{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T17:44:22Z","timestamp":1781113462149,"version":"3.54.1"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,24]],"date-time":"2024-03-24T00:00:00Z","timestamp":1711238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Pharmaceutics: X"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.ijpx.2024.100240","type":"journal-article","created":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T02:57:42Z","timestamp":1711421862000},"page":"100240","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Spanlastic-laden nanogel as a plausible platform for dermal delivery of bimatoprost with superior cutaneous deposition and hair regrowth efficiency in androgenic alopecia"],"prefix":"10.1016","volume":"7","author":[{"given":"Bjad K.","family":"Almutairy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El-Sayed","family":"Khafagy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed F.","family":"Aldawsari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah","family":"Alshetaili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadil Faris","family":"Alotaibi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amr Selim Abu","family":"Lila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijpx.2024.100240_bb0005","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1080\/10837450.2023.2233613","article-title":"Exploring the use of niosomes in cosmetics for efficient dermal drug delivery","volume":"28","author":"Abu-Huwaij","year":"2023","journal-title":"Pharm. Dev. Technol."},{"issue":"136\u2013141","key":"10.1016\/j.ijpx.2024.100240_bb0010","article-title":"The effectiveness of treatments for androgenetic alopecia: a systematic review and meta-analysis","volume":"77","author":"Adil","year":"2017","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.ijpx.2024.100240_bb0015","article-title":"Spanlastic-laden in situ gel as a promising approach for ocular delivery of Levofloxacin: In-vitro characterization, microbiological assessment, corneal permeability and in-vivo study","volume":"6","author":"Agha","year":"2023","journal-title":"Int. J. Pharm. X"},{"key":"10.1016\/j.ijpx.2024.100240_bb0020","first-page":"69","article-title":"Release Studies on Ciprofloxacin Loaded Non-ionic Surfactant Vesicles","volume":"7","author":"Akbari","year":"2015","journal-title":"Avicenna J. Med. Biotechnol."},{"key":"10.1016\/j.ijpx.2024.100240_bb0025","doi-asserted-by":"crossref","first-page":"771","DOI":"10.3390\/polym14040771","article-title":"Cefotaxime Mediated Synthesis of Gold Nanoparticles: Characterization and Antibacterial activity","volume":"14","author":"Al Hagbani","year":"2022","journal-title":"Polymers (Basel)"},{"key":"10.1016\/j.ijpx.2024.100240_bb0030","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.3390\/polym13091416","article-title":"Enhanced Cytotoxic activity of Docetaxel-Loaded Silk Fibroin Nanoparticles against Breast Cancer Cells","volume":"13","author":"Al Saqr","year":"2021","journal-title":"Polymers (Basel)"},{"key":"10.1016\/j.ijpx.2024.100240_bb0035","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1080\/10717544.2021.1989089","article-title":"Spironolactone hyaluronic acid enriched cerosomes (HAECs) for topical management of hirsutism: in silico studies, statistical optimization, ex vivo, and in vivo studies","volume":"28","author":"Albash","year":"2021","journal-title":"Drug Deliv."},{"key":"10.1016\/j.ijpx.2024.100240_bb0040","doi-asserted-by":"crossref","first-page":"2784","DOI":"10.1080\/10717544.2022.2108939","article-title":"Repurposing levocetirizine hydrochloride loaded into cationic ceramide\/phospholipid composite (CCPCs) for management of alopecia: central composite design optimization, in- silico and in-vivo studies","volume":"29","author":"Albash","year":"2022","journal-title":"Drug Deliv."},{"key":"10.1016\/j.ijpx.2024.100240_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsps.2023.101734","article-title":"Formulation optimization, in vitro and in vivo evaluation of niosomal nanocarriers for enhanced topical delivery of cetirizine","volume":"31","author":"Aldawsari","year":"2023","journal-title":"Saudi Pharm J"},{"key":"10.1016\/j.ijpx.2024.100240_bb0050","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.ijpharm.2017.03.005","article-title":"Enhanced non invasive trans-tympanic delivery of ciprofloxacin through encapsulation into nano-spanlastic vesicles: Fabrication, in-vitro characterization, and comparative ex-vivo permeation studies","volume":"522","author":"Al-mahallawi","year":"2017","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijpx.2024.100240_bb0055","doi-asserted-by":"crossref","first-page":"952","DOI":"10.3390\/gels9120952","article-title":"Development of Carvedilol Nanoformulation-Loaded Poloxamer-based in Situ Gel for the Management of