{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T14:29:00Z","timestamp":1771684140777,"version":"3.50.1"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,5]],"date-time":"2023-02-05T00:00:00Z","timestamp":1675555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004156","name":"Mahidol University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Pharmaceutics: X"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.ijpx.2023.100169","type":"journal-article","created":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T19:19:07Z","timestamp":1675883947000},"page":"100169","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Antibiotic-loaded hydroxyapatite scaffolds fabricated from Nile tilapia bones for orthopaedics"],"prefix":"10.1016","volume":"5","author":[{"given":"Atchara","family":"Khamkongkaeo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arreerat","family":"Jiamprasertboon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nanthawan","family":"Jinakul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phatraya","family":"Srabua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saran","family":"Tantavisut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amaraporn","family":"Wongrakpanich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"115","key":"10.1016\/j.ijpx.2023.100169_bb0005","doi-asserted-by":"crossref","first-page":"113871","DOI":"10.1039\/C6RA24382G","article-title":"Enhanced corrosion protection and biocompatibility of a PLGA\u2013silane coating on AZ31 Mg alloy for orthopaedic applications","volume":"6","author":"Agarwal","year":"2016","journal-title":"RSC Adv."},{"key":"10.1016\/j.ijpx.2023.100169_bb0010","series-title":"Standard Test Method for Compressive Properties of Rigid Plastics","author":"ASTM S. D695","year":"2008"},{"issue":"6","key":"10.1016\/j.ijpx.2023.100169_bb0015","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1302\/2046-3758.106.BJR-2021-0167.R1","article-title":"Fracture-related infection","volume":"10","author":"Baertl","year":"2021","journal-title":"Bone Joint Res."},{"key":"10.1016\/j.ijpx.2023.100169_bb0020","article-title":"Synthesis of B-type carbonated hydroxyapatite by a new dissolution-precipitation method","volume":"31","author":"Benataya","year":"2020","journal-title":"Mater. Today: Proc."},{"issue":"1","key":"10.1016\/j.ijpx.2023.100169_bb0025","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1038\/s41598-022-05207-w","article-title":"PLA\/Hydroxyapatite scaffolds exhibit in vitro immunological inertness and promote robust osteogenic differentiation of human mesenchymal stem cells without osteogenic stimuli","volume":"12","author":"Bernardo","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ijpx.2023.100169_bb0030","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.actbio.2020.06.022","article-title":"\u03b2-Tricalcium phosphate for bone substitution: Synthesis and properties","volume":"113","author":"Bohner","year":"2020","journal-title":"Acta Biomater."},{"issue":"25","key":"10.1016\/j.ijpx.2023.100169_bb0035","doi-asserted-by":"crossref","first-page":"6485","DOI":"10.1016\/j.biomaterials.2010.05.013","article-title":"The role of pharmacologically active microcarriers releasing TGF-\u03b23 in cartilage formation in vivo by mesenchymal stem cells","volume":"31","author":"Bouffi","year":"2010","journal-title":"Biomaterials."},{"issue":"1","key":"10.1016\/j.ijpx.2023.100169_bb0040","doi-asserted-by":"crossref","first-page":"3610","DOI":"10.1038\/s41598-017-03737-2","article-title":"Formation of biphasic hydroxylapatite-beta magnesium tricalcium phosphate in heat treated salmonid vertebrae","volume":"7","author":"Butler","year":"2017","journal-title":"Sci. Rep."},{"issue":"14","key":"10.1016\/j.ijpx.2023.100169_bb0045","doi-asserted-by":"crossref","first-page":"2969","DOI":"10.1016\/j.jeurceramsoc.2009.04.038","article-title":"Mg-substituted hydroxyapatite nanopowders: Synthesis, thermal stability and sintering behaviour","volume":"29","author":"Cacciotti","year":"2009","journal-title":"J. Eur. Ceram. Soc."},{"issue":"7","key":"10.1016\/j.ijpx.2023.100169_bb0050","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1007\/s11999-013-2875-0","article-title":"Staphylococcus aureus screening and decolonization in orthopaedic surgery and reduction of surgical site infections","volume":"471","author":"Chen","year":"2013","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.ijpx.2023.100169_bb0055","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.cej.2018.01.010","article-title":"Biocompatibility, biodegradation and excretion of polylactic acid (PLA) in medical implants and theranostic systems","volume":"340","author":"da Silva","year":"2018","journal-title":"Chem. Eng. J."