{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T21:48:03Z","timestamp":1776376083641,"version":"3.51.2"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T00:00:00Z","timestamp":1713312000000},"content-version":"vor","delay-in-days":47,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Particle Therapy"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.ijpt.2024.100010","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T03:31:37Z","timestamp":1714015897000},"page":"100010","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Dose Evaluation in 2-Phase Method for Advanced Esophageal Cancer by Hybrid Irradiation Techniques"],"prefix":"10.1016","volume":"11","author":[{"given":"Makoto","family":"Sasaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyasu","family":"Tamamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Tameshige","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuya","family":"Azuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshikazu","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichiro","family":"Matsushita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitaka","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeyuki","family":"Takamatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuya","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoji","family":"Tabata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Yoshimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazutaka","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.ijpt.2024.100010_bib1","doi-asserted-by":"crossref","first-page":"E359","DOI":"10.1002\/ijc.29210","article-title":"Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012","volume":"136","author":"Ferlay","year":"2015","journal-title":"Int J Cancer"},{"issue":"1","key":"10.1016\/j.ijpt.2024.100010_bib2","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1442-2050.2010.01086.x","article-title":"Pattern of lymph node metastases of esophageal squamous cell carcinoma based on the anatomical lymphatic drainage system","volume":"24","author":"Tachimori","year":"2011","journal-title":"Dis Esophagus"},{"issue":"4","key":"10.1016\/j.ijpt.2024.100010_bib3","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s00276-006-0115-y","article-title":"Anatomy of right recurrent nerve node: why does early metastasis of esophageal cancer occur in it?","volume":"28","author":"Mizutani","year":"2006","journal-title":"Surg Radiol Anat"},{"issue":"17","key":"10.1016\/j.ijpt.2024.100010_bib4","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1001\/jama.281.17.1623","article-title":"Chemoradiotherapy of locally advanced esophageal cancer: long-term follow-up of a prospective randomized trial (RTOG 85-01). Radiation Therapy Oncology Group","volume":"281","author":"Cooper","year":"1999","journal-title":"JAMA"},{"issue":"24","key":"10.1016\/j.ijpt.2024.100010_bib5","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1056\/NEJM199206113262403","article-title":"Combined chemotherapy and radiotherapy compared with radiotherapy alone in patients with cancer of the esophagus","volume":"326","author":"Herskovic","year":"1992","journal-title":"N Engl J Med"},{"issue":"5","key":"10.1016\/j.ijpt.2024.100010_bib6","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1200\/JCO.2002.20.5.1167","article-title":"INT 0123 (Radiation Therapy Oncology Group 94-05) phase II trial of combined modality therapy for esophageal cancer: high-dose versus standard-dose radiation therapy","volume":"20","author":"Minsky","year":"2002","journal-title":"J Clin Oncol"},{"issue":"3","key":"10.1016\/j.ijpt.2024.100010_bib7","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.ijrobp.2004.06.022","article-title":"Dose-response relationship in locoregional control for patients with stage II-III esophageal cancer treated with concurrent chemotherapy and radiotherapy","volume":"61","author":"Zhang","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"6","key":"10.1016\/j.ijpt.2024.100010_bib8","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1093\/jjco\/hyu047","article-title":"High-dose versus standard-dose radiotherapy with concurrent chemotherapy in stages II-III esophageal cancer","volume":"44","author":"Suh","year":"2014","journal-title":"Jpn J Clin Oncol"},{"issue":"1","key":"10.1016\/j.ijpt.2024.100010_bib9","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ijrobp.2004.04.003","article-title":"Clinical results of proton beam therapy for cancer of the esophagus","volume":"61","author":"Sugahara","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"10","key":"10.1016\/j.ijpt.2024.100010_bib10","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1093\/jjco\/hyh107","article-title":"Phase II study of cisplatin and 5-fluorouracil with concurrent radiotherapy in advanced squamous cell carcinoma of the esophagus: a Japan Esophageal Oncology Group (JEOG)\/Japan Clinical Oncology Group trial (JCOG9516)","volume":"34","author":"Ishida","year":"2004","journal-title":"Jpn J Clin Oncol"},{"issue":"4","key":"10.1016\/j.ijpt.2024.100010_bib11","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1515\/raon-2015-0034","article-title":"Clinical results of proton beam therapy for twenty older patients with esophageal cancer","volume":"49","author":"Ono","year":"2015","journal-title":"Radiol Oncol"},{"issue":"2","key":"10.1016\/j.ijpt.2024.100010_bib12","doi-asserted-by":"crossref","first-page":"218","DOI":"10.21614\/chirurgia.2715","article-title":"The radiotherapy of locally advanced esophageal cancer of inoperable forms with escalated dose of 66-70 Gy","volume":"117","author":"Chiricu\u0163\u0103","year":"2022","journal-title":"Chirugia"},{"key":"10.1016\/j.ijpt.2024.100010_bib13","unstructured":"National Comprehensive Cancer Network (NCCN). Clinical practice guidelines in oncology (NCCN Guidelines). Esophageal and esophagogastric junction cancers\u00a0version 2.2023. Accessed December 1, 2022. https:\/\/www.nccn.org\/guidelines\/guidelines-detail?category=1&id=1433."