{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:55:07Z","timestamp":1792716907109,"version":"4.5.0"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:00:00Z","timestamp":1744761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Particle Therapy"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.ijpt.2025.100749","type":"journal-article","created":{"date-parts":[[2025,4,20]],"date-time":"2025-04-20T09:57:56Z","timestamp":1745143076000},"page":"100749","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["First Clinical Implementation of Step-and-Shoot Proton Arc Therapy for Head and Neck Cancer Treatment"],"prefix":"10.1016","volume":"16","author":[{"given":"Peilin","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoda","family":"Cong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangkun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weili","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Stevens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohan","family":"Deraniyagala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanfeng","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.ijpt.2025.100749_bib1","first-page":"1107","article-title":"Spot-scanning proton arc (SPArc) therapy: the first robust and delivery-efficient spot-scanning proton arc therapy","volume":"96","author":"Ding","year":"2016","journal-title":"Int\u00a0J\u00a0Radiat\u00a0Oncol Biol Phys"},{"key":"10.1016\/j.ijpt.2025.100749_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.804036","article-title":"Redefine the role of spot-scanning proton beam therapy for the single brain metastasis stereotactic radiosurgery","volume":"12","author":"Chang","year":"2022","journal-title":"Front Oncol"},{"key":"10.1016\/j.ijpt.2025.100749_bib3","article-title":"Lung stereotactic body radiotherapy (SBRT) using spot-scanning proton arc (SPArc) therapy: a feasibility study","volume":"11","author":"Liu","year":"2021","journal-title":"Front Oncol"},{"key":"10.1016\/j.ijpt.2025.100749_bib4","article-title":"Investigate potential clinical benefits and linear energy transfer sparing utilizing proton arc therapy for hepatocellular carcinoma","volume":"126","author":"Liu","year":"2024","journal-title":"Phys\u00a0Med"},{"issue":"1","key":"10.1016\/j.ijpt.2025.100749_bib5","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1186\/s13014-020-01676-3","article-title":"Feasibility study: spot-scanning proton arc therapy (SPArc) for left-sided whole breast radiotherapy","volume":"15","author":"Chang","year":"2020","journal-title":"Radiat Oncol"},{"issue":"3","key":"10.1016\/j.ijpt.2025.100749_bib6","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1080\/0284186X.2017.1358463","article-title":"Have we reached proton beam therapy dosimetric limitations? \u2013 A novel robust, delivery-efficient and continuous spot-scanning proton arc (SPArc) therapy is to improve the dosimetric outcome in treating prostate cancer","volume":"57","author":"Ding","year":"2018","journal-title":"Acta Oncol"},{"key":"10.1016\/j.ijpt.2025.100749_bib7","article-title":"Linear energy transfer incorporated spot-scanning proton arc therapy optimization: a feasibility study","volume":"11","author":"Li","year":"2021","journal-title":"Front Oncol"},{"key":"10.1016\/j.ijpt.2025.100749_bib8","first-page":"130","article-title":"The first prototype of spot-scanning proton arc treatment delivery","volume":"137","author":"Li","year":"2019","journal-title":"Radiother\u00a0Oncol"},{"key":"10.1016\/j.ijpt.2025.100749_bib9","article-title":"Particle arc therapy: status and potential","volume":"199","author":"Mein","year":"2024","journal-title":"Radiother\u00a0Oncol"},{"issue":"3","key":"10.1016\/j.ijpt.2025.100749_bib10","first-page":"1305","article-title":"Spot scanning proton arc therapy reduces toxicity in oropharyngeal cancer patients","volume":"50","author":"De Jong","year":"2023","journal-title":"Med\u00a0Phys"},{"key":"10.1016\/j.ijpt.2025.100749_bib11","article-title":"Partial and full arc with DynamicARC technique in pencil beam scanning proton therapy for bilateral head and neck cancer: a feasibility and dosimetric study","author":"Rana","year":"2024","journal-title":"J Applied Clin Med Phys"},{"issue":"1","key":"10.1016\/j.ijpt.2025.100749_bib12","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s13014-020-1476-9","article-title":"Improve the dosimetric outcome in bilateral head and neck cancer (HNC) treatment using spot-scanning proton arc (SPArc) therapy: a feasibility study","volume":"15","author":"Liu","year":"2020","journal-title":"Radiat Oncol"},{"issue":"10","key":"10.1016\/j.ijpt.2025.100749_bib13","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1080\/0284186X.2020.1765415","article-title":"A novel