},{"issue":"5","key":"10.1016\/j.ijpx.2023.100169_bb0060","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.cmi.2019.08.006","article-title":"Pathogenesis and management of fracture-related infection","volume":"26","author":"Depypere","year":"2020","journal-title":"Clin. Microbiol. Infect."},{"issue":"6","key":"10.1016\/j.ijpx.2023.100169_bb0065","doi-asserted-by":"crossref","DOI":"10.1002\/advs.201700817","article-title":"A multimaterial scaffold with tunable properties: toward bone tissue repair","volume":"5","author":"Feng","year":"2018","journal-title":"Adv. Sci."},{"key":"10.1016\/j.ijpx.2023.100169_bb0070","article-title":"Hydroxyapatite nanoparticles in situ grown on carbon nanotube as a reinforcement for poly (\u03b5-caprolactone) bone scaffold","volume":"15","author":"Feng","year":"2022","journal-title":"Mater. Today Adv."},{"issue":"8","key":"10.1016\/j.ijpx.2023.100169_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2022.e10356","article-title":"Extraction of natural hydroxyapatite for biomedical applications\u2014a review","volume":"8","author":"Firdaus Hussin","year":"2022","journal-title":"Heliyon."},{"issue":"4","key":"10.1016\/j.ijpx.2023.100169_bb0080","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1080\/14787210.2020.1729740","article-title":"Fracture-related infection: current methods for prevention and treatment","volume":"18","author":"Foster","year":"2020","journal-title":"Expert Rev. Anti-Infect. Ther."},{"issue":"4","key":"10.1016\/j.ijpx.2023.100169_bb0085","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1080\/14787210.2020.1729740","article-title":"Fracture-related infection: current methods for prevention and treatment","volume":"18","author":"Foster","year":"2020","journal-title":"Expert Rev. Anti-Infect. Ther."},{"issue":"1","key":"10.1016\/j.ijpx.2023.100169_bb0090","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.ijpharm.2010.11.030","article-title":"Modelling drug release from inert matrix systems: from moving-boundary to continuous-field descriptions","volume":"418","author":"Frenning","year":"2011","journal-title":"Int. J. Pharm."},{"issue":"7, Part B","key":"10.1016\/j.ijpx.2023.100169_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.ceramint.2014.03.067","article-title":"Effects of trace elements in fish bones on crystal characteristics of hydroxyapatite obtained by calcination","volume":"40","author":"Goto","year":"2014","journal-title":"Ceram. Int."},{"issue":"2","key":"10.1016\/j.ijpx.2023.100169_bb0100","first-page":"80","article-title":"Hydroxyapatite from fish for Bone Tissue Engineering: a Promising Approach","volume":"7","author":"Granito","year":"2018","journal-title":"Int. J. Mol. Cell Med."},{"key":"10.1016\/j.ijpx.2023.100169_bb0105","doi-asserted-by":"crossref","DOI":"10.1089\/ten.tea.2008.0543","article-title":"The influence of hydroxyapatite particles on in vitro degradation behavior of poly \u025b-caprolactone\u2013based composite scaffolds","volume":"15","author":"Guarino","year":"2009","journal-title":"Tissue Eng. A"},{"issue":"9","key":"10.1016\/j.ijpx.2023.100169_bb0110","doi-asserted-by":"crossref","first-page":"14124","DOI":"10.1016\/j.ceramint.2020.02.217","article-title":"Degradation behaviors of three-dimensional hydroxyapatite fibrous scaffolds stabilized by different biodegradable polymers","volume":"46","author":"Guo","year":"2020","journal-title":"Ceram. Int."},{"issue":"4B","key":"10.1016\/j.ijpx.2023.100169_bb0115","first-page":"1684","article-title":"Spectrophotometric determination of vancomycin hydrochloride in pharmaceutical preparations through diazotization and coupling reactions","volume":"55","author":"Hadi","year":"2014","journal-title":"Iraqi J. Sci."},{"issue":"4","key":"10.1016\/j.ijpx.2023.100169_bb0120","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3390\/jfb13040187","article-title":"Calcium Phosphate-based Biomaterials for Bone Repair","volume":"13","author":"Hou","year":"2022","journal-title":"J. Funct. Biomater."},{"issue":"17","key":"10.1016\/j.ijpx.2023.100169_bb0125","doi-asserted-by":"crossref","first-page":"9721","DOI":"10.3390\/ijms23179721","article-title":"Recent advances in hydroxyapatite-based biocomposites for bone tissue regeneration in orthopedics","volume":"23","author":"Ielo","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.ijpx.2023.100169_bb0130","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/BF00120386","article-title":"Determination of the Ca\/P ratio in calcium-deficient hydroxyapatite using X-ray diffraction analysis","volume":"4","author":"Ishikawa","year":"1993","journal-title":"J. Mater. Sci. Mater. Med."