Glaucoma","volume":"9","author":"Almutairy","year":"2023","journal-title":"Gels"},{"key":"10.1016\/j.ijpx.2024.100240_bb0060","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1208\/s12249-022-02217-9","article-title":"Spanlastics a Novel Nanovesicular carrier: its potential Application and Emerging Trends in Therapeutic delivery","volume":"23","author":"Ansari","year":"2022","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.ijpx.2024.100240_bb0065","doi-asserted-by":"crossref","first-page":"3697","DOI":"10.2147\/DDDT.S265167","article-title":"Formulation of Nanospanlastics as a Promising Approach for improving the Topical delivery of a Natural Leukotriene Inhibitor (3-Acetyl-11-Keto-\u03b2-Boswellic Acid): Statistical Optimization, in vitro Characterization, and ex vivo Permeation Study","volume":"14","author":"Badria","year":"2020","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.ijpx.2024.100240_bb0070","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1080\/13543784.2017.1303480","article-title":"Bimatoprost for the treatment of eyelash, eyebrow and scalp alopecia","volume":"26","author":"Barr\u00f3n-Hern\u00e1ndez","year":"2017","journal-title":"Expert Opin. Investig. Drugs"},{"key":"10.1016\/j.ijpx.2024.100240_bb0075","doi-asserted-by":"crossref","first-page":"203","DOI":"10.3109\/08982104.2013.788025","article-title":"Design and optimization of surfactant-based nanovesicles for ocular delivery of Clotrimazole","volume":"23","author":"Basha","year":"2013","journal-title":"J. Liposome Res."},{"key":"10.1016\/j.ijpx.2024.100240_bb0080","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ejpb.2019.08.015","article-title":"Recent advances in non-ionic surfactant vesicles (niosomes): Fabrication, characterization, pharmaceutical and cosmetic applications","volume":"144","author":"Chen","year":"2019","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ijpx.2024.100240_bb0085","doi-asserted-by":"crossref","first-page":"5519","DOI":"10.1111\/jocd.15309","article-title":"Topical cetirizine for treating androgenetic alopecia: a systematic review","volume":"21","author":"Chen","year":"2022","journal-title":"J. Cosmet. Dermatol."},{"key":"10.1016\/j.ijpx.2024.100240_bb0090","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1111\/j.1524-4725.2010.01522.x","article-title":"Enhancing the growth of natural eyelashes: the mechanism of bimatoprost-induced eyelash growth","volume":"36","author":"Cohen","year":"2010","journal-title":"Dermatologic Surg."},{"key":"10.1016\/j.ijpx.2024.100240_bb0095","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1006\/jcis.2002.8399","article-title":"Release studies on niosomes containing fatty alcohols as bilayer stabilizers instead of cholesterol","volume":"251","author":"Devaraj","year":"2002","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.ijpx.2024.100240_bb0100","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/418316","article-title":"Characterization and in Vitro Skin Permeation of Meloxicam-Loaded Liposomes versus Transfersomes","volume":"2011","author":"Duangjit","year":"2011","journal-title":"J. Drug Deliv."},{"key":"10.1016\/j.ijpx.2024.100240_bb0105","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1080\/10717544.2021.1886377","article-title":"Topical delivery of l-ascorbic acid spanlastics for stability enhancement and treatment of UVB induced damaged skin","volume":"28","author":"Elhabak","year":"2021","journal-title":"Drug Deliv."},{"key":"10.1016\/j.ijpx.2024.100240_bb0110","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.3109\/10717544.2014.942811","article-title":"Enhanced corneal permeation and antimycotic activity of itraconazole against Candida albicans via a novel nanosystem vesicle","volume":"23","author":"ElMeshad","year":"2016","journal-title":"Drug Deliv."},{"key":"10.1016\/j.ijpx.2024.100240_bb0115","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1080\/08982104.2022.2100902","article-title":"Spanlastics gel-a novel drug carrier for transdermal delivery of glimepiride","volume":"33","author":"Elsaied","year":"2023","journal-title":"J. Liposome Res."},{"key":"10.1016\/j.ijpx.2024.100240_bb0120","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.1208\/s12249-017-0771-8","article-title":"Topical delivery of Fenoprofen Calcium via Elastic Nano-vesicular Spanlastics: Optimization using Experimental Design and in Vivo Evaluation","volume":"18","author":"Farghaly","year":"2017","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.ijpx.2024.100240_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111247","article-title":"Dihydrotestosterone-induced hair regrowth inhibition by activating androgen receptor in C57BL6 mice simulates androgenetic alopecia","volume":"137","author":"Fu","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ijpx.2024.100240_bb0130","first-page":"E228","article-title":"An overview of the genetic aspects of hair loss and its connection with nutrition","volume":"63","author":"Gokce","year":"2022","journal-title":"J. Prev. Med. Hyg."