{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T22:15:10Z","timestamp":1766182510687,"version":"3.41.0"},"reference-count":9,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Particle Therapy"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.ijpt.2025.100751","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T23:48:04Z","timestamp":1747871284000},"page":"100751","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Optimizing QACT Frequency and Setup Uncertainty in Cranial Proton Therapy for Normal Tissue Sparing"],"prefix":"10.1016","volume":"16","author":[{"given":"Rachel B.","family":"Ger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anh","family":"Tran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria J.","family":"Croog","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence R.","family":"Kleinberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Kut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandi R.","family":"Page","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristin J.","family":"Redmond","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.ijpt.2025.100751_bib1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.semradonc.2017.11.005","article-title":"Robust proton treatment planning: physical and biological optimization","volume":"28","author":"Unkelbach","year":"2018","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.ijpt.2025.100751_bib2","first-page":"267","article-title":"Practical robustness evaluation in radiotherapy \u2013 a photon and proton-proof alternative to PTV-based plan evaluation","volume":"141","author":"Korevaar","year":"2019","journal-title":"Radiother\u00a0Oncol"},{"issue":"2","key":"10.1016\/j.ijpt.2025.100751_bib3","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1118\/1.3679340","article-title":"Robust optimization of intensity modulated proton therapy","volume":"39","author":"Liu","year":"2012","journal-title":"Med Phys"},{"issue":"6","key":"10.1016\/j.ijpt.2025.100751_bib4","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1088\/0031-9155\/53\/6\/013","article-title":"Worst case optimization: a method to account for uncertainties in the optimization of intensity modulated proton therapy","volume":"53","author":"Pflugfelder","year":"2008","journal-title":"Phys Med Biol"},{"issue":"9","key":"10.1016\/j.ijpt.2025.100751_bib5","doi-asserted-by":"crossref","DOI":"10.1118\/1.4892601","article-title":"The influence of patient positioning uncertainties in proton radiotherapy on proton range and dose distributions","volume":"41","author":"Liebl","year":"2014","journal-title":"Med Phys"},{"issue":"5","key":"10.1016\/j.ijpt.2025.100751_bib6","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.ijrobp.2013.04.009","article-title":"Statistical assessment of proton treatment plans under setup and range uncertainties","volume":"86","author":"Park","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"22","key":"10.1016\/j.ijpt.2025.100751_bib7","doi-asserted-by":"crossref","first-page":"5486","DOI":"10.3390\/cancers15225486","article-title":"Setup uncertainty of pediatric brain tumor patients receiving proton therapy: a prospective study","volume":"15","author":"Becksfort","year":"2023","journal-title":"Cancers"},{"issue":"6","key":"10.1016\/j.ijpt.2025.100751_bib8","doi-asserted-by":"crossref","DOI":"10.1002\/acm2.13604","article-title":"Dosimetric evaluation of cone-beam CT-based synthetic CTs in pediatric patients undergoing intensity-modulated proton therapy","volume":"23","author":"Sheikh","year":"2022","journal-title":"J Appl Clin Med Phys"},{"issue":"11","key":"10.1016\/j.ijpt.2025.100751_bib9","article-title":"Use of virtual CT and on-treatment MRI to reduce radiation dose and anesthesia exposure associated with the adaptive workflow in pediatric patients treated with intensity modulated proton therapy","volume":"9","author":"Sheikh","year":"2024","journal-title":"Adv Radiat Oncol"}],"container-title":["International Journal of Particle Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2331518025000149?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2331518025000149?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T13:16:13Z","timestamp":1749215773000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2331518025000149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":9,"alternative-id":["S2331518025000149"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpt.2025.100751","relation":{},"ISSN":["2331-5180"],"issn-type":[{"type":"print","value":"2331-5180"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Optimizing QACT Frequency and Setup Uncertainty in Cranial Proton Therapy for Normal Tissue Sparing","name":"articletitle","label":"Article Title"},{"value":"International Journal of Particle Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijpt.2025.100751","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of Particle Therapy Co-operative Group.","name":"copyright","label":"Copyright"}],"article-number":"100751"}}