},{"key":"10.1016\/j.ijpt.2024.100010_bib14","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1186\/1748-717X-7-200","article-title":"Three-dimensional conformal radiation for esophageal squamous cell carcinoma with involved-field irradiation may deliver considerable doses of incidental nodal irradiation","volume":"7","author":"Ji","year":"2012","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.ijpt.2024.100010_bib15","first-page":"61","article-title":"Guidelines for the clinical and pathologic studies on carcinoma of the esophagus. 11th ed.","volume":"1","author":"Japanese Society for Esophageal Diseases","year":"2015","journal-title":"Esophagus"},{"issue":"7","key":"10.1016\/j.ijpt.2024.100010_bib16","article-title":"What is the optimal radiation technique for esophageal cancer? A dosimetric comparison of four techniques","volume":"10","author":"Fawaz","year":"2018","journal-title":"Cureus"},{"issue":"14","key":"10.1016\/j.ijpt.2024.100010_bib17","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.1200\/JCO.2003.03.055","article-title":"Long-term toxicity after definitive chemoradiotherapy for squamous cell carcinoma of the thoracic esophagus","volume":"21","author":"Ishikura","year":"2003","journal-title":"J Clin Oncol"},{"issue":"7","key":"10.1016\/j.ijpt.2024.100010_bib18","doi-asserted-by":"crossref","first-page":"993","DOI":"10.3390\/cancers11070993","article-title":"Clinical results of proton beam therapy for esophageal cancer: multicenter retrospective study in Japan","volume":"11","author":"Ono","year":"2019","journal-title":"Cancers"},{"issue":"3","key":"10.1016\/j.ijpt.2024.100010_bib19","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1093\/jrr\/rrv001","article-title":"Comparison of adverse effects of proton and X-ray chemoradiotherapy for esophageal cancer using an adaptive dose-volume histogram analysis","volume":"56","author":"Makishima","year":"2015","journal-title":"J Radiat Res"},{"key":"10.1016\/j.ijpt.2024.100010_bib20","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1186\/1748-717X-7-173","article-title":"Designed-seamless irradiation technique for extended whole mediastinal proton-beam irradiation for esophageal cancer","volume":"7","author":"Okonogi","year":"2012","journal-title":"Radiat Oncol"},{"issue":"5","key":"10.1016\/j.ijpt.2024.100010_bib21","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1016\/j.ijrobp.2011.10.053","article-title":"Comparison of heart and coronary artery doses associated with intensity-modulated radiotherapy versus three-dimensional conformal radiotherapy for distal esophageal cancer","volume":"83","author":"Kole","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1009","key":"10.1016\/j.ijpt.2024.100010_bib22","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1259\/bjr\/25428720","article-title":"Volumetric modulated arc therapy planning for distal oesophageal malignancies","volume":"85","author":"Hawkins","year":"2012","journal-title":"Br J Radiol"},{"key":"10.1016\/j.ijpt.2024.100010_bib23","series-title":"TNM Classification of Malignant Tumor","author":"Brierley","year":"2017"},{"issue":"3","key":"10.1016\/j.ijpt.2024.100010_bib24","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000014080","article-title":"Elective nodal irradiation provides a superior therapeutic modality for lymph node positivity esophageal squamous cell carcinoma patients receiving definitive radiotherapy versus involved-field irradiation","volume":"98","author":"Li","year":"2019","journal-title":"Medicine"},{"issue":"1","key":"10.1016\/j.ijpt.2024.100010_bib25","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ijrobp.2009.10.058","article-title":"Development and validation of a heart atlas to study cardiac exposure to radiation following treatment for breast cancer","volume":"79","author":"Feng","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"4","key":"10.1016\/j.ijpt.2024.100010_bib26","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1093\/jrr\/rru003","article-title":"Relative biological effectiveness of therapeutic proton beams for HSG cells at Japanese proton therapy facilities","volume":"55","author":"Aoki-Nakano","year":"2014","journal-title":"J Radiat Res"},{"issue":"3","key":"10.1016\/j.ijpt.2024.100010_bib27","doi-asserted-by":"crossref","first-page":"860","DOI":"10.3390\/cancers15030860","article-title":"Evaluation of exposure doses of elective nodal irradiation in chemoradiotherapy for advanced esophageal cancer","volume":"15","author":"Tamamura","year":"2023","journal-title":"Cancers"},{"issue":"1","key":"10.1016\/j.ijpt.2024.100010_bib28","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/s13014-021-01873-8","article-title":"Applications of various range shifters for proton pencil beam scanning radiotherapy","volume":"16","author":"Lin","year":"2021","journal-title":"Radiat Oncol"},{"issue":"4","key":"10.1016\/j.ijpt.2024.100010_bib29","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1159\/000500039","article-title":"Efficacy of endoscopic evaluation of acute radiation esophagitis during chemoradiotherapy with proton beam therapy boost for esophageal cancer","volume":"101","author":"Hasatani","year":"2020","journal-title":"Digestion"}],"container-title":["International Journal of Particle Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2331518024000763?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2331518024000763?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T15:18:22Z","timestamp":1716995902000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2331518024000763"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":29,"alternative-id":["S2331518024000763"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpt.2024.100010","relation":{},"ISSN":["2331-5180"],"issn-type":[{"value":"2331-5180","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dose Evaluation in 2-Phase Method for Advanced Esophageal Cancer by Hybrid Irradiation Techniques","name":"articletitle","label":"Article Title"},{"value":"International Journal of Particle Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijpt.2024.100010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V. on behalf of Particle Therapy Co-operative Group.","name":"copyright","label":"Copyright"}],"article-number":"100010"}}