},{"key":"10.1016\/j.ijpx.2024.100240_bb0135","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.jconrel.2023.02.006","article-title":"Skin drug delivery using lipid vesicles: a starting guideline for their development","volume":"355","author":"Guillot","year":"2023","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ijpx.2024.100240_bb0140","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ijpharm.2005.09.023","article-title":"Preparation and evaluation of reverse-phase evaporation and multilamellar niosomes as ophthalmic carriers of acetazolamide","volume":"306","author":"Guinedi","year":"2005","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijpx.2024.100240_bb0145","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/bjd.12292","article-title":"No genetic support for a contribution of prostaglandins to the aetiology of androgenetic alopecia","volume":"169","author":"Heilmann","year":"2013","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.ijpx.2024.100240_bb0150","doi-asserted-by":"crossref","first-page":"5087","DOI":"10.2147\/IJN.S138267","article-title":"Elastic liposomes as novel carriers: recent advances in drug delivery","volume":"12","author":"Hussain","year":"2017","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.ijpx.2024.100240_bb0155","doi-asserted-by":"crossref","first-page":"1130623","DOI":"10.3389\/fmed.2023.1130623","article-title":"The efficacy of topical prostaglandin analogs for hair loss: a systematic review and meta-analysis","volume":"10","author":"Jiang","year":"2023","journal-title":"Front. Med. (Lausanne)"},{"key":"10.1016\/j.ijpx.2024.100240_bb0160","doi-asserted-by":"crossref","first-page":"349","DOI":"10.2147\/OPTH.S6480","article-title":"Bimatoprost in the treatment of eyelash hypotrichosis","volume":"4","author":"Law","year":"2010","journal-title":"Clin. Ophthalmol."},{"key":"10.1016\/j.ijpx.2024.100240_bb0165","doi-asserted-by":"crossref","first-page":"726","DOI":"10.3390\/pharmaceutics14040726","article-title":"Niosomal Nanocarriers for Enhanced Dermal delivery of Epigallocatechin Gallate for Protection against Oxidative stress of the Skin","volume":"14","author":"Li","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ijpx.2024.100240_bb0170","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3390\/ph14010068","article-title":"Formulation and Optimization of Nanospanlastics for improving the Bioavailability of Green Tea Epigallocatechin Gallate","volume":"14","author":"Mazyed","year":"2021","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.ijpx.2024.100240_bb0175","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1080\/10717544.2016.1245369","article-title":"Nanotransfersomes-loaded thermosensitive in situ gel as a rectal delivery system of tizanidine HCl: preparation, in vitro and in vivo performance","volume":"24","author":"Moawad","year":"2017","journal-title":"Drug Deliv."},{"key":"10.1016\/j.ijpx.2024.100240_bb0180","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3390\/scipharm87040032","article-title":"The Optimization of Gel Preparations using the active Compounds of Arabica Coffee Ground Nanoparticles","volume":"87","author":"Nurman","year":"2019","journal-title":"Sci. Pharm."},{"key":"10.1016\/j.ijpx.2024.100240_bb0185","first-page":"327","article-title":"Hair loss and regeneration performed on animal models","volume":"89","author":"Orasan","year":"2016","journal-title":"Clujul Med."},{"key":"10.1016\/j.ijpx.2024.100240_bb0190","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S1773-2247(07)50049-3","article-title":"Elastic positively-charged liposomes for topical administration of acyclovir","volume":"17","author":"Peira","year":"2007","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.ijpx.2024.100240_bb0195","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1007\/s00403-011-1166-4","article-title":"Liposomal systems as drug delivery vehicles for dermal and transdermal applications","volume":"303","author":"Pierre","year":"2011","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.ijpx.2024.100240_bb0200","series-title":"An Overview of Alopecias","first-page":"4","author":"Qi","year":"2014"},{"key":"10.1016\/j.ijpx.2024.100240_bb0205","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1208\/s12249-010-9480-2","article-title":"Formulation and optimization of Zidovudine niosomes","volume":"11","author":"Ruckmani","year":"2010","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.ijpx.2024.100240_bb0210","article-title":"Formulation-based approaches for dermal delivery of vaccines and therapeutic nucleic acids: recent advances and future perspectives","volume":"6","author":"Sallam","year":"2021","journal-title":"Bioeng. & Translat. Med."