{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T06:53:13Z","timestamp":1773903193933,"version":"3.50.1"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T00:00:00Z","timestamp":1740009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Pharmaceutics: X"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.ijpx.2025.100320","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T03:21:43Z","timestamp":1740540103000},"page":"100320","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Oral colon-targeted delivery of recombinant human MANF for alleviation of ulcerative colitis"],"prefix":"10.1016","volume":"9","author":[{"given":"Jie","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian-Le","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue-Feng","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye-Qin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiao-Yan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng-Meng","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Xian","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijpx.2025.100320_bb0005","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.carbpol.2017.03.033","article-title":"Alginate microparticles as oral colon drug delivery device: a review","volume":"168","author":"Ag\u00fcero","year":"2017","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijpx.2025.100320_bb0010","doi-asserted-by":"crossref","first-page":"147","DOI":"10.2147\/CEG.S375969","article-title":"Emerging therapies for ulcerative colitis: updates from recent clinical trials","volume":"16","author":"AlAmeel","year":"2023","journal-title":"Clin. Exp. Gastroenterol."},{"key":"10.1016\/j.ijpx.2025.100320_bb0015","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1016\/j.yexcr.2008.05.001","article-title":"Armet, a UPR-upregulated protein, inhibits cell proliferation and ER stress-induced cell death","volume":"314","author":"Apostolou","year":"2008","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.ijpx.2025.100320_bb0020","doi-asserted-by":"crossref","first-page":"279","DOI":"10.3389\/fphar.2019.00279","article-title":"Biological therapies in immune-mediated inflammatory diseases: can biosimilars reduce access inequities?","volume":"10","author":"Baumgart","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ijpx.2025.100320_bb0025","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.3390\/molecules25112649","article-title":"Hyaluronic acid and controlled release: a review","volume":"25","author":"Bayer","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.ijpx.2025.100320_bb0030","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1053\/j.gastro.2015.03.001","article-title":"Clinical practice guidelines for the medical management of nonhospitalized ulcerative colitis: the Toronto consensus","volume":"148","author":"Bressler","year":"2015","journal-title":"Gastroenterology"},{"issue":"12","key":"10.1016\/j.ijpx.2025.100320_bb0035","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/nri2873","article-title":"Sterile inflammation: sensing and reacting to damage","volume":"10","author":"Chen","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ijpx.2025.100320_bb0040","doi-asserted-by":"crossref","first-page":"66","DOI":"10.2337\/db17-1149","article-title":"MANF is required for the postnatal expansion and maintenance of pancreatic \u03b2-cell mass in mice","volume":"68","author":"Danilova","year":"2019","journal-title":"Diabetes"},{"key":"10.1016\/j.ijpx.2025.100320_bb0045","article-title":"Oral delivery of biologics for precision medicine","volume":"32","author":"Dur\u00e1n-Lobato","year":"2020","journal-title":"Adv. Mater."},{"key":"10.1016\/j.ijpx.2025.100320_bb0050","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1136\/gut.29.8.1035","article-title":"Measurement of gastrointestinal pH profiles in normal ambulant human subjects","volume":"29","author":"Evans","year":"1988","journal-title":"Gut"},{"key":"10.1016\/j.ijpx.2025.100320_bb0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/19490976.2020.1826746","article-title":"B. adolescentis ameliorates chronic colitis by regulating Treg\/Th2 response and gut microbiota remodeling","volume":"13","author":"Fan","year":"2021","journal-title":"Gut Microbes"},{"key":"10.1016\/j.ijpx.2025.100320_bb0060","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.3390\/polym15102402","article-title":"Electrospinning and electrospraying: emerging techniques for probiotic stabilization and application","volume":"15","author":"Feng","year":"2023","journal-title":"Polymers"},{"key":"10.1016\/j.ijpx.2025.100320_bb0065","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1248\/bpb.b18-00683","article-title":"Applications of liposomal drug delivery systems to develop neuroprotective agents for the treatment of ischemic stroke","volume":"42","author":"Fukuta","year":"2019","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.ijpx.2025.100320_bb0070","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.addr.2013.01.003","article-title":"In vitro and in vivo models for the study of oral delivery of nanoparticles","volume":"65","author":"Gamboa","year":"2013","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ijpx.2025.100320_bb0075","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1007\/s00125-018-4687-y","article-title":"MANF protects human pancreatic beta cells against stress-induced cell death","volume":"61","author":"Hakonen","year":"2018","journal-title":"Diabetologia"},{"key":"10.1016\/j.ijpx.2025.100320_bb0080","doi-asserted-by":"crossref","first-page":"4234","DOI":"10.1016\/j.apsb.2023.07.027","article-title":"MANF brakes TLR4 signaling by competitively binding S100A8 with S100A9 to regulate macrophage phenotypes in hepatic fibrosis","volume":"13","author":"Hou","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.ijpx.2025.100320_bb0085","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1016\/j.ijbiomac.2022.09.247","article-title":"ROS-responsive hyaluronic acid hydrogel for targeted delivery of probiotics to relieve