{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T21:01:49Z","timestamp":1764277309821,"version":"3.38.0"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T00:00:00Z","timestamp":1735776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Particle Therapy"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.ijpt.2025.100738","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T05:11:52Z","timestamp":1736399512000},"page":"100738","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Carbon-Ion Radiotherapy for Head and Neck Mucosal Melanoma: Preliminary Clinical Outcomes and the MedAustron Approach for Reporting RBE-Weighted Dose With 2 Models"],"prefix":"10.1016","volume":"15","author":[{"given":"Ankita","family":"Nachankar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maciej","family":"Pelak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mansure","family":"Schafasand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Martino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Slavisa","family":"Tubin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugen","family":"Hug","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Carlino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carola","family":"L\u00fctgendorf-Caucig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Stock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piero","family":"Fossati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijpt.2025.100738_bib1","unstructured":"RARECAREnet. 2017. Accessed on: October 2015. http:\/\/rarecarenet.istitutotumori.mi.it\/rarecarenet\/index.php\/cancerlist."},{"issue":"8","key":"10.1016\/j.ijpt.2025.100738_bib2","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/j.ejca.2011.10.004","article-title":"Descriptive epidemiology of malignant mucosal and uveal melanomas and adnexal skin carcinomas in Europe","volume":"48","author":"Mallone","year":"2012","journal-title":"Eur J Cancer"},{"issue":"12","key":"10.1016\/j.ijpt.2025.100738_bib3","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1001\/archoto.2010.217","article-title":"Postoperative radiotherapy in head and neck mucosal melanoma","volume":"136","author":"Benlyazid","year":"2010","journal-title":"Arch Otolaryngol Neck Surg"},{"issue":"3","key":"10.1016\/j.ijpt.2025.100738_bib4","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.ijrobp.2006.01.016","article-title":"Radiotherapy in the treatment of mucosal melanoma of the upper aerodigestive tract: analysis of 74 cases. A Rare Cancer Network study","volume":"65","author":"Krengli","year":"2006","journal-title":"Int J Radiat Oncol"},{"issue":"2","key":"10.1016\/j.ijpt.2025.100738_bib5","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/cncr.20775","article-title":"Postoperative radiotherapy for primary mucosal melanoma of the head and neck","volume":"103","author":"Temam","year":"2005","journal-title":"Cancer"},{"issue":"8","key":"10.1016\/j.ijpt.2025.100738_bib6","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1001\/archotol.129.8.864","article-title":"The role of postoperative adjuvant radiation therapy in the treatment of mucosal melanomas of the head and neck region","volume":"129","author":"Owens","year":"2003","journal-title":"Arch Otolaryngol Head Neck Surg"},{"issue":"2","key":"10.1016\/j.ijpt.2025.100738_bib7","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1046\/j.1365-2273.1998.00099.x","article-title":"Mucosal melanoma of the head and neck","volume":"23","author":"Nandapalan","year":"1998","journal-title":"Clin Otolaryngol Allied Sci"},{"issue":"768","key":"10.1016\/j.ijpt.2025.100738_bib8","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1259\/0007-1285-64-768-1147","article-title":"Radical radiotherapy for 28 cases of mucosal melanoma in the nasal cavity and sinuses","volume":"64","author":"Gilligan","year":"1991","journal-title":"Br J Radiol"},{"issue":"1","key":"10.1016\/j.ijpt.2025.100738_bib9","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0360-3016(93)90142-I","article-title":"The efficacy of radiation therapy for a malignant melanoma in the mucosa of the upper jaw: an analytic study","volume":"25","author":"Shibuya","year":"1993","journal-title":"Int J Radiat Oncol"},{"issue":"2","key":"10.1016\/j.ijpt.2025.100738_bib10","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.ijrobp.2003.11.013","article-title":"A multi-institutional retrospective analysis of external radiotherapy for mucosal melanoma of the head and neck in Northern