{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T23:39:32Z","timestamp":1788392372579,"version":"build-2803163510"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,24]],"date-time":"2024-08-24T00:00:00Z","timestamp":1724457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"publisher","award":["RSPD2024R524"],"award-info":[{"award-number":["RSPD2024R524"]}],"id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Pharmaceutics: X"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.ijpx.2024.100279","type":"journal-article","created":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T23:59:50Z","timestamp":1724716790000},"page":"100279","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["HSPiP and QbD oriented optimized stearylamine-elastic liposomes for topical delivery of ketoconazole to treat deep seated fungal infections: In vitro and ex vivo evaluations"],"prefix":"10.1016","volume":"8","author":[{"given":"Afzal","family":"Hussain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad A.","family":"Altamimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaser Saleh","family":"Alneef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijpx.2024.100279_bb0005","series-title":"Chemical Compatibility of Poly(Lactic Acid): A Practical Framework Using Hansen Solubility Parameters., Chapter 1","first-page":"83","author":"Abbott","year":"2010"},{"key":"10.1016\/j.ijpx.2024.100279_bb0010","article-title":"Binary ethosomes for the enhanced topical delivery and antifungal efficacy of ketoconazole","volume":"11","author":"Aljohani","year":"2024","journal-title":"OpenNano"},{"issue":"1","key":"10.1016\/j.ijpx.2024.100279_bb0015","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jiec.2012.07.010","article-title":"Optimization of process parameters using D-optimal design for synthesis of ZnO nanoparticles via sol\u2013gel technique","volume":"19","author":"Ba-Abbad","year":"2013","journal-title":"J. Ind. Eng. Chem."},{"issue":"2","key":"10.1016\/j.ijpx.2024.100279_bb0020","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3390\/gels4020052","article-title":"Carbohydrate derived organogelators and the corresponding functional gels developed in recent time","volume":"4","author":"Basu","year":"2018","journal-title":"Gels"},{"issue":"1","key":"10.1016\/j.ijpx.2024.100279_bb0025","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0005-2736(90)90440-Y","article-title":"Liposomes for the sustained drug release in vivo","volume":"1029","author":"Blume","year":"1990","journal-title":"Biochim. Biophys. Acta"},{"issue":"1","key":"10.1016\/j.ijpx.2024.100279_bb0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/adma.202206793","article-title":"Ultrathin Hydrogel Films toward Breathable Skin-Integrated Electronics","volume":"35","author":"Cheng","year":"2023","journal-title":"Adv. Mater."},{"key":"10.1016\/j.ijpx.2024.100279_bb0035","article-title":"Nano-elastic liposomes as multidrug carrier of sodium stibogluconate and ketoconazole: a potential new approach for the topical treatment of cutaneous leishmaniasis","volume":"105256","author":"Dar","year":"2020","journal-title":"Eur. J. Pharm. Sci."},{"issue":"2","key":"10.1016\/j.ijpx.2024.100279_bb0040","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0169-7439(94)00076-X","article-title":"D-optimal designs","volume":"30","author":"De Aguiar","year":"1995","journal-title":"Chemom. Intell. Lab. Syst."},{"key":"10.1016\/j.ijpx.2024.100279_bb0045","doi-asserted-by":"crossref","first-page":"485","DOI":"10.3390\/pharmaceutics11090485","article-title":"Rational development of liposomal hydrogels: a strategy for topical vaginal antiretroviral drug delivery in the context of HIV prevention","volume":"11","author":"Faria","year":"2019","journal-title":"Pharmaceutics"},{"issue":"6","key":"10.1016\/j.ijpx.2024.100279_bb0050","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1021\/acs.molpharmaceut.7b00099","article-title":"Tuning the extent and depth of penetration of flexible liposomes in human skin","volume":"4","author":"Franz\u00e9","year":"2017","journal-title":"Mol. Pharm."