colitis","volume":"222","author":"Huang","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijpx.2025.100320_bb0090","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/nrgastro.2015.150","article-title":"The global burden of IBD: from 2015 to 2025","volume":"12","author":"Kaplan","year":"2015","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.ijpx.2025.100320_bb0095","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.molmed.2023.01.001","article-title":"IBD disease-modifying therapies: insights from emerging therapeutics","volume":"29","author":"Kotla","year":"2023","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.ijpx.2025.100320_bb0100","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/s41563-019-0462-9","article-title":"Hyaluronic acid-bilirubin nanomedicine for targeted modulation of dysregulated intestinal barrier, microbiome and immune responses in colitis","volume":"19","author":"Lee","year":"2020","journal-title":"Nat. Mater."},{"key":"10.1016\/j.ijpx.2025.100320_bb0105","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1053\/j.gastro.2006.01.048","article-title":"American Gastroenterological Association Institute technical review on corticosteroids, immunomodulators, and infliximab in inflammatory bowel disease","volume":"130","author":"Lichtenstein","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ijpx.2025.100320_bb0110","first-page":"78","article-title":"Hyaluronic acid in inflammation and tissue regeneration","volume":"28","author":"Litwiniuk","year":"2016","journal-title":"Wounds"},{"key":"10.1016\/j.ijpx.2025.100320_bb0115","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.jconrel.2022.05.025","article-title":"Oral antimicrobial peptide-EGCG nanomedicines for synergistic treatment of ulcerative colitis","volume":"347","author":"Liu","year":"2022","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ijpx.2025.100320_bb0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cytogfr.2023.07.001","article-title":"Recent advances in the treatment of IBD: targets, mechanisms and related therapies","volume":"71-72","author":"Liu","year":"2023","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.ijpx.2025.100320_bb0125","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s00535-021-01784-1","article-title":"Evidence-based clinical practice guidelines for inflammatory bowel disease 2020","volume":"56","author":"Nakase","year":"2021","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.ijpx.2025.100320_bb0130","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaf3646","article-title":"Immune modulation by MANF promotes tissue repair and regenerative success in the retina","volume":"353","author":"Neves","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.ijpx.2025.100320_bb0135","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1016\/S0140-6736(17)32448-0","article-title":"Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies","volume":"390","author":"Ng","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.ijpx.2025.100320_bb0140","doi-asserted-by":"crossref","first-page":"12193","DOI":"10.1021\/jacs.3c02179","article-title":"Oral hydrogel microbeads-mediated in situ synthesis of selenoproteins for regulating intestinal immunity and microbiota","volume":"145","author":"Ouyang","year":"2023","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.ijpx.2025.100320_bb0145","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.ijbiomac.2022.12.032","article-title":"Multifunctional hydrogels based on chitosan, hyaluronic acid and other biological macromolecules for the treatment of inflammatory bowel disease: a review","volume":"227","author":"Ouyang","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.ijpx.2025.100320_bb0150","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1208\/pt0801012","article-title":"Eudragit-coated pectin microspheres of 5-fluorouracil for colon targeting","volume":"8","author":"Paharia","year":"2007","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.ijpx.2025.100320_bb0155","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.02979-22","article-title":"Alginate alleviates dextran sulfate sodium-induced colitis by promoting bifidobacterium animalis and intestinal hyodeoxycholic acid synthesis in mice","volume":"10","author":"Pi","year":"2022","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.ijpx.2025.100320_bb0160","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nm.4236","article-title":"A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice","volume":"23","author":"Plovier","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.ijpx.2025.100320_bb0165","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.mayocp.2018.09.013","article-title":"Mechanisms of disease: inflammatory bowel diseases","volume":"94","author":"Ramos","year":"2019","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.ijpx.2025.100320_bb0170","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/apt.14794","article-title":"Long-term efficacy and safety of ustekinumab for Crohn's disease through the second year of therapy","volume":"48","author":"Sandborn","year":"2018","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.ijpx.2025.100320_bb0175","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/s41579-019-0213-6","article-title":"Microbial genes and pathways in inflammatory bowel disease","volume":"17","author":"Schirmer","year":"2019","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.ijpx.2025.100320_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.112943","article-title":"Mesencephalic astrocyte-derived neurotrophic factor attenuates acute lung injury via inhibiting macrophages' activation","volume":"150","author":"Shen","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ijpx.2025.100320_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121707","article-title":"Oral delivery of IL-22 mRNA-loaded lipid nanoparticles targeting the injured intestinal mucosa: a novel therapeutic solution to treat ulcerative colitis","volume":"288","author":"Sung","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.ijpx.2025.100320_bb0190","doi-asserted-by":"crossref","first-page":"1802342","DOI":"10.1002\/advs.201802342","article-title":"Gas-shearing fabrication of multicompartmental microspheres: a one-step and oil-free approach","volume":"6","author":"Tang","year":"2019","journal-title":"Adv. Sci."