{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T14:33:08Z","timestamp":1775485988518,"version":"3.50.1"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Particle Therapy"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.ijpt.2026.101304","type":"journal-article","created":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T16:01:58Z","timestamp":1770480118000},"page":"101304","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Long Term Results of Proton Therapy in Adult Infradiaphragmatic Lymphoma"],"prefix":"10.1016","volume":"19","author":[{"given":"Cecilia","family":"Jiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Travis","family":"Hoover","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Baron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bolin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harper","family":"Hubbeling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elise A.","family":"Chong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordan","family":"Carter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakub","family":"Svoboda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen J.","family":"Schuster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J.","family":"Landsburg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunita D.","family":"Nasta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Plastaras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"LaRiviere","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.ijpt.2026.101304_bib1","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/S0360-3016(97)00026-6","article-title":"The incidence of breast cancer following mantle field radiation therapy as a function of dose and technique","volume":"37","author":"Tinger","year":"1997","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"4","key":"10.1016\/j.ijpt.2026.101304_bib2","first-page":"1003","article-title":"Long-term cardiovascular evaluation of patients with Hodgkin's disease treated by thoracic mantle radiation therapy","volume":"66","author":"Applefeld","year":"1982","journal-title":"Cancer Treat Rep"},{"issue":"1","key":"10.1016\/j.ijpt.2026.101304_bib3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ijrobp.2015.01.009","article-title":"Modern radiation therapy for extranodal lymphomas: field and dose guidelines from the International Lymphoma Radiation Oncology Group","volume":"92","author":"Yahalom","year":"2015","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"16","key":"10.1016\/j.ijpt.2026.101304_bib4","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1182\/blood-2018-03-837633","article-title":"Proton therapy for adults with mediastinal lymphomas: the International Lymphoma Radiation Oncology Group guidelines","volume":"132","author":"Dabaja","year":"2018","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.ijpt.2026.101304_bib5","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/j.ijrobp.2008.12.048","article-title":"Dosimetric comparison of three different involved nodal irradiation techniques for stage II Hodgkin's lymphoma patients: conventional radiotherapy, intensity-modulated radiotherapy, and three-dimensional proton radiotherapy","volume":"75","author":"Chera","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"8","key":"10.1016\/j.ijpt.2026.101304_bib6","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1093\/annonc\/mdt156","article-title":"Estimated risk of cardiovascular disease and secondary cancers with modern highly conformal radiotherapy for early-stage mediastinal Hodgkin lymphoma","volume":"24","author":"Maraldo","year":"2013","journal-title":"Ann Oncol"},{"issue":"9","key":"10.1016\/j.ijpt.2026.101304_bib7","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1093\/annonc\/mdx287","article-title":"Consolidative proton therapy after chemotherapy for patients with Hodgkin lymphoma","volume":"28","author":"Hoppe","year":"2017","journal-title":"Ann Oncol"},{"key":"10.1016\/j.ijpt.2026.101304_bib8","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1748-717X-8-22","article-title":"Hodgkin's lymphoma emerging radiation treatment techniques: trade-offs between late radio-induced toxicities and secondary malignant neoplasms","volume":"8","author":"Cella","year":"2013","journal-title":"Radiat