},{"issue":"5","key":"10.1016\/j.ijpx.2024.100279_bb0055","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1007\/s13346-020-00862-w","article-title":"Formulation and optimization of microsponge-loaded emulgel to improve the transdermal application of acyclovir\u2014a DOE based approach","volume":"11","author":"Gusai","year":"2020","journal-title":"Drug Deliv. Transl. Res."},{"issue":"11","key":"10.1016\/j.ijpx.2024.100279_bb0060","doi-asserted-by":"crossref","DOI":"10.1111\/srt.13499","article-title":"A novel hydrogel-based moisturizing cream composed of hyaluronic acid for patients with xerosis: an intra individual comparative analysis","volume":"29","author":"Ha","year":"2023","journal-title":"Skin Res. Technol."},{"key":"10.1016\/j.ijpx.2024.100279_bb0065","series-title":"Hansen Solubility Parameters: A User\u2019s Handbook","first-page":"1","author":"Hansen","year":"2007"},{"key":"10.1016\/j.ijpx.2024.100279_bb0070","doi-asserted-by":"crossref","first-page":"5087","DOI":"10.2147\/IJN.S138267","article-title":"Elastic liposomes as novel carriers: recent advances in drug delivery","volume":"12","author":"Hussain","year":"2017","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.ijpx.2024.100279_bb0075","article-title":"Biocompatible solvent selection based on thermodynamic and computational solubility models, in-silico GastroPlus prediction, and cellular studies of ketoconazole for subcutaneous delivery","volume":"65","author":"Hussain","year":"2021","journal-title":"J. Drug Deliv. Sci. Technol."},{"issue":"1","key":"10.1016\/j.ijpx.2024.100279_bb0080","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1021\/acsomega.1c05788","article-title":"Preferential solvation study of the synthesized aldose reductase inhibitor (SE415) in the {PEG 400 (1) + Water (2)} cosolvent mixture and GastroPlus-based prediction","volume":"7","author":"Hussain","year":"2022","journal-title":"ACS Omega"},{"issue":"2","key":"10.1016\/j.ijpx.2024.100279_bb0085","first-page":"180","article-title":"Transepidermal water loss (TEWL) and corneometry with hydrogel vehicle in the treatment of atopic dermatitis: a randomized, investigator-blind pilot study","volume":"11","author":"Kircik","year":"2012","journal-title":"J. Drugs Dermatol."},{"key":"10.1016\/j.ijpx.2024.100279_bb0090","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3390\/medicines5030103","article-title":"Oleic acid nanovesicles of minoxidil for enhanced follicular delivery","volume":"5","author":"Kumar","year":"2018","journal-title":"Medicines"},{"key":"10.1016\/j.ijpx.2024.100279_bb0095","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1007\/s10924-019-01414-1","article-title":"Thermal and mechanical properties of CO2-based biodegradable poly(cyclohexene carbonate)\/organically modified layered zinc Phenylphosphonate Nanocomposites","volume":"27","author":"Lin","year":"2019","journal-title":"J. Polym. Environ."},{"key":"10.1016\/j.ijpx.2024.100279_bb0100","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.3390\/ph15121556","article-title":"Cationic liposomes with different lipid ratios: antibacterial activity, antibacterial mechanism, and cytotoxicity evaluations","volume":"15","author":"Lu","year":"2022","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.ijpx.2024.100279_bb0105","doi-asserted-by":"crossref","first-page":"4096","DOI":"10.1039\/C7CC01434A","article-title":"Nontoxic organic solvents identified using an a priori approach with Hansen solubility parameters","volume":"53","author":"Nakamura","year":"2017","journal-title":"Chem. Commun."},{"key":"10.1016\/j.ijpx.2024.100279_bb0110","first-page":"65","article-title":"Investigating the effect of vehicle on in vitro skin permeation of ketoconazole applied in O\/W microemulsions","volume":"52","author":"Patel","year":"2010","journal-title":"Acta Pharmaceut. Sci."},{"issue":"11","key":"10.1016\/j.ijpx.2024.100279_bb0115","doi-asserted-by":"crossref","first-page":"370","DOI":"10.3329\/icpj.v1i11.12063","article-title":"Development of ethosomes with taguchi robust design-based studies for transdermal delivery of alfuzosin hydrochloride","volume":"1","author":"Prasanthi","year":"2012","journal-title":"Int. Curr. Pharmaceut. J."},{"key":"10.1016\/j.ijpx.2024.100279_bb0120","article-title":"Ketoconazole lipidic nanoparticles for improved efficacy, enhanced topical penetration, cellular uptake (L929 and J774A.1), and safety assessment: in vitro and in vivo studies","volume":"65","author":"Ramzan","year":"2021","journal-title":"J. Drug Deliv. Sci. Technol."