Japan","volume":"59","author":"Wada","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"10.1016\/j.ijpt.2025.100738_bib11","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s00066-007-1616-2","article-title":"Local high-dose radiotherapy and sparing of normal tissue using intensity-modulated radiotherapy (IMRT) for mucosal melanoma of the nasal cavity and paranasal sinuses","volume":"183","author":"Combs","year":"2014","journal-title":"Strahlenther Onkol"},{"issue":"3","key":"10.1016\/j.ijpt.2025.100738_bib12","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/bjc.2013.373","article-title":"KIT, NRAS and BRAF mutations in sinonasal mucosal melanoma: a study of 56 cases","volume":"109","author":"Zebary","year":"2013","journal-title":"Br J Cancer"},{"issue":"3","key":"10.1016\/j.ijpt.2025.100738_bib13","doi-asserted-by":"crossref","first-page":"S118","DOI":"10.21037\/atm.2019.05.62","article-title":"Immunotherapy for mucosal melanoma","volume":"7","author":"Yentz","year":"2019","journal-title":"Ann Transl Med"},{"issue":"1","key":"10.1016\/j.ijpt.2025.100738_bib14","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.radonc.2011.12.013","article-title":"Results of carbon ion radiotherapy for head and neck cancer","volume":"103","author":"Mizoe","year":"2012","journal-title":"Radiother Oncol"},{"issue":"5","key":"10.1016\/j.ijpt.2025.100738_bib15","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.ijrobp.2016.12.028","article-title":"Multicenter study of carbon-ion radiation therapy for mucosal melanoma of the head and neck: subanalysis of the Japan Carbon-Ion Radiation Oncology Study Group (J-CROS) study (1402 HN)","volume":"97","author":"Koto","year":"2017","journal-title":"Int J Radiat Oncol"},{"issue":"1","key":"10.1016\/j.ijpt.2025.100738_bib16","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ijrobp.2008.07.056","article-title":"Mucosal malignant melanoma of the head and neck treated by carbon ion radiotherapy","volume":"74","author":"Yanagi","year":"2009","journal-title":"Int J Radiat Oncol"},{"key":"10.1016\/j.ijpt.2025.100738_bib17","first-page":"37","article-title":"ICRU report 93: prescribing, recording, and reporting light ion beam therapy","volume":"16","author":"J\u00e4kel","year":"2016","journal-title":"J ICRU"},{"key":"10.1016\/j.ijpt.2025.100738_bib18","doi-asserted-by":"crossref","first-page":"7543","DOI":"10.1088\/0031-9155\/57\/22\/7543","article-title":"Dose prescription in carbon ion radiotherapy: a planning study to compare NIRS and LEM approaches with a clinically-oriented strategy","volume":"57","author":"Fossati","year":"2012","journal-title":"Phys Med Biol"},{"issue":"1","key":"10.1016\/j.ijpt.2025.100738_bib19","doi-asserted-by":"crossref","first-page":"25","DOI":"10.14338\/IJPT-20-00093.1","article-title":"Carbon ion dose constraints in the head and neck and skull base: review of MedAustron Institutional Protocols","volume":"8","author":"Fossati Piero","year":"2021","journal-title":"Int J Part Ther"},{"key":"10.1016\/j.ijpt.2025.100738_bib20","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.radonc.2022.08.008","article-title":"Organs at risk dose constraints in carbon ion radiotherapy at MedAustron: translations between LEM and MKM RBE models and preliminary clinical results","volume":"175","author":"Grosshagauer","year":"2022","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijpt.2025.100738_bib21","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1088\/0031-9155\/60\/1\/437","article-title":"A trichrome beam model for biological dose calculation in scanned carbon-ion radiotherapy treatment planning","volume":"60","author":"Inaniwa","year":"2014","journal-title":"Phys Med Biol"},{"issue":"2","key":"10.1016\/j.ijpt.2025.100738_bib22","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.radonc.2016.05.031","article-title":"Dose prescription in carbon ion radiotherapy: how to compare two different RBE-weighted dose calculation systems","volume":"120","author":"Molinelli","year":"2016","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijpt.2025.100738_bib23","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.radonc.2019.06.028","article-title":"Optic nerve constraints for carbon ion RT at CNAO - reporting and relating outcome to European and Japanese RBE","volume":"140","author":"Dale","year":"2019","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijpt.2025.100738_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2020.531344","article-title":"Brainstem NTCP and dose constraints for carbon ion RT-application and translation from Japanese to European RBE-weighted dose","volume":"10","author":"Dale","year":"2020","journal-title":"Front