},{"issue":"24","key":"10.1016\/j.ijpx.2023.100169_bb0135","doi-asserted-by":"crossref","first-page":"34575","DOI":"10.1016\/j.ceramint.2021.08.372","article-title":"Sintering behavior and mechanical properties of hydroxyapatite ceramics prepared from Nile Tilapia (Oreochromis niloticus) bone and commercial powder for biomedical applications","volume":"47","author":"Khamkongkaeo","year":"2021","journal-title":"Ceram. Int."},{"issue":"1","key":"10.1016\/j.ijpx.2023.100169_bb0140","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.4314\/ahs.v19i1.12","article-title":"MRSA: the leading pathogen of orthopedic infection in a tertiary care hospital, South India","volume":"19","author":"Latha","year":"2019","journal-title":"Afr. Health Sci."},{"issue":"3","key":"10.1016\/j.ijpx.2023.100169_bb0145","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.3390\/polym3031377","article-title":"Poly lactic-co-glycolic acid (PLGA) as biodegradable controlled drug delivery carrier","volume":"3","author":"Makadia","year":"2011","journal-title":"Polymers (Basel)"},{"issue":"3","key":"10.1016\/j.ijpx.2023.100169_bb0150","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.3390\/polym3031377","article-title":"Poly lactic-co-glycolic acid (PLGA) as biodegradable controlled drug delivery carrier","volume":"3","author":"Makadia","year":"2011","journal-title":"Polymers."},{"issue":"1","key":"10.1016\/j.ijpx.2023.100169_bb0155","doi-asserted-by":"crossref","DOI":"10.1063\/1.4938321","article-title":"Synthesis and characterization of hydroxyapatite from fish bone waste","volume":"1699","author":"Marliana","year":"2015","journal-title":"AIP Conf. Proc."},{"issue":"2","key":"10.1016\/j.ijpx.2023.100169_bb0160","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/jbm.a.31744","article-title":"Nano hydroxyapatite structures influence early bone formation","volume":"87","author":"Meirelles","year":"2008","journal-title":"J. Biomed. Mater. Res. A"},{"issue":"5","key":"10.1016\/j.ijpx.2023.100169_bb0165","article-title":"Syntheses of hydroxyapatite from natural sources","volume":"5","author":"Mohd Pu\u2019ad","year":"2019","journal-title":"Heliyon."},{"issue":"Suppl. 1","key":"10.1016\/j.ijpx.2023.100169_bb0170","doi-asserted-by":"crossref","first-page":"S83","DOI":"10.1016\/S0020-1383(18)30310-3","article-title":"Diagnostic challenges and future perspectives in fracture-related infection","volume":"49","author":"Morgenstern","year":"2018","journal-title":"Injury."},{"key":"10.1016\/j.ijpx.2023.100169_bb0175","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.addr.2016.04.015","article-title":"Poly (lactic acid)-based biomaterials for orthopaedic regenerative engineering","volume":"107","author":"Narayanan","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"6","key":"10.1016\/j.ijpx.2023.100169_bb0180","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1093\/jac\/47.6.885","article-title":"Biomaterial-associated infection of gentamicin-loaded PMMA beads in orthopaedic revision surgery","volume":"47","author":"Neut","year":"2001","journal-title":"J. Antimicrob. Chemother."},{"issue":"8","key":"10.1016\/j.ijpx.2023.100169_bb0185","doi-asserted-by":"crossref","first-page":"3318","DOI":"10.1016\/j.apt.2020.06.022","article-title":"Faster synthesis of A-type carbonated hydroxyapatite powders prepared by high-temperature reaction","volume":"31","author":"Nowicki","year":"2020","journal-title":"Adv. Powder Technol."},{"issue":"1","key":"10.1016\/j.ijpx.2023.100169_bb0190","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/jbm.b.30136","article-title":"Comparison of hydroxyapatite and beta tricalcium phosphate as bone substitutes after excision of bone tumors","volume":"72","author":"Ogose","year":"2005","journal-title":"J Biomed Mater Res B Appl Biomater"},{"issue":"3","key":"10.1016\/j.ijpx.2023.100169_bb0195","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.biomaterials.2009.09.067","article-title":"Biological responses to hydroxyapatite surfaces deposited via a co-incident microblasting technique","volume":"31","author":"O\u2019Hare","year":"2010","journal-title":"Biomaterials."},{"issue":"2","key":"10.1016\/j.ijpx.2023.100169_bb0200","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0142-9612(91)90196-H","article-title":"Orthopaedic applications of hydroxyapatite","volume":"12","author":"Oonishi","year":"1991","journal-title":"Biomaterials."},{"key":"10.1016\/j.ijpx.2023.100169_bb0205","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/415289","article-title":"Bone regeneration from PLGA micro-nanoparticles","volume":"2015","author":"Ortega-Oller","year":"2015","journal-title":"Biomed. Res. Int."