":"Whelan","year":"2015","journal-title":"N Engl J Med"},{"issue":"3","key":"10.1016\/j.ijpt.2024.02.001_bib9","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0167-8140(03)00119-1","article-title":"Factors predicting radiation pneumonitis in lung cancer patients: a retrospective study","volume":"67","author":"Rancati","year":"2003","journal-title":"Radiother Oncol"},{"issue":"23","key":"10.1016\/j.ijpt.2024.02.001_bib10","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1093\/jnci\/93.23.1806","article-title":"Risk of pneumonitis in breast cancer patients treated with radiation therapy and combination chemotherapy with paclitaxel","volume":"93","author":"Taghian","year":"2001","journal-title":"J Natl Cancer Inst"},{"issue":"1","key":"10.1016\/j.ijpt.2024.02.001_bib11","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.ijrobp.2005.03.047","article-title":"Radiation pneumonitis and pulmonary fibrosis in non-small-cell lung cancer: pulmonary function, prediction, and prevention","volume":"63","author":"Mehta","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijpt.2024.02.001_bib12","doi-asserted-by":"crossref","first-page":"207","DOI":"10.2147\/CMAR.S136818","article-title":"Clinical features, diagnostic challenges, and management strategies in checkpoint inhibitor-related pneumonitis","volume":"9","author":"Chuzi","year":"2017","journal-title":"Cancer Manag Res"},{"issue":"6","key":"10.1016\/j.ijpt.2024.02.001_bib13","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S0093-7754(02)70008-0","article-title":"A phase III randomized evaluation of amifostine in stage IIIA\/IIIB non-small cell lung cancer patients receiving concurrent carboplatin, paclitaxel, and radiation therapy followed by gemcitabine and cisplatin intensification: preliminary findings","volume":"29","author":"Senzer","year":"2002","journal-title":"Semin Oncol"},{"issue":"3","key":"10.1016\/j.ijpt.2024.02.001_bib14","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.radonc.2008.09.009","article-title":"Dose-volume thresholds and smoking status for the risk of treatment-related pneumonitis in inoperable non-small cell lung cancer treated with definitive radiotherapy","volume":"91","author":"Jin","year":"2009","journal-title":"Radiother Oncol"},{"issue":"2","key":"10.1016\/j.ijpt.2024.02.001_bib15","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1159\/000508493","article-title":"Concomitant radiation recall dermatitis and organizing pneumonia following breast radiotherapy: a case report","volume":"13","author":"Liu","year":"2020","journal-title":"Case Rep Oncol"},{"issue":"7","key":"10.1016\/j.ijpt.2024.02.001_bib16","first-page":"42","article-title":"Image processing with ImageJ","volume":"11","author":"Abramoff","year":"2004","journal-title":"Biophotonics Intern"},{"key":"10.1016\/j.ijpt.2024.02.001_bib17","doi-asserted-by":"crossref","unstructured":"O\u2019Dell WG.Automatic segmentation of tumor-laden lung volumes from the LIDC database. In: Proceedings of the\u00a0SPIE 8315, Medical Imaging 2012: Computer-Aided Diagnosis, 831531; 2012. https:\/\/doi.org\/10.1117\/12.911379.","DOI":"10.1117\/12.911379"},{"key":"10.1016\/j.ijpt.2024.02.001_bib18","doi-asserted-by":"crossref","unstructured":"O\u2019Dell WG, Govindarajan ST, Salgia A, et al. Traversing and labeling interconnected vascular tree structures from 3D medical images. In: Proceedings of the\u00a0SPIE 9034, Medical Imaging 2014: Image Processing 90343C; 2014. doi:\u00a010.1117\/12.2044140.","DOI":"10.1117\/12.2044140"},{"key":"10.1016\/j.ijpt.2024.02.001_bib19","doi-asserted-by":"crossref","unstructured":"O\u2019Dell WG.Method for accurate sizing of pulmonary vessels from 3D medical images. In: Proceedings of the SPIE 9413, Medical Imaging 2015: Image Processing, 94132J; 2015. doi:\u00a010.1117\/12.2082644.","DOI":"10.1117\/12.2082644"},{"issue":"12","key":"10.1016\/j.ijpt.2024.02.001_bib20","article-title":"Validation