Oncol"},{"issue":"2","key":"10.1016\/j.ijpt.2025.100738_bib25","doi-asserted-by":"crossref","first-page":"203","DOI":"10.4193\/Rhino.11.267","article-title":"Sinonasal malignant melanoma: an analysis of 115 cases assessing outcomes of surgery, postoperative radiotherapy and endoscopic resection","volume":"50","author":"Lund","year":"2012","journal-title":"Rhinology"},{"issue":"2","key":"10.1016\/j.ijpt.2025.100738_bib26","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s00405-014-3119-y","article-title":"Surgical management of recurrent sinonasal mucosal melanoma: endoscopic or transfacial resection","volume":"272","author":"Ledderose","year":"2015","journal-title":"Eur Arch Oto-Rhino-Laryngol"},{"issue":"5","key":"10.1016\/j.ijpt.2025.100738_bib27","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/j.ijrobp.2014.03.042","article-title":"Mucosal melanoma of the head and neck: a systematic review of the literature","volume":"90","author":"Lazarev","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijpt.2025.100738_bib28","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.radonc.2015.10.025","article-title":"Phase II study of proton beam therapy as a nonsurgical approach for mucosal melanoma of the nasal cavity or para-nasal sinuses","volume":"118","author":"Zenda","year":"2016","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijpt.2025.100738_bib29","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1186\/1748-717X-9-162","article-title":"High-dose proton beam therapy for sinonasal mucosal malignant melanoma","volume":"23","author":"Fuji","year":"2014","journal-title":"Radiat Oncol"},{"issue":"2","key":"10.1016\/j.ijpt.2025.100738_bib30","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1007\/s00066-013-0489-9","article-title":"Particle therapy for mucosal melanoma of the head and neck. A single-institution retrospective comparison of proton and carbon ion therapy","volume":"190","author":"Demizu","year":"2014","journal-title":"Strahlenther Onkol"},{"issue":"S1","key":"10.1016\/j.ijpt.2025.100738_bib31","doi-asserted-by":"crossref","first-page":"E1445","DOI":"10.1002\/hed.24256","article-title":"Raster\u2010scanned intensity\u2010controlled carbon ion therapy for mucosal melanoma of the paranasal sinus","volume":"38","author":"Mohr","year":"2016","journal-title":"Head Neck"},{"issue":"4","key":"10.1016\/j.ijpt.2025.100738_bib32","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1093\/jrr\/rrw117","article-title":"Organizing Committee for the Working Group for Head-and-Neck Cancer. Long-term outcomes after carbon-ion radiotherapy for oral mucosal malignant melanoma","volume":"58","author":"Naganawa","year":"2017","journal-title":"J Radiat Res"},{"issue":"17","key":"10.1016\/j.ijpt.2025.100738_bib33","doi-asserted-by":"crossref","first-page":"7227","DOI":"10.1002\/cam4.2614","article-title":"Carbon\u2010ion radiotherapy combined with chemotherapy for head and neck mucosal melanoma: prospective observational study","volume":"8","author":"Takayasu","year":"2019","journal-title":"Cancer Med"},{"key":"10.1016\/j.ijpt.2025.100738_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2023.110003","article-title":"Curative carbon ion radiotherapy in a head and neck mucosal melanoma series: facing the future within multidisciplinarity","volume":"190","author":"Ronchi","year":"2024","journal-title":"Radiother Oncol"},{"issue":"6","key":"10.1016\/j.ijpt.2025.100738_bib35","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1002\/hed.25618","article-title":"Feasibility of carbon-ion radiotherapy for oral non-squamous cell carcinomas","volume":"41","author":"Ikawa","year":"2019","journal-title":"Head Neck"},{"issue":"12","key":"10.1016\/j.ijpt.2025.100738_bib36","doi-asserted-by":"crossref","first-page":"4465","DOI":"10.1111\/cas.14650","article-title":"Carbon ion radiation therapy for sinonasal malignancies: promising results from 2282 cases from the real world","volume":"111","author":"Zhang","year":"2020","journal-title":"Cancer Sci"},{"issue":"15","key":"10.1016\/j.ijpt.2025.100738_bib37","doi-asserted-by":"crossref","first-page":"5293","DOI":"10.1002\/cam4.3134","article-title":"Efficacy and safety of carbon-ion radiotherapy for the malignant melanoma: a systematic review","volume":"9","author":"Li","year":"2020","journal-title":"Cancer Med"},{"key":"10.1016\/j.ijpt.2025.100738_bib38","doi-asserted-by":"crossref","first-page":"6429","DOI":"10.21873\/anticanres.14664","article-title":"Unresectable chondrosarcomas treated with carbon ion radiotherapy: relationship between dose-averaged linear