},{"issue":"5","key":"10.1016\/j.ijpx.2023.100169_bb0210","doi-asserted-by":"crossref","DOI":"10.1088\/1748-6041\/11\/5\/055003","article-title":"Stem cell differentiation-related protein-loaded PLGA microspheres as a novel platform micro-typed scaffold for chondrogenesis","volume":"11","author":"Park","year":"2016","journal-title":"Biomed. Mater."},{"issue":"6","key":"10.1016\/j.ijpx.2023.100169_bb0215","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1007\/s10965-021-02562-6","article-title":"Potential application of PLGA microsphere for tissue engineering","volume":"28","author":"Patel","year":"2021","journal-title":"J. Polym. Res."},{"issue":"2","key":"10.1016\/j.ijpx.2023.100169_bb0220","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/BF01695730","article-title":"The use of hydroxyapatite in orthopaedic surgery: a ten-year review","volume":"9","author":"Petit","year":"1999","journal-title":"Eur. J. Orthop. Surg. Traumatol."},{"issue":"1","key":"10.1016\/j.ijpx.2023.100169_bb0225","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1186\/s12891-017-1614-1","article-title":"Outcomes of cement beads and cement spacers in the treatment of bone defects associated with post-traumatic osteomyelitis","volume":"18","author":"Qiu","year":"2017","journal-title":"BMC Musculoskelet. Disord."},{"issue":"1","key":"10.1016\/j.ijpx.2023.100169_bb0230","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1186\/s12891-018-2285-2","article-title":"Coating the plate with antibiotic cement to treat early infection after fracture fixation with retention of the implants: a technical note","volume":"19","author":"Qiu","year":"2018","journal-title":"BMC Musculoskelet. Disord."},{"key":"10.1016\/j.ijpx.2023.100169_bb0235","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jconrel.2015.08.049","article-title":"Controlled drug release for tissue engineering","volume":"219","author":"Rambhia","year":"2015","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ijpx.2023.100169_bb0240","article-title":"Ionic substituted hydroxyapatite for bone regeneration applications: a review","volume":"6","author":"Ressler","year":"2021","journal-title":"Open Ceram."},{"issue":"8","key":"10.1016\/j.ijpx.2023.100169_bb0245","doi-asserted-by":"crossref","first-page":"4568","DOI":"10.1016\/j.msec.2013.07.014","article-title":"XRD and FTIR crystallinity indices in sound human tooth enamel and synthetic hydroxyapatite","volume":"33","author":"Reyes-Gasga","year":"2013","journal-title":"Mater. Sci. Eng. C"},{"issue":"1","key":"10.1016\/j.ijpx.2023.100169_bb0250","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s40824-021-00203-z","article-title":"Bioceramic hydroxyapatite-based scaffold with a porous structure using honeycomb as a natural polymeric Porogen for bone tissue engineering","volume":"25","author":"Sari","year":"2021","journal-title":"Biomater. Res."},{"key":"10.1016\/j.ijpx.2023.100169_bb0255","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/1471-2334-14-144","article-title":"Evidence of MRSE on a gentamicin and vancomycin impregnated polymethyl-methacrylate (PMMA) bone cement spacer after two-stage exchange arthroplasty due to periprosthetic joint infection of the knee","volume":"14","author":"Schmolders","year":"2014","journal-title":"BMC Infect. Dis."},{"issue":"1","key":"10.1016\/j.ijpx.2023.100169_bb0260","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.saa.2011.07.036","article-title":"FTIR spectroscopic, thermal and XRD characterization of hydroxyapatite from new natural sources","volume":"83","author":"Shaltout","year":"2011","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.ijpx.2023.100169_bb0265","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.msec.2018.04.026","article-title":"Characterization of natural hydroxyapatite originated from fish bone and its biocompatibility with osteoblasts","volume":"90","author":"Shi","year":"2018","journal-title":"Mater. Sci. Eng. C"},{"issue":"6","key":"10.1016\/j.ijpx.2023.100169_bb0270","first-page":"377","article-title":"Effects of bead size and polymerization in PMMA bone cement on vancomycin release","volume":"18","author":"Shinsako","year":"2008","journal-title":"Biomed. Mater. Eng."