Oncol"},{"issue":"7","key":"10.1016\/j.ijpt.2026.101304_bib9","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.3109\/10428194.2014.975802","article-title":"Proton therapy to the subdiaphragmatic region in the management of patients with Hodgkin lymphoma","volume":"56","author":"Sachsman","year":"2015","journal-title":"Leuk Lymphoma"},{"issue":"1","key":"10.1016\/j.ijpt.2026.101304_bib10","article-title":"Proton radiation therapy after chemotherapy in the management of aggressive mediastinal non-hodgkin lymphomas: a Particle Therapy Cooperative Group Lymphoma Subcommittee Collaboration","volume":"8","author":"Baron","year":"2022","journal-title":"Adv Radiat Oncol"},{"issue":"4","key":"10.1016\/j.ijpt.2026.101304_bib11","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.ijrobp.2021.10.151","article-title":"Proton therapy in supradiaphragmatic lymphoma: predicting treatment-related mortality to help optimize patient selection","volume":"112","author":"Ntentas","year":"2022","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"10","key":"10.1016\/j.ijpt.2026.101304_bib12","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1200\/JCO.1986.4.10.1551","article-title":"Hodgkin's disease presenting below the diaphragm: a review","volume":"4","author":"Krikorian","year":"1986","journal-title":"J Clin Oncol"},{"issue":"6","key":"10.1016\/j.ijpt.2026.101304_bib13","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1002\/cncr.31903","article-title":"High prevalence of advanced colorectal neoplasia and serrated polyposis syndrome in Hodgkin lymphoma survivors","volume":"125","author":"Rigter","year":"2019","journal-title":"Cancer"},{"issue":"3","key":"10.1016\/j.ijpt.2026.101304_bib14","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/bjc.2017.177","article-title":"Infradiaphragmatic irradiation and high procarbazine doses increase colorectal cancer risk in Hodgkin lymphoma survivors","volume":"117","author":"van Eggermond","year":"2017","journal-title":"Br J Cancer"},{"issue":"12","key":"10.1016\/j.ijpt.2026.101304_bib15","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1158\/1055-9965.EPI-22-0019","article-title":"Cost-effectiveness of colorectal cancer surveillance in hodgkin lymphoma survivors treated with procarbazine and\/or infradiaphragmatic radiotherapy","volume":"31","author":"Ykema","year":"2022","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"4","key":"10.1016\/j.ijpt.2026.101304_bib16","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1007\/s11547-023-01615-8","article-title":"Efficacy and toxicity of infradiaphragmal radiotherapy fields in lymphoma patients: a single-centre experience","volume":"128","author":"Galunic Bilic","year":"2023","journal-title":"Radiol Med"},{"issue":"10","key":"10.1016\/j.ijpt.2026.101304_bib17","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/S1470-2045(12)70323-6","article-title":"Radiation dose to the pancreas and risk of diabetes mellitus in childhood cancer survivors: a retrospective cohort study","volume":"13","author":"de Vathaire","year":"2012","journal-title":"Lancet Oncol"},{"issue":"2","key":"10.1016\/j.ijpt.2026.101304_bib18","doi-asserted-by":"crossref","first-page":"W192","DOI":"10.2214\/AJR.13.12149","article-title":"Renal remodeling after abdominal radiation therapy: parenchymal and functional changes","volume":"203","author":"Tran","year":"2014","journal-title":"AJR Am J Roentgenol"},{"issue":"5","key":"10.1016\/j.ijpt.2026.101304_bib19","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.ijrobp.2020.03.019","article-title":"Involved site radiation therapy in adult lymphomas: an overview of International Lymphoma Radiation Oncology Group Guidelines","volume":"107","author":"Wirth","year":"2020","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"10.1016\/j.ijpt.2026.101304_bib20","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0360-3016(02)02754-2","article-title":"Relative biological effectiveness (RBE) values for proton beam therapy","volume":"53","author":"Paganetti","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"10.1016\/j.ijpt.2026.101304_bib21","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.canrad.2020.05.018","article-title":"Irradiation pelvienne et toxicit\u00e9 h\u00e9matopo\u00ef\u00e9tique: revue de la litt\u00e9rature [Pelvic irradiation and hematopoietic toxicity: A review of the