},{"key":"10.1016\/j.ijpx.2024.100240_bb0215","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1007\/s13346-020-00814-4","article-title":"Impact of the mucoadhesive lyophilized wafer loaded with novel carvedilol nano-spanlastics on biochemical markers in the heart of spontaneously hypertensive rat models","volume":"11","author":"Sallam","year":"2021","journal-title":"Drug Deliv. Transl. Res."},{"key":"10.1016\/j.ijpx.2024.100240_bb0220","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.3390\/ph16071001","article-title":"Ocular delivery of Bimatoprost-Loaded Solid Lipid Nanoparticles for Effective Management of Glaucoma","volume":"16","author":"Satyanarayana","year":"2023","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.ijpx.2024.100240_bb0225","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0168-3659(94)90039-6","article-title":"Liposomes and niosomes as topical drug carriers: dermal and transdermal drug delivery","volume":"30","author":"Schreier","year":"1994","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ijpx.2024.100240_bb0230","doi-asserted-by":"crossref","first-page":"261","DOI":"10.4274\/tjps.galenos.2022.60687","article-title":"Formulation, Characterization, and Optimization of a Topical Gel Containing Tranexamic Acid to Prevent Superficial Bleeding: In Vivo and In Vitro Evaluations","volume":"20","author":"Shiehzadeh","year":"2023","journal-title":"Turk. J. Pharm. Sci."},{"key":"10.1016\/j.ijpx.2024.100240_bb0235","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1080\/10717544.2022.2027046","article-title":"Preparation of topical bimatoprost with enhanced skin infiltration and in vivo hair regrowth efficacy in androgenic alopecia","volume":"29","author":"Subedi","year":"2022","journal-title":"Drug Deliv."},{"key":"10.1016\/j.ijpx.2024.100240_bb0240","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.2147\/DDDT.S214907","article-title":"Minoxidil and its use in hair disorders: a review","volume":"13","author":"Suchonwanit","year":"2019","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.ijpx.2024.100240_bb0245","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.5958\/0976-5506.2018.02056.9","article-title":"The Efectiveness of 0.03% Bimatoprost solution Vs Minoxidil 5% in Androgenic Alopecia","volume":"9","author":"Tabri","year":"2018","journal-title":"Indian J. Publ. Health Res. Develop."},{"key":"10.1016\/j.ijpx.2024.100240_bb0250","article-title":"In situ gel containing Bimatoprost solid lipid nanoparticles for ocular delivery: In-vitro and ex-vivo evaluation","volume":"56","author":"Wadetwar","year":"2020","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.ijpx.2024.100240_bb0255","doi-asserted-by":"crossref","first-page":"119","DOI":"10.4103\/2230-973X.138342","article-title":"Nanovesicles for transdermal delivery of felodipine: Development, characterization, and pharmacokinetics","volume":"4","author":"Yusuf","year":"2014","journal-title":"Int. J. Pharm. Investig."},{"key":"10.1016\/j.ijpx.2024.100240_bb0260","doi-asserted-by":"crossref","first-page":"418","DOI":"10.3390\/gels8070418","article-title":"Formulation and Evaluation of Moxifloxacin Loaded Bilosomes In-Situ Gel: Optimization to Antibacterial Evaluation","volume":"8","author":"Zafar","year":"2022","journal-title":"Gels"},{"key":"10.1016\/j.ijpx.2024.100240_bb0265","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.jpba.2019.06.002","article-title":"Development and validation of the stability indicating RP-UHPLC method for the determination of the chemical purity and assay of bimatoprost","volume":"174","author":"Zezula","year":"2019","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.ijpx.2024.100240_bb0270","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.3390\/ph14111128","article-title":"Alleviation of Androgenetic Alopecia with Aqueous Paeonia lactiflora and Poria cocos Extract Intake through Suppressing the Steroid Hormone and Inflammatory Pathway","volume":"14","author":"Zhang","year":"2021","journal-title":"Pharmaceuticals (Basel)"}],"container-title":["International Journal of Pharmaceutics: X"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590156724000124?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590156724000124?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,16]],"date-time":"2024-06-16T22:26:42Z","timestamp":1718576802000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590156724000124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":54,"alternative-id":["S2590156724000124"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpx.2024.100240","relation":{},"ISSN":["2590-1567"],"issn-type":[{"value":"2590-1567","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Spanlastic-laden nanogel as a plausible platform for dermal delivery of bimatoprost with superior cutaneous deposition and hair regrowth efficiency in androgenic alopecia","name":"articletitle","label":"Article Title"},{"value":"International Journal of Pharmaceutics: X","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijpx.2024.100240","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100240"}}