energy transfer and local recurrence","volume":"40","author":"Matsumoto","year":"2020","journal-title":"Anticancer Res"},{"key":"10.1016\/j.ijpt.2025.100738_bib39","first-page":"19","article-title":"Influence of dose-averaged linear energy transfer on tumour control after carbon-ion radiation therapy for pancreatic cancer","volume":"21","author":"Hagiwara","year":"2020","journal-title":"Clin Transl Radiat Oncol"},{"key":"10.1016\/j.ijpt.2025.100738_bib40","unstructured":"Kohno R, Lee SH, Yamamoto A, et al. Dose-averaged LET evaluation in head and neck adenoid cystic carcinoma patients for carbon-ion radiotherapy. Paper presented at: 63rd Annual Meeting & Exhibition of the American Association of Physicists in Medicine; July 25-29, 2021."},{"key":"10.1016\/j.ijpt.2025.100738_bib41","doi-asserted-by":"crossref","first-page":"5180","DOI":"10.1088\/1361-6560\/aa68d7","article-title":"Treatment planning of intensity modulated composite particle therapy with dose and linear energy transfer optimization","volume":"62","author":"Inaniwa","year":"2017","journal-title":"Phys Med Biol"},{"issue":"1","key":"10.1016\/j.ijpt.2025.100738_bib42","doi-asserted-by":"crossref","first-page":"101317","DOI":"10.1016\/j.adro.2023.101317","article-title":"High\u2013linear energy transfer irradiation in clinical carbon-ion beam with the linear energy transfer painting technique for patients with head and neck cancer","volume":"9","author":"Kohno","year":"2023","journal-title":"Adv Radiat Oncol"},{"key":"10.1016\/j.ijpt.2025.100738_bib43","doi-asserted-by":"crossref","first-page":"15TR02","DOI":"10.1088\/1361-6560\/ac65d3","article-title":"Roadmap: helium ion therapy","volume":"67","author":"Mairani","year":"2022","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ijpt.2025.100738_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2024.110180","article-title":"Dose-averaged LET optimized carbon-ion radiotherapy for head and neck cancers","volume":"194","author":"Koto","year":"2024","journal-title":"Radiother Oncol"},{"issue":"19","key":"10.1016\/j.ijpt.2025.100738_bib45","doi-asserted-by":"crossref","first-page":"4903","DOI":"10.3390\/cancers15194903","article-title":"Planning strategy to optimize the dose-averaged LET distribution in large pelvic sarcomas\/chordomas treated with carbon-ion radiotherapy","volume":"15","author":"Nachankar","year":"2023","journal-title":"Cancers"},{"key":"10.1016\/j.ijpt.2025.100738_bib46","first-page":"556","article-title":"Investigation on the high linear energy transfer dose distribution in small and large tumors in carbon ion therapy","volume":"10","author":"Schafasand","year":"2023","journal-title":"Med Phys"},{"issue":"11","key":"10.1016\/j.ijpt.2025.100738_bib47","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1007\/s11912-023-01453-x","article-title":"Mucosal melanoma: epidemiology, clinical features, and treatment","volume":"25","author":"Sergi","year":"2023","journal-title":"Curr Oncol Rep"},{"key":"10.1016\/j.ijpt.2025.100738_bib48","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.702287","article-title":"Mucosal melanoma: pathological evolution, pathway dependency and targeted therapy","volume":"11","author":"Ma","year":"2021","journal-title":"Front Oncol"},{"issue":"1","key":"10.1016\/j.ijpt.2025.100738_bib49","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1097\/CMR.0000000000000620","volume":"30","author":"Ren","year":"2020","journal-title":"Melanoma Res"},{"issue":"suppl_ 18","key":"10.1016\/j.ijpt.2025.100738_bib50","article-title":"Interferon-\u03b1 as adjuvant therapy for melanoma: an individual patient data meta-analysis of randomised trials","volume":"25","author":"Wheatley","year":"2007","journal-title":"J Clin Oncol"},{"issue":"7","key":"10.1016\/j.ijpt.2025.100738_bib51","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/jnci\/djq009","article-title":"Interferon alpha adjuvant therapy in patients with high-risk melanoma: a systematic review and meta-analysis","volume":"102","author":"Mocellin","year":"2010","journal-title":"JNCI J Natl Cancer Inst"},{"issue":"10212","key":"10.1016\/j.ijpt.2025.100738_bib52","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1016\/S0140-6736(19)32591-7","article-title":"Pembrolizumab alone or with chemotherapy versus cetuximab with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-048): a randomised, open-label, phase 3 study","volume":"394","author":"Burtness","year":"2019","journal-title":"Lancet"},{"issue":"11","key":"10.1016\/j.ijpt.2025.100738_bib53","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1016\/S1470-2045(18)30700-9","article-title":"Nivolumab