},{"key":"10.1016\/j.ijpx.2025.100320_bb0195","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1136\/gutjnl-2016-311785","article-title":"Preclinical disease and preventive strategies in IBD: perspectives, challenges and opportunities","volume":"65","author":"Torres","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.ijpx.2025.100320_bb0200","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1016\/S0140-6736(16)32126-2","article-title":"Ulcerative colitis","volume":"389","author":"Ungaro","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.ijpx.2025.100320_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2023.109431","article-title":"Human milk-derived MANF, as an immuno-nutritional factor, maintains the intestinal epithelial barrier and protects against necrotizing enterocolitis","volume":"121","author":"Wang","year":"2023","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.ijpx.2025.100320_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2023.123510","article-title":"Oral delivery of pectin-chitosan hydrogels entrapping macrophage-targeted curcumin-loaded liposomes for the treatment of ulcerative colitis","volume":"647","author":"Wu","year":"2023","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijpx.2025.100320_bb0215","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12974-019-1429-0","article-title":"Mesencephalic astrocyte-derived neurotrophic factor (MANF) protects against A\u03b2 toxicity via attenuating A\u03b2-induced endoplasmic reticulum stress","volume":"16","author":"Xu","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.ijpx.2025.100320_bb0220","doi-asserted-by":"crossref","first-page":"13037","DOI":"10.1021\/acsnano.2c05558","article-title":"Design of diselenide-bridged hyaluronic acid nano-antioxidant for efficient ROS scavenging to relieve colitis","volume":"16","author":"Xu","year":"2022","journal-title":"ACS Nano"},{"key":"10.1016\/j.ijpx.2025.100320_bb0225","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1159\/000353192","article-title":"Effect of sodium alginate on dextran sulfate sodium - and 2,4,6-trinitrobenzene sulfonic acid-induced experimental colitis in mice","volume":"92","author":"Yamamoto","year":"2013","journal-title":"Pharmacology"},{"key":"10.1016\/j.ijpx.2025.100320_bb0230","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1038\/s41401-022-01045-8","article-title":"MANF ameliorates DSS-induced mouse colitis via restricting Ly6C(hi)CX3CR1(int) macrophage transformation and suppressing CHOP-BATF2 signaling pathway","volume":"44","author":"Yang","year":"2023","journal-title":"Acta. Pharmacol. Sini."},{"key":"10.1016\/j.ijpx.2025.100320_bb0235","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/jcbfm.2009.181","article-title":"Induction profile of MANF\/ARMET by cerebral ischemia and its implication for neuron protection","volume":"30","author":"Yu","year":"2010","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.ijpx.2025.100320_bb0240","doi-asserted-by":"crossref","first-page":"6467679","DOI":"10.1155\/2021\/6467679","article-title":"MANF: a novel endoplasmic reticulum stress response protein-the role in neurological and metabolic disorders","volume":"2021","author":"Yu","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.ijpx.2025.100320_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109608","article-title":"rmMANF prevents sepsis-associated lung injury via inhibiting endoplasmic reticulum stress-induced ferroptosis in mice","volume":"114","author":"Zeng","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ijpx.2025.100320_bb0250","doi-asserted-by":"crossref","first-page":"eabo1981","DOI":"10.1126\/scitranslmed.abo1981","article-title":"Hormonal therapies up-regulate MANF and overcome female susceptibility to immune checkpoint inhibitor myocarditis","volume":"14","author":"Zhang","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ijpx.2025.100320_bb0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2023.120884","article-title":"Hyaluronic acid modified oral drug delivery system with mucoadhesiveness and macrophage-targeting for colitis treatment","volume":"313","author":"Zhang","year":"2023","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijpx.2025.100320_bb0260","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202201651","article-title":"Responsive hydrogels based on triggered click reactions for liver cancer","volume":"34","author":"Zhu","year":"2022","journal-title":"Adv. Mater."},{"key":"10.1016\/j.ijpx.2025.100320_bb0265","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202207418","article-title":"Oral delivery of bioactive glass-loaded core-shell hydrogel microspheres for effective treatment of inflammatory bowel disease","volume":"10","author":"Zhu","year":"2023","journal-title":"Adv. Sci."}],"container-title":["International Journal of Pharmaceutics: X"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590156725000052?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590156725000052?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T20:45:42Z","timestamp":1762634742000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590156725000052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":53,"alternative-id":["S2590156725000052"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpx.2025.100320","relation":{},"ISSN":["2590-1567"],"issn-type":[{"value":"2590-1567","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oral colon-targeted delivery of recombinant human MANF for alleviation of ulcerative colitis","name":"articletitle","label":"Article Title"},{"value":"International Journal of Pharmaceutics: X","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijpx.2025.100320","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100320"}}