of the Gatortail method for accurate sizing of pulmonary vessels from 3D medical images","volume":"44","author":"O\u2019Dell","year":"2017","journal-title":"Med Phys"},{"issue":"1","key":"10.1016\/j.ijpt.2024.02.001_bib21","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ejrad.2009.10.029","article-title":"Radiation injury of the lung after stereotactic body radiation therapy (SBRT) for lung cancer: a timeline and pattern of CT changes","volume":"79","author":"Linda","year":"2011","journal-title":"Eur J Radiol"},{"issue":"4","key":"10.1016\/j.ijpt.2024.02.001_bib22","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1002\/1097-0142(196810)22:4<767::AID-CNCR2820220412>3.0.CO;2-7","article-title":"Clinical radiation pathology as applied to curative radiotherapy","volume":"22","author":"Rubin","year":"1968","journal-title":"Cancer"},{"key":"10.1016\/j.ijpt.2024.02.001_bib23","series-title":"Vol Probability and Mathematical Statistics","article-title":"Theory of Rank Tests","author":"Hajek","year":"1999"},{"issue":"1","key":"10.1016\/j.ijpt.2024.02.001_bib24","article-title":"The dose\u2013response characteristics of four NTCP models: using a novel CT-based radiomic method to quantify radiation-induced lung density changes","volume":"10","author":"Begosh-Mayne","year":"2020","journal-title":"Sci\u00a0Rep"},{"issue":"4","key":"10.1016\/j.ijpt.2024.02.001_bib25","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.ijrobp.2018.03.037","article-title":"Asymptomatic late-phase radiographic changes among chest-wall patients are associated with a proton RBE exceeding 1.1","volume":"101","author":"Underwood","year":"2018","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"4","key":"10.1016\/j.ijpt.2024.02.001_bib26","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/bjc.1984.209","article-title":"Comparison of tumour age response to radiation for cells derived from tissue culture or solid tumours","volume":"50","author":"Keng","year":"1984","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ijpt.2024.02.001_bib27","series-title":"Clinical Oncology: A Multidisciplinary Approach for Physicians and Students","first-page":"897","article-title":"Late Effects of Cancer Treatment: Radiation and Chemotherapy Toxicity","author":"Rubin","year":"2002"},{"key":"10.1016\/j.ijpt.2024.02.001_bib28","doi-asserted-by":"crossref","unstructured":"O\u2019Dell W, Wang P, Liu H, Fuller D, Schell MC, Okunieff P.In vivo quantification of human lung dose response relationship. In: Manduca A, Hu XP, eds. Proceedings of the\u00a0SPIE 6511, Medical Imaging 2007: Physiology, Function, and Structure from Medical Images, 65110X. Vol 6511; 2007:65110X-65110X - 9. https:\/\/doi.org\/10.1117\/12.710585.","DOI":"10.1117\/12.710585"}],"container-title":["International Journal of Particle Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2331518024000702?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2331518024000702?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T15:18:18Z","timestamp":1716995898000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2331518024000702"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":28,"alternative-id":["S2331518024000702"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpt.2024.02.001","relation":{},"ISSN":["2331-5180"],"issn-type":[{"value":"2331-5180","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects on Lung Tissue After Breast Cancer Radiation: Comparing Photon and Proton Therapies","name":"articletitle","label":"Article Title"},{"value":"International Journal of Particle Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijpt.2024.02.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V. on behalf of Particle Therapy Co-operative Group.","name":"copyright","label":"Copyright"}],"article-number":"100006"}}