plus ipilimumab or nivolumab alone versus ipilimumab alone in advanced melanoma (CheckMate 067): 4-year outcomes of a multicentre, randomised, phase 3 trial","volume":"19","author":"Hodi","year":"2018","journal-title":"Lancet Oncol"},{"issue":"2","key":"10.1016\/j.ijpt.2025.100738_bib54","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1200\/JCO.2016.67.9258","article-title":"Efficacy and safety of nivolumab alone or in combination with ipilimumab in patients with mucosal melanoma: a pooled analysis","volume":"35","author":"D\u2019Angelo","year":"2017","journal-title":"J Clin Oncol"},{"issue":"14","key":"10.1016\/j.ijpt.2025.100738_bib55","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1056\/NEJMoa1709684","article-title":"Overall survival with combined nivolumab and ipilimumab in advanced melanoma","volume":"377","author":"Wolchok","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijpt.2025.100738_bib56","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1093\/jnci\/djs629","article-title":"Combining radiotherapy and cancer immunotherapy: a paradigm shift","volume":"105","author":"Formenti","year":"2013","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ijpt.2025.100738_bib57","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.molmed.2013.05.007","article-title":"Immunologically augmented cancer treatment using modern radiotherapy","volume":"19","author":"Durante","year":"2013","journal-title":"Trends Mol Med"},{"issue":"1","key":"10.1016\/j.ijpt.2025.100738_bib58","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1038\/s41467-017-01883-9","article-title":"DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells","volume":"8","author":"Sato","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.ijpt.2025.100738_bib59","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.radonc.2020.07.035","article-title":"Toxicity in combination immune checkpoint inhibitor and radiation therapy: a systematic review and meta-analysis","volume":"151","author":"Sha","year":"2020","journal-title":"Radiother Oncol"},{"issue":"4","key":"10.1016\/j.ijpt.2025.100738_bib60","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1111\/1346-8138.15256","article-title":"Local and disease control for nasal melanoma treated with radiation and concomitant anti\u2010programmed death 1 antibody","volume":"47","author":"Hanaoka","year":"2020","journal-title":"J Dermatol"},{"key":"10.1016\/j.ijpt.2025.100738_bib61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.radonc.2021.08.021","article-title":"Toxicity of carbon ion radiotherapy and immune checkpoint inhibitors in advanced melanoma","volume":"164","author":"Cavalieri","year":"2021","journal-title":"Radiother Oncol"},{"issue":"7","key":"10.1016\/j.ijpt.2025.100738_bib62","article-title":"Efficacy of immune checkpoint inhibitor treatment for head and neck mucosal melanoma recurrence in patients treated with carbon\u2010ion radiotherapy","volume":"6","author":"Musha","year":"2023","journal-title":"Cancer Rep"},{"issue":"15","key":"10.1016\/j.ijpt.2025.100738_bib63","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.3390\/cancers16152625","article-title":"Adjuvant therapy with immune checkpoint inhibitors after carbon ion radiotherapy for mucosal melanoma of the head and neck: a case-control study","volume":"16","author":"Mizoguchi","year":"2024","journal-title":"Cancers"}],"container-title":["International Journal of Particle Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2331518025000010?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2331518025000010?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,9]],"date-time":"2025-03-09T03:05:28Z","timestamp":1741489528000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2331518025000010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":63,"alternative-id":["S2331518025000010"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpt.2025.100738","relation":{},"ISSN":["2331-5180"],"issn-type":[{"type":"print","value":"2331-5180"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Carbon-Ion Radiotherapy for Head and Neck Mucosal Melanoma: Preliminary Clinical Outcomes and the MedAustron Approach for Reporting RBE-Weighted Dose With 2 Models","name":"articletitle","label":"Article Title"},{"value":"International Journal of Particle Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijpt.2025.100738","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of Particle Therapy Co-operative Group.","name":"copyright","label":"Copyright"}],"article-number":"100738"}}