literature]","volume":"25","author":"Kuntz","year":"2021","journal-title":"Cancer Radiother"},{"issue":"2","key":"10.1016\/j.ijpt.2026.101304_bib22","first-page":"195","article-title":"Bone marrow and peripheral blood cells toxicity of a Single 2.0 Gy Cobalt60 ionizing radiation: an animal model","volume":"29","author":"Akeem","year":"2019","journal-title":"Ethiop J Health Sci"},{"issue":"1","key":"10.1016\/j.ijpt.2026.101304_bib23","article-title":"The influence of pelvic bone dose-volume parameters on bone marrow suppression during radiation therapy in patients with stage i to iii rectal cancer based on real-world data","volume":"10","author":"Huang","year":"2024","journal-title":"Adv Radiat Oncol"},{"issue":"13","key":"10.1016\/j.ijpt.2026.101304_bib24","doi-asserted-by":"crossref","first-page":"5383","DOI":"10.1158\/0008-5472.CAN-08-3845","article-title":"Lymphopenia as a prognostic factor for overall survival in advanced carcinomas, sarcomas, and lymphomas","volume":"69","author":"Ray-Coquard","year":"2009","journal-title":"Cancer Res"},{"issue":"5-6","key":"10.1016\/j.ijpt.2026.101304_bib25","doi-asserted-by":"crossref","first-page":"519","DOI":"10.3109\/10428199909058479","article-title":"Therapeutic and prognostic implications of peripheral blood lymphopenia in patients with Hodgkin's disease","volume":"34","author":"Ayoub","year":"1999","journal-title":"Leuk Lymphoma"},{"issue":"5","key":"10.1016\/j.ijpt.2026.101304_bib26","doi-asserted-by":"crossref","first-page":"427","DOI":"10.3390\/jpm11050427","article-title":"Concurrent chemoradiation in anal cancer patients delivered with bone marrow-sparing IMRT: final results of a prospective phase II trial","volume":"11","author":"Arcadipane","year":"2021","journal-title":"J Pers Med"},{"issue":"6","key":"10.1016\/j.ijpt.2026.101304_bib27","article-title":"Analysis of chronic kidney disease after radiation therapy for gastric\/duodenal mucosa-associated lymphoid tissue lymphoma","volume":"6","author":"Katsuta","year":"2021","journal-title":"Adv Radiat Oncol"},{"issue":"1","key":"10.1016\/j.ijpt.2026.101304_bib28","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/S0360-3016(01)01820-X","article-title":"The dose-volume relationship of acute small bowel toxicity from concurrent 5-FU-based chemotherapy and radiation therapy for rectal cancer","volume":"52","author":"Baglan","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"7","key":"10.1016\/j.ijpt.2026.101304_bib29","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1080\/02841860701317873","article-title":"Dose-volume relationships between enteritis and irradiated bowel volumes during 5-fluorouracil and oxaliplatin based chemoradiotherapy in locally advanced rectal cancer","volume":"46","author":"Gunnlaugsson","year":"2007","journal-title":"Acta Oncol"},{"issue":"1107","key":"10.1016\/j.ijpt.2026.101304_bib30","doi-asserted-by":"crossref","DOI":"10.1259\/bjr.20190226","article-title":"Proton beam therapy for tumors of the upper abdomen","volume":"93","author":"Raldow","year":"2020","journal-title":"Br J Radiol"},{"issue":"11","key":"10.1016\/j.ijpt.2026.101304_bib31","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1080\/0284186X.2016.1197422","article-title":"Proton therapy patterns-of-care and early outcomes for Hodgkin lymphoma: results from the Proton Collaborative Group Registry","volume":"55","author":"Hoppe","year":"2016","journal-title":"Acta Oncol"},{"key":"10.1016\/j.ijpt.2026.101304_bib32","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1001\/jama.294.20.2587","article-title":"Risk of pelvic fractures in older women following pelvic irradiation","volume":"294","author":"Baxter","year":"2005","journal-title":"JAMA"},{"key":"10.1016\/j.ijpt.2026.101304_bib33","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.archger.2016.06.020","article-title":"Risk factors for pelvic insufficiency fractures and outcome after conservative therapy","volume":"67","author":"Maier","year":"2016","journal-title":"Arch Gerontol Geriatr"},{"key":"10.1016\/j.ijpt.2026.101304_bib34","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.ijrobp.2017.01.026","article-title":"Risk factors for pelvic insufficiency fractures in locally advanced cervical cancer following intensity modulated radiation