},{"issue":"2","key":"10.1016\/j.ijpx.2023.100169_bb0275","first-page":"490","article-title":"Accelerated degradation of HAP\/PLLA bone scaffold by PGA blending facilitates bioactivity and osteoconductivity","volume":"6","author":"Shuai","year":"2021","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.ijpx.2023.100169_bb0280","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jare.2021.03.009","article-title":"In situ synthesis of hydroxyapatite nanorods on graphene oxide nanosheets and their reinforcement in biopolymer scaffold","volume":"35","author":"Shuai","year":"2022","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.ijpx.2023.100169_bb0285","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.molstruc.2004.11.078","article-title":"FTIR and XRD evaluation of carbonated hydroxyapatite powders synthesized by wet methods","volume":"744-747","author":"\u015al\u00f3sarczyk","year":"2005","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.ijpx.2023.100169_bb0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmbbm.2021.104501","article-title":"Synthesis and characterization of nano-hydroxyapatite from Sardinella longiceps fish bone and its effects on human osteoblast bone cells","volume":"119","author":"Surya","year":"2021","journal-title":"J. Mech. Behav. Biomed. Mater."},{"issue":"1","key":"10.1016\/j.ijpx.2023.100169_bb0295","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1302\/0301-620X.84B1.0840070","article-title":"The use of vancomycin-impregnated cement beads in the management of infection of prosthetic joints","volume":"84","author":"Taggart","year":"2002","journal-title":"J. Bone Joint Surg. (Br.)"},{"issue":"Pt 2","key":"10.1016\/j.ijpx.2023.100169_bb0300","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.msec.2016.06.097","article-title":"Comparison of ectopic bone formation process induced by four calcium phosphate ceramics in mice","volume":"70","author":"Tang","year":"2017","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"issue":"11","key":"10.1016\/j.ijpx.2023.100169_bb0305","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0276604","article-title":"Influence of chitosan and chitosan oligosaccharide on dual antibiotic-loaded bone cement: in vitro evaluations","volume":"17","author":"Tantavisut","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.ijpx.2023.100169_bb0310","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.3389\/fmicb.2019.01626","article-title":"Antibiotic-Loaded Polymethylmethacrylate Beads and Spacers in Treatment of Orthopedic Infections and the Role of Biofilm Formation","volume":"10","author":"van Vugt","year":"2019","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.ijpx.2023.100169_bb0315","article-title":"Investigating the degradation behaviour and characteristic changes of phase pure hydroxyapatite (HAp) microsphere scaffolds under static and dynamic conditions","volume":"1-13","author":"Wee","year":"2022","journal-title":"Mater. Technol."},{"key":"10.1016\/j.ijpx.2023.100169_bb0320","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.compscitech.2017.04.037","article-title":"Development of PLA\/Mg composite for orthopedic implant: Tunable degradation and enhanced mineralization","volume":"147","author":"Zhao","year":"2017","journal-title":"Compos. Sci. Technol."},{"issue":"2","key":"10.1016\/j.ijpx.2023.100169_bb0325","first-page":"346","article-title":"Poly(lactic-co-glycolic acid)-based composite bone-substitute materials","volume":"6","author":"Zhao","year":"2021","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.ijpx.2023.100169_bb0330","first-page":"446","article-title":"Biofunctionalized composite scaffold to potentiate osteoconduction, angiogenesis, and favorable metabolic microenvironment for osteonecrosis therapy","volume":"9","author":"Zhu","year":"2022","journal-title":"Bioact. Mater."},{"issue":"6","key":"10.1016\/j.ijpx.2023.100169_bb0335","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1080\/09243046.2020.1759183","article-title":"Mechanical behavior of hydroxyapatite-poly(lactic acid) hybrid porous scaffold","volume":"29","author":"Zusho","year":"2020","journal-title":"Adv. Compos. Mater."}],"container-title":["International Journal of Pharmaceutics: X"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590156723000130?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590156723000130?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T02:41:57Z","timestamp":1762915317000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590156723000130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":67,"alternative-id":["S2590156723000130"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpx.2023.100169","relation":{},"ISSN":["2590-1567"],"issn-type":[{"value":"2590-1567","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antibiotic-loaded hydroxyapatite scaffolds fabricated from Nile tilapia bones for orthopaedics","name":"articletitle","label":"Article Title"},{"value":"International Journal of Pharmaceutics: X","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijpx.2023.100169","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100169"}}