},{"issue":"8","key":"10.1016\/j.ijpx.2024.100279_bb0125","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1007\/s13346-021-01089-z","article-title":"Design and development of topical liposomal formulations in a regulatory perspective","volume":"12","author":"Schlich","year":"2022","journal-title":"Drug Deliv. Transl. Res."},{"key":"10.1016\/j.ijpx.2024.100279_bb0130","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3923\/ajdd.2013.225.234","article-title":"Nimesulide-phosphatidylcholine complex for improvement of solubility and dissolution","volume":"3","author":"Semalty","year":"2013","journal-title":"Am. J. Drug Disc. Develop."},{"issue":"23","key":"10.1016\/j.ijpx.2024.100279_bb0135","doi-asserted-by":"crossref","first-page":"20267","DOI":"10.1021\/acsomega.2c02219","article-title":"Ketoconazole-loaded cationic nanoemulsion: in vitro\u2013ex vivo\u2013in vivo evaluations to control cutaneous fungal infections","volume":"7","author":"Shahid","year":"2022","journal-title":"ACS Omega"},{"key":"10.1016\/j.ijpx.2024.100279_bb0140","doi-asserted-by":"crossref","first-page":"352","DOI":"10.3390\/gels9050352","article-title":"Gel formulations for topical treatment of skin cancer: a review","volume":"9","author":"Slavkova","year":"2023","journal-title":"Gels"},{"issue":"4","key":"10.1016\/j.ijpx.2024.100279_bb0145","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/j.1875-9114.1984.tb03356.x","article-title":"Ketoconazole: an orally effective antifungal agent. Mechanism of action, pharmacology, clinical efficacy and adverse effects","volume":"4","author":"Smith","year":"1984","journal-title":"Pharmacotherapy"},{"issue":"1","key":"10.1016\/j.ijpx.2024.100279_bb0150","doi-asserted-by":"crossref","first-page":"7546","DOI":"10.1038\/s41598-021-87243-6","article-title":"Solubility of Ketoconazole (antifungal drug) in SC-CO2 for binary and ternary systems: measurements and empirical correlations","volume":"11","author":"Sodeifian","year":"2021","journal-title":"Sci. Rep."},{"issue":"1\u20132","key":"10.1016\/j.ijpx.2024.100279_bb0155","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.ijpharm.2018.04.001","article-title":"Effects of cationic liposomes with stearylamine against virus infection","volume":"543","author":"Tahara","year":"2018","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijpx.2024.100279_bb0160","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3390\/ddc2010006","article-title":"Stearylamine liposome as an anti-parasitic agent","volume":"2","author":"Vassoudevane","year":"2023","journal-title":"Drugs Drug Candidat."},{"key":"10.1016\/j.ijpx.2024.100279_bb0165","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0005-2736(86)90068-4","article-title":"Cytolytic activity of liposomes containing stearylamine","volume":"854","author":"Yoshihara","year":"1986","journal-title":"Biochim. Biophys. Acta (BBA)-Biomembr."},{"key":"10.1016\/j.ijpx.2024.100279_bb0170","article-title":"The use of D-optimal mixture design in optimizing development of okara tablet formulation as a dietary supplement","volume":"2015","author":"Zen","year":"2015","journal-title":"Sci. World J."}],"container-title":["International Journal of Pharmaceutics: X"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590156724000513?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590156724000513?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T02:04:28Z","timestamp":1740881068000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590156724000513"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":34,"alternative-id":["S2590156724000513"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpx.2024.100279","relation":{},"ISSN":["2590-1567"],"issn-type":[{"value":"2590-1567","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HSPiP and QbD oriented optimized stearylamine-elastic liposomes for topical delivery of ketoconazole to treat deep seated fungal infections: In vitro and ex vivo evaluations","name":"articletitle","label":"Article Title"},{"value":"International Journal of Pharmaceutics: X","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijpx.2024.100279","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100279"}}