energy sequence optimization algorithm for efficient spot-scanning proton arc (SPArc) treatment delivery","volume":"59","author":"Liu","year":"2020","journal-title":"Acta Oncol"},{"issue":"16","key":"10.1016\/j.ijpt.2025.100749_bib14","doi-asserted-by":"crossref","first-page":"16NT01","DOI":"10.1088\/1361-6560\/ac8411","article-title":"An evolutionary optimization algorithm for proton arc therapy","volume":"67","author":"Zhao","year":"2022","journal-title":"Phys Med Biol"},{"issue":"11","key":"10.1016\/j.ijpt.2025.100749_bib15","doi-asserted-by":"crossref","first-page":"R99","DOI":"10.1088\/0031-9155\/57\/11\/R99","article-title":"Range uncertainties in proton therapy and the role of Monte Carlo simulations","volume":"57","author":"Paganetti","year":"2012","journal-title":"Phys Med Biol"},{"issue":"6","key":"10.1016\/j.ijpt.2025.100749_bib16","first-page":"e210","article-title":"The clinical usability, efficiency, and accuracy of combing deep-learning-based synthetic CT and auto-contouring for daily CBCT-based online adaptive radiation therapy","volume":"50","author":"Qin","year":"2023","journal-title":"Med\u00a0Phys"},{"issue":"1","key":"10.1016\/j.ijpt.2025.100749_bib17","doi-asserted-by":"crossref","first-page":"01NT01","DOI":"10.1088\/1361-6560\/ac431c","article-title":"Building a precise machine-specific time structure of the spot and energy delivery model for a cyclotron-based proton therapy system","volume":"67","author":"Zhao","year":"2022","journal-title":"Phys Med Biol"},{"issue":"21","key":"10.1016\/j.ijpt.2025.100749_bib18","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6560\/acfec5","article-title":"The first investigation of spot-scanning proton arc (SPArc) delivery time and accuracy with different delivery tolerance window settings","volume":"68","author":"Liu","year":"2023","journal-title":"Phys Med Biol"},{"issue":"4","key":"10.1016\/j.ijpt.2025.100749_bib19","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1002\/mp.16879","article-title":"Development of a standalone delivery sequence model for proton arc therapy","volume":"51","author":"Liu","year":"2024","journal-title":"Med Phys"},{"issue":"3","key":"10.1016\/j.ijpt.2025.100749_bib20","first-page":"S98","article-title":"Investigate the feasibility of using CBCT to assess the dose validation for spot-scanning proton arc (SPArc) therapy for advanced staged lung cancer treatment","volume":"111","author":"Qin","year":"2021","journal-title":"Int\u00a0J\u00a0Radiat\u00a0Oncol\u00a0Biol\u00a0Phys"},{"issue":"9","key":"10.1016\/j.ijpt.2025.100749_bib21","first-page":"5723","article-title":"Partitioning of discrete proton arcs into interlaced subplans can bring proton arc advances to existing proton facilities","volume":"50","author":"Engwall","year":"2023","journal-title":"Med\u00a0Phys"},{"issue":"9","key":"10.1016\/j.ijpt.2025.100749_bib22","first-page":"579","article-title":"Adaptive radiotherapy in the management of cervical cancer: review of strategies and clinical implementation","volume":"33","author":"Shelley","year":"2021","journal-title":"Clin\u00a0Oncol"},{"issue":"22","key":"10.1016\/j.ijpt.2025.100749_bib23","doi-asserted-by":"crossref","first-page":"22TR01","DOI":"10.1088\/1361-6560\/ac344f","article-title":"Adaptive proton therapy","volume":"66","author":"Paganetti","year":"2021","journal-title":"Phys Med Biol"},{"issue":"4","key":"10.1016\/j.ijpt.2025.100749_bib24","first-page":"1054","article-title":"Adaptive radiation therapy (ART) strategies and technical considerations: a state of the ART review from NRG oncology","volume":"109","author":"Glide-Hurst","year":"2021","journal-title":"Int\u00a0J\u00a0Radiat\u00a0Oncol Biol Phys"}],"container-title":["International Journal of Particle Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2331518025000125?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2331518025000125?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T15:19:10Z","timestamp":1762615150000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2331518025000125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":24,"alternative-id":["S2331518025000125"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpt.2025.100749","relation":{},"ISSN":["2331-5180"],"issn-type":[{"value":"2331-5180","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"First Clinical Implementation of Step-and-Shoot Proton Arc Therapy for Head and Neck Cancer Treatment","name":"articletitle","label":"Article Title"},{"value":"International Journal of Particle Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijpt.2025.100749","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of Particle Therapy Co-operative Group.","name":"copyright","label":"Copyright"}],"article-number":"100749"}}