therapy","volume":"97","author":"Ramlov","year":"2017","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijpt.2026.101304_bib35","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.ijrobp.2009.05.059","article-title":"Insufficiency fractures after pelvic radiotherapy in patients with prostate cancer","volume":"77","author":"\u0130\u011fdem","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijpt.2026.101304_bib36","doi-asserted-by":"crossref","DOI":"10.1259\/bjr.20160885","article-title":"Pelvic insufficiency fracture (PIF) incidence in patients treated with intensity-modulated radiation therapy (IMRT) for gynaecological or anal cancer: single-institution experience and review of the literature","volume":"90","author":"Bazire","year":"2017","journal-title":"Br J Radiol"},{"issue":"1","key":"10.1016\/j.ijpt.2026.101304_bib37","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ijrobp.2024.07.2314","article-title":"Pelvic bone marrow sparing intensity modulated radiation therapy reduces the bone mineral density loss of patients with cervical cancer","volume":"121","author":"Huang","year":"2025","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"10.1016\/j.ijpt.2026.101304_bib38","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1093\/rpd\/ncr218","article-title":"Empirical model estimation of relative biological effectiveness for proton beam therapy","volume":"149","author":"Chen","year":"2012","journal-title":"Radiat Prot Dosimetry"},{"key":"10.1016\/j.ijpt.2026.101304_bib39","doi-asserted-by":"crossref","first-page":"261","DOI":"10.3389\/fonc.2015.00261","article-title":"Secondary malignancy risk following proton radiation therapy","volume":"5","author":"Eaton","year":"2015","journal-title":"Front Oncol"},{"issue":"22","key":"10.1016\/j.ijpt.2026.101304_bib40","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6560\/ac3209","article-title":"Secondary neutron dose contribution from pencil beam scanning, scattered and spatially fractionated proton therapy","volume":"66","author":"Leite","year":"2021","journal-title":"Phys Med Biol"},{"issue":"18","key":"10.1016\/j.ijpt.2026.101304_bib41","doi-asserted-by":"crossref","first-page":"4337","DOI":"10.1088\/0031-9155\/50\/18\/007","article-title":"Simulation of organ-specific patient effective dose due to secondary neutrons in proton radiation treatment","volume":"50","author":"Jiang","year":"2005","journal-title":"Phys Med Biol"},{"issue":"3","key":"10.1016\/j.ijpt.2026.101304_bib42","doi-asserted-by":"crossref","first-page":"E90","DOI":"10.1148\/rg.2021210028","article-title":"Invited commentary: secondary malignancies in patients treated with radiation therapy","volume":"41","author":"Shapiro","year":"2021","journal-title":"Radiographics"},{"key":"10.1016\/j.ijpt.2026.101304_bib43","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.893855","article-title":"Risk of secondary malignant neoplasms in children following proton therapy vs. photon therapy for primary CNS tumors: A systematic review and meta-analysis","volume":"12","author":"Upadhyay","year":"2022","journal-title":"Front Oncol"},{"issue":"1","key":"10.1016\/j.ijpt.2026.101304_bib44","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ijrobp.2013.04.030","article-title":"Incidence of second malignancies among patients treated with proton versus photon radiation","volume":"87","author":"Chung","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["International Journal of Particle Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2331518026000077?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2331518026000077?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T13:41:30Z","timestamp":1775482890000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2331518026000077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":44,"alternative-id":["S2331518026000077"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpt.2026.101304","relation":{},"ISSN":["2331-5180"],"issn-type":[{"value":"2331-5180","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long Term Results of Proton Therapy in Adult Infradiaphragmatic Lymphoma","name":"articletitle","label":"Article Title"},{"value":"International Journal of Particle Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijpt.2026.101304","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V. on behalf of Particle Therapy Co-operative Group.","name":"copyright","label":"Copyright"}],"article-number":"101304"}}